JP2009545645A5 - - Google Patents
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- Publication number
- JP2009545645A5 JP2009545645A5 JP2009522326A JP2009522326A JP2009545645A5 JP 2009545645 A5 JP2009545645 A5 JP 2009545645A5 JP 2009522326 A JP2009522326 A JP 2009522326A JP 2009522326 A JP2009522326 A JP 2009522326A JP 2009545645 A5 JP2009545645 A5 JP 2009545645A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- group
- conjugate according
- btm
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- IHDBZCJYSHDCKF-UHFFFAOYSA-N 4,6-dichlorotriazine Chemical compound ClC1=CC(Cl)=NN=N1 IHDBZCJYSHDCKF-UHFFFAOYSA-N 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical class O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- DZBUGLKDJFMEHC-UHFFFAOYSA-O acridine;hydron Chemical compound C1=CC=CC2=CC3=CC=CC=C3[NH+]=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-O 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 239000002532 enzyme inhibitor Substances 0.000 claims 1
- 229940125532 enzyme inhibitor Drugs 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- SMWDFEZZVXVKRB-UHFFFAOYSA-O hydron;quinoline Chemical compound [NH+]1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-O 0.000 claims 1
- 150000002540 isothiocyanates Chemical class 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 150000008300 phosphoramidites Chemical class 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- WVIICGIFSIBFOG-UHFFFAOYSA-N pyrylium Chemical compound C1=CC=[O+]C=C1 WVIICGIFSIBFOG-UHFFFAOYSA-N 0.000 claims 1
- 125000001453 quaternary ammonium group Chemical class 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0615211A GB0615211D0 (en) | 2006-07-31 | 2006-07-31 | Asymmetric flouro-substituted polymethine dyes |
| GB0615211.0 | 2006-07-31 | ||
| PCT/GB2007/002907 WO2008015415A2 (en) | 2006-07-31 | 2007-07-31 | Asymmetric fluoro-substituted polymethine dyes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009545645A JP2009545645A (ja) | 2009-12-24 |
| JP2009545645A5 true JP2009545645A5 (https=) | 2010-08-26 |
| JP5341757B2 JP5341757B2 (ja) | 2013-11-13 |
Family
ID=37006503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009522326A Expired - Fee Related JP5341757B2 (ja) | 2006-07-31 | 2007-07-31 | 非対称フルオロ置換ポリメチン色素 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090252687A1 (https=) |
| EP (1) | EP2046895A2 (https=) |
| JP (1) | JP5341757B2 (https=) |
| CN (1) | CN101522815A (https=) |
| GB (1) | GB0615211D0 (https=) |
| WO (1) | WO2008015415A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0718967D0 (en) * | 2007-09-28 | 2007-11-07 | Ge Healthcare Ltd | Peptide imaging agents |
| GB0718957D0 (en) * | 2007-09-28 | 2007-11-07 | Ge Healthcare Ltd | Optical imaging agents |
| EP2201009B1 (en) | 2007-10-02 | 2016-10-26 | Thermo Fisher Scientific Inc. | Monomethine dyes |
| US10493169B2 (en) | 2009-02-06 | 2019-12-03 | Beth Israel Deaconess Medical Center | Use of charge-balanced imaging agents for determining renal function |
| JP5798043B2 (ja) | 2009-02-06 | 2015-10-21 | ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド | 電荷均衡造影剤 |
| US8546586B2 (en) * | 2009-04-28 | 2013-10-01 | Wako Pure Chemical Industries, Ltd. | Pyrazole-based cyanine dye containing quaternary ammonium cation |
| TWI516264B (zh) * | 2010-05-06 | 2016-01-11 | 臺北醫學大學 | 芳香醯喹啉化合物 |
| CN103052690A (zh) * | 2010-06-29 | 2013-04-17 | 通用电气医疗集团股份有限公司 | 染料组合物和染料合成 |
| DE102010027016A1 (de) | 2010-07-09 | 2012-01-12 | Universitätsklinikum Jena | Steroid-Styrylfarbstoff-Konjugate zur Simulation und direkten lichtoptischen Detektion des Verhaltens von Steroiden im lebenden biologischen Gewebe und in Gegenwart von steroidbindenden Proteinen |
