DK0563287T3 - Fremgangsmåder, prøvesæt og reaktive underlag til 3'-mærkning af oligonucleotider - Google Patents
Fremgangsmåder, prøvesæt og reaktive underlag til 3'-mærkning af oligonucleotiderInfo
- Publication number
- DK0563287T3 DK0563287T3 DK92903476T DK92903476T DK0563287T3 DK 0563287 T3 DK0563287 T3 DK 0563287T3 DK 92903476 T DK92903476 T DK 92903476T DK 92903476 T DK92903476 T DK 92903476T DK 0563287 T3 DK0563287 T3 DK 0563287T3
- Authority
- DK
- Denmark
- Prior art keywords
- oligonucleotides
- methods
- labeling
- useful
- arm
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/630,908 US5290925A (en) | 1990-12-20 | 1990-12-20 | Methods, kits, and reactive supports for 3' labeling of oligonucleotides |
PCT/US1991/009657 WO1992011388A1 (en) | 1990-12-20 | 1991-12-19 | Methods, kits and reactive supports for 3' labeling of oligonucleotides |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0563287T3 true DK0563287T3 (da) | 1998-09-23 |
Family
ID=24529051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK92903476T DK0563287T3 (da) | 1990-12-20 | 1991-12-19 | Fremgangsmåder, prøvesæt og reaktive underlag til 3'-mærkning af oligonucleotider |
Country Status (11)
Country | Link |
---|---|
US (1) | US5290925A (da) |
EP (1) | EP0563287B1 (da) |
JP (1) | JPH06503173A (da) |
AT (1) | ATE163201T1 (da) |
AU (1) | AU9171191A (da) |
CA (1) | CA2098201C (da) |
DE (1) | DE69128918T2 (da) |
DK (1) | DK0563287T3 (da) |
ES (1) | ES2113943T4 (da) |
GR (1) | GR3026704T3 (da) |
WO (1) | WO1992011388A1 (da) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2166782A1 (en) * | 1993-07-20 | 1995-02-02 | James R. Fino | Haptens, tracers, immunogens and antibodies for carbazole and dibenzofuran derivatives |
US8236493B2 (en) * | 1994-10-21 | 2012-08-07 | Affymetrix, Inc. | Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA |
US6974666B1 (en) * | 1994-10-21 | 2005-12-13 | Appymetric, Inc. | Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA |
US6312893B1 (en) * | 1996-01-23 | 2001-11-06 | Qiagen Genomics, Inc. | Methods and compositions for determining the sequence of nucleic acid molecules |
US6027890A (en) * | 1996-01-23 | 2000-02-22 | Rapigene, Inc. | Methods and compositions for enhancing sensitivity in the analysis of biological-based assays |
US6613508B1 (en) | 1996-01-23 | 2003-09-02 | Qiagen Genomics, Inc. | Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques |
US6852487B1 (en) * | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
US20020150921A1 (en) * | 1996-02-09 | 2002-10-17 | Francis Barany | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
DE19612650C1 (de) * | 1996-04-02 | 1997-07-31 | Evotec Biosystems Gmbh | Verfahren zur Fluoreszenzmarkierung von Molekülen |
EP0912761A4 (en) * | 1996-05-29 | 2004-06-09 | Cornell Res Foundation Inc | DETERMINATION OF DIFFERENCES IN THE NUCLEIC ACID SEQUENCE BY MEANS OF A COMBINATION OF LIGASE DETERMINATION AND POLYMERASE CHAIN REACTION |
US5919638A (en) * | 1996-10-08 | 1999-07-06 | Abbott Laboratories | Reagents and methods useful for detecting prostate tumors |
US20030165971A1 (en) * | 1996-10-31 | 2003-09-04 | Billing-Medel Patricia A. | Reagents and methods useful for detecting diseases of the breast |
US20050153373A1 (en) * | 1996-10-31 | 2005-07-14 | Billing-Medel Patricia A. | Reagents and methods useful for detecting diseases of the breast |
US20050202499A1 (en) | 1996-10-31 | 2005-09-15 | Billing-Medel Patricia A. | Reagents and methods useful for detecting diseases of the breast |
SE522077C2 (sv) | 1997-09-05 | 2004-01-13 | Lightup Technologies Ab | Förfarande att välja sekvens hos sond för nukleinsyrahybridisering |
US6255476B1 (en) * | 1999-02-22 | 2001-07-03 | Pe Corporation (Ny) | Methods and compositions for synthesis of labelled oligonucleotides and analogs on solid-supports |
US6506594B1 (en) * | 1999-03-19 | 2003-01-14 | Cornell Res Foundation Inc | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
US7014994B1 (en) | 1999-03-19 | 2006-03-21 | Cornell Research Foundation,Inc. | Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process |
