DK0563287T3 - Fremgangsmåder, prøvesæt og reaktive underlag til 3'-mærkning af oligonucleotider - Google Patents

Fremgangsmåder, prøvesæt og reaktive underlag til 3'-mærkning af oligonucleotider

Info

Publication number
DK0563287T3
DK0563287T3 DK92903476T DK92903476T DK0563287T3 DK 0563287 T3 DK0563287 T3 DK 0563287T3 DK 92903476 T DK92903476 T DK 92903476T DK 92903476 T DK92903476 T DK 92903476T DK 0563287 T3 DK0563287 T3 DK 0563287T3
Authority
DK
Denmark
Prior art keywords
oligonucleotides
methods
labeling
useful
arm
Prior art date
Application number
DK92903476T
Other languages
Danish (da)
English (en)
Inventor
James R Fino
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of DK0563287T3 publication Critical patent/DK0563287T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK92903476T 1990-12-20 1991-12-19 Fremgangsmåder, prøvesæt og reaktive underlag til 3'-mærkning af oligonucleotider DK0563287T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/630,908 US5290925A (en) 1990-12-20 1990-12-20 Methods, kits, and reactive supports for 3' labeling of oligonucleotides
PCT/US1991/009657 WO1992011388A1 (en) 1990-12-20 1991-12-19 Methods, kits and reactive supports for 3' labeling of oligonucleotides

Publications (1)

Publication Number Publication Date
DK0563287T3 true DK0563287T3 (da) 1998-09-23

Family

ID=24529051

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92903476T DK0563287T3 (da) 1990-12-20 1991-12-19 Fremgangsmåder, prøvesæt og reaktive underlag til 3'-mærkning af oligonucleotider

Country Status (11)

Country Link
US (1) US5290925A (de)
EP (1) EP0563287B1 (de)
JP (1) JPH06503173A (de)
AT (1) ATE163201T1 (de)
AU (1) AU9171191A (de)
CA (1) CA2098201C (de)
DE (1) DE69128918T2 (de)
DK (1) DK0563287T3 (de)
ES (1) ES2113943T4 (de)
GR (1) GR3026704T3 (de)
WO (1) WO1992011388A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0708767B1 (de) * 1993-07-20 2001-02-14 Abbott Laboratories Haptene, tracer, immunogene und antikörper für carbazol - und dibenzofuran - derivate
US8236493B2 (en) * 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US6974666B1 (en) * 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US6312893B1 (en) 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US6852487B1 (en) * 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US20020150921A1 (en) * 1996-02-09 2002-10-17 Francis Barany Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
DE19612650C1 (de) * 1996-04-02 1997-07-31 Evotec Biosystems Gmbh Verfahren zur Fluoreszenzmarkierung von Molekülen
CA2255774C (en) * 1996-05-29 2008-03-18 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US5919638A (en) * 1996-10-08 1999-07-06 Abbott Laboratories Reagents and methods useful for detecting prostate tumors
US20050153373A1 (en) * 1996-10-31 2005-07-14 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US20050202499A1 (en) 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US20030165971A1 (en) * 1996-10-31 2003-09-04 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
SE522077C2 (sv) * 1997-09-05 2004-01-13 Lightup Technologies Ab Förfarande att välja sekvens hos sond för nukleinsyrahybridisering
US6255476B1 (en) 1999-02-22 2001-07-03 Pe Corporation (Ny) Methods and compositions for synthesis of labelled oligonucleotides and analogs on solid-supports
US6506594B1 (en) * 1999-03-19 2003-01-14 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
WO2001079548A2 (en) 2000-04-14 2001-10-25 Cornell Research Foundation, Inc. Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction
US6607607B2 (en) * 2000-04-28 2003-08-19 Bj Services Company Coiled tubing wellbore cleanout
DE10041542A1 (de) * 2000-08-24 2002-03-07 Febit Ferrarius Biotech Gmbh Neue Strategie zur Synthese von Polymeren auf Oberflächen
DE10044373A1 (de) 2000-09-08 2002-03-21 Roche Diagnostics Gmbh Neues Reagenz zur Markierung von Nukleinsäuren
JP2003043037A (ja) * 2001-07-27 2003-02-13 Inst Of Physical & Chemical Res ハイブリダイゼーション用基板、この基板の製造方法及び使用方法
CA2494571C (en) * 2003-12-02 2010-02-09 F.Hoffmann-La Roche Ag Oligonucleotides containing molecular rods
GB0410448D0 (en) * 2004-05-11 2004-06-16 Hammersmith Imanet Ltd Purification methods
EP1700922B1 (de) 2005-03-10 2016-08-24 Roche Diagnostics GmbH 3-Substituierte 5-Nitroindolderivate und diese enthaltende markierte Oligonukleotidsonden
EP1801114B8 (de) 2005-11-23 2009-12-02 Roche Diagnostics GmbH Polynukleotid mit Phosphatmimetikum
JP4713514B2 (ja) 2006-02-20 2011-06-29 エフ．ホフマン−ラ ロシュ アーゲー 改善された標識試薬
CN104945509A (zh) 2009-09-16 2015-09-30 弗·哈夫曼-拉罗切有限公司 包含卷曲螺旋和/或系链的蛋白质复合体及其用途
TW201138821A (en) 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
EP2655413B1 (de) 2010-12-23 2019-01-16 F.Hoffmann-La Roche Ag Polypeptid-polynukleotid-komplex und verwendung bei der gezielten effektorrest-bereitstellung
WO2012085064A1 (en) 2010-12-23 2012-06-28 Roche Diagnostics Gmbh Detection of a posttranslationally modified polypeptide by a bi-valent binding agent
CN103384681B (zh) 2010-12-23 2018-05-18 霍夫曼-拉罗奇有限公司 结合剂
WO2013119966A2 (en) 2012-02-10 2013-08-15 Genentech, Inc. Single-chain antibodies and other heteromultimers
JP6203838B2 (ja) 2012-06-27 2017-09-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 少なくとも２つの異なる結合実体を含む、テーラーメイドの高度に選択的かつ多重特異的なターゲティング実体を選択および作製するための方法、ならびにその使用
WO2014001325A1 (en) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
PL3227332T3 (pl) 2014-12-03 2020-06-15 F. Hoffmann-La Roche Ag Wielospecyficzne przeciwciała

