DK2054434T3 - Myostatin antagonists - Google Patents
Myostatin antagonists Download PDFInfo
- Publication number
- DK2054434T3 DK2054434T3 DK07834817.4T DK07834817T DK2054434T3 DK 2054434 T3 DK2054434 T3 DK 2054434T3 DK 07834817 T DK07834817 T DK 07834817T DK 2054434 T3 DK2054434 T3 DK 2054434T3
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- DK
- Denmark
- Prior art keywords
- myostatin
- muscle
- polypeptide
- amino acid
- mice
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Endocrinology (AREA)
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- Genetics & Genomics (AREA)
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- Toxicology (AREA)
- Child & Adolescent Psychology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83552506P | 2006-08-03 | 2006-08-03 | |
| PCT/NZ2007/000203 WO2008016314A1 (en) | 2006-08-03 | 2007-08-02 | Myostatin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2054434T3 true DK2054434T3 (en) | 2017-07-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07834817.4T DK2054434T3 (en) | 2006-08-03 | 2007-08-02 | Myostatin antagonists |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8309068B2 (enExample) |
| EP (1) | EP2054434B1 (enExample) |
| JP (3) | JP2009545313A (enExample) |
| CN (1) | CN101522707B (enExample) |
| AU (1) | AU2007279456A1 (enExample) |
| BR (1) | BRPI0715072A2 (enExample) |
| CA (1) | CA2693378C (enExample) |
| DK (1) | DK2054434T3 (enExample) |
| WO (1) | WO2008016314A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5335239B2 (ja) * | 2004-09-30 | 2013-11-06 | マイオスティン・セラピューティクス・プロプライエタリー・リミテッド | ミオスタチンアイソフォーム |
| NO2424895T3 (enExample) * | 2009-04-27 | 2018-02-03 | ||
| CN101659700B (zh) * | 2009-07-27 | 2011-11-16 | 广州罗森生物科技有限公司 | 一种短肽 |
| KR20120082909A (ko) * | 2009-10-01 | 2012-07-24 | 코비타 리미티드 | 합성 마이오스타틴 펩티드 길항제 |
| JO3340B1 (ar) * | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
| CA2808382A1 (en) * | 2010-08-16 | 2012-02-23 | Amgen Inc. | Antibodies that bind myostatin, compositions and methods |
| US8871209B2 (en) | 2011-11-14 | 2014-10-28 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing GDF8 and or Activin A |
| JP6706617B2 (ja) * | 2014-11-06 | 2020-06-10 | スカラー ロック インコーポレイテッドScholar Rock,Inc. | 抗プロ/潜在型−ミオスタチン抗体およびその使用 |
| KR20170135967A (ko) | 2015-04-15 | 2017-12-08 | 리제너론 파마슈티칼스 인코포레이티드 | Gdf8 억제제를 사용하여 강도 및 기능을 증가시키는 방법 |
| US10287345B2 (en) | 2016-01-08 | 2019-05-14 | Scholar Rock, Inc. | Methods for inhibiting myostatin activation by administering anti-pro/latent myostatin antibodies |
| US11566047B2 (en) | 2016-08-10 | 2023-01-31 | Tokyo University Of Pharmacy & Life Sciences | Peptide or pharmaceutically acceptable salt thereof, or prodrug thereof |
| SI3565592T1 (sl) * | 2017-01-06 | 2023-05-31 | Scholar Rock, Inc. | Zdravljenje presnovnih bolezni z zaviranjem aktivacije miostatina |
| US11248044B2 (en) | 2018-03-01 | 2022-02-15 | Regeneron Pharmaceuticals, Inc. | Methods for altering body composition by administering a GDF8 inhibitor and an Activin A inhibitor |
| US11672845B2 (en) | 2018-03-21 | 2023-06-13 | Soulyoung Biotech Co., Ltd. | Composition for promoting local muscle growth or slowing down or preventing local muscle atrophy and use thereof |
| TWI649332B (zh) * | 2018-03-21 | 2019-02-01 | 英屬安圭拉商維多利亞生物醫學控股股份有限公司 | Composition for promoting local muscle growth, slowing or preventing local muscle atrophy and use thereof |
| JP7300764B2 (ja) * | 2018-07-02 | 2023-06-30 | キュラミス カンパニー・リミテッド | 細胞融合技術を用いた遺伝子及び細胞治療剤、並びにその用途 |
| WO2020154034A1 (en) * | 2019-01-25 | 2020-07-30 | Children's Medical Center Corporation | Compositions and methods for treating muscular dystrophy and related disorders |
| US20220331290A1 (en) * | 2019-09-24 | 2022-10-20 | Myo-Tec-Sci | Pharmaceutical composition for preventing or treating sarcopenia, containing unnatural amino acid |
