JP2009540275A5 - - Google Patents
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- Publication number
- JP2009540275A5 JP2009540275A5 JP2009513585A JP2009513585A JP2009540275A5 JP 2009540275 A5 JP2009540275 A5 JP 2009540275A5 JP 2009513585 A JP2009513585 A JP 2009513585A JP 2009513585 A JP2009513585 A JP 2009513585A JP 2009540275 A5 JP2009540275 A5 JP 2009540275A5
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- reagent
- liquid chromatography
- releasing
- release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 10
- 229930003316 Vitamin D Natural products 0.000 claims 8
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 8
- 235000019166 vitamin D Nutrition 0.000 claims 8
- 239000011710 vitamin D Substances 0.000 claims 8
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 8
- 229940046008 vitamin d Drugs 0.000 claims 8
- 239000003153 chemical reaction reagent Substances 0.000 claims 6
- 239000002207 metabolite Substances 0.000 claims 6
- 238000004811 liquid chromatography Methods 0.000 claims 4
- 102000050760 Vitamin D-binding protein Human genes 0.000 claims 2
- 101710179590 Vitamin D-binding protein Proteins 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000004440 column chromatography Methods 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 230000006920 protein precipitation Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 235000020799 vitamin D status Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06011605 | 2006-06-06 | ||
| EP06011605.0 | 2006-06-06 | ||
| PCT/EP2007/004924 WO2007140962A2 (en) | 2006-06-06 | 2007-06-04 | Improved measurement of vitamin d |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009540275A JP2009540275A (ja) | 2009-11-19 |
| JP2009540275A5 true JP2009540275A5 (enExample) | 2010-05-20 |
| JP4953477B2 JP4953477B2 (ja) | 2012-06-13 |
Family
ID=36646176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009513585A Active JP4953477B2 (ja) | 2006-06-06 | 2007-06-04 | 改良されたビタミンｄ測定 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8003400B2 (enExample) |
| EP (1) | EP2030026B1 (enExample) |
| JP (1) | JP4953477B2 (enExample) |
| CN (1) | CN101467048B (enExample) |
| AT (1) | ATE452343T1 (enExample) |
| CA (1) | CA2649338C (enExample) |
| DE (1) | DE602007003833D1 (enExample) |
| ES (1) | ES2336382T3 (enExample) |
| WO (1) | WO2007140962A2 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7745226B2 (en) | 2005-04-06 | 2010-06-29 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites |
| US7972868B2 (en) | 2007-11-28 | 2011-07-05 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
| JP5449202B2 (ja) * | 2008-02-25 | 2014-03-19 | ウオーターズ・テクノロジーズ・コーポレイシヨン | サンプル中のビタミンｄ類似体の存在および量の決定のための方法およびキット |
| CN101978262B (zh) * | 2008-03-31 | 2013-12-25 | 积水化学工业株式会社 | 液相色谱用构件 |
| US8399829B2 (en) | 2008-12-18 | 2013-03-19 | Quest Diagnostics Investments Incorporated | Vitamin B2 detection by mass spectrometry |
| GB0903469D0 (en) * | 2009-03-02 | 2009-04-08 | Axis Shield Diagnostics Ltd | Assay |
