JP2009540831A5 - - Google Patents

Info

Publication number

JP2009540831A5

JP2009540831A5 JP2009516588A JP2009516588A JP2009540831A5 JP 2009540831 A5 JP2009540831 A5 JP 2009540831A5 JP 2009516588 A JP2009516588 A JP 2009516588A JP 2009516588 A JP2009516588 A JP 2009516588A JP 2009540831 A5 JP2009540831 A5 JP 2009540831A5

Authority

JP

Japan

Prior art keywords

molecule

composition

complement activation

portion comprises

alternative pathway

Prior art date

2007-06-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 230000024203 complement activation Effects 0.000 claims description 16
• 230000037361 pathway Effects 0.000 claims description 14
• 201000010099 disease Diseases 0.000 claims description 12
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
• 239000000203 mixture Substances 0.000 claims description 11
• 102000040430 polynucleotide Human genes 0.000 claims description 6
• 108091033319 polynucleotide Proteins 0.000 claims description 6
• 239000002157 polynucleotide Substances 0.000 claims description 6
• 239000012634 fragment Substances 0.000 claims description 5
• 239000008194 pharmaceutical composition Substances 0.000 claims description 5
• 206010063837 Reperfusion injury Diseases 0.000 claims description 4
• 206010052779 Transplant rejections Diseases 0.000 claims description 4
• 150000001413 amino acids Chemical class 0.000 claims description 4
• 108020001507 fusion proteins Proteins 0.000 claims description 4
• 102000037865 fusion proteins Human genes 0.000 claims description 4
• 208000012947 ischemia reperfusion injury Diseases 0.000 claims description 4
• 208000002780 macular degeneration Diseases 0.000 claims description 4
• 210000000056 organ Anatomy 0.000 claims description 4
• 208000004451 Membranoproliferative Glomerulonephritis Diseases 0.000 claims description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
• 208000005777 Lupus Nephritis Diseases 0.000 claims description 2
• 206010064930 age-related macular degeneration Diseases 0.000 claims description 2
• 239000003937 drug carrier Substances 0.000 claims description 2
• 238000001361 intraarterial administration Methods 0.000 claims description 2
• 238000001990 intravenous administration Methods 0.000 claims description 2
• 239000003446 ligand Substances 0.000 claims description 2
• 208000011511 primary membranoproliferative glomerulonephritis Diseases 0.000 claims description 2
• 206010039073 rheumatoid arthritis Diseases 0.000 claims description 2
• 238000007920 subcutaneous administration Methods 0.000 claims description 2
• 208000009304 Acute Kidney Injury Diseases 0.000 claims 1
• 102000011412 Complement 3d Receptors Human genes 0.000 claims 1
• 108010023729 Complement 3d Receptors Proteins 0.000 claims 1
• 102000016550 Complement Factor H Human genes 0.000 claims 1
• 108010053085 Complement Factor H Proteins 0.000 claims 1
• 208000033626 Renal failure acute Diseases 0.000 claims 1
• 201000011040 acute kidney failure Diseases 0.000 claims 1
• 208000012998 acute renal failure Diseases 0.000 claims 1
• 208000007475 hemolytic anemia Diseases 0.000 claims 1
• 230000002949 hemolytic effect Effects 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• 206010043554 thrombocytopenia Diseases 0.000 claims 1
• 238000000034 method Methods 0.000 description 5