JP2018502051A5 - - Google Patents
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- JP2018502051A5 JP2018502051A5 JP2017518540A JP2017518540A JP2018502051A5 JP 2018502051 A5 JP2018502051 A5 JP 2018502051A5 JP 2017518540 A JP2017518540 A JP 2017518540A JP 2017518540 A JP2017518540 A JP 2017518540A JP 2018502051 A5 JP2018502051 A5 JP 2018502051A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- cancer
- polypeptide
- seq
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462062323P | 2014-10-10 | 2014-10-10 | |
| US62/062,323 | 2014-10-10 | ||
| US201562118549P | 2015-02-20 | 2015-02-20 | |
| US62/118,549 | 2015-02-20 | ||
| US201562133597P | 2015-03-16 | 2015-03-16 | |
| US62/133,597 | 2015-03-16 | ||
| US201562188881P | 2015-07-06 | 2015-07-06 | |
| US62/188,881 | 2015-07-06 | ||
| PCT/EP2015/073370 WO2016055609A1 (en) | 2014-10-10 | 2015-10-09 | Cd73 blockade |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020122032A Division JP7132981B2 (ja) | 2014-10-10 | 2020-07-16 | Ｃｄ７３遮断 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018502051A JP2018502051A (ja) | 2018-01-25 |
| JP2018502051A5 true JP2018502051A5 (https=) | 2018-11-22 |
| JP7037359B2 JP7037359B2 (ja) | 2022-03-16 |
Family
ID=54291300
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518540A Active JP7037359B2 (ja) | 2014-10-10 | 2015-10-09 | Ｃｄ７３遮断 |
| JP2020122032A Active JP7132981B2 (ja) | 2014-10-10 | 2020-07-16 | Ｃｄ７３遮断 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020122032A Active JP7132981B2 (ja) | 2014-10-10 | 2020-07-16 | Ｃｄ７３遮断 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10766966B2 (https=) |
| EP (2) | EP3204417B1 (https=) |
| JP (2) | JP7037359B2 (https=) |
| KR (1) | KR102536786B1 (https=) |
| CN (1) | CN106852149B (https=) |
| AU (2) | AU2015329982B2 (https=) |
| CA (1) | CA2957813C (https=) |
| DK (1) | DK3204417T3 (https=) |
| ES (1) | ES2821964T3 (https=) |
| IL (1) | IL250579B2 (https=) |
| MX (1) | MX384346B (https=) |
| PT (1) | PT3204417T (https=) |
| RU (1) | RU2746804C2 (https=) |
| SG (1) | SG11201701341UA (https=) |
| WO (1) | WO2016055609A1 (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3204417B1 (en) * | 2014-10-10 | 2020-07-22 | Innate Pharma | Cd73 blockade |
| WO2016131950A1 (en) * | 2015-02-20 | 2016-08-25 | Innate Pharma | Cd73 blockade |
| GB2537445A (en) | 2014-11-10 | 2016-10-19 | Medimmune Ltd | Binding molecules specific for CD73 and uses thereof |
| AU2015349878A1 (en) | 2014-11-21 | 2017-05-25 | Bristol-Myers Squibb Company | Antibodies against CD73 and uses thereof |
| JP6668345B2 (ja) | 2014-11-21 | 2020-03-18 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 修飾された重鎖定常領域を含む抗体 |
| US11130817B2 (en) | 2015-10-12 | 2021-09-28 | Innate Pharma | CD73 blocking agents |
| WO2017118613A1 (en) * | 2016-01-08 | 2017-07-13 | Syddansk Universitet | Bispecific antibodies targeting human cd73 |
| EP3423494A1 (en) | 2016-03-04 | 2019-01-09 | Bristol-Myers Squibb Company | Combination therapy with anti-cd73 antibodies |
| RU2769282C2 (ru) | 2016-06-20 | 2022-03-30 | Кимаб Лимитед | Анти-PD-L1 и IL-2 цитокины |
| WO2018013611A1 (en) * | 2016-07-11 | 2018-01-18 | Corvus Pharmaceuticals, Inc. | Anti-cd73 antibodies |
| RU2754058C2 (ru) * | 2016-12-13 | 2021-08-26 | Астеллас Фарма Инк. | Антитело к cd73 человека |
| CA3045376C (en) | 2017-01-24 | 2022-08-30 | I-Mab | Anti-cd73 antibodies and uses thereof |