| US7977117B2 (en) | 2009-12-03 | 2011-07-12 | Quest Diagnostics Investments Incorprated | Vitamin D metabolite determination utilizing mass spectrometry following derivatization |
| WO2011072152A1 (en) * | 2009-12-11 | 2011-06-16 | Quest Diagnostics Investments Incorporated | Mass spectrometry of steroidal compounds in multiplex samples |
| JP6113504B2 (ja) | 2009-12-11 | 2017-04-12 | クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
| JP5351076B2 (ja) * | 2010-02-26 | 2013-11-27 | 杏林製薬株式会社 | オンライン固相抽出による生体試料液中薬剤成分の定量方法 |
| EP2372365A1 (en) * | 2010-04-01 | 2011-10-05 | Future Diagnostics B.V. | Direct immunoassay for vitamin D |
| ES2795849T3 (es) * | 2010-05-20 | 2020-11-25 | Hoffmann La Roche | Reactivo de liberación para compuestos de vitamina D |
| CA2821415C (en) * | 2010-12-28 | 2017-08-01 | Future Diagnostics B.V. | Release reagent for vitamin d |
| EP2661632B1 (en) | 2011-01-07 | 2018-03-07 | The General Hospital Corporation | Assays and methods of treatment relating to vitamin d insufficiency |
| US9052308B2 (en) | 2011-01-07 | 2015-06-09 | The General Hospital Corporation | Assays and methods of treatment relating to vitamin D insufficiency |
| WO2014179737A2 (en) | 2013-05-03 | 2014-11-06 | The General Hospital Corporation | Assays and methods of treatment relating to vitamin d insufficiency |
| US8785603B2 (en) | 2011-05-20 | 2014-07-22 | Siemens Healthcare Diagnostics Inc. | Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof |
| BR112014009500B1 (pt) * | 2011-11-18 | 2022-04-19 | F. Hoffmann-La Roche Ag | Método in vitro para a liberação de um composto de vitamina d, método in vitro para medição de um composto de vitamina d e uso de uma composição reagente |
| CN102692514A (zh) * | 2012-06-21 | 2012-09-26 | 厦门大学 | 血液25-羟基维生素d3腺癌检测试剂盒及其制备方法 |
| US9244083B2 (en) | 2012-11-30 | 2016-01-26 | Siemens Healthcare Diagnostics Inc. | Compositions and methods for detecting vitamin D |
| JP6171333B2 (ja) * | 2012-12-26 | 2017-08-02 | 東ソー株式会社 | 安定化したビタミンｄ類標準液 |
| KR101840525B1 (ko) | 2013-02-06 | 2018-03-20 | 후지레비오 가부시키가이샤 | 비타민 d 의 측정 방법 및 측정용 키트 |
| US9618523B2 (en) | 2013-02-28 | 2017-04-11 | Siemens Healthcare Diagnostics Inc. | Methods and reagents for determining isomeric analytes |
| US20140273021A1 (en) * | 2013-03-14 | 2014-09-18 | Enzo Biochem, Inc. | Vitamin d assays |
| DE102013205055A1 (de) * | 2013-03-21 | 2014-09-25 | Orgentec Diagnostika Gmbh | Verfahren und Reagenz zur Bestimmung von Vitamin D Metaboliten |
| DE102013215580A1 (de) | 2013-08-07 | 2015-02-12 | Orgentec Diagnostika Gmbh | 25-OH Vitamin D Derivate zur Bestimmung von Vitamin D Metaboliten |
| CN103467382A (zh) * | 2013-09-16 | 2013-12-25 | 浙江丽晶化学有限公司 | 含硫氰酸根离子液体的制备方法及其在聚丙烯腈纺丝加工中的应用 |
| WO2015061598A1 (en) | 2013-10-24 | 2015-04-30 | Quidel Corporation | Systems and methods for whole blood assays |
| EP3168619B1 (en) | 2014-07-10 | 2021-10-20 | Shenzhen New Industries Biomedical Engineering Co., Ltd. | Detection agent for detecting 25-hydroxy vitamin d, preparation method and use |
