JP2009539938A5 - - Google Patents
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- Publication number
- JP2009539938A5 JP2009539938A5 JP2009514801A JP2009514801A JP2009539938A5 JP 2009539938 A5 JP2009539938 A5 JP 2009539938A5 JP 2009514801 A JP2009514801 A JP 2009514801A JP 2009514801 A JP2009514801 A JP 2009514801A JP 2009539938 A5 JP2009539938 A5 JP 2009539938A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- phenyl
- piperidinecarboxamide
- piperazinyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
- 125000001072 heteroaryl group Chemical group 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- VAHGCBIEHWKWMD-IBGZPJMESA-N 4-(3-fluoroanilino)-n-methyl-n-[4-[[(3s)-3-methylpiperazin-1-yl]methyl]phenyl]piperidine-1-carboxamide Chemical compound C1CN[C@@H](C)CN1CC1=CC=C(N(C)C(=O)N2CCC(CC2)NC=2C=C(F)C=CC=2)C=C1 VAHGCBIEHWKWMD-IBGZPJMESA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- -1 (piperazinyl) methylene substituent Chemical group 0.000 claims 1
- AEMCAHYRZPQHGI-IBGZPJMESA-N 4-(2-carbamoylanilino)-n-methyl-n-[4-[[(3s)-3-methylpiperazin-1-yl]methyl]phenyl]piperidine-1-carboxamide Chemical compound C1CN[C@@H](C)CN1CC1=CC=C(N(C)C(=O)N2CCC(CC2)NC=2C(=CC=CC=2)C(N)=O)C=C1 AEMCAHYRZPQHGI-IBGZPJMESA-N 0.000 claims 1
- NOOCUGDSASZTIW-FQEVSTJZSA-N 4-(2-cyanoanilino)-n-methyl-n-[4-[[(3s)-3-methylpiperazin-1-yl]methyl]phenyl]piperidine-1-carboxamide Chemical compound C1CN[C@@H](C)CN1CC1=CC=C(N(C)C(=O)N2CCC(CC2)NC=2C(=CC=CC=2)C#N)C=C1 NOOCUGDSASZTIW-FQEVSTJZSA-N 0.000 claims 1
- RVEDDKMAENNWSJ-IBGZPJMESA-N 4-(2-fluoroanilino)-n-methyl-n-[4-[[(3s)-3-methylpiperazin-1-yl]methyl]phenyl]piperidine-1-carboxamide Chemical compound C1CN[C@@H](C)CN1CC1=CC=C(N(C)C(=O)N2CCC(CC2)NC=2C(=CC=CC=2)F)C=C1 RVEDDKMAENNWSJ-IBGZPJMESA-N 0.000 claims 1
- POTIXHFLOMRIPL-UHFFFAOYSA-N 4-(3-cyanoanilino)-n-methyl-n-[4-(piperazin-1-ylmethyl)phenyl]piperidine-1-carboxamide Chemical compound C=1C=C(CN2CCNCC2)C=CC=1N(C)C(=O)N(CC1)CCC1NC1=CC=CC(C#N)=C1 POTIXHFLOMRIPL-UHFFFAOYSA-N 0.000 claims 1
- YTEWUWUUWKZUEH-FQEVSTJZSA-N 4-(3-cyanoanilino)-n-methyl-n-[4-[[(3s)-3-methylpiperazin-1-yl]methyl]phenyl]piperidine-1-carboxamide Chemical compound C1CN[C@@H](C)CN1CC1=CC=C(N(C)C(=O)N2CCC(CC2)NC=2C=C(C=CC=2)C#N)C=C1 YTEWUWUUWKZUEH-FQEVSTJZSA-N 0.000 claims 1
- CBGQNRZLQSNQNS-FQEVSTJZSA-N 4-(3-cyanophenyl)-n-methyl-n-[4-[[(3s)-3-methylpiperazin-1-yl]methyl]phenyl]piperidine-1-carboxamide Chemical compound C1CN[C@@H](C)CN1CC1=CC=C(N(C)C(=O)N2CCC(CC2)C=2C=C(C=CC=2)C#N)C=C1 CBGQNRZLQSNQNS-FQEVSTJZSA-N 0.000 claims 1
- WMSXCTMDOXKYEK-IBGZPJMESA-N 4-(3-fluoro-4-methoxyanilino)-n-methyl-n-[4-[[(3s)-3-methylpiperazin-1-yl]methyl]phenyl]piperidine-1-carboxamide Chemical compound C1=C(F)C(OC)=CC=C1NC1CCN(C(=O)N(C)C=2C=CC(CN3C[C@H](C)NCC3)=CC=2)CC1 WMSXCTMDOXKYEK-IBGZPJMESA-N 0.000 claims 1
- UGSIGXWFIZZAAR-FQEVSTJZSA-N 4-(3-fluoroanilino)-n-methyl-n-[3-methyl-4-[[(3s)-3-methylpiperazin-1-yl]methyl]phenyl]piperidine-1-carboxamide Chemical compound C1CN[C@@H](C)CN1CC1=CC=C(N(C)C(=O)N2CCC(CC2)NC=2C=C(F)C=CC=2)C=C1C UGSIGXWFIZZAAR-FQEVSTJZSA-N 0.000 claims 1