| GB201013808D0 (en) | 2010-08-18 | 2010-09-29 | Ge Healthcare Ltd | Peptide radiotracer compositions |
| US20130287689A1 (en) * | 2010-11-02 | 2013-10-31 | Life Technologies Corporation | Modified Hydrocyanine Dyes for the Detection of Reactive Oxygen Species |
| US9518981B2 (en) | 2012-03-30 | 2016-12-13 | Life Technologies Corporation | Modified nucleic acid binding cyanine dyes for the detection of reactive oxygen species |
| US9676787B2 (en) | 2012-08-28 | 2017-06-13 | Pierce Biotechnology, Inc. | Benzopyrylium compounds |
| CA2891280C (en) | 2012-11-24 | 2018-03-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| EP2970318B1 (en) | 2013-03-14 | 2018-11-21 | Profusa, Inc. | Oxygen sensors comprising a polymer and a luminescent dye |
| GB201314936D0 (en) | 2013-08-21 | 2013-10-02 | Ge Healthcare Ltd | Radiolabelling method |
| GB201322456D0 (en) | 2013-12-18 | 2014-02-05 | Ge Healthcare Ltd | Radiotracer compositions and methods |
| CN104804463B (zh) * | 2015-03-10 | 2016-08-24 | 西安交通大学第一附属医院 | 用于靶向肿瘤组织的近红外荧光染色剂及制备方法和应用 |
| CN110352036B (zh) * | 2016-12-21 | 2022-11-15 | 普罗菲尤萨股份有限公司 | 可聚合的近红外染料 |
| EP3375353A1 (en) * | 2017-03-16 | 2018-09-19 | Universität Zürich | Photoacoustic imaging of inflamed tissue |
| WO2018187295A1 (en) | 2017-04-03 | 2018-10-11 | Massachusetts Institute Of Technology | Near and shortwave infrared polymethine dyes |
| EP3634397A4 (en) | 2017-06-05 | 2021-03-17 | The Regents of The University of California | HETEROCYCLYL POLYMETHINE-BASED IR CHROMOPHORES |
| CN111712468A (zh) * | 2017-12-22 | 2020-09-25 | 北卡罗莱纳州立大学 | 聚合物荧光团、包含其的组合物及制备和使用其的方法 |
| KR20210040953A (ko) | 2018-06-27 | 2021-04-14 | 프로퓨사 인코퍼레이티드 | 근적외선 글루코스 센서 |
| CN117368301B (zh) * | 2022-06-29 | 2026-04-14 | 中国科学院大连化学物理研究所 | 一种组织中巯基化合物的质谱成像检测方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5658751A (en) * | 1993-04-13 | 1997-08-19 | Molecular Probes, Inc. | Substituted unsymmetrical cyanine dyes with selected permeability |
| US6495692B1 (en) * | 1996-12-10 | 2002-12-17 | Abbott Laboratories | Helium-neon excitable reticulocyte dyes derivable from halolepidines |
| WO2000034394A2 (de) * | 1998-12-05 | 2000-06-15 | Otto Samuel Wolfbeis | Pyridin- und chinolin-farbstoffe als marker für biomoleküle, polymere, arzneistoffe und partikel |
| DE19917713A1 (de) * | 1999-04-09 | 2000-10-19 | Diagnostikforschung Inst | Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik |
| TR201809435T4 (tr) * | 2000-01-19 | 2018-07-23 | Abbvie Inc | Geliştirilmiş farmasötik formülasyonlar. |
| EP1283855B1 (de) * | 2000-05-23 | 2005-11-02 | Dyomics GmbH | Stabile nir-marker-farbstoffe auf der basis von benzopyrylium-polymethinen |
| BRPI0210886B8 (pt) * | 2001-07-10 | 2021-05-25 | Amersham Health As | composto, composição farmacêutica, uso de um composto, e, métodos de geração de imagens, de monitoração do efeito do tratamento de um corpo humano ou animal com uma droga para combater uma condição associada com câncer e de tratamento de câncer ou de uma doença relacionada em um corpo humano ou animal |
| TWI244494B (en) * | 2003-05-14 | 2005-12-01 | Ritek Corp | Optical recording medium dye |
| CA2599709A1 (en) * | 2005-03-09 | 2006-09-21 | Cepheid | Polar dyes |
-
2006
- 2006-07-31 GB GB0615211A patent/GB0615211D0/en not_active Ceased
-
2007
- 2007-07-31 JP JP2009522326A patent/JP5341757B2/ja not_active Expired - Fee Related
- 2007-07-31 EP EP07789086A patent/EP2046895A2/en not_active Withdrawn
- 2007-07-31 WO PCT/GB2007/002907 patent/WO2008015415A2/en not_active Ceased
- 2007-07-31 US US12/375,239 patent/US20090252687A1/en not_active Abandoned
- 2007-07-31 CN CN 200780036717 patent/CN101522815A/zh active Pending
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