| IL269150B2 (en) | 2017-03-16 | 2025-04-01 | Innate Pharma | Cancer treatment preparations and methods |
| US20210107989A1 (en) * | 2017-04-04 | 2021-04-15 | Corvus Pharmaceuticals, Inc. | Methods for treating cd73hi tumors |
| US11530273B2 (en) * | 2017-05-23 | 2022-12-20 | Helmholtz Zentrum München—Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Anti-CD73 monoclonal antibody, encoding nucleic acids and method for producing |
| EP3642240A1 (en) | 2017-06-22 | 2020-04-29 | Novartis AG | Antibody molecules to cd73 and uses thereof |
| MY204117A (en) * | 2017-06-22 | 2024-08-08 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| BR112020006809A2 (pt) * | 2017-10-06 | 2020-10-06 | Innate Pharma | anticorpos, agente, uso, composto, composição farmacêutica, kits e composição ou uso |
| KR102781619B1 (ko) * | 2017-11-15 | 2025-03-14 | 이나뜨 파르마 에스.에이. | 암의 치료를 위한 인간 CD39 단백질의 ATPase 활성을 결합 및 저해하는 항체 |
| US20200371091A1 (en) | 2017-11-30 | 2020-11-26 | Novartis Ag | Bcma-targeting chimeric antigen receptor, and uses thereof |
| TWI877770B (zh) | 2018-02-27 | 2025-03-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之咪唑并嘧啶及三唑并嘧啶 |
| EP3762030A4 (en) | 2018-03-09 | 2022-01-05 | Phanes Therapeutics, Inc. | ANTI-CD73 ANTIBODIES AND USES THEREOF |
| WO2019173692A2 (en) | 2018-03-09 | 2019-09-12 | Agenus Inc. | Anti-cd73 antibodies and methods of use thereof |
| BR112020020826A2 (pt) | 2018-04-12 | 2021-01-19 | Bristol-Myers Squibb Company | Terapia de combinação anticâncer com anticorpo antagonista de cd73 e anticorpo antagonista do eixo pd-1/pd-l1 |
| EP3810610A1 (en) | 2018-05-18 | 2021-04-28 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
| EP3569618A1 (en) | 2018-05-19 | 2019-11-20 | Boehringer Ingelheim International GmbH | Antagonizing cd73 antibody |
| TWI869346B (zh) | 2018-05-30 | 2025-01-11 | 瑞士商諾華公司 | Ｅｎｔｐｄ２抗體、組合療法、及使用該等抗體和組合療法之方法 |
| KR102870868B1 (ko) | 2018-06-01 | 2025-10-15 | 노파르티스 아게 | Bcma에 대한 결합 분자 및 이의 용도 |
| DK3807316T3 (da) | 2018-06-18 | 2024-07-29 | Innate Pharma | Sammensætninger og fremgangsmåder til behandling af cancer |
| WO2020010197A1 (en) | 2018-07-05 | 2020-01-09 | Incyte Corporation | Fused pyrazine derivatives as a2a / a2b inhibitors |
| WO2020020307A1 (en) | 2018-07-25 | 2020-01-30 | I-Mab Biopharma Co., Ltd. | Anti-cd73 anti-pd-l1 bispecific antibodies |
| CN111499747B (zh) * | 2019-01-11 | 2022-03-18 | 康诺亚生物医药科技（成都）有限公司 | 一种抗cd73单克隆抗体及其应用 |
| MX2021008094A (es) | 2019-01-11 | 2021-09-21 | Omeros Corp | Metodos y composiciones para el tratamiento del cancer. |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| MX2021012769A (es) | 2019-04-23 | 2021-11-18 | Innate Pharma | Anticuerpos bloqueadores cd73. |
| JP7623706B2 (ja) * | 2019-06-06 | 2025-01-29 | ジャコバイオ ファーマスーティカルズ カンパニー リミテッド | Ｃｄ７３に特異的な結合分子と結合分子の使用 |
| CN112300279A (zh) * | 2019-07-26 | 2021-02-02 | 上海复宏汉霖生物技术股份有限公司 | 针对抗cd73抗体和变体的方法和组合物 |
| JP7471016B2 (ja) * | 2019-08-21 | 2024-04-19 | ハーバー・バイオメド・（シャンハイ）・カンパニー・リミテッド | 抗ｃｄ７３抗体およびその適用 |
| UA130408C2 (uk) | 2019-09-06 | 2026-02-11 | Ле Лаборатуар Сервьє | Антитіла до cd73 |
| CN114502590A (zh) | 2019-09-18 | 2022-05-13 | 诺华股份有限公司 | Entpd2抗体、组合疗法、以及使用这些抗体和组合疗法的方法 |
| CA3161717A1 (en) * | 2019-11-15 | 2021-05-20 | Dana LORD | Biparatopic cd73 antibodies |
| CA3165384A1 (en) * | 2019-12-19 | 2021-06-24 | Board Of Regents, The University Of Texas System | Methods for treating glioblastoma |