- GBDNMGFJZHEWJK-UHFFFAOYSA-N 4-(3-fluoroanilino)-n-methyl-n-[4-(piperazin-1-ylmethyl)phenyl]piperidine-1-carboxamide Chemical compound C=1C=C(CN2CCNCC2)C=CC=1N(C)C(=O)N(CC1)CCC1NC1=CC=CC(F)=C1 GBDNMGFJZHEWJK-UHFFFAOYSA-N 0.000 claims 1
- VAHGCBIEHWKWMD-LJQANCHMSA-N 4-(3-fluoroanilino)-n-methyl-n-[4-[[(3r)-3-methylpiperazin-1-yl]methyl]phenyl]piperidine-1-carboxamide Chemical compound C1CN[C@H](C)CN1CC1=CC=C(N(C)C(=O)N2CCC(CC2)NC=2C=C(F)C=CC=2)C=C1 VAHGCBIEHWKWMD-LJQANCHMSA-N 0.000 claims 1
- QEJHPRPCSRIROF-SFHVURJKSA-N 4-(3-fluoroanilino)-n-methyl-n-[6-[[(3s)-3-methylpiperazin-1-yl]methyl]pyridin-3-yl]piperidine-1-carboxamide Chemical compound C1CN[C@@H](C)CN1CC1=CC=C(N(C)C(=O)N2CCC(CC2)NC=2C=C(F)C=CC=2)C=N1 QEJHPRPCSRIROF-SFHVURJKSA-N 0.000 claims 1
- MHWVNOWZAYMLBI-IBGZPJMESA-N 4-(3-fluorophenoxy)-n-methyl-n-[4-[[(3s)-3-methylpiperazin-1-yl]methyl]phenyl]piperidine-1-carboxamide Chemical compound C1CN[C@@H](C)CN1CC1=CC=C(N(C)C(=O)N2CCC(CC2)OC=2C=C(F)C=CC=2)C=C1 MHWVNOWZAYMLBI-IBGZPJMESA-N 0.000 claims 1
- ZMIHIMYJXRASEQ-IBGZPJMESA-N 4-(3-fluorophenyl)-n-methyl-n-[4-[[(3s)-3-methylpiperazin-1-yl]methyl]phenyl]piperidine-1-carboxamide Chemical compound C1CN[C@@H](C)CN1CC1=CC=C(N(C)C(=O)N2CCC(CC2)C=2C=C(F)C=CC=2)C=C1 ZMIHIMYJXRASEQ-IBGZPJMESA-N 0.000 claims 1
- VBSRCXCGKMBKIV-FQEVSTJZSA-N 4-(4-cyanoanilino)-n-methyl-n-[4-[[(3s)-3-methylpiperazin-1-yl]methyl]phenyl]piperidine-1-carboxamide Chemical compound C1CN[C@@H](C)CN1CC1=CC=C(N(C)C(=O)N2CCC(CC2)NC=2C=CC(=CC=2)C#N)C=C1 VBSRCXCGKMBKIV-FQEVSTJZSA-N 0.000 claims 1
- FQQOBLHOKLMWSN-IBGZPJMESA-N 4-(4-fluoro-3-methoxyanilino)-n-methyl-n-[4-[[(3s)-3-methylpiperazin-1-yl]methyl]phenyl]piperidine-1-carboxamide Chemical compound C1=C(F)C(OC)=CC(NC2CCN(CC2)C(=O)N(C)C=2C=CC(CN3C[C@H](C)NCC3)=CC=2)=C1 FQQOBLHOKLMWSN-IBGZPJMESA-N 0.000 claims 1
- PDPFEGLNWDJQTL-UHFFFAOYSA-N 4-(4-fluoroanilino)-n-methyl-n-[4-(piperazin-1-ylmethyl)phenyl]piperidine-1-carboxamide Chemical compound C=1C=C(CN2CCNCC2)C=CC=1N(C)C(=O)N(CC1)CCC1NC1=CC=C(F)C=C1 PDPFEGLNWDJQTL-UHFFFAOYSA-N 0.000 claims 1
- OKKIPMUUMQAQDL-IBGZPJMESA-N 4-(4-fluoroanilino)-n-methyl-n-[4-[[(3s)-3-methylpiperazin-1-yl]methyl]phenyl]piperidine-1-carboxamide Chemical compound C1CN[C@@H](C)CN1CC1=CC=C(N(C)C(=O)N2CCC(CC2)NC=2C=CC(F)=CC=2)C=C1 OKKIPMUUMQAQDL-IBGZPJMESA-N 0.000 claims 1
- OJJXMMVVELBULF-IBGZPJMESA-N 4-(4-fluorophenyl)-n-methyl-n-[4-[[(3s)-3-methylpiperazin-1-yl]methyl]phenyl]piperidine-1-carboxamide Chemical compound C1CN[C@@H](C)CN1CC1=CC=C(N(C)C(=O)N2CCC(CC2)C=2C=CC(F)=CC=2)C=C1 OJJXMMVVELBULF-IBGZPJMESA-N 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 150000001299 aldehydes Chemical class 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- LOZWNVRRUMVRHD-BGYRXZFFSA-N n-[4-[[(3s,5r)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]-4-(3-fluoroanilino)-n-methylpiperidine-1-carboxamide Chemical compound C1[C@@H](C)N[C@@H](C)CN1CC1=CC=C(N(C)C(=O)N2CCC(CC2)NC=2C=C(F)C=CC=2)C=C1 LOZWNVRRUMVRHD-BGYRXZFFSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 238000006722 reduction reaction Methods 0.000 claims 1
