DE69726709T2 - Verbindungen und verfahren zur herstellung von sulphoindocyaninfarbstoffen - Google Patents

Verbindungen und verfahren zur herstellung von sulphoindocyaninfarbstoffen Download PDF

Info

Publication number
DE69726709T2
DE69726709T2 DE69726709T DE69726709T DE69726709T2 DE 69726709 T2 DE69726709 T2 DE 69726709T2 DE 69726709 T DE69726709 T DE 69726709T DE 69726709 T DE69726709 T DE 69726709T DE 69726709 T2 DE69726709 T2 DE 69726709T2
Authority
DE
Germany
Prior art keywords
dyes
intermediates
sulphoindocyanine
compounds
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69726709T
Other languages
English (en)
Other versions
DE69726709D1 (de
Inventor
Norman Bobrow
Joseph Erickson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PerkinElmer Health Sciences Inc
Original Assignee
NEN Life Science Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NEN Life Science Products Inc filed Critical NEN Life Science Products Inc
Publication of DE69726709D1 publication Critical patent/DE69726709D1/de
Application granted granted Critical
Publication of DE69726709T2 publication Critical patent/DE69726709T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69726709T 1996-07-26 1997-07-21 Verbindungen und verfahren zur herstellung von sulphoindocyaninfarbstoffen Expired - Lifetime DE69726709T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/687,853 US5688966A (en) 1996-07-26 1996-07-26 Compounds and method for synthesizing sulfoindocyanine dyes
PCT/US1997/012797 WO1998004635A1 (en) 1996-07-26 1997-07-21 Compounds and method for synthesizing sulfoindocyanine dyes

Publications (2)

Publication Number Publication Date
DE69726709D1 DE69726709D1 (de) 2004-01-22
DE69726709T2 true DE69726709T2 (de) 2004-10-07

Family

ID=24762139

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69726709T Expired - Lifetime DE69726709T2 (de) 1996-07-26 1997-07-21 Verbindungen und verfahren zur herstellung von sulphoindocyaninfarbstoffen

Country Status (6)

Country Link
US (2) US5688966A (de)
EP (1) EP0882097B1 (de)
JP (2) JP3863920B2 (de)
AT (1) ATE256166T1 (de)
DE (1) DE69726709T2 (de)
WO (1) WO1998004635A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5741632A (en) * 1995-12-14 1998-04-21 Agfa-Gevaert, N.V. Class of non-sensitizing infra-red dyes for use in photosensitive elements
US5688966A (en) * 1996-07-26 1997-11-18 E. I. Du Pont De Nemours And Company Compounds and method for synthesizing sulfoindocyanine dyes
US6307029B1 (en) 1996-11-08 2001-10-23 Matsushita Electric Industrial Co., Ltd. Dye-labeled protein conjugate and method for preparing the same
JPH11322800A (ja) * 1998-05-14 1999-11-24 Matsushita Electric Ind Co Ltd 色素標識タンパク質複合体およびその製造方法
DE19824487A1 (de) 1998-06-02 1999-12-09 Bayer Ag Substituierte 3-Thiocarbamoylpyrazole
US6372937B1 (en) 1998-11-09 2002-04-16 Mark Norman Bobrow Enhanced catalyzed reporter deposition
US6114350A (en) * 1999-04-19 2000-09-05 Nen Life Science Products, Inc. Cyanine dyes and synthesis methods thereof
EP2325263B1 (de) 2000-09-29 2013-01-23 Life Technologies Corporation Modifizierte Carbocyaninfarbstoffe und deren Konjugate
AU2002306620A1 (en) * 2001-02-28 2002-09-12 Stratagene Fluorescent dye
US6617125B2 (en) 2001-06-29 2003-09-09 Perkinelmer Life Sciences, Inc. Compositions for enhanced catalyzed reporter deposition
AU2003280470A1 (en) * 2002-07-01 2004-01-19 Guava Technologies, Inc. Fluorescent dyes, energy transfer couples and methods
CN101836117B (zh) 2007-09-18 2014-07-23 丹麦达科有限公司 用于检测生物靶点的快速和灵敏的方法
US8435735B2 (en) 2009-02-19 2013-05-07 Dako Denmark A/S Methods and compounds for detection of molecular targets
WO2010120058A2 (ko) 2009-04-17 2010-10-21 한국과학기술연구원 생체 분자 표지를 위한 신규 시아닌 화합물 및 그 제조방법
WO2011047680A1 (en) 2009-10-20 2011-04-28 Dako Denmark A/S Immunochemical detection of single target entities
ES2678211T3 (es) 2012-03-27 2018-08-09 Ventana Medical Systems, Inc. Conjugados de señalización y procedimientos de uso
BR112015003160A2 (pt) 2012-10-24 2017-07-04 Becton Dickinson Co corantes de azaindolina - cianina substituídos por hidroxamato e bioconjugados dos mesmos
KR101953819B1 (ko) * 2017-12-22 2019-03-06 (주)바이오액츠 생체 분자 표지를 위한 신규 시아닌 화합물 및 그 제조방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948882A (en) * 1983-02-22 1990-08-14 Syngene, Inc. Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
JPS62123454A (ja) * 1985-08-08 1987-06-04 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
DE3912046B4 (de) * 1988-09-02 2004-03-25 Carnegie Mellon University Verfahren zum Markieren einer Komponente einer wäßrigen Flüssigkeit und lumineszenzphotostabiles Reaktionsprodukt
US5196306A (en) * 1989-03-29 1993-03-23 E. I. Du Pont De Nemours And Company Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system
US4981977A (en) * 1989-06-09 1991-01-01 Carnegie-Mellon University Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups
US5378634A (en) * 1992-08-20 1995-01-03 Matsushita Electric Industrial Co., Ltd. Labelling color for detecting methamphetamine
JPH06123740A (ja) * 1992-10-12 1994-05-06 Canon Inc 蛋白質標識用（メロ）シアニン色素、及び色素標識蛋白質
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
US5688966A (en) * 1996-07-26 1997-11-18 E. I. Du Pont De Nemours And Company Compounds and method for synthesizing sulfoindocyanine dyes

