JP2009531283A5 - - Google Patents

Download PDF

Info

Publication number
JP2009531283A5
JP2009531283A5 JP2008552923A JP2008552923A JP2009531283A5 JP 2009531283 A5 JP2009531283 A5 JP 2009531283A5 JP 2008552923 A JP2008552923 A JP 2008552923A JP 2008552923 A JP2008552923 A JP 2008552923A JP 2009531283 A5 JP2009531283 A5 JP 2009531283A5
Authority
JP
Japan
Prior art keywords
seq
inhibitor
cxcr4
nucleotide sequence
region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008552923A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009531283A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2007/003262 external-priority patent/WO2008029276A2/en
Publication of JP2009531283A publication Critical patent/JP2009531283A/ja
Publication of JP2009531283A5 publication Critical patent/JP2009531283A5/ja
Pending legal-status Critical Current

Links

JP2008552923A 2006-02-02 2007-02-02 眼系疾患の処置のための組成物および方法 Pending JP2009531283A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76489206P 2006-02-02 2006-02-02
PCT/IB2007/003262 WO2008029276A2 (en) 2006-02-02 2007-02-02 Compositions and methods for the treatment of ophthalmic disease

Publications (2)

Publication Number Publication Date
JP2009531283A JP2009531283A (ja) 2009-09-03
JP2009531283A5 true JP2009531283A5 (https=) 2010-03-25

Family

ID=39157630

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008552923A Pending JP2009531283A (ja) 2006-02-02 2007-02-02 眼系疾患の処置のための組成物および方法

Country Status (8)

Country Link
US (2) US7964191B2 (https=)
EP (3) EP2397148A3 (https=)
JP (1) JP2009531283A (https=)
AU (1) AU2007293169A1 (https=)
BR (1) BRPI0707446A2 (https=)
CA (1) CA2640080A1 (https=)
ES (1) ES2385924T3 (https=)
WO (1) WO2008029276A2 (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080220049A1 (en) * 2003-12-05 2008-09-11 Adnexus, A Bristol-Myers Squibb R&D Company Compositions and methods for intraocular delivery of fibronectin scaffold domain proteins
CN1946417A (zh) 2003-12-05 2007-04-11 阿德内克休斯治疗公司 2型血管内皮生长因子受体的抑制剂
US8680092B2 (en) 2005-02-25 2014-03-25 Ono Pharmaceutical Co., Ltd. Nitrogenous heterocyclic compound and medicinal use thereof
TW200808328A (en) * 2006-06-02 2008-02-16 Alcon Mfg Ltd RNAi-mediated inhibition of stromal cell-derived factor 1-related targets for treatment of neovascularization-related conditions
RU2590709C2 (ru) 2006-07-18 2016-07-10 Ноксон Фарма Аг Sdf-1-связывающие нуклеиновые кислоты
CA2670471A1 (en) 2006-11-22 2008-06-05 Adnexus, A Bristol-Myers Squibb R&D Company (A Delaware Corporation) Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir
US11078262B2 (en) * 2007-04-30 2021-08-03 Allergan, Inc. High viscosity macromolecular compositions for treating ocular conditions
KR101589442B1 (ko) 2007-08-06 2016-02-01 녹손 파르마 아게 에스디에프-1 결합형 핵산 및 이의 용도
CN102007145A (zh) 2008-02-14 2011-04-06 百时美施贵宝公司 基于结合egfr的工程化蛋白质的靶向治疗剂
PE20091931A1 (es) 2008-05-22 2009-12-31 Bristol Myers Squibb Co Proteinas de dominio de armazon basadas en fibronectina multivalentes
WO2010037042A2 (en) 2008-09-26 2010-04-01 The General Hospital Corporation Methods for detecting and treating cancer
US11029313B2 (en) 2008-09-26 2021-06-08 The General Hospital Corporation Method of treating cervical neoplasia in patients infected with human papilloma virus
TWI496582B (zh) 2008-11-24 2015-08-21 必治妥美雅史谷比公司 雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子
US20100204325A1 (en) * 2009-02-11 2010-08-12 Allergan, Inc. Valproic acid drug delivery systems and intraocular therapeutic uses thereof
LT2523669T (lt) 2010-01-11 2017-04-25 Inotek Pharmaceuticals Corporation Akispūdžio mažinimo būdas, derinys ir rinkinys
PH12012501906A1 (en) 2010-03-26 2013-01-14 Inotek Pharmaceuticals Corp Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof
ES2573108T3 (es) 2010-05-26 2016-06-06 Bristol-Myers Squibb Company Proteínas de armazón a base de fibronectina que tienen estabilidad mejorada
SG10201605512WA (en) 2011-07-06 2016-09-29 Novartis Ag Oil-in-water emulsions that contain nucleic acids
CA2840965C (en) 2011-07-06 2021-03-02 Novartis Ag Cationic oil-in-water emulsions
PT2807178T (pt) 2012-01-26 2017-08-08 Inotek Pharmaceuticals Corp Polimorfos anidros de nitrato de (2r,3s,4r,5r)-5-(6-(ciclopentilamino)-9h-purin-9-il)-3,4-dihidroxitetrahidrofuran-2-il)}metilo e seus processos de preparação
NZ630759A (en) 2013-03-15 2017-07-28 Inotek Pharmaceuticals Corp Ophthalmic formulations comprising an a1 agonist
PE20160671A1 (es) 2013-08-02 2016-07-09 Pfizer Anticuerpos anti-cxcr4 y conjugados de anticuerpo y farmaco
WO2015031722A1 (en) 2013-08-30 2015-03-05 Ramot At Tel-Aviv University Ltd. Method for treating amyotrophic lateral sclerosis by inhibition of cxcr4/cxcl12 signaling
EP3305304A4 (en) * 2015-05-29 2019-01-23 Seikagaku Corporation COMPOSITION WITH GLUCOSAMINATE SCANDERIVATE AND CHEMOKIN RECEPTOR ACTIVITY CONTROLLER
CA3004738A1 (en) * 2015-11-09 2017-05-18 Aperisys, Inc. Modified immune cells and uses thereof
CN109053697A (zh) * 2018-09-27 2018-12-21 张淑华 一种用于抗癌的嘧啶类化合物及其制备方法