| AU2021390998A1 (en) * | 2020-12-03 | 2023-06-29 | Kyungsangbukdo (Kyungsangbukdo Livestock Research Institute) | Transgenic animal having modified myostatin gene |
| KR20250122524A (ko) | 2022-12-22 | 2025-08-13 | 스칼러 락, 인크. | 미오스타틴 활성화의 선택적이고 강력한 억제 항체 |
| CN120192396A (zh) * | 2023-12-21 | 2025-06-24 | 江苏省农业科学院 | 一种肌肉生长抑制素mstn蛋白突变体及其制备方法和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4847325A (en) * | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| US7393682B1 (en) | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| US5874409A (en) * | 1995-06-07 | 1999-02-23 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
| WO1998033887A1 (en) | 1997-02-05 | 1998-08-06 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| US6369201B1 (en) | 1998-02-19 | 2002-04-09 | Metamorphix International, Inc. | Myostatin multimers |
| EE200200025A (et) | 1999-07-20 | 2003-04-15 | Pharmexa A/S | Meetod GDF-8 aktiivsuse allareguleerimiseks, meetod looma lihasmassi suurendamiseks, GDF-8 analoog,immunogeenne kompositsioon, nukleiinhappefragment, vektor, transformeeritud rakk ja selle valmistamismeetod, kompositsioon GDF-8 vastaste antikehadeto |
| WO2001053350A1 (en) | 2000-01-18 | 2001-07-26 | Agresearch Limited | Myostatin and mimetics thereof |
| AU2003254585A1 (en) | 2002-07-24 | 2004-02-16 | Intercell Ag | Antigens encoded by alternative reading frame from pathogenic viruses |
| BR0314270A (pt) | 2002-09-16 | 2005-08-02 | Univ Johns Hopkins | Ativação de miostatina com metaloprotease e processos de modulação da atividade da miostatina |
| NZ529860A (en) * | 2003-11-28 | 2006-10-27 | Ovita Ltd | Muscle growth regulator mighty and use in promoting muscle mass and treating muscle wasting diseases |
| WO2005066204A2 (en) | 2003-12-31 | 2005-07-21 | Schering-Plough Ltd. | Neutralizing epitope-based growth enhancing vaccine |
| US20060034831A1 (en) * | 2004-08-12 | 2006-02-16 | Wyeth | Combination therapy for diabetes, obesity and cardiovascular diseases using GDF-8 inhibitors |
| NZ538097A (en) * | 2005-02-07 | 2006-07-28 | Ovita Ltd | Method and compositions for improving wound healing |
| US20070190056A1 (en) * | 2006-02-07 | 2007-08-16 | Ravi Kambadur | Muscle regeneration compositions and uses therefor |
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2007
- 2007-08-02 US US12/376,289 patent/US8309068B2/en not_active Expired - Fee Related
- 2007-08-02 AU AU2007279456A patent/AU2007279456A1/en not_active Abandoned
- 2007-08-02 CA CA2693378A patent/CA2693378C/en not_active Expired - Fee Related
- 2007-08-02 DK DK07834817.4T patent/DK2054434T3/en active
- 2007-08-02 BR BRPI0715072-5A patent/BRPI0715072A2/pt not_active Application Discontinuation
- 2007-08-02 WO PCT/NZ2007/000203 patent/WO2008016314A1/en not_active Ceased
- 2007-08-02 CN CN2007800366228A patent/CN101522707B/zh not_active Expired - Fee Related
- 2007-08-02 JP JP2009522733A patent/JP2009545313A/ja active Pending
- 2007-08-02 EP EP07834817.4A patent/EP2054434B1/en not_active Not-in-force
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2013
- 2013-09-27 JP JP2013201653A patent/JP5993827B2/ja not_active Expired - Fee Related
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2016
- 2016-04-01 JP JP2016074671A patent/JP2016130251A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US8309068B2 (en) | 2012-11-13 |
| CA2693378A1 (en) | 2008-02-07 |
| WO2008016314A1 (en) | 2008-02-07 |
| AU2007279456A1 (en) | 2008-02-07 |
| EP2054434B1 (en) | 2017-03-15 |
| BRPI0715072A2 (pt) | 2013-06-25 |
| JP2014057584A (ja) | 2014-04-03 |
| JP2016130251A (ja) | 2016-07-21 |
| CA2693378C (en) | 2020-04-14 |
| EP2054434A4 (en) | 2011-07-13 |
| EP2054434A1 (en) | 2009-05-06 |
| US20090324590A1 (en) | 2009-12-31 |
| JP5993827B2 (ja) | 2016-09-14 |
| JP2009545313A (ja) | 2009-12-24 |
| CN101522707B (zh) | 2013-08-28 |
| CN101522707A (zh) | 2009-09-02 |
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