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4757141A (en) * 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
US5082830A (en) * 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe

Also Published As

Publication number Publication date
EP0563287A4 (en) 1996-01-10
ES2113943T3 (es) 1998-05-16
ES2113943T4 (es) 1998-10-01
EP0563287A1 (de) 1993-10-06
DE69128918T2 (de) 1998-08-20
EP0563287B1 (de) 1998-02-11
JPH06503173A (ja) 1994-04-07
CA2098201A1 (en) 1992-06-20
US5290925A (en) 1994-03-01
DE69128918D1 (de) 1998-03-19
WO1992011388A1 (en) 1992-07-09
ATE163201T1 (de) 1998-02-15
CA2098201C (en) 2000-05-16
AU9171191A (en) 1992-07-22
GR3026704T3 (en) 1998-07-31

Similar Documents

Publication Publication Date Title
DK0563287T3 (da) Fremgangsmåder, prøvesæt og reaktive underlag til 3'-mærkning af oligonucleotider
US4495281A (en) Tricyclic antidepressant drug immunogens, antibodies, labeled conjugates, and related derivatives
ATE369878T1 (de) Träger-pharmaka-konjugate
AU7433891A (en) Electrochemiluminescent assays
EP1110964A1 (de) Calix-Kronenether zum Immobilisieren von Proteinen
ATE74662T1 (de) Immunoanalysetestverfahren fuer cholesterolepoxide.
CA2148595A1 (en) Molecule labelling using 2-hydrazinopyridine derivatives
CA1250099A (en) Immunogens, antibodies, labeled conjugates and related derivatives for lidocaine and analogs thereof
US4287345A (en) Polyfunctional disulfide compounds having S--S exchange reactivity
EP0851228A4 (de) Hochempfindlicehr fluoreszenz-immunoassay
DK0546046T3 (da) Etiketter og fremstilling af disse
DE69323713D1 (de) Neue verbindungen und konjugate
KR960704902A (ko) 하전된 링커를 갖는 금속 착물 (metal complexes with charged linker)
DK0923528T3 (da) Syntese af oligosaccharid
EP1383920A4 (de) Zur vereinfachung komplexer peptidgemische geeignete verfahren und kits
CA2211385A1 (en) N-1-carboxyalkyl derivatives of lsd
DK0763047T3 (da) Ny fremgangsmåde til fremstilling af nucleosider
ES8504928A1 (es) Procedimiento para la preparacion de un compuesto marcado con la acetilcolinestearasa de electrofurus electricus
ATE175426T1 (de) Enzymatische bindung von bioaktiven materialien an proteine
CA2178915A1 (en) Maleimide adduct conjugates of procainamide and napa
FR2422699A1 (fr) Procede de preparation d'un materiau solide poreux revetu de cellulose ou de cellulose modifiee
SE9904222D0 (sv) New functionalized polymeric reagents
EP0251527A3 (de) Haptenylierte Reagenzien und Immunotests
Okamura et al. Anti-bilirubin monoclonal antibody III. Preparation and properties of monoclonal antibodies to unconjugated bilirubin-IXα
US4673763A (en) Alpha-functionalized derivatives and labeled conjugates of procainamide and NAPA