JP2009538932A5 - - Google Patents

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JP2009538932A5
JP2009538932A5 JP2009513445A JP2009513445A JP2009538932A5 JP 2009538932 A5 JP2009538932 A5 JP 2009538932A5 JP 2009513445 A JP2009513445 A JP 2009513445A JP 2009513445 A JP2009513445 A JP 2009513445A JP 2009538932 A5 JP2009538932 A5 JP 2009538932A5
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cancer
antibody
cells
substance
composition according
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JP2009513445A
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Japanese (ja)
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JP6017108B2 (ja
JP2009538932A (ja
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Priority claimed from US11/755,721 external-priority patent/US9217749B2/en
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JP2009513445A 2006-05-31 2007-05-31 リゾホスファチジン酸に反応する、免疫により誘導される物質(imune−derivedmoiety) Expired - Fee Related JP6017108B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US81018506P 2006-05-31 2006-05-31
US60/810,185 2006-05-31
US83556906P 2006-08-04 2006-08-04
US60/835,569 2006-08-04
US92364407P 2007-04-16 2007-04-16
US60/923,644 2007-04-16
US11/755,721 US9217749B2 (en) 2006-05-31 2007-05-30 Immune-derived moieties reactive against lysophosphatidic acid
US11/755,721 2007-05-30
PCT/US2007/070016 WO2007140434A2 (en) 2006-05-31 2007-05-31 Immune-derived moieties reactive against lysophosphatidic acid

Related Child Applications (1)

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JP2013173754A Division JP2014028817A (ja) 2006-05-31 2013-08-23 リゾホスファチジン酸に反応する、免疫により誘導される物質(imune−derivedmoiety)

Publications (3)

Publication Number Publication Date
JP2009538932A JP2009538932A (ja) 2009-11-12
JP2009538932A5 true JP2009538932A5 (enExample) 2015-10-29
JP6017108B2 JP6017108B2 (ja) 2016-11-02

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ID=38779460

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JP2009513445A Expired - Fee Related JP6017108B2 (ja) 2006-05-31 2007-05-31 リゾホスファチジン酸に反応する、免疫により誘導される物質(imune−derivedmoiety)
JP2013173754A Pending JP2014028817A (ja) 2006-05-31 2013-08-23 リゾホスファチジン酸に反応する、免疫により誘導される物質(imune−derivedmoiety)

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JP2013173754A Pending JP2014028817A (ja) 2006-05-31 2013-08-23 リゾホスファチジン酸に反応する、免疫により誘導される物質(imune−derivedmoiety)

Country Status (6)

Country Link
US (2) US9217749B2 (enExample)
EP (1) EP2029626B1 (enExample)
JP (2) JP6017108B2 (enExample)
AU (1) AU2007266493A1 (enExample)
CA (1) CA2653931A1 (enExample)
WO (1) WO2007140434A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9274129B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Methods and reagents for detecting bioactive lipids
US9274130B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Prevention and treatment of pain using antibodies to lysophosphatidic acid
US8796429B2 (en) * 2006-05-31 2014-08-05 Lpath, Inc. Bioactive lipid derivatives, and methods of making and using same
DK2164992T3 (en) * 2007-05-30 2016-08-15 Lpath Inc COMPOSITIONS AND METHODS FOR BONDING OF LYTHOPHOSPHATIC ACID
US9163091B2 (en) 2007-05-30 2015-10-20 Lpath, Inc. Compositions and methods for binding lysophosphatidic acid
AU2009322185A1 (en) * 2008-12-05 2011-07-21 Lpath, Inc. Antibody design using anti-lipid antibody crystal structures
US8401799B2 (en) * 2008-12-05 2013-03-19 Lpath, Inc. Antibody design using anti-lipid antibody crystal structures
US20100292443A1 (en) * 2009-02-26 2010-11-18 Sabbadini Roger A Humanized platelet activating factor antibody design using anti-lipid antibody templates
EP2419446A4 (en) * 2009-04-17 2013-01-23 Lpath Inc HUMANIZED ANTIBODY COMPOSITIONS AND METHOD FOR BINDING LYSOPHOSPHACIDIC ACID
EP2445531A4 (en) * 2009-06-24 2013-04-24 Lpath Inc PROCESS FOR INCREASED NEURONAL DIFFERENTIATION USING ANTIBODIES TO LYSOPHOSPHACIDIC ACID
WO2012109569A1 (en) * 2011-02-11 2012-08-16 The Trustees Of Columbia University In The City Of New York The receptor for advanced glycation endproducts (rage) is a receptor for lysophosphatidic acid (lpa)
US20130302831A1 (en) * 2012-02-29 2013-11-14 Roger A. Sabbadini Methods and kits for detecting and diagnosing neurotrauma
WO2014160305A1 (en) * 2013-03-14 2014-10-02 Albany Molecular Research, Inc. Ligand-therapeutic agent conjugates and silicon-based linkers
KR102421469B1 (ko) * 2021-10-06 2022-07-18 (주)이노베이션바이오 암 진단용 바이오마커 및 이의 용도

