JP2009536189A5 - - Google Patents
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- Publication number
- JP2009536189A5 JP2009536189A5 JP2009508506A JP2009508506A JP2009536189A5 JP 2009536189 A5 JP2009536189 A5 JP 2009536189A5 JP 2009508506 A JP2009508506 A JP 2009508506A JP 2009508506 A JP2009508506 A JP 2009508506A JP 2009536189 A5 JP2009536189 A5 JP 2009536189A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- ring
- cyclohexyl
- carboxylic acid
- pyrrolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 87
- 229910052739 hydrogen Inorganic materials 0.000 claims 37
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 36
- 125000003545 alkoxy group Chemical group 0.000 claims 35
- 229910052736 halogen Inorganic materials 0.000 claims 33
- 229910052760 oxygen Inorganic materials 0.000 claims 33
- 125000005842 heteroatom Chemical group 0.000 claims 29
- 239000001257 hydrogen Substances 0.000 claims 29
- 229910052717 sulfur Inorganic materials 0.000 claims 28
- 125000003118 aryl group Chemical group 0.000 claims 20
- WULHWYZFPFHCPV-UHFFFAOYSA-N pyrrolo[3,2-d][2]benzazepine-7-carboxylic acid Chemical compound N1=CC=C2C=NC=C3C(=C21)C=CC=C3C(=O)O WULHWYZFPFHCPV-UHFFFAOYSA-N 0.000 claims 20
- 150000002367 halogens Chemical class 0.000 claims 19
- 150000002431 hydrogen Chemical class 0.000 claims 19
- 125000005843 halogen group Chemical group 0.000 claims 14
- 229910052757 nitrogen Inorganic materials 0.000 claims 14
- 125000006413 ring segment Chemical group 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000001072 heteroaryl group Chemical group 0.000 claims 12
- -1 hydroxyoxadiazolyl Chemical group 0.000 claims 12
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 11
- 125000004429 atom Chemical group 0.000 claims 10
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 10
- JLWSZXGCTYXADY-UHFFFAOYSA-N pyrrolo[3,2-d][2]benzazepine Chemical compound N1=CC=C2C=NC=C3C(=C21)C=CC=C3 JLWSZXGCTYXADY-UHFFFAOYSA-N 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 7
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 6
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000001931 aliphatic group Chemical group 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000003831 tetrazolyl group Chemical group 0.000 claims 3
- CBWBTGXYYAVXJC-UHFFFAOYSA-N 14'-cyclohexyl-1-[2-(dimethylamino)ethyl]spiro[azetidine-3,7'-indolo[1,2-e][1,5]benzoxazocine]-11'-carboxylic acid Chemical compound C1N(CCN(C)C)CC21CN1C3=CC(C(O)=O)=CC=C3C(C3CCCCC3)=C1C1=CC=CC=C1OC2 CBWBTGXYYAVXJC-UHFFFAOYSA-N 0.000 claims 2
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- 150000008038 benzoazepines Chemical class 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- AHOTVVDUKWNCKP-UHFFFAOYSA-N 1'-benzyl-19-cyclohexylspiro[8-oxa-12-azatetracyclo[10.7.0.02,7.013,18]nonadeca-1(19),2,4,6,13(18),14,16-heptaene-10,3'-azetidine]-15-carboxylic acid Chemical compound C=12C3=CC=CC=C3OCC3(CN(CC=4C=CC=CC=4)C3)CN2C2=CC(C(=O)O)=CC=C2C=1C1CCCCC1 AHOTVVDUKWNCKP-UHFFFAOYSA-N 0.000 claims 1
