JP2009538920A5 - - Google Patents
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- JP2009538920A5 JP2009538920A5 JP2009513318A JP2009513318A JP2009538920A5 JP 2009538920 A5 JP2009538920 A5 JP 2009538920A5 JP 2009513318 A JP2009513318 A JP 2009513318A JP 2009513318 A JP2009513318 A JP 2009513318A JP 2009538920 A5 JP2009538920 A5 JP 2009538920A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- phenylephrine
- composition
- hours
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims description 106
- 239000000203 mixture Substances 0.000 claims description 105
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 claims description 104
- 229960001802 phenylephrine Drugs 0.000 claims description 104
- 150000003839 salts Chemical class 0.000 claims description 49
- 239000003814 drug Substances 0.000 claims description 37
- 210000001072 colon Anatomy 0.000 claims description 34
- 239000011248 coating agent Substances 0.000 claims description 27
- 238000000576 coating method Methods 0.000 claims description 27
- 229940124597 therapeutic agent Drugs 0.000 claims description 27
- 230000037406 food intake Effects 0.000 claims description 22
- 229920000642 polymer Polymers 0.000 claims description 19
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 18
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 18
- 230000003628 erosive effect Effects 0.000 claims description 15
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 12
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 10
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 10
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 10
- 229960003088 loratadine Drugs 0.000 claims description 10
- JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 claims description 10
- 239000008188 pellet Substances 0.000 claims description 10
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 8
- JAUOIFJMECXRGI-UHFFFAOYSA-N Neoclaritin Chemical compound C=1C(Cl)=CC=C2C=1CCC1=CC=CN=C1C2=C1CCNCC1 JAUOIFJMECXRGI-UHFFFAOYSA-N 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 8
- 229960001271 desloratadine Drugs 0.000 claims description 8
- 229920000578 graft copolymer Polymers 0.000 claims description 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims description 8
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 7
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 6
- 235000019359 magnesium stearate Nutrition 0.000 claims description 6
- 229920002554 vinyl polymer Polymers 0.000 claims description 6
- 239000002702 enteric coating Substances 0.000 claims description 5
- 238000009505 enteric coating Methods 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 5
- 229920000856 Amylose Polymers 0.000 claims description 4
- 229920001661 Chitosan Polymers 0.000 claims description 4
- 206010039085 Rhinitis allergic Diseases 0.000 claims description 4
- 230000000172 allergic effect Effects 0.000 claims description 4
- 201000010105 allergic rhinitis Diseases 0.000 claims description 4
- 210000005095 gastrointestinal system Anatomy 0.000 claims description 4
- 206010022000 influenza Diseases 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 208000037916 non-allergic rhinitis Diseases 0.000 claims description 4
- 239000012730 sustained-release form Substances 0.000 claims description 4
- 208000024891 symptom Diseases 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 230000036470 plasma concentration Effects 0.000 claims description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 239000001856 Ethyl cellulose Substances 0.000 claims description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
- -1 Nt-butylacrylamide Chemical compound 0.000 claims description 2
- 229920001800 Shellac Polymers 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 229940035676 analgesics Drugs 0.000 claims description 2
- 239000000730 antalgic agent Substances 0.000 claims description 2
- 230000001754 anti-pyretic effect Effects 0.000 claims description 2
- 229940125715 antihistaminic agent Drugs 0.000 claims description 2
