JP5341757B2 - 非対称フルオロ置換ポリメチン色素 - Google Patents
非対称フルオロ置換ポリメチン色素 Download PDFInfo
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- JP5341757B2 JP5341757B2 JP2009522326A JP2009522326A JP5341757B2 JP 5341757 B2 JP5341757 B2 JP 5341757B2 JP 2009522326 A JP2009522326 A JP 2009522326A JP 2009522326 A JP2009522326 A JP 2009522326A JP 5341757 B2 JP5341757 B2 JP 5341757B2
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- 229960003742 phenol Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
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- DHHKPEUQJIEKOA-UHFFFAOYSA-N tert-butyl 2-[6-(nitromethyl)-6-bicyclo[3.2.0]hept-3-enyl]acetate Chemical compound C1C=CC2C(CC(=O)OC(C)(C)C)(C[N+]([O-])=O)CC21 DHHKPEUQJIEKOA-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/06—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups three >CH- groups, e.g. carbocyanines
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4842—Monitoring progression or stage of a disease
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0615211.0 | 2006-07-31 | ||
| GB0615211A GB0615211D0 (en) | 2006-07-31 | 2006-07-31 | Asymmetric flouro-substituted polymethine dyes |
| PCT/GB2007/002907 WO2008015415A2 (en) | 2006-07-31 | 2007-07-31 | Asymmetric fluoro-substituted polymethine dyes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009545645A JP2009545645A (ja) | 2009-12-24 |
| JP2009545645A5 JP2009545645A5 (https=) | 2010-08-26 |
| JP5341757B2 true JP5341757B2 (ja) | 2013-11-13 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009522326A Expired - Fee Related JP5341757B2 (ja) | 2006-07-31 | 2007-07-31 | 非対称フルオロ置換ポリメチン色素 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090252687A1 (https=) |
| EP (1) | EP2046895A2 (https=) |
| JP (1) | JP5341757B2 (https=) |
| CN (1) | CN101522815A (https=) |
| GB (1) | GB0615211D0 (https=) |
| WO (1) | WO2008015415A2 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9533059B2 (en) | 2010-08-18 | 2017-01-03 | Ge Healthcare Limited | Peptide radiotracer compositions |
| US10300156B2 (en) | 2013-12-18 | 2019-05-28 | Ge Healthcare Limited | Radiotracer compositions and methods |
| US10548995B2 (en) | 2013-08-21 | 2020-02-04 | Ge Healthcare Limited | Radiolabelling method |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0718967D0 (en) * | 2007-09-28 | 2007-11-07 | Ge Healthcare Ltd | Peptide imaging agents |
| GB0718957D0 (en) * | 2007-09-28 | 2007-11-07 | Ge Healthcare Ltd | Optical imaging agents |
| EP2436780B1 (en) * | 2007-10-02 | 2016-06-08 | Thermo Fisher Scientific Inc. | Monomethine dyes |
| US10493169B2 (en) | 2009-02-06 | 2019-12-03 | Beth Israel Deaconess Medical Center | Use of charge-balanced imaging agents for determining renal function |
| US9023611B2 (en) | 2009-02-06 | 2015-05-05 | Beth Israel Deaconess Medical Center | Charged-balanced imaging agents |
| US8546586B2 (en) * | 2009-04-28 | 2013-10-01 | Wako Pure Chemical Industries, Ltd. | Pyrazole-based cyanine dye containing quaternary ammonium cation |
| TWI516264B (zh) * | 2010-05-06 | 2016-01-11 | 臺北醫學大學 | 芳香醯喹啉化合物 |
| CN103052690A (zh) * | 2010-06-29 | 2013-04-17 | 通用电气医疗集团股份有限公司 | 染料组合物和染料合成 |
| DE102010027016A1 (de) | 2010-07-09 | 2012-01-12 | Universitätsklinikum Jena | Steroid-Styrylfarbstoff-Konjugate zur Simulation und direkten lichtoptischen Detektion des Verhaltens von Steroiden im lebenden biologischen Gewebe und in Gegenwart von steroidbindenden Proteinen |
| WO2012061403A1 (en) * | 2010-11-02 | 2012-05-10 | Life Technologies Corporation | Modified hydrocyanine dyes for the detection of reactive oxygen species |
| EP2831179B1 (en) * | 2012-03-30 | 2016-04-20 | Life Technologies Corporation | Modified nucleic acid binding cyanine dyes for the detection of reactive oxygen species |