- MJDONOKZTOLSKP-UHFFFAOYSA-N 11-cyclohexyl-2-[2-(dimethylamino)ethyl]-1,2,3,4,17,17a-hexahydro-6h-indolo[2,1-a]pyrazino[2,1-d][2,5]-benzodiazocine-14-carboxylic acid Chemical compound C1C(CCN(C)C)CCC(CN2C=CN=CC2=2)=C1C1CC3=CC=C(C(O)=O)C=C3N1C=2C1CCCCC1 MJDONOKZTOLSKP-UHFFFAOYSA-N 0.000 claims 1
- RTQBGZGSWQAZHL-UHFFFAOYSA-N 13-cyclohexyl-6,7-dihydro-4h-indolo[4',3':3,4,5]azepino[1,2-a]indole-10-carboxylic acid Chemical compound C=12C(C3=4)=CC=CC=4NC=C3CCN2C2=CC(C(=O)O)=CC=C2C=1C1CCCCC1 RTQBGZGSWQAZHL-UHFFFAOYSA-N 0.000 claims 1
- AITNCBOXVZOQQC-UHFFFAOYSA-N 14-cyclohexyl-5-methyl-7,8-dihydroimidazo[4,5,1-jk]indolo[1,2-d][1,4]-benzodiazepine-11-carboxylic acid Chemical compound C12=CC=C(C(O)=O)C=C2N2CCN(C3=4)C(C)=NC3=CC=CC=4C2=C1C1CCCCC1 AITNCBOXVZOQQC-UHFFFAOYSA-N 0.000 claims 1
- PJXFQKVZEASZLW-UHFFFAOYSA-N 16-cyclohexyl-3-methyl-9,14-diazapentacyclo[12.7.0.02,7.08,12.015,20]henicosa-1(21),2(7),4,8,10,12,15(20),16,18-nonaene-11-carboxylic acid Chemical compound CC1C=CCC(C2=NC=C(C2=CN2C3=4)C(O)=O)=C1C2=CC3=CC=CC=4C1CCCCC1 PJXFQKVZEASZLW-UHFFFAOYSA-N 0.000 claims 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 125000001340 2-chloroethyl group Chemical group [H]C([H])(Cl)C([H])([H])* 0.000 claims 1
- SFVYUAJWNYVQDB-UHFFFAOYSA-N 2h-1,2-benzoxazocine Chemical compound O1NC=CC=CC2=CC=CC=C21 SFVYUAJWNYVQDB-UHFFFAOYSA-N 0.000 claims 1
- XUUSYXJGMRQBKQ-UHFFFAOYSA-N 2h-2-benzazepine Chemical compound N1C=CC=C2C=CC=CC2=C1 XUUSYXJGMRQBKQ-UHFFFAOYSA-N 0.000 claims 1
- QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 claims 1
- BGHWDQSKCIBAAL-UHFFFAOYSA-N 6h-1-benzazepine-7-carboxylic acid Chemical compound N1=CC=CC=C2CC(C(=O)O)=CC=C21 BGHWDQSKCIBAAL-UHFFFAOYSA-N 0.000 claims 1
- YYKDCKAFZRTPEQ-UHFFFAOYSA-N 7H-indolo[2,1-a][2]benzazepine-7-carboxylic acid Chemical compound C1=CC=CC=2C=CC(N3C(C21)=CC=2C=CC=CC23)C(=O)O YYKDCKAFZRTPEQ-UHFFFAOYSA-N 0.000 claims 1
- YAYHUAKOMQJTIK-UHFFFAOYSA-N 9,12-diazatetracyclo[10.7.0.02,7.013,18]nonadeca-1(19),2,4,6,8,10,13,15,17-nonaene-17-carboxylic acid Chemical compound C1=CC=CC=2C=NC=CN3C(C=21)=CC=1C(=CC=CC=13)C(=O)O YAYHUAKOMQJTIK-UHFFFAOYSA-N 0.000 claims 1
- KKNREZWFCFXTHI-UHFFFAOYSA-N C(=O)(O)C1=CN=C2C1=CN1C(C3C2CCCC3C)=CC=2C(=CC=C(C=21)C1CCCCC1)OC Chemical compound C(=O)(O)C1=CN=C2C1=CN1C(C3C2CCCC3C)=CC=2C(=CC=C(C=21)C1CCCCC1)OC KKNREZWFCFXTHI-UHFFFAOYSA-N 0.000 claims 1
- WBQKUUFKFBIIGA-UHFFFAOYSA-N C1=CC(=C2C=NC=C3C=NC=CN3C2=C1)C(=O)O Chemical compound C1=CC(=C2C=NC=C3C=NC=CN3C2=C1)C(=O)O WBQKUUFKFBIIGA-UHFFFAOYSA-N 0.000 claims 1
- JIIPKLADCLPENE-UHFFFAOYSA-N C1=CC2=C(C=NC=C3C2=CC(=N3)C(=O)O)C(=C1)C(=O)O Chemical compound C1=CC2=C(C=NC=C3C2=CC(=N3)C(=O)O)C(=C1)C(=O)O JIIPKLADCLPENE-UHFFFAOYSA-N 0.000 claims 1
- XHVYIHFFQVDUSX-UHFFFAOYSA-N C1=CC2=C3C=CN=C3C=NC=C2C(=C1)C(=O)O Chemical compound C1=CC2=C3C=CN=C3C=NC=C2C(=C1)C(=O)O XHVYIHFFQVDUSX-UHFFFAOYSA-N 0.000 claims 1
- FVXQPEZPSOQOPQ-UHFFFAOYSA-N C1=CC=C2C(=C1)C=C3N2C=C4C=CN=C4C5=CC=CC=C53 Chemical compound C1=CC=C2C(=C1)C=C3N2C=C4C=CN=C4C5=CC=CC=C53 FVXQPEZPSOQOPQ-UHFFFAOYSA-N 0.000 claims 1
