JP2009535351A - シグモイド放出プロファイルを有するオキサカルバゼピンの制御放出製剤 - Google Patents
シグモイド放出プロファイルを有するオキサカルバゼピンの制御放出製剤 Download PDFInfo
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- JP2009535351A JP2009535351A JP2009507891A JP2009507891A JP2009535351A JP 2009535351 A JP2009535351 A JP 2009535351A JP 2009507891 A JP2009507891 A JP 2009507891A JP 2009507891 A JP2009507891 A JP 2009507891A JP 2009535351 A JP2009535351 A JP 2009535351A
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- oxacarbazepine
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Abstract
【選択図】なし
Description
本出願は、2006年4月26日に出願された米国仮出願第60/794,837号(この開示は、その全体が参照により本明細書に援用される)に対する優先権を主張する。
[実施例]
第1表は、シグモイド放出プロファイルを有するオキサカルバゼピン制御放出製剤の配合組成を提供する。顆粒は、造粒液として無水エタノールを使用した高せん断造粒により調製された。ステアリン酸マグネシウムを除く全ての成分を、VG−65/10M高せん断造粒機へ装填した。乾燥粉末は、3分間ブレードを作動させることによりブレンドされ、その後、無水エタノールを、およそ40〜60gm/分の噴霧速度で混合ブレンド上へ噴霧した。約1分の噴霧後、VG−65/10M上のチョッパーを始動させて、噴霧全体にわたって作動させた。造粒がひとたび完了したら、造粒物はVG高せん断造粒機から排出されて、適切なトレイ上に広げられて、炉中に配置されて、40℃で24時間乾燥させた。或いは、顆粒は、流動床加工機を使用して乾燥させることができる。乾燥顆粒は、18メッシュスクリーンに通して篩過した。篩過された顆粒は、顆粒99.5%及びステアリン酸マグネシウム0.5%の比率でステアリン酸マグネシウムとブレンドした。続いて、ブレンドは、ロータリー式錠剤成形機上で錠剤化した。
実施例1からの3つの配合物をヒトにおいて評価して、薬物動態情報を得た。即時放出錠剤(Trileptal(登録商標)600mg)を対照参照として使用した。配合物は、健常なヒトボランティアにおいて無作為化単回投与交差研究で検査した。血液サンプルを、親分子オキサカルバゼピン及びその代謝産物(モノヒドロキシ誘導体、MHD)の両方に関して分析した。
賦形剤の存在下でのオキサカルバゼピンの溶解度を下記のように評価した。
第4表及び第5表は、溶解度増強剤及び放出増強剤を含有する配合物の組成を提供する。顆粒は、造粒液として水を使用した高せん断造粒により製造された。ステアリン酸マグネシウムを除く全ての成分を、VG−65/10M高せん断造粒機へ装填した。乾燥粉末は、3分間ブレードを作動させることによりブレンドされ、その際、水を、およそ40〜60gm/分の噴霧速度で混合ブレンド上へ噴霧させた。約1分の噴霧後、VG−65/10M上のチョッパーを始動させて、噴霧全体にわたって作動させた。造粒がひとたび完了したら、造粒物はVG高せん断造粒機から排出されて、適切なトレイ上に広げられて、炉中に配置されて、40℃で24時間乾燥させた。或いは、顆粒は、流動床加工機を使用して乾燥させることができる。乾燥顆粒は、18メッシュスクリーンに通して篩過する。篩過された顆粒は、顆粒99.5%及びステアリン酸マグネシウム0.5%の比率でステアリン酸マグネシウムとブレンドした。続いて、得られたブレンドは、ロータリー式錠剤成形機上で錠剤化した。これらの配合物に関する溶解プロファイルは、図5及び図6に示される。
6匹の雄ビーグル犬に、第6表に付与される順に配合物を経口投薬した。血液を24時間にわたって採取して、血液サンプルをHPLCで分析した。データのノンコンパートメント解析を使用して、Tmax、Cmax、AUClast及びAUCinfを作成した。相対バイオアベイラビリティは、対照としてのCRf配合物に関するAUClast及びAUCinfを使用してExcelで算出した。オキサカルバゼピン及び10−ヒドロキシカルバゼピンに関するPKプロファイルは、図7及び図8で与えられる。
コンピュータによるモデリングを、様々な仮想システムに関して実施した。結果は図9〜図11に示される。
