JP2009544599A5 - - Google Patents

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Publication number
JP2009544599A5
JP2009544599A5 JP2009519995A JP2009519995A JP2009544599A5 JP 2009544599 A5 JP2009544599 A5 JP 2009544599A5 JP 2009519995 A JP2009519995 A JP 2009519995A JP 2009519995 A JP2009519995 A JP 2009519995A JP 2009544599 A5 JP2009544599 A5 JP 2009544599A5
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JP
Japan
Prior art keywords
alkyl
tetrahydro
dioxo
cycloalkyl
lambda
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2009519995A
Other languages
English (en)
Japanese (ja)
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JP2009544599A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2007/057540 external-priority patent/WO2008009750A2/en
Publication of JP2009544599A publication Critical patent/JP2009544599A/ja
Publication of JP2009544599A5 publication Critical patent/JP2009544599A5/ja
Withdrawn legal-status Critical Current

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JP2009519995A 2006-07-20 2007-07-20 Ｂａｃｅ阻害剤として有用な大環状化合物 Withdrawn JP2009544599A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06117571 2006-07-20
PCT/EP2007/057540 WO2008009750A2 (en) 2006-07-20 2007-07-20 Macrocyclic compounds useful as bace inhibitors

Publications (2)

Publication Number Publication Date
JP2009544599A JP2009544599A (ja) 2009-12-17
JP2009544599A5 true JP2009544599A5 (enExample) 2010-08-26

Family

ID=37467481

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009519995A Withdrawn JP2009544599A (ja) 2006-07-20 2007-07-20 Ｂａｃｅ阻害剤として有用な大環状化合物

Country Status (11)

Country Link
US (1) US20090312370A1 (enExample)
EP (1) EP2046761A2 (enExample)
JP (1) JP2009544599A (enExample)
KR (1) KR20090039726A (enExample)
CN (1) CN101490018A (enExample)
AU (1) AU2007275067A1 (enExample)
BR (1) BRPI0715440A2 (enExample)
CA (1) CA2657280A1 (enExample)
MX (1) MX2009000710A (enExample)
RU (1) RU2009105762A (enExample)
WO (1) WO2008009750A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0325830D0 (en) * 2003-11-05 2003-12-10 Novartis Ag Organic compounds
BRPI0606636A2 (pt) * 2005-01-13 2009-07-07 Novartis Ag compostos macrocìclicos úteis como inibidores de bace
GB0500683D0 (en) * 2005-01-13 2005-02-23 Novartis Ag Organic compounds
GB0526614D0 (en) 2005-12-30 2006-02-08 Novartis Ag Organic compounds
KR20090041387A (ko) * 2006-07-20 2009-04-28 노파르티스 아게 마크로시클릭 락탐
CN104619707A (zh) 2012-07-31 2015-05-13 协和发酵麒麟株式会社 稠环杂环化合物
EP3653609B1 (en) 2013-02-12 2024-04-03 Buck Institute for Research on Aging Hydantoins that modulate bace-mediated app processing
CN108732355B (zh) * 2017-04-25 2021-06-25 首都医科大学附属北京安定医院 一种测定bace1酶切nrg1活性的检测方法及其试剂盒

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1395257A1 (en) * 2001-06-12 2004-03-10 Elan Pharmaceuticals, Inc. Macrocycles useful in the treatment of alzheimer's disease
JP2004534064A (ja) * 2001-06-12 2004-11-11 イーラン　ファーマスーティカルズ、インコーポレイテッド アルツハイマー病の治療に有用な大環状分子
GB0325830D0 (en) * 2003-11-05 2003-12-10 Novartis Ag Organic compounds
BRPI0606636A2 (pt) * 2005-01-13 2009-07-07 Novartis Ag compostos macrocìclicos úteis como inibidores de bace
GB0500683D0 (en) * 2005-01-13 2005-02-23 Novartis Ag Organic compounds
GB0526614D0 (en) * 2005-12-30 2006-02-08 Novartis Ag Organic compounds
KR20090041387A (ko) * 2006-07-20 2009-04-28 노파르티스 아게 마크로시클릭 락탐
WO2008009458A1 (en) * 2006-07-21 2008-01-24 Novartis Ag 2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as jak kinases inhibitors

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