Also Published As

Publication number Publication date
US5688966A (en) 1997-11-18
WO1998004635A1 (en) 1998-02-05
JP2007016038A (ja) 2007-01-25
JP3863920B2 (ja) 2006-12-27
DE69726709D1 (de) 2004-01-22
JP2000503707A (ja) 2000-03-28
US5767287A (en) 1998-06-16
EP0882097B1 (de) 2003-12-10
EP0882097A1 (de) 1998-12-09
ATE256166T1 (de) 2003-12-15

Similar Documents

Publication Publication Date Title
DE69726709T2 (de) Verbindungen und verfahren zur herstellung von sulphoindocyaninfarbstoffen
WO1998030992A3 (en) Fluorescent cyanine dyes
HK1093520A1 (en) Cyanine dye labelling reagents
DE69128918T2 (de) Verfahren, testsätze und reaktive träger zur 3'-markierung von oligonukleotiden
DE69632456D1 (de) Nukleinsäuresynthese unter verwendung von mittels licht abspaltbaren schutzgruppen
DE69711395D1 (de) Verfahren zur herstellung von cyclohexen-carboxylatderivate
DE69737683D1 (de) Antikörper gegen die ed-b domäne von fibronektin, ihre herstellung und verwendungen
DE59708838D1 (de) Spiegelselektion und spiegelevolution von nucleinsäuren
CY1111278T1 (el) Συστημα ασφαλειας
ATE249628T1 (de) Chemilumineszente energietransfer-konjugate und ihre verwendung als markierungsmittel in bindungstests
ATE208827T1 (de) Konjugate von dns und pns und verfahren zu deren herstellung
CA2181841A1 (en) Transport vehicles for macromolecules
AU3143897A (en) Oligonucleotides which specifically bind retroviral nucleocapsid proteins
ATE237585T1 (de) Substituierte 3,3-diamino-2-propennitrile, ihre herstellung und verwendung
WO2004039894A3 (en) Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups
ATE271394T1 (de) Hybride zusammensetzungen für intrazellulaire verabreichung
ATE208502T1 (de) Reagenzien und verfahren zur detektion und quantitativen bestimmung von testosteron in flüssigen proben
DE69731112D1 (de) Verfahren zur synthese von phosphorothioat-oligonukelotiden
DE69808771D1 (de) Ein verfahren zur herstellung von tetraaza makrocyclen
ATE389696T1 (de) Farbstoffmischungen von faserreaktiven azofarbstoffen, deren herstellung und ihre verwendung
DE60002644D1 (de) Farbstoffmischungen von faserreaktiven Azofarbstoffen und ihre Verwendung zum Färben von hydroxy- und/oder carbonamidgruppenhaltigem Material
ES2156128T3 (es) Haptenos, trazadores, inmunogenos y anticuerpos para derivados de carbazol y de dibenzofurano.
DE50214965D1 (de) Reaktive azofarbstoffe, verfahren zu ihrer herstellung und ihre verwendung
KR970703395A (ko) 친핵성기 및 친전자성기를 갖는 염료(Dyes Containing Nucleophilic and Electrophilic Groups)

Legal Events

Date Code Title Description
8364 No opposition during term of opposition