- 239000005973 Carvone Substances 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- ZTOKLXGDTUVKJO-UHFFFAOYSA-N methyl 6h-1-benzazepine-7-carboxylate Chemical compound N1=CC=CC=C2CC(C(=O)OC)=CC=C21 ZTOKLXGDTUVKJO-UHFFFAOYSA-N 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- DXASQZJWWGZNSF-UHFFFAOYSA-N n,n-dimethylmethanamine;sulfur trioxide Chemical group CN(C)C.O=S(=O)=O DXASQZJWWGZNSF-UHFFFAOYSA-N 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0608928.8 | 2006-05-08 | ||
| GBGB0608928.8A GB0608928D0 (en) | 2006-05-08 | 2006-05-08 | Therapeutic agents |
| PCT/GB2007/050239 WO2007129119A1 (en) | 2006-05-08 | 2007-05-04 | Pentacyclic indole derivatives as antiviral agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009536189A JP2009536189A (ja) | 2009-10-08 |
| JP2009536189A5 true JP2009536189A5 (enExample) | 2013-04-18 |
| JP5276582B2 JP5276582B2 (ja) | 2013-08-28 |
Family
ID=36604009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009508506A Expired - Fee Related JP5276582B2 (ja) | 2006-05-08 | 2007-05-04 | 抗ウイルス剤としての五環インドール誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8232390B2 (enExample) |
| EP (1) | EP2027125A1 (enExample) |
| JP (1) | JP5276582B2 (enExample) |
| CN (1) | CN101437826A (enExample) |
| AU (1) | AU2007246850B2 (enExample) |
| CA (1) | CA2651226A1 (enExample) |
| GB (1) | GB0608928D0 (enExample) |
| WO (1) | WO2007129119A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070049593A1 (en) | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
| US7659263B2 (en) | 2004-11-12 | 2010-02-09 | Japan Tobacco Inc. | Thienopyrrole compound and use thereof as HCV polymerase inhibitor |
| US8003624B2 (en) | 2005-08-25 | 2011-08-23 | Schering Corporation | Functionally selective ALPHA2C adrenoreceptor agonists |
| GB0608928D0 (en) | 2006-05-08 | 2006-06-14 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| US7456166B2 (en) * | 2006-05-17 | 2008-11-25 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| US7541351B2 (en) | 2007-01-11 | 2009-06-02 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US7541352B2 (en) | 2007-02-02 | 2009-06-02 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US7517872B2 (en) | 2007-02-22 | 2009-04-14 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US7998951B2 (en) | 2007-03-05 | 2011-08-16 | Bristol-Myers Squibb Company | HCV NS5B inhibitors |
| US7541353B2 (en) | 2007-03-14 | 2009-06-02 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US7538102B2 (en) | 2007-03-14 | 2009-05-26 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
| US7521444B2 (en) | 2007-03-14 | 2009-04-21 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US7547690B2 (en) | 2007-03-14 | 2009-06-16 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
| US7538103B2 (en) | 2007-03-15 | 2009-05-26 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| AU2008277442A1 (en) | 2007-07-17 | 2009-01-22 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Macrocyclic indole derivatives for the treatment of hepatitis C infections |