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4521210A (en) 1982-12-27 1985-06-04 Wong Vernon G Eye implant for relieving glaucoma, and device and method for use therewith
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4997652A (en) 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
BR9106702A (pt) 1990-07-27 1993-06-08 Isis Pharmaceuticals Inc Analogo de oligonucleotideos e processos para modular a producao de uma proteina por um organismo e para tratar um organismo
KR0185215B1 (ko) 1990-11-30 1999-05-01 요시다 쇼오지 서방성 안구삽입용 약제
KR940703846A (ko) 1991-12-24 1994-12-12 비. 린네 파샬 갭(gap)이 형성된 2′ 변성된 올리고뉴클레오티드(gapped 2′ modifed oligonucleotides)
US5874082A (en) * 1992-07-09 1999-02-23 Chiron Corporation Humanized anti-CD40 monoclonal antibodies and fragments capable of blocking B cell proliferation
AU4684993A (en) 1992-07-23 1994-02-14 Isis Pharmaceuticals, Inc. Novel 2'-o-alkyl nucleosides and phosphoramidites processes for the preparation and uses thereof
JPH08503957A (ja) 1993-02-19 1996-04-30 アイシス・ファーマシューティカルス・インコーポレーテッド シクロブチルアンチセンスオリゴヌクレオチド、その作成および使用方法
WO1995003009A1 (en) 1993-07-22 1995-02-02 Oculex Pharmaceuticals, Inc. Method of treatment of macular degeneration
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5869079A (en) 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US6369116B1 (en) 1995-06-02 2002-04-09 Oculex Pharmaceuticals, Inc. Composition and method for treating glaucoma
US6506770B1 (en) 1996-06-06 2003-01-14 Anormed, Inc. Antiviral compounds
US5994515A (en) 1996-06-25 1999-11-30 Trustees Of The University Of Pennsylvania Antibodies directed against cellular coreceptors for human immunodeficiency virus and methods of using the same
CA2300154C (en) 1997-08-11 2008-07-08 Allergan Sales, Inc. Sterile bioerodible implant device with improved biocompatability and method
JP4312957B2 (ja) * 1998-01-15 2009-08-12 キングス・カレツジ・ロンドン Ｃｃｒ５あるいはｃｘｃｒ４を開裂するリボザイム核酸
CA2305787A1 (en) 2000-05-09 2001-11-09 The University Of British Columbia Cxcr4 antagonist treatment of hematopoietic cells
CA2245224A1 (en) 1998-08-14 2000-02-14 Jiang-Hong Giong Chemokine receptor antagonists and chemotherapeutics
WO1999047158A2 (en) * 1998-03-13 1999-09-23 The University Of British Columbia Therapeutic chemokine receptor antagonists
EP1745797A3 (en) 1998-03-24 2007-07-18 Chugai Seiyaku Kabushiki Kaisha Vascularization inhibitors
WO1999062535A2 (en) 1998-06-01 1999-12-09 University Of Maryland Biotechnology Institute Receptor ligand antagonist complexes and their use in treating or preventing receptor mediated diseases
US20050202005A1 (en) 1998-07-31 2005-09-15 The Trustees Of Columbia University In The City Of New York Uses of inhibitors for the activation of CXCR4 receptor by SDF-1 in treating rheumatoid arthritis
WO2000006086A2 (en) 1998-07-31 2000-02-10 The Trustees Of Columbia University In The City Of New York Use of inhibitors of the activation of cxcr4 receptor by sdf-1 in treating rheumatoid arthritis
US20030099645A1 (en) 2000-10-10 2003-05-29 Lobo Peter Isaac Naturally occuring IgM antibodies that bind to membrane receptors on lymphocytes
US20050220787A1 (en) 2002-11-07 2005-10-06 Lobo Peter I Naturally occuring IgM antibodies that bind to lymphocytes
US6610834B1 (en) 1998-11-18 2003-08-26 Peter I. Lobo Human IgM antibodies to chemokine receptors
EP1050583A4 (en) 1998-11-24 2005-02-02 Hisamitsu Pharmaceutical Co INHIBITORS OF HIV INFECTIONS
EP1176195B1 (en) 1999-04-09 2013-05-22 Kyowa Hakko Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US6949243B1 (en) 1999-11-24 2005-09-27 Schering Corporation Methods of inhibiting metastasis
DE60042030D1 (de) 1999-12-17 2009-05-28 Genzyme Corp Chemokinrezeptor-bindende heterocyclische verbindungen
CA2369056A1 (en) 2000-02-03 2001-08-09 Thomas Jefferson University Vmip-ii peptide antagonists of cxcr4
