JP2009542680A5 - - Google Patents

Download PDF

Info

Publication number
JP2009542680A5
JP2009542680A5 JP2009518322A JP2009518322A JP2009542680A5 JP 2009542680 A5 JP2009542680 A5 JP 2009542680A5 JP 2009518322 A JP2009518322 A JP 2009518322A JP 2009518322 A JP2009518322 A JP 2009518322A JP 2009542680 A5 JP2009542680 A5 JP 2009542680A5
Authority
JP
Japan
Prior art keywords
alkyl
compound
compounds
aryl
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009518322A
Other languages
English (en)
Japanese (ja)
Other versions
JP5564251B2 (ja
JP2009542680A (ja
Filing date
Publication date
Priority claimed from US11/480,174 external-priority patent/US7968574B2/en
Application filed filed Critical
Priority claimed from PCT/US2007/015273 external-priority patent/WO2008002676A2/en
Publication of JP2009542680A publication Critical patent/JP2009542680A/ja
Publication of JP2009542680A5 publication Critical patent/JP2009542680A5/ja
Application granted granted Critical
Publication of JP5564251B2 publication Critical patent/JP5564251B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2009518322A 2006-06-29 2007-06-29 キナーゼカスケードを調節するためのビアリール組成物および方法 Active JP5564251B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11/480,174 2006-06-29
US11/480,174 US7968574B2 (en) 2004-12-28 2006-06-29 Biaryl compositions and methods for modulating a kinase cascade
US92349607P 2007-04-13 2007-04-13
US60/923,496 2007-04-13
PCT/US2007/015273 WO2008002676A2 (en) 2006-06-29 2007-06-29 Biaryl compositions and methods for modulating a kinase cascade

Publications (3)

Publication Number Publication Date
JP2009542680A JP2009542680A (ja) 2009-12-03
JP2009542680A5 true JP2009542680A5 (https=) 2010-08-12
JP5564251B2 JP5564251B2 (ja) 2014-07-30

Family

ID=39608403

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009518322A Active JP5564251B2 (ja) 2006-06-29 2007-06-29 キナーゼカスケードを調節するためのビアリール組成物および方法

Country Status (8)