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US653432A (en) * 1899-11-11 1900-07-10 George J Winter Door.
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
GB1573212A (en) * 1976-04-15 1980-08-20 Technicon Instr Immunoassay for gentamicin
US4275149A (en) * 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
SE455445B (sv) 1984-08-28 1988-07-11 Pharmacia Ab Antikroppar mot sialosyllaktotetraos (iv?723neuaclcose?714) och antikroppens resp antigenets anvendning vid tumordiagnostik
EP0173648A3 (en) 1984-08-30 1988-04-27 Ciba-Geigy Ag New monoclonal antibodies to glycoconjugates, processes for their production, and applications
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPH01502584A (ja) * 1986-03-24 1989-09-07 ザ ユニバーシティー オブ シドニー 抗原性物質
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4937232A (en) * 1986-09-15 1990-06-26 Duke University Inhibition of protein kinase C by long-chain bases
US4816450A (en) * 1986-09-15 1989-03-28 Duke University Inhibition of protein kinase C by long-chain bases
DE3741056A1 (de) * 1987-12-04 1989-08-24 Behringwerke Ag Manumycin-derivate, verfahren zu ihrer herstellung und ihre verwendung
US5110987A (en) * 1988-06-17 1992-05-05 Emory University Method of preparing sphingosine derivatives
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5620689A (en) * 1989-10-20 1997-04-15 Sequus Pharmaceuuticals, Inc. Liposomes for treatment of B-cell and T-cell disorders
US5248824A (en) * 1990-12-31 1993-09-28 The Biomembrane Institute Method of preparing N,N,N-trimethylsphingosine
US5151360A (en) * 1990-12-31 1992-09-29 Biomembrane Institute Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation
US5137919A (en) * 1990-12-31 1992-08-11 Biomembrane Institute Effect of N,N,N,-trimethylsphingosine on protein kinase C activity melanoma cell growth in vitro; metastatic potential in vivo and human platelet aggregation
US5677288A (en) * 1991-05-15 1997-10-14 Cypros Pharmaceutical Corporation Use of aminoglycosides to protect against excitotoxic neuron damage
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
EP1136556B1 (en) 1991-11-25 2005-06-08 Enzon, Inc. Method of producing multivalent antigen-binding proteins
US5260288A (en) * 1992-04-03 1993-11-09 The Biomembrane Institute Method for inhibition of cell motility by sphingosine-1-phosphate and derivatives
ATE143730T1 (de) 1992-04-22 1996-10-15 Ecole Polytech Lipidmembranen fur biosensoranwendungen
US5369030A (en) * 1992-09-11 1994-11-29 Duke University Method of inducing cellular differentiations and altering cell phenotype using ceramide analogs
AU672638B2 (en) 1992-10-01 1996-10-10 Ambri Limited Improved sensor membranes
ES2196024T3 (es) * 1993-01-22 2003-12-16 Sloan Kettering Inst Cancer Vacunas conjugadas de gangliosido-klh con qs-21.
US5444087A (en) * 1993-10-19 1995-08-22 Bristol-Myers Squibb Company Manumycin compounds
CA2176220A1 (en) * 1993-11-15 1995-05-26 Elizabeth Anne Woodcock A method for treating cardiac dysfunction and pharmaceutical compositions useful therefor
AU691886B2 (en) 1994-02-02 1998-05-28 Transave, Inc. Pharmaceutically active compounds and liposomes, and methods of use thereof
