AU2007272730B2 - Cyclopentane derivatives as antiglaucoma agents - Google Patents

Cyclopentane derivatives as antiglaucoma agents Download PDF

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AU2007272730B2
AU2007272730B2 AU2007272730A AU2007272730A AU2007272730B2 AU 2007272730 B2 AU2007272730 B2 AU 2007272730B2 AU 2007272730 A AU2007272730 A AU 2007272730A AU 2007272730 A AU2007272730 A AU 2007272730A AU 2007272730 B2 AU2007272730 B2 AU 2007272730B2
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compound
carbon atoms
treatment
compound according
intraocular pressure
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AU2007272730A1 (en
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Vinh X. Ngo
David W. Old
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Allergan Inc
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Allergan Inc
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3834—Aromatic acids (P-C aromatic linkage)
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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AU2007272617B2 (en) * 2006-07-11 2012-11-01 Allergan, Inc. Cyclopentane derivatives as antiglaucoma agents
JP5453254B2 (ja) * 2007-07-03 2014-03-26 アラーガン インコーポレイテッド 眼圧降下用の治療用置換シクロペンタン類
CA2706879A1 (en) * 2007-11-29 2009-06-11 Robert M. Burk Substituted cyclopentanes having prostaglandin activity
US8569349B2 (en) * 2008-05-09 2013-10-29 Allergan, Inc. Therapeutic compounds
US8592413B2 (en) 2008-05-15 2013-11-26 Allergan, Inc. Therapeutic substituted cyclopentanes
US8867820B2 (en) * 2009-10-07 2014-10-21 Microsoft Corporation Systems and methods for removing a background of an image
CA2939569A1 (en) * 2014-02-20 2015-11-19 Allergan, Inc. Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes
ES2693255T3 (es) * 2014-02-27 2018-12-10 Ono Pharmaceutical Co., Ltd. Compuesto que presenta actividad agonista de EP2 selectiva
ES2721525T3 (es) 2014-06-06 2019-08-01 Allergan Inc Novedosos agonistas de EP4 como compuestos terapéuticos
JP6773035B2 (ja) 2015-07-23 2020-10-21 小野薬品工業株式会社 Ｅｐ２アゴニスト活性を有する化合物

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BRPI0714286A2 (pt) 2013-02-26
EP2066615A2 (en) 2009-06-10
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JP2009543792A (ja) 2009-12-10
WO2008008660A2 (en) 2008-01-17

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