| US8143243B2 (en) | 2007-08-09 | 2012-03-27 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US7652004B2 (en) | 2007-08-09 | 2010-01-26 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US7642251B2 (en) | 2007-08-09 | 2010-01-05 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US8129367B2 (en) | 2007-11-21 | 2012-03-06 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
| US8124601B2 (en) | 2007-11-21 | 2012-02-28 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
| EP2234977A4 (en) | 2007-12-19 | 2011-04-13 | Boehringer Ingelheim Int | VIRAL POLYMERASE INHIBITORS |
| US20090197856A1 (en) * | 2007-12-21 | 2009-08-06 | Genelabs Technologies, Inc. | Antiviral compounds |
| US8138171B2 (en) | 2008-03-27 | 2012-03-20 | Bristol-Myers Squibb Company | Dioxolane and dioxolanone fused indolobenzadiazepine HCV NS5B inhibitors |
| ATE531373T1 (de) * | 2008-03-27 | 2011-11-15 | Bristol Myers Squibb Co | Aromatische heterocyclische kondensierte indolobenzadiazepin-hcv-ns5b-inhibitoren |
| KR20100126560A (ko) | 2008-03-27 | 2010-12-01 | 브리스톨-마이어스 스큅 컴퍼니 | 피롤리딘 융합된 인돌로벤자디아제핀 ｈｃｖ ｎｓ5ｂ 억제제 |
| US8178523B2 (en) | 2008-03-27 | 2012-05-15 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US8133884B2 (en) | 2008-05-06 | 2012-03-13 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| KR20110116136A (ko) | 2009-01-07 | 2011-10-25 | 싸이넥시스, 인크. | Ｈｃｖ 및 ｈｉｖ 감염의 치료에 사용하기 위한 사이클로스포린 유도체 |
| WO2010082050A1 (en) | 2009-01-16 | 2010-07-22 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections |
| US8143244B2 (en) | 2009-02-26 | 2012-03-27 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| US8828930B2 (en) | 2009-07-30 | 2014-09-09 | Merck Sharp & Dohme Corp. | Hepatitis C virus NS3 protease inhibitors |
| KR20120106942A (ko) | 2009-10-30 | 2012-09-27 | 베링거 인겔하임 인터내셔날 게엠베하 | Ｂｉ２０１３３５, 인터페론 알파 및 리바비린을 포함하는 ｈｃｖ 병용 치료요법을 위한 투여 용법 |
| MX2012007076A (es) * | 2009-12-18 | 2012-07-20 | Boehringer Ingelheim Int | Terapia combinada de hcv. |
| EP2886632A1 (en) | 2013-02-19 | 2015-06-24 | LUKOIL Marine Lubricants Germany GmbH | Process and apparatus for the preparation of a cylinder oil |
| US12703680B2 (en) | 2019-11-21 | 2026-08-11 | University Of Utah Research Foundation | TRPV4 receptor ligands |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206382A (en) | 1991-06-27 | 1993-04-27 | Fidia Georgetown Institute For The Neurosciences | Indole derivatives, pharmaceutical compositions and methods of treating neurological and psychiatric disorders |
| IT1278077B1 (it) | 1995-05-25 | 1997-11-17 | Angeletti P Ist Richerche Bio | Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal |
| ES2156725B1 (es) | 1999-05-07 | 2002-03-01 | Consejo Superior Investigacion | Derivados de dioxidos n,n- y n,x-disustituidos de 1,2,6-tiadiazina fusionadas y procedimiento de obtencion. |
| EP2050822B1 (en) | 2001-01-23 | 2013-07-31 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Hepatitis C virus replicons and replicon enhanced cells |
