JP2009545313A - ミオスタチンアンタゴニスト - Google Patents
ミオスタチンアンタゴニスト Download PDFInfo
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- JP2009545313A JP2009545313A JP2009522733A JP2009522733A JP2009545313A JP 2009545313 A JP2009545313 A JP 2009545313A JP 2009522733 A JP2009522733 A JP 2009522733A JP 2009522733 A JP2009522733 A JP 2009522733A JP 2009545313 A JP2009545313 A JP 2009545313A
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- myostatin
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018030432A1 (ja) * | 2016-08-10 | 2018-02-15 | 学校法人東京薬科大学 | ペプチドもしくはその薬学的に許容される塩、またはそれらのプロドラッグ |
| JP2020127430A (ja) * | 2014-11-06 | 2020-08-27 | スカラー ロック インコーポレイテッドＳｃｈｏｌａｒ Ｒｏｃｋ，Ｉｎｃ． | 抗プロ／潜在型−ミオスタチン抗体およびその使用 |
| WO2021060880A1 (ko) * | 2019-09-24 | 2021-04-01 | 마이오텍사이언스 주식회사 | 비천연 아미노산을 함유하는 근감소증의 예방 또는 치료용 약학적 조성물 |
| JP2021516252A (ja) * | 2018-03-21 | 2021-07-01 | 傅▲恵▼芳ＣＨＡＲＯＥＮＦＵＰＲＡＳＥＲＴ， Ｓｕｌａｗａｎ | 局部の筋肉増加を促進し、若しくは局部の筋萎縮を抑制又は防止する組成物及び当該組成物を使用して製造された薬物 |
| US12006359B2 (en) | 2016-01-08 | 2024-06-11 | Scholar Rock, Inc. | Methods for altering body composition by administering anti-pro/latent myostatin antibodies |
| US12338279B2 (en) | 2022-12-22 | 2025-06-24 | Scholar Rock, Inc. | Selective and potent inhibitory antibodies of myostatin activation |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5335239B2 (ja) * | 2004-09-30 | 2013-11-06 | マイオスティン・セラピューティクス・プロプライエタリー・リミテッド | ミオスタチンアイソフォーム |
| NO2424895T3 (enExample) * | 2009-04-27 | 2018-02-03 | ||
| CN101659700B (zh) * | 2009-07-27 | 2011-11-16 | 广州罗森生物科技有限公司 | 一种短肽 |
| KR20120082909A (ko) * | 2009-10-01 | 2012-07-24 | 코비타 리미티드 | 합성 마이오스타틴 펩티드 길항제 |
| JO3340B1 (ar) * | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
| CA2808382A1 (en) * | 2010-08-16 | 2012-02-23 | Amgen Inc. | Antibodies that bind myostatin, compositions and methods |
| US8871209B2 (en) | 2011-11-14 | 2014-10-28 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing GDF8 and or Activin A |
| KR20170135967A (ko) | 2015-04-15 | 2017-12-08 | 리제너론 파마슈티칼스 인코포레이티드 | Gdf8 억제제를 사용하여 강도 및 기능을 증가시키는 방법 |
| SI3565592T1 (sl) * | 2017-01-06 | 2023-05-31 | Scholar Rock, Inc. | Zdravljenje presnovnih bolezni z zaviranjem aktivacije miostatina |
| US11248044B2 (en) | 2018-03-01 | 2022-02-15 | Regeneron Pharmaceuticals, Inc. | Methods for altering body composition by administering a GDF8 inhibitor and an Activin A inhibitor |
| TWI649332B (zh) * | 2018-03-21 | 2019-02-01 | 英屬安圭拉商維多利亞生物醫學控股股份有限公司 | Composition for promoting local muscle growth, slowing or preventing local muscle atrophy and use thereof |
| JP7300764B2 (ja) * | 2018-07-02 | 2023-06-30 | キュラミス カンパニー・リミテッド | 細胞融合技術を用いた遺伝子及び細胞治療剤、並びにその用途 |
| WO2020154034A1 (en) * | 2019-01-25 | 2020-07-30 | Children's Medical Center Corporation | Compositions and methods for treating muscular dystrophy and related disorders |
| AU2021390998A1 (en) * | 2020-12-03 | 2023-06-29 | Kyungsangbukdo (Kyungsangbukdo Livestock Research Institute) | Transgenic animal having modified myostatin gene |
| CN120192396A (zh) * | 2023-12-21 | 2025-06-24 | 江苏省农业科学院 | 一种肌肉生长抑制素mstn蛋白突变体及其制备方法和应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002504326A (ja) * | 1998-02-19 | 2002-02-12 | バイオスター インコーポレイティド | 脊椎動物被験体における免疫学的ミオスタチン調節法 |
| WO2005066204A2 (en) * | 2003-12-31 | 2005-07-21 | Schering-Plough Ltd. | Neutralizing epitope-based growth enhancing vaccine |
| WO2006083183A1 (en) * | 2005-02-07 | 2006-08-10 | Orico Limited | Use of myostatin (gdf-8) antagonists for treatment of sarcopenia (age-related muscle-wasting) |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4847325A (en) * | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| US7393682B1 (en) | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| US5874409A (en) * | 1995-06-07 | 1999-02-23 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