Country Link
US (3) US10196357B2 (https=)
EP (1) EP2041071B1 (https=)
JP (1) JP5564251B2 (https=)
CN (1) CN101595084B (https=)
AU (1) AU2007265373B2 (https=)
CA (1) CA2656564C (https=)
IL (1) IL196168A (https=)
WO (1) WO2008127728A1 (https=)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0519424B8 (pt) 2004-12-28 2021-05-25 Athenex Inc compostos, composição e uso dos ditos compostos para a preparação de um medicamento para prevenção ou tratamento de um distúrbio de proliferação celular ou infecção microbiana
US7968574B2 (en) 2004-12-28 2011-06-28 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
EP2041071B1 (en) 2006-06-29 2014-06-18 Kinex Pharmaceuticals, LLC Biaryl compositions and methods for modulating a kinase cascade
TWI457336B (zh) * 2006-12-28 2014-10-21 Kinex Pharmaceuticals Llc 調節激酶級聯之組成物及方法
US7935697B2 (en) 2006-12-28 2011-05-03 Kinex Pharmaceuticals, Llc Compositions for modulating a kinase cascade and methods of use thereof
US7939529B2 (en) 2007-05-17 2011-05-10 Kinex Pharmaceuticals, Llc Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
US20100256147A1 (en) * 2007-04-13 2010-10-07 Hangauer Jr David G Biaryl acetamide derivatives as modulators of the kinase cascade for the treatment of hearing loss, osteoporosis and cell proliferation disorders
US8124605B2 (en) 2007-07-06 2012-02-28 Kinex Pharmaceuticals, Llc Compositions and methods for modulating a kinase cascade
EP3777832A1 (en) * 2007-10-20 2021-02-17 Athenex, Inc. Pharmaceutical compositions for modulating a kinase cascade and methods of use thereof
TW200920369A (en) 2007-10-26 2009-05-16 Amira Pharmaceuticals Inc 5-lipoxygenase activating protein (flap) inhibitor
JP5791500B2 (ja) 2008-05-23 2015-10-07 パンミラ ファーマシューティカルズ,エルエルシー. 5−リポキシゲナーゼ活性化タンパク質阻害剤
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
EP2558085B1 (en) * 2010-04-16 2017-08-30 Athenex, Inc. Compositions and methods for the prevention and treatment of cancer
MX2012014537A (es) 2010-07-05 2013-02-21 Merck Patent Gmbh Derivados de bipiridilo utiles para el tratamiento de enfermedades inducidas por cinasa.
KR101851140B1 (ko) * 2011-02-25 2018-04-23 얀센 파마슈티카 엔.브이. 알파 7 nAChR의 알로스테릭 조절자로서의 (피리딘-4-일)벤질아미드
US9926273B2 (en) * 2012-08-30 2018-03-27 Athenex, Inc. Composition and methods for modulating a kinase cascade
JP6437452B2 (ja) 2013-01-14 2018-12-12 インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation Pimキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物
RS60244B1 (sr) 2013-01-15 2020-06-30 Incyte Holdings Corp Jedinjenja tiazolkarboksamida i piridinkarboksamida korisna kao inhibitori pim kinaze
WO2014209034A1 (en) * 2013-06-27 2014-12-31 Lg Life Sciences Ltd. Biaryl derivatives as gpr120 agonists
CN105658653A (zh) 2013-08-23 2016-06-08 因赛特公司 可用作pim激酶抑制剂的呋喃并-和噻吩并-吡啶甲酰胺化合物
WO2016010897A1 (en) 2014-07-14 2016-01-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
AU2015367977B9 (en) 2014-12-24 2020-02-06 Lg Chem, Ltd Biaryl derivative as GPR120 agonist
WO2016196244A1 (en) 2015-05-29 2016-12-08 Incyte Corporation Pyridineamine compounds useful as pim kinase inhibitors
TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Pim激酶抑制劑之鹽
US9920032B2 (en) 2015-10-02 2018-03-20 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
CN106902357B (zh) * 2015-12-21 2021-08-03 广州市香雪制药股份有限公司 药物组合物及其应用、药物包合物、静脉制剂及制备方法
CN118384166A (zh) 2016-08-12 2024-07-26 阿西纳斯公司 用于调节激酶级联的联芳组合物和方法
CN106810490A (zh) * 2017-02-06 2017-06-09 重庆泰润制药有限公司 一种二芳基化合物的晶型及其制备方法和应用
WO2018165647A1 (en) 2017-03-10 2018-09-13 Athenex, Inc. Methods of treating and/or preventing actinic keratosis
AR113922A1 (es) 2017-12-08 2020-07-01 Incyte Corp Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas
BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
CN108467358A (zh) * 2018-05-29 2018-08-31 湖南华腾制药有限公司 一种2-取代-5-吡啶乙酸盐酸盐的化合物及其制备方法
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
CN113461665B (zh) * 2020-03-31 2023-05-19 成都赜灵生物医药科技有限公司 二芳基衍生物及其制备方法和用途
WO2023134753A1 (zh) * 2022-01-14 2023-07-20 武汉人福创新药物研发中心有限公司 微管蛋白-src双靶点抑制剂
US20250115613A1 (en) * 2022-01-14 2025-04-10 Wuhan Humanwell Innovative Drug Research and Development Center Limited Company Diaryl compound as tubulin/src dual target inhibitor
CN117624139A (zh) * 2022-08-25 2024-03-01 武汉人福创新药物研发中心有限公司 二芳基类化合物及其制备方法和用途
CN116854689B (zh) * 2023-09-04 2023-11-17 中国药科大学 一种咪唑[4,5f][1,10]邻菲啰啉类化合物及其制备方法和应用

