JP2010011868A5 - - Google Patents
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- Publication number
- JP2010011868A5 JP2010011868A5 JP2009238784A JP2009238784A JP2010011868A5 JP 2010011868 A5 JP2010011868 A5 JP 2010011868A5 JP 2009238784 A JP2009238784 A JP 2009238784A JP 2009238784 A JP2009238784 A JP 2009238784A JP 2010011868 A5 JP2010011868 A5 JP 2010011868A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- bacteria
- immune response
- neisseria meningitidis
- serosubtype
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000894006 Bacteria Species 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 3
- 241000588677 Neisseria meningitidis serogroup B Species 0.000 claims 2
- 241000588650 Neisseria meningitidis Species 0.000 claims 1
- 229940052778 Neisseria meningitidis Drugs 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000000844 anti-bacterial Effects 0.000 claims 1
- 230000000295 complement Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000001747 exhibiting Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated Effects 0.000 claims 1
- 102000005614 monoclonal antibodies Human genes 0.000 claims 1
- 108010045030 monoclonal antibodies Proteins 0.000 claims 1
Claims (2)
- ＧＮＡ３３ペプチドに対して指向されるモノクローナル抗体を含む、哺乳動物被験体において、Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｂ血清亜型Ｐ１．２細菌に対する免疫応答を誘発するための組成物であって、該ペプチドが、ＤＶＳＡＱＡＦＱＴＰ（配列番号１２）、ＶＳＡＱＡＦＱＴＰＶ（配列番号１３）およびＳＡＱＡＦＱＴＰＶＨ（配列番号１４）からなる群より選択されるアミノ酸配列からなり、該免疫応答は、Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓの血清型Ｂ血清亜型Ｐ１．２細菌に対して補体媒介性殺菌活性および／またはオプソニン活性を示す、組成物。
- 哺乳動物被験体において、Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｂ血清亜型Ｐ１．２細菌に対する免疫応答を誘発するための医薬の製造のための、請求項１に記載の組成物の使用。
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28455401P | 2001-04-17 | 2001-04-17 | |
| US60/284,554 | 2001-04-17 | ||
| US32683801P | 2001-10-03 | 2001-10-03 | |
| US60/326,838 | 2001-10-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008074708A Division JP2008259503A (ja) | 2001-04-17 | 2008-03-21 | 機能活性抗体を誘発する髄膜炎菌性ｂエピトープの分子模倣物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010011868A JP2010011868A (ja) | 2010-01-21 |
| JP2010011868A5 true JP2010011868A5 (ja) | 2012-01-05 |
| JP5215275B2 JP5215275B2 (ja) | 2013-06-19 |
Family
ID=26962673
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002581466A Withdrawn JP2004529643A (ja) | 2001-04-17 | 2002-04-11 | 機能活性抗体を誘発する髄膜炎菌性ｂエピトープの分子模倣物 |
| JP2008074708A Withdrawn JP2008259503A (ja) | 2001-04-17 | 2008-03-21 | 機能活性抗体を誘発する髄膜炎菌性ｂエピトープの分子模倣物 |
| JP2009238784A Expired - Fee Related JP5215275B2 (ja) | 2001-04-17 | 2009-10-15 | 機能活性抗体を誘発する髄膜炎菌性ｂエピトープの分子模倣物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002581466A Withdrawn JP2004529643A (ja) | 2001-04-17 | 2002-04-11 | 機能活性抗体を誘発する髄膜炎菌性ｂエピトープの分子模倣物 |
| JP2008074708A Withdrawn JP2008259503A (ja) | 2001-04-17 | 2008-03-21 | 機能活性抗体を誘発する髄膜炎菌性ｂエピトープの分子模倣物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7534444B2 (ja) |
| EP (1) | EP1379272B1 (ja) |
| JP (3) | JP2004529643A (ja) |
| CN (1) | CN1306956C (ja) |
| AT (1) | ATE455793T1 (ja) |
| AU (1) | AU2002252638A1 (ja) |
| CA (1) | CA2439428C (ja) |
| DE (1) | DE60235155D1 (ja) |
| RU (1) | RU2322451C2 (ja) |
