WO2010120058A2 - 생체 분자 표지를 위한 신규 시아닌 화합물 및 그 제조방법 - Google Patents

생체 분자 표지를 위한 신규 시아닌 화합물 및 그 제조방법 Download PDF

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Publication number
WO2010120058A2
WO2010120058A2 PCT/KR2010/002046 KR2010002046W WO2010120058A2 WO 2010120058 A2 WO2010120058 A2 WO 2010120058A2 KR 2010002046 W KR2010002046 W KR 2010002046W WO 2010120058 A2 WO2010120058 A2 WO 2010120058A2
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
cyanine compound
novel cyanine
labelling biomolecules
biomolecules
Prior art date
Application number
PCT/KR2010/002046
Other languages
English (en)
French (fr)
Other versions
WO2010120058A3 (ko
Inventor
김동진
김영수
나종주
박진우
김기원
Original Assignee
한국과학기술연구원
주식회사 디케이씨코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한국과학기술연구원, 주식회사 디케이씨코포레이션 filed Critical 한국과학기술연구원
Priority to US13/264,258 priority Critical patent/US8729276B2/en
Publication of WO2010120058A2 publication Critical patent/WO2010120058A2/ko
Publication of WO2010120058A3 publication Critical patent/WO2010120058A3/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Abstract

본 발명은 생체 분자 표지를 위한 다음 화학식 1로 표시되는 신규 시아닌 화합물 및 그 제조 방법에 관한 것이다. [화학식 1] 식 중에서, R1, R2, R3, R4, B, m 및 n은 각각 명세서에 정의한 바와 같다.
PCT/KR2010/002046 2009-04-17 2010-04-02 생체 분자 표지를 위한 신규 시아닌 화합물 및 그 제조방법 WO2010120058A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/264,258 US8729276B2 (en) 2009-04-17 2010-04-02 Cyanine compound for labeling biomolecule and preparation method thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0033867 2009-04-17
KR20090033867 2009-04-17

Publications (2)

Publication Number Publication Date
WO2010120058A2 true WO2010120058A2 (ko) 2010-10-21
WO2010120058A3 WO2010120058A3 (ko) 2011-03-31

Family

ID=42982957

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/002046 WO2010120058A2 (ko) 2009-04-17 2010-04-02 생체 분자 표지를 위한 신규 시아닌 화합물 및 그 제조방법

Country Status (4)

Country Link
US (1) US8729276B2 (ko)
KR (1) KR101149535B1 (ko)
TW (1) TWI429627B (ko)
WO (1) WO2010120058A2 (ko)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4066818A1 (en) 2021-04-01 2022-10-05 Agfa-Gevaert Nv Near infrared absorbing composite resin particles
WO2022207534A1 (en) 2021-04-01 2022-10-06 Agfa-Gevaert Nv Nir absorbing capsules

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101612095B1 (ko) * 2014-01-16 2016-04-26 한국과학기술연구원 바이오마커의 조기 검출 및 정밀 정량화가 가능한 바이오마커 탐지용 프로브 및 이의 용도
KR102253839B1 (ko) 2017-11-16 2021-05-20 에스에프씨 주식회사 표지용 염료 및 이를 포함하는 키트
WO2019098756A2 (ko) * 2017-11-16 2019-05-23 주식회사 에스에프씨 표지용 염료 및 이를 포함하는 키트
KR101953819B1 (ko) * 2017-12-22 2019-03-06 (주)바이오액츠 생체 분자 표지를 위한 신규 시아닌 화합물 및 그 제조방법
CN113462186A (zh) * 2021-08-23 2021-10-01 江西高信前沿科技有限公司 一种磺基-Cy3羧酸荧光染料及其制备工艺
KR102617827B1 (ko) * 2021-12-30 2023-12-27 (주)바이오액츠 미생물을 검출하기 위한 조성물

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6002003A (en) * 1998-04-14 1999-12-14 Beckman Instruments, Inc. Cyanine dye activating group with improved coupling selectivity
WO2004005933A1 (en) * 2002-07-08 2004-01-15 Amersham Biosciences Uk Limited Reagents and a method for saturation labelling of proteins
US20040023408A1 (en) * 2002-07-30 2004-02-05 Cotton Graham John Site-specific labelling of proteins using cyanine dye reporters

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268486A (en) 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US6127134A (en) 1995-04-20 2000-10-03 Carnegie Mellon University Difference gel electrophoresis using matched multiple dyes
US5688966A (en) 1996-07-26 1997-11-18 E. I. Du Pont De Nemours And Company Compounds and method for synthesizing sulfoindocyanine dyes
JP4104704B2 (ja) 1997-10-01 2008-06-18 シスメックス株式会社 自動分析装置用洗浄剤
JP3698708B2 (ja) * 2003-08-07 2005-09-21 旭電化工業株式会社 シアニン化合物、光学記録材料及び光学記録媒体
US7750163B2 (en) * 2003-10-31 2010-07-06 GE Healthcare U.K. Limited Cyanine dye labelling reagents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6002003A (en) * 1998-04-14 1999-12-14 Beckman Instruments, Inc. Cyanine dye activating group with improved coupling selectivity
WO2004005933A1 (en) * 2002-07-08 2004-01-15 Amersham Biosciences Uk Limited Reagents and a method for saturation labelling of proteins
US20040023408A1 (en) * 2002-07-30 2004-02-05 Cotton Graham John Site-specific labelling of proteins using cyanine dye reporters

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HERMANN J. GRUBER ET AL.: 'Preparation of Thiol-Reactive Cy5 Derivatives from Commercial Cy5 Succinimidyl Ester' BIOCONJUGATE CHEM. vol. 11, 2000, pages 161 - 166 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4066818A1 (en) 2021-04-01 2022-10-05 Agfa-Gevaert Nv Near infrared absorbing composite resin particles
WO2022207705A1 (en) 2021-04-01 2022-10-06 Agfa-Gevaert Nv Near infrared absorbing composite resin particles
WO2022207534A1 (en) 2021-04-01 2022-10-06 Agfa-Gevaert Nv Nir absorbing capsules

Also Published As

Publication number Publication date
WO2010120058A3 (ko) 2011-03-31
KR20100115301A (ko) 2010-10-27
US20120095187A1 (en) 2012-04-19
KR101149535B1 (ko) 2012-05-25
TWI429627B (zh) 2014-03-11
US8729276B2 (en) 2014-05-20
TW201043600A (en) 2010-12-16

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