US5585476A (en) * 1994-02-15 1996-12-17 Maclennan; Alexander J. Molecular cloning and expression of G-protein coupled receptors
US5627171A (en) * 1994-04-11 1997-05-06 Oncomembrane, Inc. Sphingosine-1-phosphate/trimethylsphingosine composition
US6323201B1 (en) * 1994-12-29 2001-11-27 The Regents Of The University Of California Compounds for inhibition of ceramide-mediated signal transduction
EP0736770A3 (fr) 1995-04-05 1997-05-02 Anda Biolog Sa Conjugué immunoréactif, procédé d'obtention de ce conjugué, anticorps dirigés contre ledit conjugué, composition pharmaceutique et dispositif de diagnostic les comprenant
US7060808B1 (en) * 1995-06-07 2006-06-13 Imclone Systems Incorporated Humanized anti-EGF receptor monoclonal antibody
US5667337A (en) * 1995-09-15 1997-09-16 Lazes; Richard J. Rotating containment and repelling boom and method for confining a material floatable on a liquid surface
WO2001004108A1 (en) 1999-07-09 2001-01-18 Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
WO1997010817A1 (en) * 1995-09-20 1997-03-27 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
JPH09110722A (ja) 1995-10-20 1997-04-28 Toray Ind Inc 抗腫瘍活性物質の腫瘍細胞内導入用イムノリポソーム及びその調製法
US5830916A (en) * 1996-05-23 1998-11-03 Duke University Inhibitor of ceramidase
DE19621038A1 (de) * 1996-05-24 1997-11-27 Boehringer Ingelheim Kg Aminoguanidine, Verfahren zu ihrer Herstellung und Arzneimittel, die diese Verbindungen enthalten
KR100468306B1 (ko) 1996-07-19 2005-01-27 다카라 바이오 가부시키가이샤 스핑고지질 및 스핑고지질 유도체의 제조방법
US6140060A (en) * 1996-12-12 2000-10-31 Chun; Jerold J. M. Cloned lysophosphatidic acid receptors
US5919687A (en) * 1996-12-24 1999-07-06 John Hopkins University Recombinant N-SMases and nucleic acids encoding same
WO1998040349A1 (en) 1997-03-12 1998-09-17 Takara Shuzo Co., Ltd. Sphingosine analogues
IL131985A0 (en) * 1997-03-21 2001-03-19 Atairgin Biotechnologies Inc Method for detecting cancer associated with altered concentrations of lysophospholipids
ATE489633T1 (de) * 1997-06-10 2010-12-15 Lpath Inc Verfahren zum frühzeitigen nachweis herzerkrankungen
US6740512B1 (en) 1997-08-11 2004-05-25 Memorec Biotec Gmbh Neutral sphingomyelinase
US5989803A (en) * 1997-09-05 1999-11-23 The Trustees Of Columbia University In The City Of New York Method for treating a subject suffering from a condition associated with an extracellular zinc sphingomyelinase
US6649362B2 (en) * 1997-09-08 2003-11-18 Medvet Science Pty. Ltd. Screening method for an agent having an effect on a sphingosine kinase signaling pathway
AU9002298A (en) 1997-09-11 1999-03-29 Takara Shuzo Co., Ltd. Sphingosine derivatives and medicinal composition
US6423527B1 (en) 1997-09-29 2002-07-23 Children's Hospital Medical Center Of Northern California Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor
US6057126A (en) 1997-12-24 2000-05-02 Allelix Biopharmaceuticals, Inc. Mammalian EDG-5 receptor homologs
US6300308B1 (en) * 1997-12-31 2001-10-09 Board Of Regents, The University Of Texas System Methods and compositions for inducing autoimmunity in the treatment of cancers
WO1999038983A1 (en) * 1998-01-29 1999-08-05 Smithkline Beecham Plc Novel sphingosine-1 phosphate lyase
CA2320117A1 (en) 1998-02-12 1999-08-19 Emory University Sphingolipid derivatives and their methods of use