CA2399032A1 (en) 2000-02-04 2001-08-09 The Government Of The United States Of America Ligands for fpr class receptors that induce a host immune response to a pathogen or inhibit hiv infection
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
US6835731B2 (en) 2000-09-15 2004-12-28 Anormed, Inc. Chemokine receptor binding heterocyclic compounds
US20030165988A1 (en) 2002-02-08 2003-09-04 Shaobing Hua High throughput generation of human monoclonal antibody against peptide fragments derived from membrane proteins
AU2002236495B2 (en) 2000-11-29 2006-05-11 Allergan, Inc. Intraocular implants for preventing transplant rejection in the eye
US20060019917A1 (en) 2001-05-18 2006-01-26 Sirna Therapeutics, Inc. RNA interference mediated inhibition of stromal cell-derived factor-1 (SDF-1) gene expression using short interfering nucleic acid (siNA)
US20050124569A1 (en) * 2001-05-18 2005-06-09 Sirna Therapeutics, Inc. RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA)
WO2002094261A1 (fr) 2001-05-24 2002-11-28 Kureha Chemical Industry Company, Limited Medicaments antagonistes de cxcr4 comprenant un compose contenant de l'azote
US20040254221A1 (en) 2001-09-28 2004-12-16 Toru Yamazaki Novel Nitrogenous Compound and use thereof
US7354932B2 (en) 2001-12-21 2008-04-08 Anormed, Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy
CA2467718C (en) 2001-12-21 2011-04-26 Anormed Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy
CA2471744A1 (en) 2001-12-31 2003-07-24 Consejo Superior De Investigaciones Cientificas Functional inactivation of cxcr4-mediated responses in growth hormone transgenic mice through socs3 upregulation
AU2003228667A1 (en) * 2002-04-22 2003-12-19 Sirna Therapeutics Inc. Nucleic acid mediated disruption of hiv fusogenic peptide interactions
US20040018528A1 (en) * 2002-05-17 2004-01-29 Sugen, Inc. Novel biomarkers of tyrosine kinase inhibitor exposure and activity in mammals
US7148342B2 (en) * 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
US20050002939A1 (en) 2002-12-23 2005-01-06 Albert Zlotnik Tumor killing/tumor regression using CXCR4 antagonists
JP2006524242A (ja) * 2003-03-27 2006-10-26 エモリー ユニバーシティー Ｃｘｃｒ４アンタゴニストおよびそれらの使用方法
EP1613613B1 (en) 2003-04-11 2021-06-02 Genzyme Corporation Cxcr4 chemokine receptor binding compounds
WO2005002522A2 (en) 2003-06-30 2005-01-13 Caritas St. Elizabeth's Medical Center Of Boston, Inc. Compositions and methods for treating tissue ischemia
US20050266009A1 (en) 2003-06-30 2005-12-01 Savient Pharmaceuticals, Inc. Antibodies and uses thereof
US20050019927A1 (en) * 2003-07-13 2005-01-27 Markus Hildinger DECREASING GENE EXPRESSION IN A MAMMALIAN SUBJECT IN VIVO VIA AAV-MEDIATED RNAi EXPRESSION CASSETTE TRANSFER
JP2007523159A (ja) 2004-02-20 2007-08-16 ジェネシス リサーチ アンド デベロップメント コーポレイション リミテッド Ｒｎａ干渉分子の標的送達
JP4939396B2 (ja) 2004-03-26 2012-05-23 ノヴァレメッド リミテッド Ａｉｄｓ及び他のウイルス性疾患及びｈｉｖ関連感染症の改善又はその治療用化合物及びそのような化合物を含む組成物、そのような疾患及び感染症の治療方法及びそのような化合物及び組成物の製造方法
EP1796675A4 (en) * 2004-10-01 2009-03-04 Merck & Co Inc COMPOSITIONS AND METHODS FOR THE TREATMENT OF EYE DISEASES
US20060110429A1 (en) * 2004-11-24 2006-05-25 Therakine Corporation Implant for intraocular drug delivery
WO2006074428A2 (en) 2005-01-07 2006-07-13 Emory University Cxcr4 antagonists for the treatment of medical disorders
AU2006203826A1 (en) 2005-01-07 2006-07-13 Emory University CXCR4 antagonists for the treatment of HIV infection
US8680092B2 (en) 2005-02-25 2014-03-25 Ono Pharmaceutical Co., Ltd. Nitrogenous heterocyclic compound and medicinal use thereof
US20060257359A1 (en) * 2005-02-28 2006-11-16 Cedric Francois Modifying macrophage phenotype for treatment of disease
EP1866414B9 (en) * 2005-03-31 2012-10-03 Calando Pharmaceuticals, Inc. Inhibitors of ribonucleotide reductase subunit 2 and uses thereof