- 238000006268 reductive amination reaction Methods 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 0 CN1C(*)CN(C/C2=C\C=C\C(\N(*)C(N3CCC(**)CC3)=O)=C/C=C2)CC1* Chemical compound CN1C(*)CN(C/C2=C\C=C\C(\N(*)C(N3CCC(**)CC3)=O)=C/C=C2)CC1* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0611907.7A GB0611907D0 (en) | 2006-06-15 | 2006-06-15 | Compounds |
| GB0611907.7 | 2006-06-15 | ||
| PCT/EP2007/055890 WO2007144400A1 (en) | 2006-06-15 | 2007-06-14 | Benzylpiperazine derivatives as motilin receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009539938A JP2009539938A (ja) | 2009-11-19 |
| JP2009539938A5 true JP2009539938A5 (https=) | 2013-03-21 |
| JP5232143B2 JP5232143B2 (ja) | 2013-07-10 |
Family
ID=36775731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009514801A Expired - Fee Related JP5232143B2 (ja) | 2006-06-15 | 2007-06-14 | モチリン受容体アンタゴニストとしてのベンジルピペラジン誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8012981B2 (https=) |
| EP (1) | EP2029538B1 (https=) |
| JP (1) | JP5232143B2 (https=) |
| AT (1) | ATE542795T1 (https=) |
| ES (1) | ES2379658T3 (https=) |
| GB (1) | GB0611907D0 (https=) |
| WO (1) | WO2007144400A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0611907D0 (en) * | 2006-06-15 | 2006-07-26 | Glaxo Group Ltd | Compounds |
| AU2006274212B2 (en) | 2005-07-26 | 2011-06-09 | Glaxo Group Limited | Benzylpiperazine derivates and their medical use |
| GB0524814D0 (en) * | 2005-12-05 | 2006-01-11 | Glaxo Group Ltd | Compounds |
| US8494661B2 (en) | 2007-12-28 | 2013-07-23 | Server Technology, Inc. | Power distribution, management, and monitoring systems and methods |
| DE602007006019D1 (de) | 2006-06-28 | 2010-06-02 | Glaxo Group Ltd | Für die behandlung von durch den gpr38-rezeptor vermittelten krankheiten geeignete piperazinylderivate |
| US8321163B2 (en) | 2009-03-04 | 2012-11-27 | Server Technology, Inc. | Monitoring power-related parameters in a power distribution unit |
| US9452980B2 (en) * | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| PL2560658T3 (pl) | 2010-04-21 | 2017-08-31 | Ventirx Pharmaceuticals, Inc. | Wzmacnianie cytotoksyczności komórkowej zależnej od przeciwciał |
| MY157542A (en) | 2010-09-27 | 2016-06-15 | Daiichi Sankyo Co Ltd | Cyclohexane derivative compound |
| WO2012109267A2 (en) | 2011-02-07 | 2012-08-16 | The Trustees Of The University Of Pennsylvania | Novel peptides and methods using same |
| WO2017157873A1 (en) | 2016-03-17 | 2017-09-21 | F. Hoffmann-La Roche Ag | 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5385912A (en) * | 1991-03-08 | 1995-01-31 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Multicyclic tertiary amine polyaromatic squalene synthase inhibitors |
