JP2009532373A5 - - Google Patents
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- Publication number
- JP2009532373A5 JP2009532373A5 JP2009503137A JP2009503137A JP2009532373A5 JP 2009532373 A5 JP2009532373 A5 JP 2009532373A5 JP 2009503137 A JP2009503137 A JP 2009503137A JP 2009503137 A JP2009503137 A JP 2009503137A JP 2009532373 A5 JP2009532373 A5 JP 2009532373A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- jnk
- intraocular
- formulation
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/394,893 | 2006-03-31 | ||
| US11/394,893 US7803824B2 (en) | 2004-10-29 | 2006-03-31 | Use of inhibitors of Jun N-terminal kinases to treat glaucoma |
| PCT/US2007/063961 WO2007117849A2 (en) | 2006-03-31 | 2007-03-14 | Use of inhibitors of jun n-terminal kinases to treat glaucoma |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009532373A JP2009532373A (ja) | 2009-09-10 |
| JP2009532373A5 true JP2009532373A5 (https=) | 2011-03-10 |
| JP5241033B2 JP5241033B2 (ja) | 2013-07-17 |
Family
ID=38523463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009503137A Expired - Fee Related JP5241033B2 (ja) | 2006-03-31 | 2007-03-14 | 緑内障を処置するためのｊｕｎｎ末端キナーゼの阻害剤の使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US7803824B2 (https=) |
| EP (1) | EP2004158A2 (https=) |
| JP (1) | JP5241033B2 (https=) |
| KR (1) | KR20080108503A (https=) |
| CN (1) | CN101415407B (https=) |
| AR (1) | AR060222A1 (https=) |
| AU (1) | AU2007235111B2 (https=) |
| BR (1) | BRPI0710099A2 (https=) |
| CA (1) | CA2644721A1 (https=) |
| MX (1) | MX2008011319A (https=) |
| TW (1) | TWI419694B (https=) |
| WO (1) | WO2007117849A2 (https=) |
| ZA (1) | ZA200807667B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7803824B2 (en) * | 2004-10-29 | 2010-09-28 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases to treat glaucoma |
| US20060094753A1 (en) * | 2004-10-29 | 2006-05-04 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases |
| US20090202524A1 (en) * | 2007-10-31 | 2009-08-13 | Alcon Research, Ltd. | Pai-1 expression and activity inhibitors for the treatment of ocular disorders |
| US20100056609A1 (en) * | 2008-08-26 | 2010-03-04 | Washington University | Methods and compositions for inhibition of axonal degeneration by modulation of the dlk/jnk pathway |
| US20120077753A1 (en) * | 2009-06-25 | 2012-03-29 | Laxman Gangwani | Jnk inhibitors for use in treating spinal muscular atrophy |
| CN103458970A (zh) * | 2011-03-07 | 2013-12-18 | 泰莱托恩基金会 | Tfeb磷酸化抑制剂及其应用 |
| KR20160023669A (ko) * | 2013-06-26 | 2016-03-03 | 자이겐 인플라메이션 리미티드 | 다양한 질병의 치료를 위한 jnk 신호 전달 경로의 세포 투과성 펩타이드 억제자의 새로운 용도 |
| AU2015281361A1 (en) * | 2014-06-26 | 2016-11-17 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of various diseases |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997040847A1 (en) * | 1996-04-26 | 1997-11-06 | University Of Ottawa | Therapeutic and drug screening methods for the treatment and prevention of neuronal disease |
| KR20010083884A (ko) * | 1998-10-13 | 2001-09-03 | 세파론, 인코포레이티드 | 눈 질환 치료제 |
| BR9916272A (pt) | 1998-12-17 | 2001-09-04 | Hoffmann La Roche | 4 e 5-alquiniloxindóis e 4 e 5-alqueniloxindóis |
| DE60041763D1 (de) | 1999-04-23 | 2009-04-23 | Vertex Pharma | Inhibitoren von c-jun n-terminal kinasen (jnk) |
| BR0013551A (pt) | 1999-08-13 | 2003-06-17 | Vertex Pharma | Inibidores de cinases n-terminal cjun (jnk) e outras cinases de proteìnas |
| US20040072888A1 (en) * | 1999-08-19 | 2004-04-15 | Bennett Brydon L. | Methods for treating inflammatory conditions or inhibiting JNK |
| KR20080028516A (ko) | 1999-08-19 | 2008-03-31 | 시그널 파머슈티컬스 인크 | Ｊｎｋ억제제로서의 피라졸로안트론과 그 유도체 및 이를함유하는 조성물 |
| EP1088822A1 (en) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonyl hydrazide derivatives |
| EP1088821A1 (en) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonamide derivatives |
