JP2009543792A - 抗緑内障薬としてのシクロペンタン誘導体 - Google Patents

抗緑内障薬としてのシクロペンタン誘導体 Download PDF

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JP2009543792A
JP2009543792A JP2009519586A JP2009519586A JP2009543792A JP 2009543792 A JP2009543792 A JP 2009543792A JP 2009519586 A JP2009519586 A JP 2009519586A JP 2009519586 A JP2009519586 A JP 2009519586A JP 2009543792 A JP2009543792 A JP 2009543792A
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compound
compound according
intraocular pressure
carbon atoms
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JP2009543792A5 (enExample
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ディヴィッド ダブリュー オールド
ヴィン エックス ヌゴ
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Allergan Inc
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    • C—CHEMISTRY; METALLURGY
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    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
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    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
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    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
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    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
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    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
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    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
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    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
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    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
    • C07C65/36—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic containing rings other than six-membered aromatic rings
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    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009543794A (ja) * 2006-07-10 2009-12-10 アラーガン インコーポレイテッド 治療化合物
JP2009543795A (ja) * 2006-07-11 2009-12-10 アラーガン インコーポレイテッド 抗緑内障薬としてのシクロペンタン誘導体
WO2015129782A1 (ja) * 2014-02-27 2015-09-03 小野薬品工業株式会社 選択的ｅｐ２アゴニスト活性を有する化合物
JP2017509610A (ja) * 2014-02-20 2017-04-06 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ ベータ−クロロシクロペンタンの親水性エステルプロドラッグの使用による角膜中心肥厚の減少
JP2017518317A (ja) * 2014-06-06 2017-07-06 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 治療用化合物としての新規のｅｐ４アゴニスト
US10385045B2 (en) 2015-07-23 2019-08-20 Ono Pharmaceutical Co., Ltd. Compound having EP2 agonist activity

Families Citing this family (5)

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DK2170345T3 (da) 2007-07-03 2013-05-13 Allergan Inc Terapeutiske substituerede cyclopentaner til reduktion af intraokulært tryk
BRPI0819707A2 (pt) * 2007-11-29 2015-06-16 Allergan Inc Ciclopentanos substituídas tendo atividade de prostaglandina
US8569349B2 (en) * 2008-05-09 2013-10-29 Allergan, Inc. Therapeutic compounds
US8592413B2 (en) 2008-05-15 2013-11-26 Allergan, Inc. Therapeutic substituted cyclopentanes
US8867820B2 (en) * 2009-10-07 2014-10-21 Microsoft Corporation Systems and methods for removing a background of an image

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5053352A (enExample) * 1973-09-17 1975-05-12
US3980700A (en) * 1971-10-07 1976-09-14 G. D. Searle & Co. Prostaglandin intermediates and optically active isomers thereof
JPH07238068A (ja) * 1994-02-24 1995-09-12 Taisho Pharmaceut Co Ltd プロスタグランジンｅ１類縁体
JPH08501310A (ja) * 1992-09-21 1996-02-13 アラーガン、インコーポレイテッド 医薬としての非酸性シクロペンタンヘプタン酸，２−シクロアルキルまたはアリールアルキル誘導体
WO1997030710A1 (en) * 1996-02-22 1997-08-28 Vision Pharmaceuticals L.P. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
JP2001527063A (ja) * 1998-12-24 2001-12-25 小野薬品工業株式会社 ω−シクロアルキル−プロスタグランジンＥ２誘導体
JP2004538306A (ja) * 2001-07-31 2004-12-24 スキャンポ・アーゲー 高眼圧症および緑内障の処置
JP2008526970A (ja) * 2005-01-14 2008-07-24 アラーガン インコーポレイテッド 高眼圧症状を処置するための置換シクロペンタンまたはシクロペンタノン
JP2009543795A (ja) * 2006-07-11 2009-12-10 アラーガン インコーポレイテッド 抗緑内障薬としてのシクロペンタン誘導体

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3980700A (en) * 1971-10-07 1976-09-14 G. D. Searle & Co. Prostaglandin intermediates and optically active isomers thereof
JPS5053352A (enExample) * 1973-09-17 1975-05-12
JPH08501310A (ja) * 1992-09-21 1996-02-13 アラーガン、インコーポレイテッド 医薬としての非酸性シクロペンタンヘプタン酸，２−シクロアルキルまたはアリールアルキル誘導体
JPH07238068A (ja) * 1994-02-24 1995-09-12 Taisho Pharmaceut Co Ltd プロスタグランジンｅ１類縁体
WO1997030710A1 (en) * 1996-02-22 1997-08-28 Vision Pharmaceuticals L.P. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
JP2001527063A (ja) * 1998-12-24 2001-12-25 小野薬品工業株式会社 ω−シクロアルキル−プロスタグランジンＥ２誘導体
JP2004538306A (ja) * 2001-07-31 2004-12-24 スキャンポ・アーゲー 高眼圧症および緑内障の処置
JP2008526970A (ja) * 2005-01-14 2008-07-24 アラーガン インコーポレイテッド 高眼圧症状を処置するための置換シクロペンタンまたはシクロペンタノン
JP2009543795A (ja) * 2006-07-11 2009-12-10 アラーガン インコーポレイテッド 抗緑内障薬としてのシクロペンタン誘導体

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009543794A (ja) * 2006-07-10 2009-12-10 アラーガン インコーポレイテッド 治療化合物
JP2009543795A (ja) * 2006-07-11 2009-12-10 アラーガン インコーポレイテッド 抗緑内障薬としてのシクロペンタン誘導体
JP2017509610A (ja) * 2014-02-20 2017-04-06 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ ベータ−クロロシクロペンタンの親水性エステルプロドラッグの使用による角膜中心肥厚の減少
WO2015129782A1 (ja) * 2014-02-27 2015-09-03 小野薬品工業株式会社 選択的ｅｐ２アゴニスト活性を有する化合物
JPWO2015129782A1 (ja) * 2014-02-27 2017-03-30 小野薬品工業株式会社 選択的ｅｐ２アゴニスト活性を有する化合物
US9890146B2 (en) 2014-02-27 2018-02-13 Ono Pharmaceutical Co., Ltd. Compound having selective EP2 agonist activity
JP2017518317A (ja) * 2014-06-06 2017-07-06 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 治療用化合物としての新規のｅｐ４アゴニスト
US10407382B2 (en) 2014-06-06 2019-09-10 Allergan, Inc. EP4 agonists as therapeutic compounds
US10385045B2 (en) 2015-07-23 2019-08-20 Ono Pharmaceutical Co., Ltd. Compound having EP2 agonist activity

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