| CN104076155B (zh) * | 2014-07-10 | 2016-08-31 | 深圳市新产业生物医学工程股份有限公司 | 用于检测25-羟基维生素d的检测剂及制备方法和应用 |
| CN105372337B (zh) * | 2014-08-07 | 2017-11-10 | 山东达因海洋生物制药股份有限公司 | 一种检测维生素d滴剂中维生素d含量的方法 |
| WO2017039574A1 (en) * | 2015-08-28 | 2017-03-09 | Enzo Life Sciences, Inc. | Vitamin d assays |
| MX379918B (es) * | 2015-11-25 | 2025-03-11 | Del Mar Pharmaceuticals Bc Ltd | Metodos para analisis y resolucion de preparaciones de dianhidrogalactitol y derivados o analogos del mismo. |
| US10852310B2 (en) | 2015-12-11 | 2020-12-01 | Opko Diagnostics, Llc | Fluidic systems involving incubation of samples and/or reagents |
| CN106199015B (zh) * | 2016-06-27 | 2018-08-17 | 江苏拜明生物技术有限公司 | 用于血清样品检测的维生素d释放剂、制备方法及应用 |
| CN110068641A (zh) * | 2018-01-22 | 2019-07-30 | 上海可力梅塔生物医药科技有限公司 | 25-羟基维生素d2和25-羟基维生素d3的hplc-ms/ms非衍生检测法 |
| CN108982882A (zh) * | 2018-06-22 | 2018-12-11 | 卢氏实验室公司 | 一种数字化信息化维生素d快速检测系统和方法 |
| CN110794065A (zh) * | 2018-08-03 | 2020-02-14 | 郑州泰丰制药有限公司 | 利用双三元检测骨化三醇软胶囊含量的方法 |
| CN108663461B (zh) * | 2018-08-06 | 2021-03-19 | 通标标准技术服务(上海)有限公司 | 一种测定奶粉中维生素d的方法 |
| CN109358148A (zh) * | 2018-09-20 | 2019-02-19 | 杭州和合医学检验实验室有限公司 | 血液中维生素d的检验方法 |
| CN116209901A (zh) * | 2020-09-29 | 2023-06-02 | 豪夫迈·罗氏有限公司 | 用于测定维生素d及其代谢物的量的方法 |
| CN119322137A (zh) * | 2024-12-17 | 2025-01-17 | 凯莱谱科技股份有限公司 | 血清维生素d代谢通路代谢物的液相色谱串联质谱检测方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5821020A (en) * | 1995-07-14 | 1998-10-13 | Nhh Biologics | Vitamin D assay |
| WO1997024127A1 (en) * | 1995-12-29 | 1997-07-10 | A And D Assay, Incorporated | Labeled vitamin d compounds and the use thereof |
| DE19981132D2 (de) * | 1998-06-25 | 2001-10-18 | Immundiagnostik Ges Fuer Produ | Funktionelle Vitamin-D-Derivate und Verfahren zur Bestimmung von 25-Hydroxy- und 1alpha,25-Dihydroxy-Vitamin-D |
| GB0029729D0 (en) * | 2000-12-06 | 2001-01-17 | Ids Ltd | Method for detection of vitamin D metabolites |
| US7087395B1 (en) * | 2001-01-16 | 2006-08-08 | Quest Diagnostics Investments Incorporated | Vitamin D assay |
| US20040132104A1 (en) * | 2003-01-07 | 2004-07-08 | Sackrison James L. | Vitamin D assay |
| CA2624129C (en) * | 2005-09-29 | 2011-03-29 | F. Hoffmann-La Roche Ag | Release reagent for vitamin d compounds |
-
2007
- 2007-06-04 ES ES07725793T patent/ES2336382T3/es active Active
- 2007-06-04 CA CA2649338A patent/CA2649338C/en active Active
- 2007-06-04 CN CN200780021252.0A patent/CN101467048B/zh active Active
- 2007-06-04 AT AT07725793T patent/ATE452343T1/de active
- 2007-06-04 JP JP2009513585A patent/JP4953477B2/ja active Active
- 2007-06-04 DE DE602007003833T patent/DE602007003833D1/de active Active
- 2007-06-04 EP EP07725793A patent/EP2030026B1/en active Active
- 2007-06-04 WO PCT/EP2007/004924 patent/WO2007140962A2/en not_active Ceased
-
2008
- 2008-12-03 US US12/326,972 patent/US8003400B2/en active Active
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