| TW202135823A (zh) | 2020-01-03 | 2021-10-01 | 美商英塞特公司 | Ｃｄ７３抑制劑及ａ２ａ／ａ２ｂ腺苷受體抑制劑組合療法 |
| PE20221409A1 (es) | 2020-01-03 | 2022-09-20 | Incyte Corp | Anticuerpos anti-cd73 y usos de estos |
| US20230159655A1 (en) * | 2020-04-22 | 2023-05-25 | Akeso Biopharma, Inc | Anti-cd73 antibody and use thereof |
| WO2021247188A1 (en) | 2020-06-05 | 2021-12-09 | Bristol-Myers Squibb Company | Cd73 antagonist potency assay and methods of use thereof |
| JP2023532234A (ja) * | 2020-06-22 | 2023-07-27 | イノベント バイオロジクス（スーチョウ）カンパニー，リミティド | 抗ｃｄ７３抗体とその用途 |
| TW202216777A (zh) * | 2020-07-10 | 2022-05-01 | 美商生質分子控股有限責任公司 | 四面體抗體 |
| KR20230050378A (ko) | 2020-08-13 | 2023-04-14 | 이나뜨 파르마 에스.에이. | 항-cd73 항체를 사용하여 암을 치료하는 방법 |
| US20240218074A1 (en) * | 2020-08-17 | 2024-07-04 | Akeso Biopharma, Inc. | Anti-cd73 antibody and use thereof |
| CN120590533A (zh) * | 2020-10-23 | 2025-09-05 | 中山康方生物医药有限公司 | 抗cd73的抗体及其用途 |
| CA3199095A1 (en) | 2020-11-06 | 2022-05-12 | Novartis Ag | Cd19 binding molecules and uses thereof |
| TWI900705B (zh) * | 2020-12-11 | 2025-10-11 | 大陸商上海華奧泰生物藥業股份有限公司 | Ｃｄ７３的抗原結合蛋白及其應用 |
| AR124414A1 (es) | 2020-12-18 | 2023-03-22 | Century Therapeutics Inc | Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable |
| TW202241441A (zh) | 2020-12-29 | 2022-11-01 | 美商英塞特公司 | 包含ａ２ａ／ａ２ｂ抑制劑、ｐｄ－１／ｐｄ－ｌ１抑制劑及抗ｃｄ７３抗體之組合療法 |
| US20240301082A1 (en) * | 2021-05-05 | 2024-09-12 | Corvus Pharmaceuticals, Inc. | Anti-cd73 compounds to treat oncovirus-positive cancers |
| US12187806B2 (en) | 2022-03-04 | 2025-01-07 | Development Center For Biotechnology | Anti-CD73 antibodies and use thereof |
| JP2025512384A (ja) | 2022-04-13 | 2025-04-17 | ギリアード サイエンシーズ， インコーポレイテッド | Ｔｒｏｐ－２発現がんを治療するための併用療法 |
| US20240368299A1 (en) * | 2022-04-28 | 2024-11-07 | Xintrum Pharmaceuticals, Ltd. | Anti-human CD73 monoclonal antibody without hook effect |
| WO2025137640A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| WO2025162964A1 (en) | 2024-01-30 | 2025-08-07 | Institut National de la Santé et de la Recherche Médicale | Methods for the treatment of endometriosis |
| WO2025233264A1 (en) | 2024-05-07 | 2025-11-13 | Innate Pharma | Use of cd73 blocking agents in combination with anti-cd20 x cd3 t cell engagers |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5776427A (en) | 1992-03-05 | 1998-07-07 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| ATE483472T1 (de) | 2002-05-30 | 2010-10-15 | Macrogenics Inc | Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten |
| JP4462964B2 (ja) * | 2003-03-10 | 2010-05-12 | 第一三共株式会社 | 癌特異的抗原を標的とした抗体 |
| DK2439273T3 (da) | 2005-05-09 | 2019-06-03 | Ono Pharmaceutical Co | Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika |
| PT1907424E (pt) | 2005-07-01 | 2015-10-09 | Squibb & Sons Llc | Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1) |
| JP5382692B2 (ja) | 2006-07-10 | 2014-01-08 | 学校法人藤田学園 | 抗体の分類法、抗原の同定法、抗体又は抗体セットの取得法、抗体パネルの作成法、並びに抗体又は抗体セット及びその用途 |
| WO2009014708A2 (en) | 2007-07-23 | 2009-01-29 | Cell Genesys, Inc. | Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof |
| US20090130092A1 (en) * | 2007-10-30 | 2009-05-21 | Pinsky David J | Nucleotide phosphate dissipation as a treatment for vascular disorders |
| CN101970499B (zh) | 2008-02-11 | 2014-12-31 | 治疗科技公司 | 用于肿瘤治疗的单克隆抗体 |
| EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