| CN104540819B (zh) * | 2012-08-28 | 2019-04-19 | 皮尔斯生物科技有限公司 | 苯并吡喃鎓化合物 |
| US10131682B2 (en) | 2012-11-24 | 2018-11-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules |
| BR112015022763A8 (pt) | 2013-03-14 | 2019-11-26 | Profusa Inc | sensor para detectar um analito |
| CN104804463B (zh) * | 2015-03-10 | 2016-08-24 | 西安交通大学第一附属医院 | 用于靶向肿瘤组织的近红外荧光染色剂及制备方法和应用 |
| WO2018119204A1 (en) | 2016-12-21 | 2018-06-28 | Profusa, Inc. | Polymerizable near-ir dyes |
| EP3375353A1 (en) * | 2017-03-16 | 2018-09-19 | Universität Zürich | Photoacoustic imaging of inflamed tissue |
| WO2018187295A1 (en) | 2017-04-03 | 2018-10-11 | Massachusetts Institute Of Technology | Near and shortwave infrared polymethine dyes |
| US11292778B2 (en) | 2017-06-05 | 2022-04-05 | The Regents Of The University Of California | Heterocyclyl polymethine IR chromophores |
| CN111712468A (zh) * | 2017-12-22 | 2020-09-25 | 北卡罗莱纳州立大学 | 聚合物荧光团、包含其的组合物及制备和使用其的方法 |
| AU2019293250A1 (en) | 2018-06-27 | 2021-01-07 | Profusa, Inc. | Near-IR glucose sensors |
| CN117368301B (zh) * | 2022-06-29 | 2026-04-14 | 中国科学院大连化学物理研究所 | 一种组织中巯基化合物的质谱成像检测方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5658751A (en) * | 1993-04-13 | 1997-08-19 | Molecular Probes, Inc. | Substituted unsymmetrical cyanine dyes with selected permeability |
| US6495692B1 (en) * | 1996-12-10 | 2002-12-17 | Abbott Laboratories | Helium-neon excitable reticulocyte dyes derivable from halolepidines |
| WO2000034394A2 (de) * | 1998-12-05 | 2000-06-15 | Otto Samuel Wolfbeis | Pyridin- und chinolin-farbstoffe als marker für biomoleküle, polymere, arzneistoffe und partikel |
| DE19917713A1 (de) * | 1999-04-09 | 2000-10-19 | Diagnostikforschung Inst | Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik |
| DK2269591T3 (en) * | 2000-01-19 | 2018-07-16 | Abbvie Inc | IMPROVED PHARMACEUTICAL FORMULATIONS |
| DE50107913D1 (de) * | 2000-05-23 | 2005-12-08 | Dyomics Gmbh | Stabile nir-marker-farbstoffe auf der basis von benzopyrylium-polymethinen |
| WO2003006491A2 (en) * | 2001-07-10 | 2003-01-23 | Amersham Health As | Peptide-based compounds for targeting intergin receptors |
| TWI244494B (en) * | 2003-05-14 | 2005-12-01 | Ritek Corp | Optical recording medium dye |
| CA2599709A1 (en) * | 2005-03-09 | 2006-09-21 | Cepheid | Polar dyes |
-
2006
- 2006-07-31 GB GB0615211A patent/GB0615211D0/en not_active Ceased
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2007
- 2007-07-31 CN CN 200780036717 patent/CN101522815A/zh active Pending
- 2007-07-31 WO PCT/GB2007/002907 patent/WO2008015415A2/en not_active Ceased
- 2007-07-31 JP JP2009522326A patent/JP5341757B2/ja not_active Expired - Fee Related
- 2007-07-31 US US12/375,239 patent/US20090252687A1/en not_active Abandoned
- 2007-07-31 EP EP07789086A patent/EP2046895A2/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9533059B2 (en) | 2010-08-18 | 2017-01-03 | Ge Healthcare Limited | Peptide radiotracer compositions |
| US10548995B2 (en) | 2013-08-21 | 2020-02-04 | Ge Healthcare Limited | Radiolabelling method |
| US10300156B2 (en) | 2013-12-18 | 2019-05-28 | Ge Healthcare Limited | Radiotracer compositions and methods |
| US11311636B2 (en) | 2013-12-18 | 2022-04-26 | Ge Healthcare Limited | Radiotracer compositions and methods |
Also Published As
| Publication number | Publication date |
|---|---|
| GB0615211D0 (en) | 2006-09-06 |
| EP2046895A2 (en) | 2009-04-15 |
| CN101522815A (zh) | 2009-09-02 |
| WO2008015415A3 (en) | 2008-05-08 |
| US20090252687A1 (en) | 2009-10-08 |
| JP2009545645A (ja) | 2009-12-24 |
| WO2008015415A2 (en) | 2008-02-07 |
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