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3761477A (en) * 1968-11-08 1973-09-25 Mc Neil Labor Inc Pyrazineacetic acids, lower alkyl esters, amides and salts
US3731477A (en) * 1972-01-24 1973-05-08 J Coon Harvester for headed vegetables
IT1044222B (it) * 1972-05-23 1980-03-20 Zambeletti Spa L Bifenilil alcanoilaminopiridine ad attivita anti infiammatoria di lunga durata
AT341512B (de) * 1975-01-09 1978-02-10 Thomae Gmbh Dr K Verfahren zur herstellung von neuen biphenylathern
CA1261835A (en) 1984-08-20 1989-09-26 Masaaki Toda (fused) benz(thio)amides
JPS62252755A (ja) 1986-04-11 1987-11-04 Daikin Ind Ltd 新規n−ベンジルベンズアミド誘導体およびこれを有効成分として含有する除草剤
US5232948A (en) 1990-09-10 1993-08-03 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted monocyclic aryl compounds exhibiting selective leukotriene b4 antagonist activity
CH685875A5 (fr) 1991-04-26 1995-10-31 Pierre Baudet Les N-phényl-benzamides protecteurs contre les effets nocifs de la lumière ultra-violette
CA2103367A1 (en) * 1991-05-20 1992-11-21 Akihide Koda Phellodendrine analogs and allergy type iv suppressor containing the same as active ingredient
DE4236103A1 (de) 1992-10-26 1994-04-28 Hoechst Ag Verfahren zur Kreuzkupplung von aromatischen Boronsäuren mit aromatischen Halogenverbindungen oder Perfluoralkylsulfonaten
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
FR2705671B1 (fr) 1993-05-26 1995-07-07 Inst Nat Sante Rech Med Nouveaux dérivés de l'hydroxybiphényle, leur préparation et les compositions pharmaceutiques qui les contiennent.
CA2144669A1 (en) 1994-03-29 1995-09-30 Kozo Akasaka Biphenyl derivatives
FR2737721B1 (fr) 1995-08-08 1997-09-05 Roussel Uclaf Nouveaux composes biphenyles, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicament et les compositions pharmaceutiques les contenant
AU4885097A (en) 1996-11-08 1998-06-03 Sankyo Company Limited Arylureas or arylmethylcarbamoyl derivatives
ZA985542B (en) 1997-07-03 1999-04-07 Smithkline Beecham Corp Substituted benzanilides as CCR5 receptor ligands antiinflammatory agents and antiviral agents
JP2001023259A (ja) * 1999-07-09 2001-01-26 Sony Corp 光磁気記録媒体およびその製造方法
US6844367B1 (en) * 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
DE60040676D1 (de) 1999-09-17 2008-12-11 Millennium Pharm Inc BENZAMIDE UND ÄHNLICHE INHIBITOREN VON FAKTOR Xa
US6372752B1 (en) 2000-02-07 2002-04-16 Genzyme Corporation Inha inhibitors and methods of use thereof
US20040039048A1 (en) * 2000-02-11 2004-02-26 Manuel Guzman Pastor Therapy with cannabinoid compounds for the treatment of brain tumors
KR100423899B1 (ko) 2000-05-10 2004-03-24 주식회사 엘지생명과학 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸
UY26780A1 (es) 2000-06-15 2002-01-31 Pharmacia Corp Cicloalquil avb3 antagonistas
US6376524B1 (en) 2000-06-21 2002-04-23 Sunesis Pharmaceuticals, Inc. Triphenyl compounds as interleukin-4 antagonists
JP2002020362A (ja) 2000-07-06 2002-01-23 Nippon Oruganon Kk 新規ビフェニル誘導体
EP1351686A2 (en) * 2000-11-20 2003-10-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade
EP1373257B9 (en) 2001-03-29 2008-10-15 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
DE10201764A1 (de) 2002-01-18 2003-07-31 Bayer Cropscience Ag Substituierte 4-Aminopyridin-Derivate
JP2003231633A (ja) 2002-02-06 2003-08-19 Tanabe Seiyaku Co Ltd 医薬組成物
US20050027016A1 (en) 2002-02-07 2005-02-03 Fahl Kathleen L Polyamine compounds and compositions for use in conjection with cancer therapy
JP2005517007A (ja) * 2002-02-07 2005-06-09 アクシス・ファーマスーティカルズ ヒストンデアセチラーゼ阻害剤としての新規二環式ヒドロキサメート
FR2836917B1 (fr) 2002-03-11 2006-02-24 Lipha Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant en tant que medicaments utilisables dans le traitement des pathologies caracterisees par une situation de stress oxydatif
GB0206215D0 (en) * 2002-03-15 2002-05-01 Novartis Ag Organic compounds
TWI319387B (en) 2002-04-05 2010-01-11 Astrazeneca Ab Benzamide derivatives
DE10219294A1 (de) 2002-04-25 2003-11-13 Schering Ag Substituierte N-(1,4,5,6-Tetrahydro-cyclopentapyrazol-3-yl)-Derivate, deren Herstellung und Verwendung als Arzneimittel
GB0209891D0 (en) 2002-04-30 2002-06-05 Glaxo Group Ltd Novel compounds
EP1501514B1 (en) 2002-05-03 2012-12-19 Exelixis, Inc. Protein kinase modulators and methods of use
