JP2000503707A - スルホインドシアニン染料の合成のための化合物及び合成方法 - Google Patents
スルホインドシアニン染料の合成のための化合物及び合成方法Info
- Publication number
- JP2000503707A JP2000503707A JP10508925A JP50892598A JP2000503707A JP 2000503707 A JP2000503707 A JP 2000503707A JP 10508925 A JP10508925 A JP 10508925A JP 50892598 A JP50892598 A JP 50892598A JP 2000503707 A JP2000503707 A JP 2000503707A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- sulfoindocyanine
- dyes
- group
- synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. スルホインドシアニン染料を合成するためのインドレニン核を有する化合物 であって、下記構造を有する化合物: (式中、XはCH3 −C−CH3 、O及びSからなる群から選択され; Zはインドレニン核がAに結合するための結合基であり;及び Aは酵素基質及び特異的結合対のメンバーからなる群から選択される) 2. XがCH3 −C−CH3 であり、Zが−(CH2 )5 −C(O)−NH−( CH2 )2 −であり、Aがフェノール基である、請求の範囲第1項記載の化合 物。 3. 下記式を有するスルホインドシアニン染料。 (式中、mは1、2又は3である。) 4. 以下の第一の化合物、第二の化合物及び試薬を弱塩基溶媒中で還流下に少な くとも1時間反応させる、スルホインドシアニン染料の製造方法。 a)インドルニン核を有する第一の化合物であり、下記構造を有する化合物 ; (式中、XはCH3 −C−CH3 、O及びSからなる群から選択され; Zはインドレニン核がAに結合するための結合基であり:及び Aは酵素基質及び特異的結合対のメンバーからなる群から選択される) b)第一の化合物と、同一又は異なる、インドレニン核を有する第二の化合 物; c)第一の化合物を第二の化合物に結合するための試薬。 5. XがCH3 −C−CH3 であり、Zが−(CH2 )5 −C(O)−NH−( CH2 )2 −であり、Aがフェノール基である、請求の範囲第4項記載の製造 方法。 6. 請求の範囲第4項又は5項に記載の製造方法により製造されたスルホインド シアニン染料。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/687,853 US5688966A (en) | 1996-07-26 | 1996-07-26 | Compounds and method for synthesizing sulfoindocyanine dyes |
US08/687,853 | 1996-07-26 | ||
PCT/US1997/012797 WO1998004635A1 (en) | 1996-07-26 | 1997-07-21 | Compounds and method for synthesizing sulfoindocyanine dyes |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006221123A Division JP2007016038A (ja) | 1996-07-26 | 2006-08-14 | スルホインドシアニン染料の合成のための化合物及び合成方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000503707A true JP2000503707A (ja) | 2000-03-28 |
JP3863920B2 JP3863920B2 (ja) | 2006-12-27 |
Family
ID=24762139
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50892598A Expired - Lifetime JP3863920B2 (ja) | 1996-07-26 | 1997-07-21 | スルホインドシアニン染料の合成のための化合物及び合成方法 |
JP2006221123A Pending JP2007016038A (ja) | 1996-07-26 | 2006-08-14 | スルホインドシアニン染料の合成のための化合物及び合成方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006221123A Pending JP2007016038A (ja) | 1996-07-26 | 2006-08-14 | スルホインドシアニン染料の合成のための化合物及び合成方法 |
Country Status (6)
Country | Link |
---|---|
US (2) | US5688966A (ja) |
EP (1) | EP0882097B1 (ja) |
JP (2) | JP3863920B2 (ja) |
AT (1) | ATE256166T1 (ja) |
DE (1) | DE69726709T2 (ja) |
WO (1) | WO1998004635A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002542365A (ja) * | 1999-04-19 | 2002-12-10 | エヌ・イー・エヌ・ライフ・サイエンス・プロダクツ・インコーポレイテッド | シアニン色素及びその合成法 |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5741632A (en) * | 1995-12-14 | 1998-04-21 | Agfa-Gevaert, N.V. | Class of non-sensitizing infra-red dyes for use in photosensitive elements |
US5688966A (en) * | 1996-07-26 | 1997-11-18 | E. I. Du Pont De Nemours And Company | Compounds and method for synthesizing sulfoindocyanine dyes |
US6307029B1 (en) | 1996-11-08 | 2001-10-23 | Matsushita Electric Industrial Co., Ltd. | Dye-labeled protein conjugate and method for preparing the same |
JPH11322800A (ja) * | 1998-05-14 | 1999-11-24 | Matsushita Electric Ind Co Ltd | 色素標識タンパク質複合体およびその製造方法 |
DE19824487A1 (de) | 1998-06-02 | 1999-12-09 | Bayer Ag | Substituierte 3-Thiocarbamoylpyrazole |
US6372937B1 (en) | 1998-11-09 | 2002-04-16 | Mark Norman Bobrow | Enhanced catalyzed reporter deposition |
ATE352586T2 (de) | 2000-09-29 | 2007-02-15 | Molecular Probes Inc | Modifizierte carbocyaninfarbstoffe und deren konjugate |
US6706879B2 (en) * | 2001-02-28 | 2004-03-16 | Stratagene | Fluorescent dye |