| WO (1) | WO2002083711A2 (ja) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2228454T3 (es) * | 1999-02-26 | 2005-04-16 | Chiron S.R.L. | Mejora de la actividad bacteriana de antigenos de neisseria con oligonucleotidos que contienen motivos cg. |
| US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| CA2929348A1 (en) | 1999-05-19 | 2000-11-30 | Novartis Vaccines And Diagnostics S.R.L. | Combination neisserial compositions |
| AU2000278267A1 (en) | 2000-09-01 | 2002-03-22 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Vibrio cholerae o139 conjugate vaccines |
| GB0024200D0 (en) * | 2000-10-03 | 2000-11-15 | Smithkline Beecham Sa | Component vaccine |
| US7666674B2 (en) | 2001-07-27 | 2010-02-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo |
| WO2003020884A2 (en) * | 2001-08-14 | 2003-03-13 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Method for rapid generation of mature dendritic cells |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| AU2002366710A1 (en) | 2001-12-20 | 2003-07-09 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS |
| US8466116B2 (en) | 2001-12-20 | 2013-06-18 | The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of CpG oligodeoxynucleotides to induce epithelial cell growth |
| US8263091B2 (en) * | 2002-09-18 | 2012-09-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides |
| WO2005023295A2 (en) * | 2003-09-10 | 2005-03-17 | De Staat Der Nederlanden, Vert. Door De Minister Van Vws | Naturally processed immunodominant peptides derived from neisseria meningitidis porin a protein and their use |
| CA2555342A1 (en) * | 2004-02-18 | 2005-09-01 | Merck & Co., Inc. | Polypeptides for inducing a protective immune response against staphylococcus aureus |
| DE102004023906A1 (de) * | 2004-05-13 | 2005-12-22 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Verfahren zur Herstellung von chemischen Mikroarrays |
| ES2352855T3 (es) | 2005-11-30 | 2011-02-23 | International Institute Of Cancer Immunology, Inc. | Nuevos compuestos peptídicos del tumor de wilms. |
| GB0611914D0 (en) * | 2006-06-15 | 2006-07-26 | Teti Giuseppe | Peptides that mimic non-human cross-reactive protective epitopes of the group Bmeningococcal capsulsar polysaccharide |
| US10527329B2 (en) | 2008-04-18 | 2020-01-07 | Denso Corporation | Ejector-type refrigeration cycle device |
| EP3246044B2 (en) | 2010-08-23 | 2024-04-10 | Wyeth LLC | Stable formulations of neisseria meningitidis rlp2086 antigens |
| ES2864635T3 (es) | 2010-09-10 | 2021-10-14 | Wyeth Llc | Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis |
| JP2015517089A (ja) * | 2012-03-08 | 2015-06-18 | ノバルティス アーゲー | タンパク質ベースの髄膜炎菌ワクチンのためのインビトロ有効性アッセイ |
| MY167723A (en) | 2012-03-09 | 2018-09-21 | Pfizer | Neisseria meningitidis compositions and methods thereof |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| ES2685894T3 (es) | 2013-03-08 | 2018-10-15 | Pfizer Inc. | Polipéptidos de fusión inmunogénicos |
| WO2015033251A2 (en) | 2013-09-08 | 2015-03-12 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| KR20190049940A (ko) | 2015-02-19 | 2019-05-09 | 화이자 인코포레이티드 | 나이세리아 메닌지티디스 조성물 및 그의 방법 |
