JP2005508282A - 新規な脈管形成抑制剤としてのリポキシン類似物 - Google Patents

新規な脈管形成抑制剤としてのリポキシン類似物 Download PDF

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Publication number
JP2005508282A
JP2005508282A JP2002569237A JP2002569237A JP2005508282A JP 2005508282 A JP2005508282 A JP 2005508282A JP 2002569237 A JP2002569237 A JP 2002569237A JP 2002569237 A JP2002569237 A JP 2002569237A JP 2005508282 A JP2005508282 A JP 2005508282A
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lxb
epi
carbon atoms
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lipoxin
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JP2002569237A
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Japanese (ja)
Inventor
サーハン,チヤールズ・エヌ
フイエロ,イオランダ・エム
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ザ・ブリガム・アンド・ウイメンズ・ホスピタル
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203Retinoic acids ; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2002569237A 2001-03-02 2002-03-01 新規な脈管形成抑制剤としてのリポキシン類似物 Withdrawn JP2005508282A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27293101P 2001-03-02 2001-03-02
PCT/US2002/006404 WO2002070068A2 (en) 2001-03-02 2002-03-01 Lipoxin analogs as novel inhibitors of angiogenesis
US10/086,609 US6627658B2 (en) 2001-03-02 2002-03-01 Lipoxin analogs as novel inhibitors of angiogenesis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009256184A Division JP5302856B2 (ja) 2001-03-02 2009-11-09 新規な脈管形成抑制剤としてのリポキシン類似物

Publications (1)

Publication Number Publication Date
JP2005508282A true JP2005508282A (ja) 2005-03-31

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
JP2002569237A Withdrawn JP2005508282A (ja) 2001-03-02 2002-03-01 新規な脈管形成抑制剤としてのリポキシン類似物
JP2009256184A Expired - Fee Related JP5302856B2 (ja) 2001-03-02 2009-11-09 新規な脈管形成抑制剤としてのリポキシン類似物
JP2012195046A Ceased JP2012255025A (ja) 2001-03-02 2012-09-05 新規な脈管形成抑制剤としてのリポキシン類似物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2009256184A Expired - Fee Related JP5302856B2 (ja) 2001-03-02 2009-11-09 新規な脈管形成抑制剤としてのリポキシン類似物
JP2012195046A Ceased JP2012255025A (ja) 2001-03-02 2012-09-05 新規な脈管形成抑制剤としてのリポキシン類似物

Country Status (11)

Country Link
US (4) US6627658B2 (enExample)
EP (2) EP2221089A1 (enExample)
JP (3) JP2005508282A (enExample)
AT (1) ATE412448T1 (enExample)
AU (1) AU2002252175A1 (enExample)
CY (1) CY1108670T1 (enExample)
DE (1) DE60229640D1 (enExample)
DK (1) DK1406698T3 (enExample)
ES (1) ES2316553T3 (enExample)
PT (1) PT1406698E (enExample)
WO (1) WO2002070068A2 (enExample)