US6617125B2 (en) | 2001-06-29 | 2003-09-09 | Perkinelmer Life Sciences, Inc. | Compositions for enhanced catalyzed reporter deposition |
CA2490961A1 (en) * | 2002-07-01 | 2004-01-08 | Guava Technologies, Inc. | Fluorescent dyes, energy transfer couples and methods |
CA2698390C (en) | 2007-09-18 | 2018-05-22 | Dako Denmark A/S | A rapid and sensitive method for detection of biological targets |
JP5721639B2 (ja) | 2009-02-19 | 2015-05-20 | ダコ・デンマーク・エー/エス | 分子標的の検出のための方法と化合物 |
WO2010120058A2 (ko) | 2009-04-17 | 2010-10-21 | 한국과학기술연구원 | 생체 분자 표지를 위한 신규 시아닌 화합물 및 그 제조방법 |
CN104714007B (zh) | 2009-10-20 | 2017-04-12 | 丹麦达科有限公司 | 单个靶实体的免疫化学检测 |
DK2831587T3 (en) | 2012-03-27 | 2018-07-23 | Ventana Med Syst Inc | Signaling conjugates and methods of use |
US9012643B2 (en) | 2012-10-24 | 2015-04-21 | Becton, Dickinson And Company | Hydroxamate substituted azaindoline-cyanine dyes and bioconjugates of the same |
KR101953819B1 (ko) * | 2017-12-22 | 2019-03-06 | (주)바이오액츠 | 생체 분자 표지를 위한 신규 시아닌 화합물 및 그 제조방법 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4948882A (en) * | 1983-02-22 | 1990-08-14 | Syngene, Inc. | Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis |
JPS62123454A (ja) * | 1985-08-08 | 1987-06-04 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
US5268486A (en) * | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
DE3912046B4 (de) * | 1988-09-02 | 2004-03-25 | Carnegie Mellon University | Verfahren zum Markieren einer Komponente einer wäßrigen Flüssigkeit und lumineszenzphotostabiles Reaktionsprodukt |
US5196306A (en) * | 1989-03-29 | 1993-03-23 | E. I. Du Pont De Nemours And Company | Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system |
US4981977A (en) * | 1989-06-09 | 1991-01-01 | Carnegie-Mellon University | Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups |
US5378634A (en) * | 1992-08-20 | 1995-01-03 | Matsushita Electric Industrial Co., Ltd. | Labelling color for detecting methamphetamine |
JPH06123740A (ja) * | 1992-10-12 | 1994-05-06 | Canon Inc | 蛋白質標識用(メロ)シアニン色素、及び色素標識蛋白質 |
DE4445065A1 (de) * | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
US5688966A (en) * | 1996-07-26 | 1997-11-18 | E. I. Du Pont De Nemours And Company | Compounds and method for synthesizing sulfoindocyanine dyes |
-
1996
- 1996-07-26 US US08/687,853 patent/US5688966A/en not_active Expired - Lifetime
-
1997
- 1997-06-04 US US08/869,032 patent/US5767287A/en not_active Expired - Lifetime
- 1997-07-21 DE DE69726709T patent/DE69726709T2/de not_active Expired - Lifetime
- 1997-07-21 AT AT97938012T patent/ATE256166T1/de not_active IP Right Cessation
- 1997-07-21 EP EP97938012A patent/EP0882097B1/en not_active Expired - Lifetime
- 1997-07-21 WO PCT/US1997/012797 patent/WO1998004635A1/en active IP Right Grant
- 1997-07-21 JP JP50892598A patent/JP3863920B2/ja not_active Expired - Lifetime
-
2006
- 2006-08-14 JP JP2006221123A patent/JP2007016038A/ja active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002542365A (ja) * | 1999-04-19 | 2002-12-10 | エヌ・イー・エヌ・ライフ・サイエンス・プロダクツ・インコーポレイテッド | シアニン色素及びその合成法 |
Also Published As
Publication number | Publication date |
---|---|
DE69726709T2 (de) | 2004-10-07 |
JP3863920B2 (ja) | 2006-12-27 |
DE69726709D1 (de) | 2004-01-22 |
EP0882097A1 (en) | 1998-12-09 |
WO1998004635A1 (en) | 1998-02-05 |
JP2007016038A (ja) | 2007-01-25 |
EP0882097B1 (en) | 2003-12-10 |
ATE256166T1 (de) | 2003-12-15 |
US5767287A (en) | 1998-06-16 |
US5688966A (en) | 1997-11-18 |
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