| TW200400963A (en) | 2002-05-21 | 2004-01-16 | Wyeth Corp | R-enantiomers of pyranoindole derivatives and the use thereof for the treatment of hepatitis C virus infection or disease |
| US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| GB0307891D0 (en) | 2003-04-04 | 2003-05-14 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
| US20050239767A1 (en) | 2003-10-28 | 2005-10-27 | Chan Michael K | Intermolecular SNAr of the heterocycle-activated nitro and fluoro groups-application in the synthesis of polyazamacrocyclic ligands |
| US20050119318A1 (en) | 2003-10-31 | 2005-06-02 | Hudyma Thomas W. | Inhibitors of HCV replication |
| CN1922174A (zh) | 2004-02-20 | 2007-02-28 | 贝林格尔·英格海姆国际有限公司 | 病毒聚合酶抑制剂 |
| US20070049593A1 (en) | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
| WO2005080399A1 (ja) | 2004-02-24 | 2005-09-01 | Japan Tobacco Inc. | ４環縮合複素環化合物及びそのｈｃｖポリメラーゼ阻害剤としての利用 |
| GB0413087D0 (en) | 2004-06-11 | 2004-07-14 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| UY29017A1 (es) | 2004-07-16 | 2006-02-24 | Boehringer Ingelheim Int | Inhibidores de polimerasa viral |
| US7153848B2 (en) * | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| US7795247B2 (en) | 2004-10-26 | 2010-09-14 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Tetracyclic indole derivatives as antiviral agents |
| RU2007119562A (ru) * | 2004-10-26 | 2008-12-10 | Институто Ди Ричерке Ди Биолоджиа Молеколаре П Анджелетти Спа (It) | Тетрациклические производные индолов в качестве противовирусных агентов |
| US7659263B2 (en) | 2004-11-12 | 2010-02-09 | Japan Tobacco Inc. | Thienopyrrole compound and use thereof as HCV polymerase inhibitor |
| GB0518390D0 (en) | 2005-09-09 | 2005-10-19 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| US7399758B2 (en) | 2005-09-12 | 2008-07-15 | Meanwell Nicholas A | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| US7473688B2 (en) | 2005-09-13 | 2009-01-06 | Bristol-Myers Squibb Company | Indolobenzazepine HCV NS5B inhibitors |
| GB0522881D0 (en) * | 2005-11-10 | 2005-12-21 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| GB0608928D0 (en) | 2006-05-08 | 2006-06-14 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| GB0609492D0 (en) | 2006-05-15 | 2006-06-21 | Angeletti P Ist Richerche Bio | Therapeutic agents |
-
2006
- 2006-05-08 GB GBGB0608928.8A patent/GB0608928D0/en not_active Ceased
-
2007
- 2007-05-04 CA CA002651226A patent/CA2651226A1/en not_active Abandoned
- 2007-05-04 US US12/299,833 patent/US8232390B2/en not_active Expired - Fee Related
- 2007-05-04 JP JP2009508506A patent/JP5276582B2/ja not_active Expired - Fee Related
- 2007-05-04 WO PCT/GB2007/050239 patent/WO2007129119A1/en not_active Ceased
- 2007-05-04 EP EP07733660A patent/EP2027125A1/en not_active Withdrawn
- 2007-05-04 CN CNA2007800166679A patent/CN101437826A/zh active Pending
- 2007-05-04 AU AU2007246850A patent/AU2007246850B2/en not_active Ceased
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