| WO1998033887A1 (en) | 1997-02-05 | 1998-08-06 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| EE200200025A (et) | 1999-07-20 | 2003-04-15 | Pharmexa A/S | Meetod GDF-8 aktiivsuse allareguleerimiseks, meetod looma lihasmassi suurendamiseks, GDF-8 analoog,immunogeenne kompositsioon, nukleiinhappefragment, vektor, transformeeritud rakk ja selle valmistamismeetod, kompositsioon GDF-8 vastaste antikehadeto |
| WO2001053350A1 (en) | 2000-01-18 | 2001-07-26 | Agresearch Limited | Myostatin and mimetics thereof |
| AU2003254585A1 (en) | 2002-07-24 | 2004-02-16 | Intercell Ag | Antigens encoded by alternative reading frame from pathogenic viruses |
| BR0314270A (pt) | 2002-09-16 | 2005-08-02 | Univ Johns Hopkins | Ativação de miostatina com metaloprotease e processos de modulação da atividade da miostatina |
| NZ529860A (en) * | 2003-11-28 | 2006-10-27 | Ovita Ltd | Muscle growth regulator mighty and use in promoting muscle mass and treating muscle wasting diseases |
| US20060034831A1 (en) * | 2004-08-12 | 2006-02-16 | Wyeth | Combination therapy for diabetes, obesity and cardiovascular diseases using GDF-8 inhibitors |
| US20070190056A1 (en) * | 2006-02-07 | 2007-08-16 | Ravi Kambadur | Muscle regeneration compositions and uses therefor |
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- 2007-08-02 AU AU2007279456A patent/AU2007279456A1/en not_active Abandoned
- 2007-08-02 CA CA2693378A patent/CA2693378C/en not_active Expired - Fee Related
- 2007-08-02 DK DK07834817.4T patent/DK2054434T3/en active
- 2007-08-02 BR BRPI0715072-5A patent/BRPI0715072A2/pt not_active Application Discontinuation
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2013
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2016
- 2016-04-01 JP JP2016074671A patent/JP2016130251A/ja not_active Withdrawn
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020127430A (ja) * | 2014-11-06 | 2020-08-27 | スカラー ロック インコーポレイテッドＳｃｈｏｌａｒ Ｒｏｃｋ，Ｉｎｃ． | 抗プロ／潜在型−ミオスタチン抗体およびその使用 |
| JP2022166238A (ja) * | 2014-11-06 | 2022-11-01 | スカラー ロック インコーポレイテッド | 抗プロ／潜在型－ミオスタチン抗体およびその使用 |
| US11925683B2 (en) | 2014-11-06 | 2024-03-12 | Scholar Rock, Inc. | Compositions for making and using anti-Myostatin antibodies |
| JP2024109663A (ja) * | 2014-11-06 | 2024-08-14 | スカラー ロック インコーポレイテッド | 抗プロ／潜在型－ミオスタチン抗体およびその使用 |
| US12006359B2 (en) | 2016-01-08 | 2024-06-11 | Scholar Rock, Inc. | Methods for altering body composition by administering anti-pro/latent myostatin antibodies |
| WO2018030432A1 (ja) * | 2016-08-10 | 2018-02-15 | 学校法人東京薬科大学 | ペプチドもしくはその薬学的に許容される塩、またはそれらのプロドラッグ |
| US11566047B2 (en) | 2016-08-10 | 2023-01-31 | Tokyo University Of Pharmacy & Life Sciences | Peptide or pharmaceutically acceptable salt thereof, or prodrug thereof |
| JP2021516252A (ja) * | 2018-03-21 | 2021-07-01 | 傅▲恵▼芳ＣＨＡＲＯＥＮＦＵＰＲＡＳＥＲＴ， Ｓｕｌａｗａｎ | 局部の筋肉増加を促進し、若しくは局部の筋萎縮を抑制又は防止する組成物及び当該組成物を使用して製造された薬物 |
| JP7183291B2 (ja) | 2018-03-21 | 2022-12-05 | 松陽生技股▲分▼有限公司 | 局部の筋肉増加を促進し、若しくは局部の筋萎縮を抑制又は防止する組成物及び当該組成物を使用して製造された薬物 |
| WO2021060880A1 (ko) * | 2019-09-24 | 2021-04-01 | 마이오텍사이언스 주식회사 | 비천연 아미노산을 함유하는 근감소증의 예방 또는 치료용 약학적 조성물 |
| US12338279B2 (en) | 2022-12-22 | 2025-06-24 | Scholar Rock, Inc. | Selective and potent inhibitory antibodies of myostatin activation |
Also Published As
| Publication number | Publication date |
|---|---|
| US8309068B2 (en) | 2012-11-13 |
| CA2693378A1 (en) | 2008-02-07 |
| WO2008016314A1 (en) | 2008-02-07 |
| AU2007279456A1 (en) | 2008-02-07 |
| EP2054434B1 (en) | 2017-03-15 |
| BRPI0715072A2 (pt) | 2013-06-25 |
| JP2014057584A (ja) | 2014-04-03 |
| JP2016130251A (ja) | 2016-07-21 |
| CA2693378C (en) | 2020-04-14 |
| EP2054434A4 (en) | 2011-07-13 |
| EP2054434A1 (en) | 2009-05-06 |
| US20090324590A1 (en) | 2009-12-31 |
| JP5993827B2 (ja) | 2016-09-14 |
| CN101522707B (zh) | 2013-08-28 |
| CN101522707A (zh) | 2009-09-02 |
| DK2054434T3 (en) | 2017-07-03 |
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