| AU2018215585B2 (en) | 2017-01-31 | 2022-03-17 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4356170A (en) * | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| EP0145359B1 (en) | 1983-11-21 | 1991-01-16 | The Wellcome Foundation Limited | Improved complexes, processes for obtaining them and formulations containing such complexes |
| US4727136A (en) * | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
| US4970070A (en) * | 1986-02-07 | 1990-11-13 | Genetic Systems Corporation | Protective monoclonal antibody compositions for infections due to group B streptococcus |
| AU640118B2 (en) | 1988-12-19 | 1993-08-19 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezonheid En Cultuur | Meningococcal class 1 outer-membrane protein vaccine |
| US5128460A (en) * | 1989-04-04 | 1992-07-07 | Genelabs Incorporated | Recombinant trichosanthin and coding sequence |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| KR0158436B1 (ko) | 1989-12-14 | 1998-12-01 | 피에르 오. 페론 | 개선된 수막염균성 폴리사카라이드 결합체 백신 |
| US5510264A (en) * | 1993-09-28 | 1996-04-23 | Insight Biotech Inc. | Antibodies which bind meningitis related homologous antigenic sequences |
| GB9422096D0 (en) | 1994-11-02 | 1994-12-21 | Biocine Spa | Combined meningitis vaccine |
| US5811102A (en) * | 1995-06-07 | 1998-09-22 | National Research Council Of Canada | Modified meningococcal polysaccharide conjugate vaccines |
| ATE208629T1 (de) | 1996-08-27 | 2001-11-15 | Chiron Corp | Neisseria meningitidis serogruppe b glykokonjugate und verfahren zu deren verwendung |
| ATE252602T1 (de) * | 1996-08-27 | 2003-11-15 | Chiron Corp | Meningokokkus b-epitop ausbildende monoklonale antikoerper und deren verwendung zur herstellung von impfstoffzusammenstellungen |
| ATE505478T1 (de) * | 1997-08-27 | 2011-04-15 | Novartis Vaccines & Diagnostic | Molekular-mimetika von meningokokkalen b epitopen |
| CN101293920B (zh) * | 1998-05-01 | 2012-07-18 | 诺华疫苗和诊断公司 | 脑膜炎奈瑟球菌抗原和组合物 |
| ES2228454T3 (es) * | 1999-02-26 | 2005-04-16 | Chiron S.R.L. | Mejora de la actividad bacteriana de antigenos de neisseria con oligonucleotidos que contienen motivos cg. |
| NZ530640A (en) * | 1999-04-30 | 2006-06-30 | Chiron S | Conserved neisserial antigens |
| ES2391153T3 (es) * | 2000-02-28 | 2012-11-22 | Novartis Vaccines And Diagnostics S.R.L. | Expresión heteróloga de proteínas de Neisseria |
-
2002
- 2002-04-11 US US10/121,456 patent/US7534444B2/en not_active Expired - Fee Related
- 2002-04-11 JP JP2002581466A patent/JP2004529643A/ja not_active Withdrawn
- 2002-04-11 CN CNB028081668A patent/CN1306956C/zh not_active Expired - Fee Related
- 2002-04-11 WO PCT/US2002/011501 patent/WO2002083711A2/en active Search and Examination
- 2002-04-11 AU AU2002252638A patent/AU2002252638A1/en not_active Abandoned
- 2002-04-11 CA CA2439428A patent/CA2439428C/en not_active Expired - Fee Related
- 2002-04-11 AT AT02721722T patent/ATE455793T1/de not_active IP Right Cessation
- 2002-04-11 RU RU2003133300/13A patent/RU2322451C2/ru not_active IP Right Cessation
- 2002-04-11 EP EP02721722A patent/EP1379272B1/en not_active Expired - Lifetime
- 2002-04-11 DE DE60235155T patent/DE60235155D1/de not_active Expired - Lifetime
-
2008
- 2008-03-21 JP JP2008074708A patent/JP2008259503A/ja not_active Withdrawn
-
2009
- 2009-10-15 JP JP2009238784A patent/JP5215275B2/ja not_active Expired - Fee Related
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