実施例4からの3つの溶解度増強プロトタイプをヒトにおいて評価して、薬物動態情報を得た。BID付与した即時放出錠剤(Trileptal(登録商標)300mg)を参照として使用した。配合物は、健常なヒトボランティアにおいて無作為化単回投与交差研究で検査した。血液サンプルを、親分子オキサカルバゼピン及びその代謝産物(モノヒドロキシ誘導体、MHD)の両方に関して分析した。
Claims (23)
- オキサカルバゼピン、少なくとも1つの溶解度増強剤及び少なくとも1つの放出促進剤を含むオキサカルバゼピンの1日1回投与用の薬学的配合物。
- 前記溶解度増強剤が、界面活性剤、錯化剤、分子捕捉剤、pH調整剤及び水和促進剤を含む群から選択される、請求項1に記載の薬学的配合物。
- 前記界面活性剤が、ソディウムドキュセート、ラウリル硫酸ナトリウム、ソディウムステアリルフマレート、ポリエチレンオキシド(PEO)変性ソルビタンモノエステル、脂肪酸ソルビタンエステル及びポリエチレンオキシド−ポリプロピレンオキシド−(ポリ(エチレンオキシド))ブロック共重合体を含む群から選択される、請求項2に記載の薬学的配合物。
- 前記放出促進剤が、pH依存性ポリマーを含む、請求項1に記載の薬学的配合物。
- 膨潤性ポリマー及びゲル形成ポリマーを含む群から選択されるマトリックス形成ポリマーをさらに含む、請求項1に記載の薬学的配合物。
- 前記さらなるポリマーが、セルロースポリマー、アルギン酸塩、ガム類、架橋ポリアクリル酸誘導体、カラギーナン;ポリビニルピロリドン及びその誘導体;ポリエチレンオキサイド;並びにポリビニルアルコールを含む群から選択される、請求項5に記載の薬学的配合物。
- pH依存性ポリマーが、4より低いpH値で元の状態(intact)を保ち、4よりも大きいpH値で溶解する、請求項4に記載の薬学的配合物。
- 前記pH依存性ポリマーが、5よりも大きいpH値で溶解する、請求項7に記載の薬学的配合物。
- 前記pH依存性ポリマーが、6よりも大きいpH値で溶解する、請求項7に記載の薬学的配合物。
- 前記pH依存性ポリマーが、セルロースアセテートフタレート、セルロースアセテートサクシネート、メチルセルロースフタレート、エチルヒドロキシセルロースフタレート、ポリビニルアセテートフタレート、ポリビニルブチレートアセテート、ビニルアセテート−無水マレイン酸共重合体、スチレン−マレイン酸モノエステル共重合体、及びメチルアクリレート−メタクリル酸共重合体を含む群から選択される、請求項4に記載の薬学的配合物。
- 前記放出促進剤の量が、投薬形態の10重量%〜90重量%であることができ、可溶化剤の量は、1重量%〜80重量%であることができる、請求項1に記載の薬学的配合物。
- 前記放出促進剤の量が、前記投薬形態の30重量%〜70重量%であることができ、前記可溶化剤の量は、1重量%〜50重量%であることができる、請求項11に記載の薬学的配合物。
- 前記オキサカルバゼピンの量が、約2μg/ml〜約10μg/mlの範囲でオキサカルバゼピンのモノヒドロキシ誘導体の定常状態血中レベルを生じるのに有効である、請求項1に記載の薬学的配合物。
- オキサカルバゼピンのモノヒドロキシ誘導体のCminとCmaxとの間での変動を最低限に抑えるのに有効な、請求項13に記載の薬学的配合物。
- MHDのCmaxレベルが、約6μg/ml〜約10μg/mlの範囲であり、MHDのCminレベルは、約2μg/ml〜約5μg/mlの範囲である、請求項14に記載の薬学的配合物。
- 胃腸管において可変速度のオキサカルバゼピン放出を提供する、請求項1に記載の薬学的配合物。
- オキサカルバゼピンの低速度の放出、続く増大された速度を提供する、請求項16に記載の薬学的配合物。
- オキサカルバゼピンの初期即時放出様式、続く調節放出様式を提供する、請求項16に記載の薬学的配合物。
- 前記調節放出様式が、遅延放出様式、持続放出様式、並びにそれぞれが異なる放出速度を特徴とする任意数の遅延放出様式及び持続放出様式の組合せを含む群から選択される、請求項18に記載の薬学的配合物。
- 1つの投薬単位において調節放出様式を有する多重単位を組み合わせる、請求項16に記載の薬学的配合物。
- 前記調節放出様式が、遅延放出様式、持続放出様式、並びにそれぞれが異なる放出速度を特徴とする任意数の遅延放出様式及び持続放出様式の組合せを含む群から選択される、請求項20に記載の薬学的配合物。
- 前記単位は、(ミニ)ペレット、(ミニ)顆粒、(ミニ)錠剤及び層の形態である、請求項21に記載の薬学的配合物。
- ペレット、錠剤、顆粒又はカプセルの形態である、請求項1に記載の薬学的配合物。
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