TW200406374A (en) 2002-05-29 2004-05-01 Novartis Ag Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
SE0201937D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab Therapeutic agents
WO2004011427A2 (en) 2002-07-31 2004-02-05 Smithkline Beecham Corporation Substituted benzanilides as modulators of the ccr5 receptor
US7585866B2 (en) 2002-07-31 2009-09-08 Critical Outcome Technologies, Inc. Protein tyrosine kinase inhibitors
AU2002331472A1 (en) * 2002-08-07 2004-02-25 Xavier, Mauro Stretching lumbar-sacral floating (slsf) vest
MXPA05001804A (es) 2002-08-14 2005-05-27 Vertex Pharma Inhibidores de proteinas cinasas y usos de los mismos.
DE10238865A1 (de) 2002-08-24 2004-03-11 Boehringer Ingelheim International Gmbh Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US20040242572A1 (en) * 2002-08-24 2004-12-02 Boehringer Ingelheim International Gmbh New carboxamide compounds having melanin concentrating hormone antagonistic activity, pharmaceutical preparations comprising these compounds and process for their manufacture
JP2006512314A (ja) * 2002-11-01 2006-04-13 バーテックス ファーマシューティカルズ インコーポレイテッド Jakインヒビターおよび他のプロテインキナーゼインヒビターとしての組成物の使用
ATE552253T1 (de) 2002-11-08 2012-04-15 Novartis Int Pharm Ltd 3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren
SI1569907T1 (sl) * 2002-12-13 2016-06-30 Ym Biosciences Australia Pty Ltd Na nikotinamidu osnovani kinazni inhibitorji
WO2004056774A2 (en) 2002-12-19 2004-07-08 Neurogen Corporation Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
JP5043428B2 (ja) * 2003-06-03 2012-10-10 リブ−エックス ファーマシューティカルズ,インコーポレイテッド ビアリール複素環式化合物ならびにその製造および使用方法
US7501538B2 (en) * 2003-08-08 2009-03-10 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions and methods of use
US8202861B2 (en) 2003-08-08 2012-06-19 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of voltage-gated sodium channels
US8067608B2 (en) * 2003-09-29 2011-11-29 The Johns Hopkins University Hedgehog pathway antagonists
JP2007525482A (ja) 2003-10-07 2007-09-06 レノビス, インコーポレイテッド イオンチャネルリガンドとしてのアミド化合物およびその使用
CN1875002B (zh) 2003-11-05 2011-08-03 霍夫曼-拉罗奇有限公司 作为ppar激动剂的苯基衍生物
PE20060285A1 (es) 2004-03-30 2006-05-08 Aventis Pharma Inc Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp)
US20080269282A1 (en) 2004-08-02 2008-10-30 Genmedica Therapeutics Sl Compounds for Inhibiting Copper-Containing Amine Oxidases and Uses Thereof
US7968574B2 (en) 2004-12-28 2011-06-28 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
BRPI0519424B8 (pt) * 2004-12-28 2021-05-25 Athenex Inc compostos, composição e uso dos ditos compostos para a preparação de um medicamento para prevenção ou tratamento de um distúrbio de proliferação celular ou infecção microbiana
US8211919B2 (en) 2005-09-02 2012-07-03 Astellas Pharma Inc. Amide derivatives as rock inhibitors
WO2007095383A2 (en) 2006-02-15 2007-08-23 Myriad Genetics, Inc. Prodrugs
MX2008014450A (es) 2006-05-18 2009-03-09 Mannkind Corp Inhibidores de cinasa intracelular.
EP2041071B1 (en) 2006-06-29 2014-06-18 Kinex Pharmaceuticals, LLC Biaryl compositions and methods for modulating a kinase cascade
WO2008002676A2 (en) 2006-06-29 2008-01-03 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
CA2673299C (en) * 2006-12-21 2016-04-12 Sloan-Kettering Institute For Cancer Research Pyridazinone compounds for the treatment of proliferative diseases
US7939529B2 (en) 2007-05-17 2011-05-10 Kinex Pharmaceuticals, Llc Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
TWI457336B (zh) 2006-12-28 2014-10-21 Kinex Pharmaceuticals Llc 調節激酶級聯之組成物及方法
US7935697B2 (en) * 2006-12-28 2011-05-03 Kinex Pharmaceuticals, Llc Compositions for modulating a kinase cascade and methods of use thereof
US20100256147A1 (en) 2007-04-13 2010-10-07 Hangauer Jr David G Biaryl acetamide derivatives as modulators of the kinase cascade for the treatment of hearing loss, osteoporosis and cell proliferation disorders
US8124605B2 (en) 2007-07-06 2012-02-28 Kinex Pharmaceuticals, Llc Compositions and methods for modulating a kinase cascade
EP3777832A1 (en) 2007-10-20 2021-02-17 Athenex, Inc. Pharmaceutical compositions for modulating a kinase cascade and methods of use thereof
EP2558085B1 (en) * 2010-04-16 2017-08-30 Athenex, Inc. Compositions and methods for the prevention and treatment of cancer