JP5508654B2 (ja) | 2000-04-14 | 2014-06-04 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | リガーゼ検出反応を用いた核酸配列の違いの検出のための位置特定可能なアレイの設計方法 |
US6607607B2 (en) * | 2000-04-28 | 2003-08-19 | Bj Services Company | Coiled tubing wellbore cleanout |
DE10041542A1 (de) * | 2000-08-24 | 2002-03-07 | Febit Ferrarius Biotech Gmbh | Neue Strategie zur Synthese von Polymeren auf Oberflächen |
DE10044373A1 (de) * | 2000-09-08 | 2002-03-21 | Roche Diagnostics Gmbh | Neues Reagenz zur Markierung von Nukleinsäuren |
JP2003043037A (ja) * | 2001-07-27 | 2003-02-13 | Inst Of Physical & Chemical Res | ハイブリダイゼーション用基板、この基板の製造方法及び使用方法 |
CA2494571C (en) * | 2003-12-02 | 2010-02-09 | F.Hoffmann-La Roche Ag | Oligonucleotides containing molecular rods |
GB0410448D0 (en) * | 2004-05-11 | 2004-06-16 | Hammersmith Imanet Ltd | Purification methods |
EP1700922B1 (en) | 2005-03-10 | 2016-08-24 | Roche Diagnostics GmbH | 3-Substituted 5-Nitroindole derivatives and labeled oligonucleotide probes containing them |
ES2332139T3 (es) | 2005-11-23 | 2010-01-27 | F. Hoffmann-La Roche Ag | Polinucleotidos con mimetico de fosfato. |
US7759470B2 (en) | 2006-02-20 | 2010-07-20 | Roche Diagnostics Operations, Inc. | Labeling reagent |
US20120302737A1 (en) | 2009-09-16 | 2012-11-29 | Genentech, Inc. | Coiled coil and/or tether containing protein complexes and uses thereof |
TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
WO2012085064A1 (en) | 2010-12-23 | 2012-06-28 | Roche Diagnostics Gmbh | Detection of a posttranslationally modified polypeptide by a bi-valent binding agent |
WO2012085113A1 (en) | 2010-12-23 | 2012-06-28 | Roche Diagnostics Gmbh | Binding agent |
SG191153A1 (en) | 2010-12-23 | 2013-07-31 | Hoffmann La Roche | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
JP6486686B2 (ja) | 2012-02-10 | 2019-03-20 | ジェネンテック, インコーポレイテッド | 単鎖抗体及び他のヘテロ多量体 |
WO2014001325A1 (en) | 2012-06-27 | 2014-01-03 | F. Hoffmann-La Roche Ag | Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof |
RU2639287C2 (ru) | 2012-06-27 | 2017-12-20 | Ф. Хоффманн-Ля Рош Аг | Способ отбора и получения высокоселективных и мультиспецифичных нацеливающих групп с заданными свойствами, включающих по меньшей мере две различные связывающие группировки, и их применения |
ES2764111T3 (es) | 2014-12-03 | 2020-06-02 | Hoffmann La Roche | Anticuerpos multiespecíficos |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4757141A (en) * | 1985-08-26 | 1988-07-12 | Applied Biosystems, Incorporated | Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof |
US5082830A (en) * | 1988-02-26 | 1992-01-21 | Enzo Biochem, Inc. | End labeled nucleotide probe |
-
1990
- 1990-12-20 US US07/630,908 patent/US5290925A/en not_active Expired - Lifetime
-
1991
- 1991-12-19 ES ES92903476T patent/ES2113943T4/es not_active Expired - Lifetime
- 1991-12-19 DK DK92903476T patent/DK0563287T3/da active
- 1991-12-19 DE DE69128918T patent/DE69128918T2/de not_active Expired - Fee Related
- 1991-12-19 JP JP4503406A patent/JPH06503173A/ja active Pending
- 1991-12-19 CA CA002098201A patent/CA2098201C/en not_active Expired - Fee Related
- 1991-12-19 AT AT92903476T patent/ATE163201T1/de not_active IP Right Cessation
- 1991-12-19 EP EP92903476A patent/EP0563287B1/en not_active Expired - Lifetime
- 1991-12-19 AU AU91711/91A patent/AU9171191A/en not_active Abandoned
- 1991-12-19 WO PCT/US1991/009657 patent/WO1992011388A1/en active IP Right Grant
-
1998
- 1998-04-23 GR GR980400892T patent/GR3026704T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0563287B1 (en) | 1998-02-11 |
AU9171191A (en) | 1992-07-22 |
CA2098201C (en) | 2000-05-16 |
GR3026704T3 (en) | 1998-07-31 |
ATE163201T1 (de) | 1998-02-15 |
WO1992011388A1 (en) | 1992-07-09 |
EP0563287A1 (en) | 1993-10-06 |
DE69128918T2 (de) | 1998-08-20 |
DE69128918D1 (de) | 1998-03-19 |
EP0563287A4 (en) | 1996-01-10 |
US5290925A (en) | 1994-03-01 |
JPH06503173A (ja) | 1994-04-07 |
CA2098201A1 (en) | 1992-06-20 |
ES2113943T3 (es) | 1998-05-16 |
ES2113943T4 (es) | 1998-10-01 |
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