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EP1762557B1 (en) 2000-02-16 2011-04-06 The Brigham And Women's Hospital, Inc. Aspirin-triggered lipid mediators
US7700650B2 (en) 2000-03-20 2010-04-20 Trustees Of Boston University Lipoxin analogs and method for the treatment of periodontal disease
DE60229640D1 (de) * 2001-03-02 2008-12-11 Brigham & Womens Hospital Lipoxin analoge als neue inhibitoren der angiogenese
US8722654B2 (en) 2001-03-02 2014-05-13 The Brigham And Women's Hospital, Inc. Lipoxin analogs as novel inhibitors of angiogenesis
US7902257B2 (en) * 2002-04-01 2011-03-08 University Of Southern California Trihydroxy polyunsaturated eicosanoid
US8481772B2 (en) 2002-04-01 2013-07-09 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
WO2004014835A2 (en) * 2002-08-12 2004-02-19 Brigham And Women's Hospital Resolvins: biotemplates for therapeutic interventions
US7759395B2 (en) 2002-08-12 2010-07-20 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
WO2004078143A2 (en) * 2003-03-05 2004-09-16 The Brigham And Women's Hospital Inc. Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs
US20050238589A1 (en) * 2004-04-14 2005-10-27 Van Dyke Thomas E Methods and compositions for preventing or treating periodontal diseases
EP1809270B1 (en) * 2004-11-09 2010-03-24 Alcon Inc. 5,6,7-trihydroxyheptanoic acid and analogs for the treatment of ocular diseases and diseases associated with hyperproliferative and angiogenic responses
WO2007041440A2 (en) * 2005-10-03 2007-04-12 The Brigham And Women's Hospital, Inc. Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers
WO2007061783A1 (en) * 2005-11-18 2007-05-31 Trustees Of Boston University Treatment and prevention of bone loss using resolvins
CA2650607A1 (en) * 2006-04-28 2007-11-08 Resolvyx Pharmaceuticals, Inc. Compositions and methods for the treatment of cardiovascular disease
EP2049099A1 (en) * 2006-07-19 2009-04-22 Resolvyx Pharmaceuticals, Inc. Compositions and methods for the treatment of mucositis
EP2131833A2 (en) * 2006-10-26 2009-12-16 Resolvyx Pharmaceuticals, Inc. Use of resolvins for inhibition of bone loss
WO2008070129A2 (en) * 2006-12-05 2008-06-12 Resolvyx Pharmaceuticals, Inc. Compositions and methods for the treatment of inflammatory disease
EP2184993B1 (en) * 2007-08-08 2011-10-19 Basf Se Aqueous microemulsions containing organic insecticide compounds
EP2207543A2 (en) * 2007-09-14 2010-07-21 Resolvyx Pharmaceuticals, Inc. Omega-3 fatty acids, hydroxy polyunsaturated fatty acids, lipoxin compounds, or oxylipin compounds for treating autoimmune diseases or inhibiting immune function
US20090118243A1 (en) * 2007-10-12 2009-05-07 Resolvyx Pharmaceuticals, Inc. Compositions and methods for the treatment of ophthalmic conditions
EP2219638A2 (en) * 2007-10-29 2010-08-25 Board of Supervisors of Louisiana State University and Agricultural and Mechanical College Lipoxin a4 protection for retinal cells
US7601693B2 (en) * 2008-02-05 2009-10-13 National Taiwan University Composition for treating cancer and use thereof
US20100105772A1 (en) * 2008-04-25 2010-04-29 Serhan Charles N Use of novel lipid mediators to inhibit angiogenesis
AU2014218666B2 (en) * 2013-02-22 2018-11-01 University Of Southern California Methods for treatment of ophthalmic diseases and disorders
KR20160048029A (ko) 2013-03-15 2016-05-03 마르쿠스 카레 토를레이프 라르손 제대혈 수집 및 세포의 분리를 위한 세포, 방법 및 장치
EP3020398A1 (en) * 2014-11-17 2016-05-18 Nitto Denko Corporation Compounds and formulations for reducing scarring
US10130719B2 (en) 2016-06-03 2018-11-20 Thetis Pharmaceuticals Llc Compositions and methods relating to salts of specialized pro-resolving mediators
WO2018073615A1 (en) 2016-10-21 2018-04-26 Longboat Explorers Ab Methods and compositions for generating hematopoietic cells
WO2018144316A1 (en) 2017-01-31 2018-08-09 The Brigham And Women's Hospital, Inc. Alx receptor ligands define a biochemical endotype for inflammation-based diseases
CA3055093A1 (en) * 2017-03-09 2018-09-13 University Health Network Lipoxin and lipoxin analogue mediated neuroprotection and treatments
US12465878B2 (en) 2019-06-20 2025-11-11 Amniotics Ab Apparatus for filtering amniotic fluid
CN114765957B (zh) 2019-10-18 2025-09-12 Amniotics公司 从羊水中获得羊膜间充质干细胞的方法和设备及其来源的细胞
US12435308B2 (en) 2020-11-06 2025-10-07 Amniotics Ab Immunomodulation by amniotic fluid mesenchymal stem cells
KR20240150603A (ko) 2022-03-03 2024-10-15 테티스 파마수티컬스 엘엘씨 특수화된 해소촉진 매개체의 시클로덱스트린 복합체

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US4576758A (en) 1984-06-01 1986-03-18 The Upjohn Company Anti-inflammatory lipoxin B analogs
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EP1762557B1 (en) * 2000-02-16 2011-04-06 The Brigham And Women's Hospital, Inc. Aspirin-triggered lipid mediators
US7700650B2 (en) 2000-03-20 2010-04-20 Trustees Of Boston University Lipoxin analogs and method for the treatment of periodontal disease
DE60229640D1 (de) 2001-03-02 2008-12-11 Brigham & Womens Hospital Lipoxin analoge als neue inhibitoren der angiogenese

Also Published As

Publication number Publication date
WO2002070068A2 (en) 2002-09-12
JP2010059183A (ja) 2010-03-18
US6627658B2 (en) 2003-09-30
EP1406698A2 (en) 2004-04-14
DE60229640D1 (de) 2008-12-11
EP2221089A1 (en) 2010-08-25
US20080064749A1 (en) 2008-03-13
WO2002070068A3 (en) 2003-12-31
ATE412448T1 (de) 2008-11-15
AU2002252175A1 (en) 2002-09-19
JP2012255025A (ja) 2012-12-27
DK1406698T3 (da) 2009-02-09
EP1406698B1 (en) 2008-10-29
JP5302856B2 (ja) 2013-10-02
CY1108670T1 (el) 2014-04-09
US20060009521A1 (en) 2006-01-12
ES2316553T3 (es) 2009-04-16
PT1406698E (pt) 2009-01-12
US20040053998A1 (en) 2004-03-18
US8008282B2 (en) 2011-08-30
US20020193431A1 (en) 2002-12-19

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