EP1055682B1 (en) 1998-02-16 2004-10-13 The Kitasato Institute Novel substances kf-1040 and process for producing the same
US5888793A (en) * 1998-02-25 1999-03-30 Incyte Pharmaceuticals, Inc. Human lysophosphatidic acid acyltransferase
EP1070080A4 (en) 1998-03-09 2004-12-29 Smithkline Beecham Corp HUMAN EDG-1c POLYNUCLEOTIDES AND POLYPEPTIDES AND THEIR APPLICATIONS
US6130067A (en) * 1998-05-20 2000-10-10 Smithkline Beecham Corporation Human EDG3sb gene
EP1235913A2 (en) 1998-05-26 2002-09-04 Sarah Spiegel Sphingosine kinase, cloning, expression and methods of use
DE19828850A1 (de) 1998-06-27 1999-12-30 Gvs Ges Fuer Erwerb Und Verwer Sphingolipid-Desaturase
ES2316188T3 (es) * 1998-06-29 2009-04-01 Children's Hospital Los Angeles Tratamiento de transtornos hiperproliferativos.
US7067109B1 (en) * 1998-07-13 2006-06-27 Board Of Regents, The University Of Texas System Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids
US6818213B1 (en) * 1998-07-13 2004-11-16 Board Of Regents, The University Of Texas System Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
DE19847149A1 (de) 1998-10-13 2000-04-20 Max Planck Gesellschaft Pseudo-Ceramide
US6248553B1 (en) * 1998-10-22 2001-06-19 Atairgin Technologies, Inc. Enzyme method for detecting lysophospholipids and phospholipids and for detecting and correlating conditions associated with altered levels of lysophospholipids
DK1140170T3 (da) 1999-01-05 2006-10-23 Univ Southern Australia Antistoffragmenter til topisk behandling af öjensygdomme
WO2000052173A2 (en) 1999-03-02 2000-09-08 Nps Allelix Corp. Cloned human sphingosine kinase homologues
US6812335B1 (en) 1999-03-23 2004-11-02 The Regents Of The University Of California Human polypeptide receptors for lysophospholipids and sphingolipids and nucleic acids encoding the same
AU2856499A (en) 1999-03-25 2000-10-16 Kitasato Institute, The Novel substances kf-1040t4a, kf-1040t4b, kf-1040t5a and kf-1040t5b and process for producing the same
WO2000058448A1 (en) 1999-03-26 2000-10-05 Takara Shuzo Co., Ltd. Ceramidase gene
US7820718B1 (en) 1999-04-07 2010-10-26 Roger Williams Hospital Combinations of ceramide and chemotherapeutic agents for inducing cell death and uses thereof in treating cancer
JP2000293181A (ja) 1999-04-12 2000-10-20 Daiichikosho Co Ltd 歌詞画像描出機能に特徴を有するカラオケ装置
EP1192247B9 (en) 1999-05-13 2007-10-31 Johnson & Johnson Pharmaceutical Research and Development LLC Sphingosine kinase enzyme
DE19924148A1 (de) 1999-05-26 2000-12-07 Univ Heidelberg Sphingomyelinasehemmer
WO2001004139A2 (en) 1999-07-13 2001-01-18 Smithkline Beecham Corporation Human axor29 receptor
IT1307786B1 (it) 1999-07-22 2001-11-19 Bracco Spa Analoghi di ceramidi, processo per la loro preparazione e loro usocome antitumorali.
AU1020201A (en) 1999-10-28 2001-05-08 Warner-Lambert Company Human sphingosine kinase gene
AU1548101A (en) 1999-11-24 2001-06-04 Sagami Chemical Research Center Sphingosine derivatives
US6312294B1 (en) * 1999-12-27 2001-11-06 Hon Hai Precision Ind. Co., Ltd. Cable connector with improved terminals
AU2001233086A1 (en) 2000-01-28 2001-08-07 Musc Foundation For Research Development Ceramidase compositions and methods based thereon