Similar Documents

Publication Publication Date Title
JP5564251B2 (ja) キナーゼカスケードを調節するためのビアリール組成物および方法
US20240050438A1 (en) Biaryl compositions and methods for modulating a kinase cascade
JP2009542680A5 (https=)
US20210252008A1 (en) Biaryl compositions and methods for modulating a kinase cascade
ES2500165T3 (es) Composiciones de biarilo y métodos para modular una cascada de quinasas
US20100256147A1 (en) Biaryl acetamide derivatives as modulators of the kinase cascade for the treatment of hearing loss, osteoporosis and cell proliferation disorders
JP2016222733A (ja) キナーゼカスケードを調節するための組成物および方法
JP2009542679A (ja) キナーゼカスケードを調節するための二環式組成物および方法
JP2009542679A5 (https=)
US20220160672A1 (en) Pharmaceutical compositions for modulating a kinase cascade and methods of use thereof
TWI398440B (zh) 雙芳基組成物與調節激酶級聯之方法
HK40046527A (en) Pharmaceutical compositions for modulating a kinase cascade and methods of use thereof
HK1147432B (en) Pharmaceutical compositions for modulating a kinase cascade and methods of use thereof
HK1147432A (en) Pharmaceutical compositions for modulating a kinase cascade and methods of use thereof