| EP1088815A1 (en) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonyl amino acid derivatives |
| EP1110957A1 (en) | 1999-12-24 | 2001-06-27 | Applied Research Systems ARS Holding N.V. | Benzazole derivatives and their use as JNK modulators |
| WO2001091749A1 (en) | 2000-06-01 | 2001-12-06 | Merck & Co., Inc. | Use of (di-substituted-phenyl)-pyrimidinyl-imidazole derivatives as jnk-inhibitors |
| EP1193256A1 (en) | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins |
| US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
| US7199124B2 (en) | 2001-02-02 | 2007-04-03 | Takeda Pharmaceutical Company Limited | JNK inhibitor |
| GB0108770D0 (en) | 2001-04-06 | 2001-05-30 | Eisai London Res Lab Ltd | Inhibitors |
| CN1300116C (zh) | 2001-04-16 | 2007-02-14 | 卫材株式会社 | 1h－吲唑化合物 |
| WO2003018020A1 (en) | 2001-08-23 | 2003-03-06 | Takeda Chemical Industries, Ltd. | Jnk inhibitors |
| BR0212760A (pt) | 2001-09-19 | 2004-12-07 | Aventis Pharma Sa | Compostos quìmicos |
| JP2003129190A (ja) | 2001-10-19 | 2003-05-08 | Sumitomo Metal Ind Ltd | マルテンサイト系ステンレス鋼およびその製造方法 |
| US20030138819A1 (en) | 2001-10-26 | 2003-07-24 | Haiqing Gong | Method for detecting disease |
| ATE465153T1 (de) * | 2002-02-28 | 2010-05-15 | Eisai R&D Man Co Ltd | Neue indazolverbindungen mit kondensiertem ring |
| US7351407B2 (en) * | 2002-04-30 | 2008-04-01 | Alcon, Inc. | Agents which regulate, inhibit, or modulate the activity and/or expression of connective tissue growth factor (CTGF) as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies |
| WO2003106455A1 (en) | 2002-06-14 | 2003-12-24 | Applied Research Systems Ars Holding N.V. | Azole methylidene cyanide derivatives and their use as protein kinase modulators |
| EP1542768A1 (en) * | 2002-09-20 | 2005-06-22 | Alcon, Inc. | Use of cytokine synthesis inhibitors for the treatment of dry eye disorders |
| US20040092568A1 (en) * | 2002-10-31 | 2004-05-13 | Zeldis Jerome B. | Methods for the treatment, prevention and management of macular degeneration |
| US20060094753A1 (en) | 2004-10-29 | 2006-05-04 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases |
| US7803824B2 (en) * | 2004-10-29 | 2010-09-28 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases to treat glaucoma |
| US20060275797A1 (en) * | 2005-03-21 | 2006-12-07 | Alcon Manufacturing, Ltd. | Use of agents which inhibit connective tissue growth factor (CTGF) binding and signaling via the TrkA/p75NTR receptor complex for the prevention and treatment of CTGF-mediated ocular disorders |
-
2006
- 2006-03-31 US US11/394,893 patent/US7803824B2/en not_active Expired - Fee Related
-
2007
- 2007-03-14 CN CN2007800116928A patent/CN101415407B/zh not_active Expired - Fee Related
- 2007-03-14 AU AU2007235111A patent/AU2007235111B2/en not_active Ceased
- 2007-03-14 KR KR1020087023895A patent/KR20080108503A/ko not_active Ceased
- 2007-03-14 JP JP2009503137A patent/JP5241033B2/ja not_active Expired - Fee Related
- 2007-03-14 ZA ZA200807667A patent/ZA200807667B/xx unknown
- 2007-03-14 EP EP07758510A patent/EP2004158A2/en not_active Withdrawn
- 2007-03-14 WO PCT/US2007/063961 patent/WO2007117849A2/en not_active Ceased
- 2007-03-14 MX MX2008011319A patent/MX2008011319A/es active IP Right Grant
- 2007-03-14 BR BRPI0710099-0A patent/BRPI0710099A2/pt not_active IP Right Cessation
- 2007-03-14 CA CA002644721A patent/CA2644721A1/en not_active Abandoned
- 2007-03-19 TW TW096109322A patent/TWI419694B/zh not_active IP Right Cessation
- 2007-03-29 AR ARP070101334A patent/AR060222A1/es not_active Application Discontinuation
-
2010
- 2010-08-18 US US12/858,739 patent/US20100311716A1/en not_active Abandoned
-
2011
- 2011-09-14 US US13/232,410 patent/US20120004274A1/en not_active Abandoned
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