US6306911B1 (en) * 2000-02-07 2001-10-23 Ortho-Mcneil Pharmaceutical, Inc. Substituted amino acids as neutral sphingomyelinase inhibitors
EP1257559A1 (en) 2000-02-07 2002-11-20 Merck & Co., Inc. Mammalian sphingosine-1-phosphate phosphatase
AU2001238283C1 (en) 2000-02-14 2006-02-02 Curagen Corporation Sphingosine kinases
JP2001261575A (ja) * 2000-03-13 2001-09-26 General Hospital Corp 血管収縮を調節する方法とその組成物
AU2001247755A1 (en) 2000-03-23 2001-10-03 Millennium Pharmaceuticals, Inc. High throughput screening for inhibitors of fatty acid, ergosterol, sphingolipid, or phospholipid synthesis in fungi
CA2402769A1 (en) 2000-03-28 2001-10-04 The Liposome Company, Inc. Ceramide derivatives and method of use
AU2001255477A1 (en) 2000-04-19 2001-11-07 The Trustees Of Columbia University In The City Of New York Detection and treatment of atherosclerosis based on plasma sphingomyelin concentration
US6500633B1 (en) * 2000-04-26 2002-12-31 Atairgin Technologies, Inc. Method of detecting carcinomas
WO2002017899A2 (en) 2000-08-31 2002-03-07 University Of Connecticut Regulation of angiogenesis via modulation of edg receptor mediated signal transduction comprising sphingosine-1-phosphate administration
US20030125533A1 (en) * 2000-10-06 2003-07-03 Sophia Kossida Regulation of human sphingosine kinase-like protein
ES2523856T3 (es) * 2000-12-22 2014-12-02 Lpath, Inc. Anticuerpos de esfingosina-1-fosfato para el tratamiento de enfermedades asociadas con elevadas concentraciones de esfingolípidos
US20020150582A1 (en) * 2001-02-08 2002-10-17 Friedrichs Gregory S. Method of treating or inhibiting cellular injury or cell death
JP2002243737A (ja) 2001-02-09 2002-08-28 Azwell Inc 抗スフィンゴ脂質モノクローナル抗体
US6486334B1 (en) 2001-06-25 2002-11-26 Wisconsin Alumni Research Foundation Biomembrane mimetic surface coatings
US7674580B2 (en) * 2002-01-17 2010-03-09 Children's Hospital & Research Center At Oakland Compositions and methods for the modulation of sphingolipid metabolism and/or signaling
PT2269656E (pt) 2002-07-15 2014-12-02 Univ Texas Anticorpos selecionados e peptídeos de duramicina que se ligam a fosfolipídios aniônicos e aminofosfolipídios e seus usos no tratamento de infecções virais e câncer
DE10325829A1 (de) * 2003-06-06 2004-12-30 Asc Biotech Gmbh Derivate natürlicher, halbsynthetischer und syntetischer Lipide aus der Gruppe der Ceramide und der Sphingosine und ihre Verwendung als Therapeutica in der Medizin, speziell in der Dermatologie
WO2005064332A1 (ja) * 2003-12-26 2005-07-14 Ono Pharmaceutical Co., Ltd. 高活性型リゾホスファチジン酸およびそれを用いたスクリーニング方法
US7794713B2 (en) * 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US20100104564A1 (en) 2005-03-29 2010-04-29 Genevieve Hansen Altered Antibody Fc Regions and Uses Thereof
DK2164992T3 (en) 2007-05-30 2016-08-15 Lpath Inc COMPOSITIONS AND METHODS FOR BONDING OF LYTHOPHOSPHATIC ACID
US20110064744A1 (en) * 2007-05-30 2011-03-17 Sabbadini Roger A Prevention and treatment of pain using antibodies to lysophosphatidic acid
US9163091B2 (en) * 2007-05-30 2015-10-20 Lpath, Inc. Compositions and methods for binding lysophosphatidic acid
EP2419446A4 (en) * 2009-04-17 2013-01-23 Lpath Inc HUMANIZED ANTIBODY COMPOSITIONS AND METHOD FOR BINDING LYSOPHOSPHACIDIC ACID

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