- 239000000739 antihistaminic agent Substances 0.000 claims description 2
- 239000002221 antipyretic Substances 0.000 claims description 2
- 229940125716 antipyretic agent Drugs 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 229940105329 carboxymethylcellulose Drugs 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 229920001249 ethyl cellulose Polymers 0.000 claims description 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 claims description 2
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 claims description 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims description 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 2
- 239000001814 pectin Substances 0.000 claims description 2
- 229920001277 pectin Polymers 0.000 claims description 2
- 235000010987 pectin Nutrition 0.000 claims description 2
- 239000003961 penetration enhancing agent Substances 0.000 claims description 2
- 239000004208 shellac Substances 0.000 claims description 2
- 229940113147 shellac Drugs 0.000 claims description 2
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims description 2
- 235000013874 shellac Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 238000013268 sustained release Methods 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 238000009472 formulation Methods 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940057948 magnesium stearate Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81002106P | 2006-06-01 | 2006-06-01 | |
| US60/810,021 | 2006-06-01 | ||
| US87483006P | 2006-12-14 | 2006-12-14 | |
| US60/874,830 | 2006-12-14 | ||
| PCT/US2007/013050 WO2007143158A2 (en) | 2006-06-01 | 2007-06-01 | Sustained release pharmaceutical formulation comprising phenylephrine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012224253A Division JP2013006878A (ja) | 2006-06-01 | 2012-10-09 | 結腸吸収のためのフェニレフリン薬学的製剤および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009538920A JP2009538920A (ja) | 2009-11-12 |
| JP2009538920A5 true JP2009538920A5 (https=) | 2009-12-24 |
| JP5175278B2 JP5175278B2 (ja) | 2013-04-03 |
Family
ID=38659360
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009513318A Active JP5175278B2 (ja) | 2006-06-01 | 2007-06-01 | 結腸吸収のためのフェニレフリン薬学的製剤および組成物 |
| JP2012224253A Pending JP2013006878A (ja) | 2006-06-01 | 2012-10-09 | 結腸吸収のためのフェニレフリン薬学的製剤および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012224253A Pending JP2013006878A (ja) | 2006-06-01 | 2012-10-09 | 結腸吸収のためのフェニレフリン薬学的製剤および組成物 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8956662B2 (https=) |
| EP (2) | EP2366381A1 (https=) |
| JP (2) | JP5175278B2 (https=) |
| KR (1) | KR101643626B1 (https=) |
| CN (1) | CN104161736A (https=) |
| AR (1) | AR061169A1 (https=) |
| AU (1) | AU2007254821B2 (https=) |
| BR (1) | BRPI0712532A2 (https=) |
| CA (1) | CA2653953C (https=) |
| CL (1) | CL2007001584A1 (https=) |
| ES (1) | ES2391585T3 (https=) |
| MX (1) | MX2008015360A (https=) |
| NO (1) | NO20085420L (https=) |
| NZ (1) | NZ573173A (https=) |
| PE (1) | PE20080151A1 (https=) |
| PL (1) | PL2034970T3 (https=) |
| RU (1) | RU2454225C2 (https=) |
| SG (1) | SG172664A1 (https=) |
| TW (1) | TWI411451B (https=) |
| WO (1) | WO2007143158A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070253927A1 (en) * | 2006-04-13 | 2007-11-01 | Gwenaelle Jegou | Cosmetic compositions comprising at least one dielectrophile monomer and at least one radical initiator |
| KR20090088913A (ko) | 2006-11-21 | 2009-08-20 | 맥네일-피피씨, 인코포레이티드 | 개질된 방출형 진통 현탁제 |
| CN101848706A (zh) * | 2007-06-01 | 2010-09-29 | 先灵-普劳健康护理产品公司 | 包含底物和含活性成分和聚乙烯醇的包衣的药用组合物 |
| US9833510B2 (en) * | 2007-06-12 | 2017-12-05 | Johnson & Johnson Consumer Inc. | Modified release solid or semi-solid dosage forms |
| US8323695B2 (en) * | 2007-08-13 | 2012-12-04 | Mcneil-Ppc, Inc. | Method for stabilizing phenylephrine |
| EP2313088A2 (en) * | 2008-08-11 | 2011-04-27 | Mepha GmbH | Oral pharmaceutical formulation for omeprazole comprising a specific separation layer |