| CA2105655A1 (en) | 1991-03-08 | 1992-09-09 | Kent Neuenschwander | Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors |
| JPH06211886A (ja) | 1992-11-04 | 1994-08-02 | Chugai Pharmaceut Co Ltd | エリスロマイシン誘導体 |
| TW355711B (en) | 1992-11-04 | 1999-04-11 | Chugai Pharmaceutical Co Ltd | Erythromycin derivatives |
| US5593994A (en) * | 1994-09-29 | 1997-01-14 | The Dupont Merck Pharmaceutical Company | Prostaglandin synthase inhibitors |
| JP3901239B2 (ja) | 1996-03-13 | 2007-04-04 | 大正製薬株式会社 | アリールアルカン誘導体 |
| JP2000508631A (ja) | 1996-04-03 | 2000-07-11 | メルク エンド カンパニー インコーポレーテッド | ファルネシルタンパク質トランスフェラーゼの阻害剤 |
| US5965578A (en) * | 1996-04-03 | 1999-10-12 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| DE19644195A1 (de) * | 1996-10-24 | 1998-04-30 | Solvay Pharm Gmbh | 10,13,15-Trioxatricyclo[9.2.1.1.·9·.·6·]-pentadecanon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| WO1998023629A1 (fr) | 1996-11-26 | 1998-06-04 | Chugai Seiyaku Kabushiki Kaisha | Composes de macrolides comportant une chaine a 13 elements, medicament les contenant et leur procede de preparation |
| US6060491A (en) * | 1997-06-19 | 2000-05-09 | Dupont Pharmaceuticals | 6-membered aromatics as factor Xa inhibitors |
| US5972939A (en) | 1997-10-28 | 1999-10-26 | Ortho-Mcneil Pharmaceutical, Inc. | Cyclopentene derivatives useful as antagonists of the motilin receptor |
| DE19805822B4 (de) | 1998-02-13 | 2009-02-05 | Solvay Pharmaceuticals Gmbh | 11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US6165985A (en) * | 1998-02-13 | 2000-12-26 | Solvay Pharmaceuticals Gmbh | 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them |
| GB9804734D0 (en) * | 1998-03-05 | 1998-04-29 | Pfizer Ltd | Compounds |
| US20020052380A1 (en) * | 2000-02-18 | 2002-05-02 | Dinsmore Christopher J. | Inhibitors of prenyl-protein transferase |
| US20020010184A1 (en) * | 2000-02-18 | 2002-01-24 | Dinsmore Christopher J. | Inhibitors of prenyl-protein transferase |
| AU2001250820A1 (en) * | 2000-03-13 | 2001-09-24 | Ortho-Mcneil Pharmaceutical, Inc. | Novel cyclohexene derivatives useful as antagonists of the motilin receptor |
| US6384031B2 (en) * | 2000-03-13 | 2002-05-07 | Ortho-Mcneil Pharmaceutical, Inc. | Cyclobutene derivatives useful as antagonists of the motilin receptor |
| WO2001068620A1 (en) | 2000-03-13 | 2001-09-20 | Ortho-Mcneil Pharmaceutical, Inc. | Novel cyclopentene derivatives useful as antagonists of the motilin receptor |
| US6511980B2 (en) * | 2000-05-05 | 2003-01-28 | Ortho Mcneil Pharmaceutical, Inc. | Substituted diamine derivatives useful as motilin antagonists |
| US7102009B2 (en) * | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
| DE50204789D1 (de) | 2001-05-10 | 2005-12-08 | Solvay Pharm Gmbh | Neue 1-amidomethylcarbonyl-piperidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US6977264B2 (en) | 2001-07-25 | 2005-12-20 | Amgen Inc. | Substituted piperidines and methods of use |