| EP3255060A1 (en) | 2008-12-09 | 2017-12-13 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| PL2504364T3 (pl) | 2009-11-24 | 2017-12-29 | Medimmune Limited | Ukierunkowane środki wiążące przeciwko B7-H1 |
| US8961967B2 (en) | 2009-11-30 | 2015-02-24 | Janssen Biotech, Inc. | Antibody Fc mutants with ablated effector functions |
| AR083847A1 (es) | 2010-11-15 | 2013-03-27 | Novartis Ag | Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40 |
| ES2623912T3 (es) | 2010-12-23 | 2017-07-12 | Janssen Biotech, Inc. | Mutantes FC de anticuerpo activo resistente a proteasa |
| JP6072771B2 (ja) | 2011-04-20 | 2017-02-01 | メディミューン，エルエルシー | Ｂ７−ｈ１およびｐｄ−１に結合する抗体およびその他の分子 |
| MX368257B (es) | 2011-08-01 | 2019-09-26 | Genentech Inc | Antagonistas de unión al eje pd-1e inhibidores de mek y sus usos en el tratamiento de cáncer. |
| US10011660B2 (en) | 2012-04-30 | 2018-07-03 | Medimmune, Llc | Molecules with reduced effector function and extended half-lives, compositions, and uses thereof |
| US9090697B2 (en) * | 2013-03-15 | 2015-07-28 | Bayer Healthcare Llc | Methods for treating bleeding disorders |
| CN103278634B (zh) * | 2013-05-16 | 2015-01-07 | 中国科学院近代物理研究所 | Cd73作为肾透明细胞癌干细胞表面标志物的应用 |
| SG10201804945WA (en) | 2013-12-12 | 2018-07-30 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
| WO2016131950A1 (en) | 2015-02-20 | 2016-08-25 | Innate Pharma | Cd73 blockade |
| US20180030144A1 (en) | 2014-10-10 | 2018-02-01 | Innate Pharma | Cd73 blockade |
| EP3204417B1 (en) | 2014-10-10 | 2020-07-22 | Innate Pharma | Cd73 blockade |
| US10736963B2 (en) | 2015-07-24 | 2020-08-11 | Innate Pharma | Methods for detecting tissue infiltrating NK cells |
| US11130817B2 (en) | 2015-10-12 | 2021-09-28 | Innate Pharma | CD73 blocking agents |
| EP3912681A1 (en) | 2016-03-14 | 2021-11-24 | Orega Biotech | Anti-cd39 antibodies |
| EP3577138A1 (en) | 2017-02-06 | 2019-12-11 | Innate Pharma | Immunomodulatory antibody drug conjugates binding to a human mica polypeptide |
| MX2021012769A (es) | 2019-04-23 | 2021-11-18 | Innate Pharma | Anticuerpos bloqueadores cd73. |
-
2015
- 2015-10-09 EP EP15778310.1A patent/EP3204417B1/en active Active
- 2015-10-09 KR KR1020177011231A patent/KR102536786B1/ko active Active
- 2015-10-09 CN CN201580055012.7A patent/CN106852149B/zh active Active
- 2015-10-09 EP EP20180074.5A patent/EP3736294A3/en active Pending
- 2015-10-09 WO PCT/EP2015/073370 patent/WO2016055609A1/en not_active Ceased
- 2015-10-09 IL IL250579A patent/IL250579B2/en unknown
- 2015-10-09 US US15/517,991 patent/US10766966B2/en active Active
- 2015-10-09 MX MX2017004691A patent/MX384346B/es unknown
- 2015-10-09 ES ES15778310T patent/ES2821964T3/es active Active
- 2015-10-09 DK DK15778310.1T patent/DK3204417T3/da active
- 2015-10-09 SG SG11201701341UA patent/SG11201701341UA/en unknown
- 2015-10-09 RU RU2017105119A patent/RU2746804C2/ru active
- 2015-10-09 PT PT157783101T patent/PT3204417T/pt unknown
- 2015-10-09 JP JP2017518540A patent/JP7037359B2/ja active Active
- 2015-10-09 CA CA2957813A patent/CA2957813C/en active Active
- 2015-10-09 AU AU2015329982A patent/AU2015329982B2/en active Active
-
2020
- 2020-07-16 JP JP2020122032A patent/JP7132981B2/ja active Active
- 2020-09-02 US US17/009,817 patent/US11958907B2/en active Active
-
2021
- 2021-08-16 AU AU2021215306A patent/AU2021215306A1/en not_active Abandoned
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