| DE102008059206A1 (de) * | 2008-11-27 | 2010-06-10 | Bayer Schering Pharma Aktiengesellschaft | Pharmazeutische Darreichungsform enthaltend Nifedipin oder Nisoldipin und einen Angiotensin-II Antagonisten und/oder ein Diuretikum |
| EP2210595A1 (en) | 2009-01-14 | 2010-07-28 | LEK Pharmaceuticals d.d. | Active coating of pharmaceutical dosage forms |
| MX2009001925A (es) * | 2009-02-20 | 2010-08-20 | Senosiain S A De C V Lab | Composicion farmaceutica oral para uso en enfermedades respiratorias. |
| AU2012316001A1 (en) * | 2011-09-27 | 2014-04-10 | Virginia Commonwealth University | Selective metabolic approach to increasing oral bioavailability of phenylephrine and other phenolic bioactives |
| RU2540509C1 (ru) * | 2013-02-04 | 2015-02-10 | АФТ Фармасьютиклс Лтд | Лекарство |
| ITMI20132066A1 (it) * | 2013-12-11 | 2015-06-12 | Farmatron Ltd | Sistemi terapeutici a rilascio modificato per la somministrazione orale di mentolo nel trattamento delle malattie intestinali |
| KR20170038039A (ko) | 2014-07-30 | 2017-04-05 | 메르크 파텐트 게엠베하 | 분상, 직접 압축성 유형의 폴리비닐 알코올 |
| CN114796137A (zh) * | 2014-07-30 | 2022-07-29 | 默克专利股份有限公司 | 包含微晶纤维素的可直接压制的组合物 |
| EP3193845A1 (en) * | 2014-09-19 | 2017-07-26 | The Procter and Gamble Company | Pulsed release phenylephrine dosage forms |
| GB201420306D0 (en) * | 2014-11-14 | 2014-12-31 | Bio Images Drug Delivery Ltd | Compositions |
| US11065207B2 (en) | 2016-03-25 | 2021-07-20 | Universiteit Gent | Oral dosage form |
| US10966928B2 (en) | 2016-03-25 | 2021-04-06 | Universiteit Gent | Oral dosage form |
| CA3019745A1 (en) * | 2016-03-30 | 2017-10-05 | Vital Beverages Global Inc. | Compositions and methods for selective gi tract delivery |
| US10278930B2 (en) * | 2017-03-16 | 2019-05-07 | The Procter & Gamble Company | Method for relieving sinus congestion |
| CA3072399A1 (en) * | 2017-08-09 | 2019-02-14 | Helmholtz-Zentrum Fur Infektionsforschung Gmbh | New targeted cytotoxic ratjadone derivatives and conjugates thereof |
| EP3622948B1 (en) | 2018-09-11 | 2026-05-06 | I.P.S. International Products & Services S.r.l. | Multilayered formulations with dual release rate of one or more active principles |
| JP7263047B2 (ja) * | 2019-02-25 | 2023-04-24 | 沢井製薬株式会社 | フィルムコーティング錠剤 |
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-
2007
- 2007-06-01 WO PCT/US2007/013050 patent/WO2007143158A2/en not_active Ceased
- 2007-06-01 PL PL07777373T patent/PL2034970T3/pl unknown
- 2007-06-01 TW TW096119770A patent/TWI411451B/zh active
- 2007-06-01 CL CL2007001584A patent/CL2007001584A1/es unknown
- 2007-06-01 MX MX2008015360A patent/MX2008015360A/es active IP Right Grant
- 2007-06-01 EP EP11158570A patent/EP2366381A1/en not_active Withdrawn
- 2007-06-01 CA CA2653953A patent/CA2653953C/en active Active
- 2007-06-01 AU AU2007254821A patent/AU2007254821B2/en not_active Ceased
- 2007-06-01 CN CN201410407684.7A patent/CN104161736A/zh active Pending
- 2007-06-01 NZ NZ573173A patent/NZ573173A/en not_active IP Right Cessation
- 2007-06-01 PE PE2007000684A patent/PE20080151A1/es active IP Right Grant
- 2007-06-01 JP JP2009513318A patent/JP5175278B2/ja active Active
- 2007-06-01 BR BRPI0712532-1A patent/BRPI0712532A2/pt not_active IP Right Cessation
- 2007-06-01 ES ES07777373T patent/ES2391585T3/es active Active
- 2007-06-01 EP EP07777373A patent/EP2034970B1/en active Active
- 2007-06-01 AR ARP070102387A patent/AR061169A1/es unknown
- 2007-06-01 RU RU2008151949/15A patent/RU2454225C2/ru active
- 2007-06-01 US US11/756,881 patent/US8956662B2/en active Active
- 2007-06-01 KR KR1020087031284A patent/KR101643626B1/ko not_active Expired - Fee Related
- 2007-06-01 SG SG2011039914A patent/SG172664A1/en unknown
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2008
- 2008-12-30 NO NO20085420A patent/NO20085420L/no not_active Application Discontinuation
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2012
- 2012-10-09 JP JP2012224253A patent/JP2013006878A/ja active Pending
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2014
- 2014-12-16 US US14/571,890 patent/US20150290147A1/en not_active Abandoned
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