| US7279491B2 (en) * | 2002-10-23 | 2007-10-09 | Janssen Pharmaceutica N.V. | Phenylpiperidines and phenylpyrrolidines |
| US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| US7338954B2 (en) * | 2003-09-17 | 2008-03-04 | Bristol-Myers Squibb Company | Compounds useful as motilin agonists and method |
| US7262195B2 (en) | 2003-09-17 | 2007-08-28 | Bristol-Myers Squibb Company | Compounds useful as motilin agonists and method |
| WO2005063720A1 (ja) | 2003-12-25 | 2005-07-14 | Nippon Shinyaku Co., Ltd. | アミド誘導体及び医薬 |
| WO2005077368A2 (en) | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Treatment of gastro-esophageal reflux disease (gerd) |
| WO2005077373A2 (en) | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Treatment of gastro-esophageal reflux disease (gerd) |
| WO2005077345A1 (en) | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Compounds for the treatment of gastro-esophageal reflux disease |
| US20070293539A1 (en) * | 2004-03-18 | 2007-12-20 | Lansbury Peter T | Methods for the treatment of synucleinopathies |
| US20060106060A1 (en) * | 2004-03-18 | 2006-05-18 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies (Lansbury) |
| US20050272722A1 (en) * | 2004-03-18 | 2005-12-08 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| CA2559285A1 (en) | 2004-03-18 | 2005-09-29 | Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| CA2559282A1 (en) * | 2004-03-18 | 2005-09-29 | Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| SE0401345D0 (sv) | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds: Pyridine as scaffold |
| SE0401970D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Novel compounds |
| GB0611907D0 (en) * | 2006-06-15 | 2006-07-26 | Glaxo Group Ltd | Compounds |
| JP2009501199A (ja) | 2005-07-12 | 2009-01-15 | グラクソ グループ リミテッド | Ｇｐｒ３８アゴニストとしてのピペラジンヘテロアリール誘導体 |
| AU2006274212B2 (en) | 2005-07-26 | 2011-06-09 | Glaxo Group Limited | Benzylpiperazine derivates and their medical use |
| GB0524814D0 (en) * | 2005-12-05 | 2006-01-11 | Glaxo Group Ltd | Compounds |
| DE602007006019D1 (de) * | 2006-06-28 | 2010-06-02 | Glaxo Group Ltd | Für die behandlung von durch den gpr38-rezeptor vermittelten krankheiten geeignete piperazinylderivate |
| GB0723317D0 (en) * | 2007-11-28 | 2008-01-09 | Glaxo Group Ltd | Compounds |
-
2006
- 2006-06-15 GB GBGB0611907.7A patent/GB0611907D0/en not_active Ceased
-
2007
- 2007-06-14 JP JP2009514801A patent/JP5232143B2/ja not_active Expired - Fee Related
- 2007-06-14 EP EP07765418A patent/EP2029538B1/en active Active
- 2007-06-14 AT AT07765418T patent/ATE542795T1/de active
- 2007-06-14 US US12/304,539 patent/US8012981B2/en not_active Expired - Fee Related
- 2007-06-14 ES ES07765418T patent/ES2379658T3/es active Active
- 2007-06-14 WO PCT/EP2007/055890 patent/WO2007144400A1/en not_active Ceased
-
2011
- 2011-07-20 US US13/186,869 patent/US8236953B2/en not_active Expired - Fee Related
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