JP2009540275A5 - - Google Patents
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- JP2009540275A5 JP2009540275A5 JP2009513585A JP2009513585A JP2009540275A5 JP 2009540275 A5 JP2009540275 A5 JP 2009540275A5 JP 2009513585 A JP2009513585 A JP 2009513585A JP 2009513585 A JP2009513585 A JP 2009513585A JP 2009540275 A5 JP2009540275 A5 JP 2009540275A5
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- JP
- Japan
- Prior art keywords
- vitamin
- reagent
- liquid chromatography
- releasing
- release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940046008 Vitamin D Drugs 0.000 claims 10
- 229930003316 Vitamin D Natural products 0.000 claims 10
- 235000019166 vitamin D Nutrition 0.000 claims 10
- 239000011710 vitamin D Substances 0.000 claims 10
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 8
- 239000003153 chemical reaction reagent Substances 0.000 claims 6
- 239000002207 metabolite Substances 0.000 claims 6
- 238000004811 liquid chromatography Methods 0.000 claims 4
- 150000001768 cations Chemical class 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 102000028599 vitamin D binding proteins Human genes 0.000 claims 2
- 108091022026 vitamin D binding proteins Proteins 0.000 claims 2
- 210000002381 Plasma Anatomy 0.000 claims 1
- 210000002966 Serum Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000004440 column chromatography Methods 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 235000020799 vitamin D status Nutrition 0.000 claims 1
Claims (10)
- 試料中のビタミンD代謝産物を測定する方法であって、
a)ビタミンD結合タンパク質からビタミンD代謝産物を放出するが、タンパク質沈殿を生じないことに適した条件下で、試料を放出試薬で処理する工程、
b)工程(a)で得られた処理試料を液体クロマトグラフィーにかける工程、および
c)液体クロマトグラフィー中または後にビタミンD代謝産物を測定する工程
を含み、該放出試薬がカチオンとして4級N-複素環を有する塩に基づいている、方法。 - 前記液体クロマトグラフィーがフリットおよび床物質を含むカラムの使用によって行われるカラムクロマトグラフィーである、請求項1記載の方法。
- 前記フリットが0.2または0.5μmの孔径を有する、請求項1または2記載の方法。
- 前記床物質が粒子状であり、粒子が1〜10μmの直径を有する、請求項1〜3いずれか記載の方法。
- 前記液体クロマトグラフィーが高速液体クロマトグラフィー(HPLC)である、請求項1〜4いずれか記載の方法。
- 前記放出試薬がビタミンD結合タンパク質から少なくとも99%の25 OH-ビタミンD3を放出することができる試薬である、請求項1記載の方法。
- ビタミンD代謝産物が25 OH-ビタミンD3である、請求項1〜6いずれか記載の方法。
- 前記試料が血清または血漿である、請求項1〜7いずれか記載の方法。
- 個体のビタミンD状態の測定における請求項1〜8いずれか記載の方法の使用。
- ビタミンD放出試薬およびさらにアイソトープ標識ビタミンD代謝産物を含むキットであって、該アイソトープ標識ビタミンD代謝産物は別個の成分として存在し得るか、またはビタミンD放出試薬内に既に含まれ、該放出試薬はカチオンとして4級N-複素環を有する塩に基づいている、キット。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06011605.0 | 2006-06-06 | ||
EP06011605 | 2006-06-06 | ||
PCT/EP2007/004924 WO2007140962A2 (en) | 2006-06-06 | 2007-06-04 | Improved measurement of vitamin d |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009540275A JP2009540275A (ja) | 2009-11-19 |
JP2009540275A5 true JP2009540275A5 (ja) | 2010-05-20 |
JP4953477B2 JP4953477B2 (ja) | 2012-06-13 |
Family
ID=36646176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009513585A Active JP4953477B2 (ja) | 2006-06-06 | 2007-06-04 | 改良されたビタミンd測定 |
Country Status (9)
Country | Link |
---|---|
US (1) | US8003400B2 (ja) |
EP (1) | EP2030026B1 (ja) |
JP (1) | JP4953477B2 (ja) |
CN (1) | CN101467048B (ja) |
AT (1) | ATE452343T1 (ja) |
CA (1) | CA2649338C (ja) |
DE (1) | DE602007003833D1 (ja) |
ES (1) | ES2336382T3 (ja) |
WO (1) | WO2007140962A2 (ja) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7745226B2 (en) | 2005-04-06 | 2010-06-29 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites |
US7972868B2 (en) | 2007-11-28 | 2011-07-05 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
WO2009108571A1 (en) * | 2008-02-25 | 2009-09-03 | Waters Technologies Corporation | Methods and kits for the determination of the presence and quantity of vitamin d analogs in samples |
WO2009123199A1 (ja) * | 2008-03-31 | 2009-10-08 | 積水化学工業株式会社 | 液体クロマトグラフィー用部材 |
US8399829B2 (en) | 2008-12-18 | 2013-03-19 | Quest Diagnostics Investments Incorporated | Vitamin B2 detection by mass spectrometry |
GB0903469D0 (en) * | 2009-03-02 | 2009-04-08 | Axis Shield Diagnostics Ltd | Assay |
US7977117B2 (en) | 2009-12-03 | 2011-07-12 | Quest Diagnostics Investments Incorprated | Vitamin D metabolite determination utilizing mass spectrometry following derivatization |
EP3693734A3 (en) | 2009-12-11 | 2020-12-23 | Quest Diagnostics Investments Incorporated | Mass spectrometry of steroidal compounds in multiplex samples |
US20110240840A1 (en) | 2009-12-11 | 2011-10-06 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of cookson-derivatized, non-metabolized vitamin d |
JP5351076B2 (ja) * | 2010-02-26 | 2013-11-27 | 杏林製薬株式会社 | オンライン固相抽出による生体試料液中薬剤成分の定量方法 |
EP2372365A1 (en) * | 2010-04-01 | 2011-10-05 | Future Diagnostics B.V. | Direct immunoassay for vitamin D |
AU2011254567B2 (en) * | 2010-05-20 | 2014-04-10 | F. Hoffmann-La Roche Ag | Release reagent for vitamin D compounds |
EP2635611B1 (en) * | 2010-12-28 | 2017-01-11 | Future Diagnostics B.V. | Release reagent for vitamin d |
WO2012094550A2 (en) * | 2011-01-07 | 2012-07-12 | The General Hospital Corporation | Assays and methods of treatment relating to vitamin d insufficiency |
US9052308B2 (en) | 2011-01-07 | 2015-06-09 | The General Hospital Corporation | Assays and methods of treatment relating to vitamin D insufficiency |
WO2014179737A2 (en) | 2013-05-03 | 2014-11-06 | The General Hospital Corporation | Assays and methods of treatment relating to vitamin d insufficiency |
US8785603B2 (en) | 2011-05-20 | 2014-07-22 | Siemens Healthcare Diagnostics Inc. | Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof |
BR112014009500B1 (pt) * | 2011-11-18 | 2022-04-19 | F. Hoffmann-La Roche Ag | Método in vitro para a liberação de um composto de vitamina d, método in vitro para medição de um composto de vitamina d e uso de uma composição reagente |
CN102692514A (zh) * | 2012-06-21 | 2012-09-26 | 厦门大学 | 血液25-羟基维生素d3腺癌检测试剂盒及其制备方法 |
US9244083B2 (en) | 2012-11-30 | 2016-01-26 | Siemens Healthcare Diagnostics Inc. | Compositions and methods for detecting vitamin D |
JP6171333B2 (ja) * | 2012-12-26 | 2017-08-02 | 東ソー株式会社 | 安定化したビタミンd類標準液 |
JP6281497B2 (ja) * | 2013-02-06 | 2018-02-21 | 富士レビオ株式会社 | ビタミンdの測定方法および測定用キット |
US9618523B2 (en) | 2013-02-28 | 2017-04-11 | Siemens Healthcare Diagnostics Inc. | Methods and reagents for determining isomeric analytes |
US20140273021A1 (en) * | 2013-03-14 | 2014-09-18 | Enzo Biochem, Inc. | Vitamin d assays |
DE102013205055A1 (de) * | 2013-03-21 | 2014-09-25 | Orgentec Diagnostika Gmbh | Verfahren und Reagenz zur Bestimmung von Vitamin D Metaboliten |
DE102013215580A1 (de) * | 2013-08-07 | 2015-02-12 | Orgentec Diagnostika Gmbh | 25-OH Vitamin D Derivate zur Bestimmung von Vitamin D Metaboliten |
CN103467382A (zh) * | 2013-09-16 | 2013-12-25 | 浙江丽晶化学有限公司 | 含硫氰酸根离子液体的制备方法及其在聚丙烯腈纺丝加工中的应用 |
US20150118689A1 (en) | 2013-10-24 | 2015-04-30 | Quidel Corporation | Systems and methods for whole blood assays |
EP3168619B1 (en) | 2014-07-10 | 2021-10-20 | Shenzhen New Industries Biomedical Engineering Co., Ltd. | Detection agent for detecting 25-hydroxy vitamin d, preparation method and use |
CN104076155B (zh) * | 2014-07-10 | 2016-08-31 | 深圳市新产业生物医学工程股份有限公司 | 用于检测25-羟基维生素d的检测剂及制备方法和应用 |
CN105372337B (zh) * | 2014-08-07 | 2017-11-10 | 山东达因海洋生物制药股份有限公司 | 一种检测维生素d滴剂中维生素d含量的方法 |
WO2017039574A1 (en) * | 2015-08-28 | 2017-03-09 | Enzo Life Sciences, Inc. | Vitamin d assays |
US10591445B2 (en) | 2015-11-25 | 2020-03-17 | Del Mar Pharmaceuticals (Bc) Ltd. | Methods for analysis and resolution of preparations of dianhydrogalactitol and derivatives or analogs thereof |
CA3005084A1 (en) * | 2015-12-11 | 2017-06-15 | Opko Diagnostics, Llc | Fluidic systems involving incubation of samples and/or reagents |
CN106199015B (zh) * | 2016-06-27 | 2018-08-17 | 江苏拜明生物技术有限公司 | 用于血清样品检测的维生素d释放剂、制备方法及应用 |
CN108982882A (zh) * | 2018-06-22 | 2018-12-11 | 卢氏实验室公司 | 一种数字化信息化维生素d快速检测系统和方法 |
CN110794065A (zh) * | 2018-08-03 | 2020-02-14 | 郑州泰丰制药有限公司 | 利用双三元检测骨化三醇软胶囊含量的方法 |
CN108663461B (zh) * | 2018-08-06 | 2021-03-19 | 通标标准技术服务(上海)有限公司 | 一种测定奶粉中维生素d的方法 |
CN109358148A (zh) * | 2018-09-20 | 2019-02-19 | 杭州和合医学检验实验室有限公司 | 血液中维生素d的检验方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5821020A (en) * | 1995-07-14 | 1998-10-13 | Nhh Biologics | Vitamin D assay |
EP0873126A4 (en) * | 1995-12-29 | 2000-04-19 | A And D Assay Inc | BRANDED VITAMIN COMPOUNDS AND THEIR USE |
DE19981132D2 (de) * | 1998-06-25 | 2001-10-18 | Immundiagnostik Ges Fuer Produ | Funktionelle Vitamin-D-Derivate und Verfahren zur Bestimmung von 25-Hydroxy- und 1alpha,25-Dihydroxy-Vitamin-D |
GB0029729D0 (en) * | 2000-12-06 | 2001-01-17 | Ids Ltd | Method for detection of vitamin D metabolites |
US7087395B1 (en) * | 2001-01-16 | 2006-08-08 | Quest Diagnostics Investments Incorporated | Vitamin D assay |
US20040132104A1 (en) * | 2003-01-07 | 2004-07-08 | Sackrison James L. | Vitamin D assay |
CN101273272B (zh) * | 2005-09-29 | 2012-11-07 | 霍夫曼-拉罗奇有限公司 | 维生素d化合物的释放试剂 |
-
2007
- 2007-06-04 ES ES07725793T patent/ES2336382T3/es active Active
- 2007-06-04 EP EP07725793A patent/EP2030026B1/en active Active
- 2007-06-04 CN CN200780021252.0A patent/CN101467048B/zh active Active
- 2007-06-04 CA CA2649338A patent/CA2649338C/en active Active
- 2007-06-04 WO PCT/EP2007/004924 patent/WO2007140962A2/en active Application Filing
- 2007-06-04 JP JP2009513585A patent/JP4953477B2/ja active Active
- 2007-06-04 DE DE602007003833T patent/DE602007003833D1/de active Active
- 2007-06-04 AT AT07725793T patent/ATE452343T1/de active
-
2008
- 2008-12-03 US US12/326,972 patent/US8003400B2/en active Active
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