Similar Documents

Publication Publication Date Title
JP2009531283A5 (https=)
JP2012012402A5 (https=)
JP2018198596A5 (https=)
JP2018502051A5 (https=)
JP2017113019A5 (https=)
JP2010516708A5 (https=)
JP2020515643A5 (https=)
JP2019506159A5 (https=)
RU2008119689A (ru) Человеческие антитела к il-13 и их терапевтическое применение
RU2011144166A (ru) Способы применения антител к il-22 человека
GEP20105059B (en) Anti-cd154 antibodies
AU2014268316B2 (en) Anti-CCL2 and anti-LOXL2 combination therapy for treatment of scleroderma
BRPI0612273A2 (pt) anticorpo de ligaÇço a il-1 beta ou fragmento de ligaÇço a il-1 beta do mesmo, Ácido nucleico, vetor, cÉlula, animal transgÊnico, hibridoma, composiÇço, e, mÉtodos de tratamento ou prevenÇço de uma doenÇa ou doenÇa relacionada a il-1 em um mamÍfero, e de preparaÇço de um polipeptÍdeo de ligaÇço a il-1 beta maturado por afinidade
JP2010510223A5 (https=)
JP2019510739A5 (https=)
JP2012504602A5 (https=)
US9453050B2 (en) Compositions for treating glioma
JP2015508063A5 (https=)
US9067989B2 (en) Eotaxin-2 (CCL24) inhibitors in inflammatory, autoimmune, and cardiovascular disorders
JP2010504336A5 (https=)
JP2020524696A5 (https=)
RU2017120031A (ru) Способ лечения или предотвращения инсульта
JP2018501201A5 (https=)
Ren et al. Down-regulation of surface fractalkine by RNA interference in B16 melanoma reduced tumor growth in mice
JP2005536220A5 (https=)