DE69128918T2 - Verfahren, testsätze und reaktive träger zur 3'-markierung von oligonukleotiden - Google Patents

Verfahren, testsätze und reaktive träger zur 3'-markierung von oligonukleotiden

Info

Publication number
DE69128918T2
DE69128918T2 DE69128918T DE69128918T DE69128918T2 DE 69128918 T2 DE69128918 T2 DE 69128918T2 DE 69128918 T DE69128918 T DE 69128918T DE 69128918 T DE69128918 T DE 69128918T DE 69128918 T2 DE69128918 T2 DE 69128918T2
Authority
DE
Germany
Prior art keywords
oligonucleotides
labeling
useful
arm
attaches
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69128918T
Other languages
English (en)
Other versions
DE69128918D1 (de
Inventor
James Fino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of DE69128918D1 publication Critical patent/DE69128918D1/de
Application granted granted Critical
Publication of DE69128918T2 publication Critical patent/DE69128918T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
DE69128918T 1990-12-20 1991-12-19 Verfahren, testsätze und reaktive träger zur 3'-markierung von oligonukleotiden Expired - Fee Related DE69128918T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/630,908 US5290925A (en) 1990-12-20 1990-12-20 Methods, kits, and reactive supports for 3' labeling of oligonucleotides
PCT/US1991/009657 WO1992011388A1 (en) 1990-12-20 1991-12-19 Methods, kits and reactive supports for 3' labeling of oligonucleotides

Publications (2)

Publication Number Publication Date
DE69128918D1 DE69128918D1 (de) 1998-03-19
DE69128918T2 true DE69128918T2 (de) 1998-08-20

Family

ID=24529051

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69128918T Expired - Fee Related DE69128918T2 (de) 1990-12-20 1991-12-19 Verfahren, testsätze und reaktive träger zur 3'-markierung von oligonukleotiden

Country Status (11)

Country Link
US (1) US5290925A (de)
EP (1) EP0563287B1 (de)
JP (1) JPH06503173A (de)
AT (1) ATE163201T1 (de)
AU (1) AU9171191A (de)
CA (1) CA2098201C (de)
DE (1) DE69128918T2 (de)
DK (1) DK0563287T3 (de)
ES (1) ES2113943T4 (de)
GR (1) GR3026704T3 (de)
WO (1) WO1992011388A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003296A1 (en) * 1993-07-20 1995-02-02 Abbott Laboratories Haptens, tracers, immunogens and antibodies for carbazole and dibenzofuran derivatives
US8236493B2 (en) * 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US6974666B1 (en) * 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US6312893B1 (en) 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
US6613508B1 (en) * 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US20020150921A1 (en) * 1996-02-09 2002-10-17 Francis Barany Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
DE19612650C1 (de) * 1996-04-02 1997-07-31 Evotec Biosystems Gmbh Verfahren zur Fluoreszenzmarkierung von Molekülen
EP1736554B1 (de) * 1996-05-29 2013-10-09 Cornell Research Foundation, Inc. Bestimmung von Unterschieden in der Nukleinsäuresequenz mittels einer Kombination von Ligasebestimmung und Polymerasekettenreaktion
US5919638A (en) * 1996-10-08 1999-07-06 Abbott Laboratories Reagents and methods useful for detecting prostate tumors
US20030165971A1 (en) * 1996-10-31 2003-09-04 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US20050153373A1 (en) * 1996-10-31 2005-07-14 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US20050202499A1 (en) * 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
SE522077C2 (sv) 1997-09-05 2004-01-13 Lightup Technologies Ab Förfarande att välja sekvens hos sond för nukleinsyrahybridisering
US6255476B1 (en) 1999-02-22 2001-07-03 Pe Corporation (Ny) Methods and compositions for synthesis of labelled oligonucleotides and analogs on solid-supports
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
US6506594B1 (en) * 1999-03-19 2003-01-14 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
AU2001293366A1 (en) 2000-04-14 2001-10-30 Cornell Research Foundation, Inc. Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction
US6607607B2 (en) * 2000-04-28 2003-08-19 Bj Services Company Coiled tubing wellbore cleanout
DE10041542A1 (de) * 2000-08-24 2002-03-07 Febit Ferrarius Biotech Gmbh Neue Strategie zur Synthese von Polymeren auf Oberflächen
DE10044373A1 (de) 2000-09-08 2002-03-21 Roche Diagnostics Gmbh Neues Reagenz zur Markierung von Nukleinsäuren
JP2003043037A (ja) * 2001-07-27 2003-02-13 Inst Of Physical & Chemical Res ハイブリダイゼーション用基板、この基板の製造方法及び使用方法
CA2494571C (en) * 2003-12-02 2010-02-09 F.Hoffmann-La Roche Ag Oligonucleotides containing molecular rods
GB0410448D0 (en) * 2004-05-11 2004-06-16 Hammersmith Imanet Ltd Purification methods
EP1700922B1 (de) 2005-03-10 2016-08-24 Roche Diagnostics GmbH 3-Substituierte 5-Nitroindolderivate und diese enthaltende markierte Oligonukleotidsonden
ES2332139T3 (es) 2005-11-23 2010-01-27 F. Hoffmann-La Roche Ag Polinucleotidos con mimetico de fosfato.
US7759470B2 (en) 2006-02-20 2010-07-20 Roche Diagnostics Operations, Inc. Labeling reagent
RU2015153109A (ru) 2009-09-16 2019-01-15 Дженентек, Инк. Содержащие суперспираль и/или привязку белковые комплексы и их применения
TW201138821A (en) 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
CN103384681B (zh) 2010-12-23 2018-05-18 霍夫曼-拉罗奇有限公司 结合剂
SG191153A1 (en) 2010-12-23 2013-07-31 Hoffmann La Roche Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
EP2659269B1 (de) 2010-12-23 2016-10-26 Roche Diagniostics GmbH Erkennung von posttranslational modifiziertem polypeptid durch ein bivalentes bindungsmolekül
KR20140127854A (ko) 2012-02-10 2014-11-04 제넨테크, 인크. 단일-쇄 항체 및 다른 이종다량체
RU2015100656A (ru) 2012-06-27 2016-08-20 Ф. Хоффманн-Ля Рош Аг Способ получения конъюгатов fc-фрагмента антитела, включающих по меньшей мере одну связывающую группировку, которая специфически связывается с мишенью, и их применения
WO2014001324A1 (en) 2012-06-27 2014-01-03 Hoffmann-La Roche Ag Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof
EP3227332B1 (de) 2014-12-03 2019-11-06 F.Hoffmann-La Roche Ag Multispezifische antikörper

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4757141A (en) * 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
US5082830A (en) * 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe

Also Published As

Publication number Publication date
ES2113943T3 (es) 1998-05-16
CA2098201A1 (en) 1992-06-20
ES2113943T4 (es) 1998-10-01
US5290925A (en) 1994-03-01
GR3026704T3 (en) 1998-07-31
EP0563287A4 (en) 1996-01-10
WO1992011388A1 (en) 1992-07-09
DE69128918D1 (de) 1998-03-19
ATE163201T1 (de) 1998-02-15
CA2098201C (en) 2000-05-16
EP0563287A1 (de) 1993-10-06
EP0563287B1 (de) 1998-02-11
DK0563287T3 (da) 1998-09-23
AU9171191A (en) 1992-07-22
JPH06503173A (ja) 1994-04-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee