JP2020515643A5 - - Google Patents
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- Publication number
- JP2020515643A5 JP2020515643A5 JP2020502768A JP2020502768A JP2020515643A5 JP 2020515643 A5 JP2020515643 A5 JP 2020515643A5 JP 2020502768 A JP2020502768 A JP 2020502768A JP 2020502768 A JP2020502768 A JP 2020502768A JP 2020515643 A5 JP2020515643 A5 JP 2020515643A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- binding
- use according
- antigen
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102100031506 Complement C5 Human genes 0.000 claims 15
- 208000009954 pyoderma gangrenosum Diseases 0.000 claims 14
- 239000000427 antigen Substances 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 10
- 208000002874 Acne Vulgaris Diseases 0.000 claims 9
- 206010000496 acne Diseases 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 206010000269 abscess Diseases 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 8
- 239000003112 inhibitor Substances 0.000 claims 8
- 210000000106 sweat gland Anatomy 0.000 claims 8
- 210000000440 neutrophil Anatomy 0.000 claims 7
- 206010000748 Acute febrile neutrophilic dermatosis Diseases 0.000 claims 6
- 108010059426 Anaphylatoxin C5a Receptor Proteins 0.000 claims 6
- 102000005590 Anaphylatoxin C5a Receptor Human genes 0.000 claims 6
- 208000010265 Sweet syndrome Diseases 0.000 claims 6
- 206010053555 Arthritis bacterial Diseases 0.000 claims 5
- 208000027866 inflammatory disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 108091023037 Aptamer Proteins 0.000 claims 3
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 206010015150 Erythema Diseases 0.000 claims 2
- 206010016207 Familial Mediterranean fever Diseases 0.000 claims 2
- 201000005569 Gout Diseases 0.000 claims 2
- 102100022691 NACHT, LRR and PYD domains-containing protein 3 Human genes 0.000 claims 2
- 101710126825 NACHT, LRR and PYD domains-containing protein 3 Proteins 0.000 claims 2
- 206010033645 Pancreatitis Diseases 0.000 claims 2
- 208000006311 Pyoderma Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 231100000321 erythema Toxicity 0.000 claims 2
- 208000002557 hidradenitis Diseases 0.000 claims 2
- 201000007162 hidradenitis suppurativa Diseases 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 108020004491 Antisense DNA Proteins 0.000 claims 1
- 108020005544 Antisense RNA Proteins 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000011594 Autoinflammatory disease Diseases 0.000 claims 1
- 102100032957 C5a anaphylatoxin chemotactic receptor 1 Human genes 0.000 claims 1
- 101710098483 C5a anaphylatoxin chemotactic receptor 1 Proteins 0.000 claims 1
- 102100032996 C5a anaphylatoxin chemotactic receptor 2 Human genes 0.000 claims 1
- 102000003712 Complement factor B Human genes 0.000 claims 1
- 108090000056 Complement factor B Proteins 0.000 claims 1
- 108091008102 DNA aptamers Proteins 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 208000017415 Functional neutrophil defect Diseases 0.000 claims 1
- 101000868001 Homo sapiens C5a anaphylatoxin chemotactic receptor 2 Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 208000033809 Suppuration Diseases 0.000 claims 1
- 239000003816 antisense DNA Substances 0.000 claims 1
- PUKBOVABABRILL-YZNIXAGQSA-N avacopan Chemical compound C1=C(C(F)(F)F)C(C)=CC=C1NC(=O)[C@@H]1[C@H](C=2C=CC(NC3CCCC3)=CC=2)N(C(=O)C=2C(=CC=CC=2C)F)CCC1 PUKBOVABABRILL-YZNIXAGQSA-N 0.000 claims 1
- 229950001740 avacopan Drugs 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000024203 complement activation Effects 0.000 claims 1
- 239000003184 complementary RNA Substances 0.000 claims 1
- 229960002224 eculizumab Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 229950009686 mirococept Drugs 0.000 claims 1
- 230000002956 necrotizing effect Effects 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 239000002924 silencing RNA Substances 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022127667A JP2022176946A (ja) | 2017-04-03 | 2022-08-10 | Ｃ５ａ活性のインヒビターでの炎症性疾患の処置 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17164573 | 2017-04-03 | ||
| EP17164573.2 | 2017-04-03 | ||
| EP17177657.8 | 2017-06-23 | ||
| EP17177657 | 2017-06-23 | ||
| EP17189938.8 | 2017-09-07 | ||
| EP17189938 | 2017-09-07 | ||
| PCT/EP2018/050146 WO2018184739A1 (en) | 2017-04-03 | 2018-01-03 | Treatment of inflammatory diseases with inhibitors of c5a activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022127667A Division JP2022176946A (ja) | 2017-04-03 | 2022-08-10 | Ｃ５ａ活性のインヒビターでの炎症性疾患の処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020515643A JP2020515643A (ja) | 2020-05-28 |
| JP2020515643A5 true JP2020515643A5 (https=) | 2021-01-07 |
| JP7486415B2 JP7486415B2 (ja) | 2024-05-17 |
Family
ID=61024731
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502768A Active JP7486415B2 (ja) | 2017-04-03 | 2018-01-03 | Ｃ５ａ活性のインヒビターでの炎症性疾患の処置 |
| JP2022127667A Withdrawn JP2022176946A (ja) | 2017-04-03 | 2022-08-10 | Ｃ５ａ活性のインヒビターでの炎症性疾患の処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022127667A Withdrawn JP2022176946A (ja) | 2017-04-03 | 2022-08-10 | Ｃ５ａ活性のインヒビターでの炎症性疾患の処置 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US11273225B2 (https=) |
| EP (3) | EP3411400B1 (https=) |
| JP (2) | JP7486415B2 (https=) |
| KR (1) | KR20190138806A (https=) |
| CN (1) | CN111108118A (https=) |
| AU (1) | AU2018249310A1 (https=) |
| CA (1) | CA3058023A1 (https=) |
| CL (1) | CL2018002698A1 (https=) |
| DK (1) | DK3411400T3 (https=) |
| ES (1) | ES2893769T3 (https=) |
| IL (1) | IL261809B2 (https=) |
| MX (1) | MX2019011825A (https=) |
| PL (1) | PL3411400T3 (https=) |
| SG (1) | SG11201807998WA (https=) |
| TW (2) | TWI826364B (https=) |
| WO (1) | WO2018184739A1 (https=) |
| ZA (1) | ZA201906485B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2892925T3 (es) | 2006-03-31 | 2022-02-07 | Chugai Pharmaceutical Co Ltd | Métodos para controlar la farmacocinética en sangre de anticuerpos |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| KR102057826B1 (ko) | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| TWI812066B (zh) | 2010-11-30 | 2023-08-11 | 日商中外製藥股份有限公司 | 具有鈣依存性的抗原結合能力之抗體 |
| CN107207607B (zh) | 2014-12-19 | 2021-05-04 | 中外制药株式会社 | 抗-c5抗体及使用方法 |
| KR101860280B1 (ko) | 2014-12-19 | 2018-05-21 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
| CN114773470A (zh) | 2015-02-05 | 2022-07-22 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用 |
| TWI693940B (zh) | 2016-08-05 | 2020-05-21 | 日商中外製藥股份有限公司 | Ｉｌ-８相關疾病之治療用或預防用組成物 |
| TWI826364B (zh) | 2017-04-03 | 2023-12-21 | 德商因夫萊亞斯有限公司 | 活性抑制劑於發炎性疾病之治療 |
| US10376595B2 (en) | 2017-04-03 | 2019-08-13 | Inflarx Gmbh | Treatment of inflammatory diseases with inhibitors of C5a activity |
| EP3642230A1 (en) * | 2017-06-23 | 2020-04-29 | InflaRx GmbH | Treatment of inflammatory diseases with inhibitors of c5a activity |
| SMT202400521T1 (it) | 2018-11-30 | 2025-01-14 | Chemocentryx Inc | Formulazioni di capsula |
| EP3934675A2 (en) * | 2019-03-08 | 2022-01-12 | RA Pharmaceuticals, Inc. | Zilucoplan as deep tissue penetrating c5 inhibitor |
| US11149009B2 (en) | 2019-03-11 | 2021-10-19 | Inflarx Gmbh | Fused piperidinyl bicyclic and related compounds as modulators of C5A receptor |
| BR112021017820A2 (pt) * | 2019-04-24 | 2022-02-08 | Ra Pharmaceuticals Inc | Composições e métodos para modulação da atividade de complemento |
| TWI869528B (zh) | 2020-01-13 | 2025-01-11 | 美商威特拉公司 | C5ar1抗體分子及其用途 |
| TW202208427A (zh) | 2020-05-06 | 2022-03-01 | 德商因夫萊亞斯有限公司 | 人源化抗ｃ５ａ抗體 |
| AU2021324314A1 (en) * | 2020-08-12 | 2023-05-25 | Innate Pharma | Subcutaneous anti-c5ar antagonist treatment regimen with avdoralimab |
| CN116529241A (zh) * | 2020-10-28 | 2023-08-01 | 坎莫森特里克斯公司 | 治疗化脓性汗腺炎的方法 |
| WO2022093971A1 (en) * | 2020-10-28 | 2022-05-05 | Chemocentryx, Inc. | Methods of treating hidradenitis suppurativa |
| AU2022207985A1 (en) | 2021-01-13 | 2023-07-06 | Visterra, Inc. | Humanized complement 5a receptor 1 antibodies and methods of use thereof |
| CN116036233A (zh) * | 2023-01-10 | 2023-05-02 | 中山大学附属第八医院（深圳福田） | 小分子化合物pmx 53在制备抑制血管钙化和血管纤维化药物中的应用 |
| US12180274B2 (en) | 2023-05-26 | 2024-12-31 | Inflarx Gmbh | Treatment of pneumonia and ARDS with inhibitors of C5a and IL-6 activity |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4704355A (en) | 1985-03-27 | 1987-11-03 | New Horizons Diagnostics Corporation | Assay utilizing ATP encapsulated within liposome particles |
| CA2025907A1 (en) | 1989-09-21 | 1991-03-22 | Franklin D. Collins | Method of transporting compositions across the blood brain barrier |
| EP1690934A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| AUPO755097A0 (en) | 1997-06-25 | 1997-07-17 | University Of Queensland, The | Receptor agonist and antagonist |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| AUPR833401A0 (en) | 2001-10-17 | 2001-11-08 | University Of Queensland, The | G protein-coupled receptor antagonists |
| AU2003217912A1 (en) | 2002-03-01 | 2003-09-16 | Xencor | Antibody optimization |
| PL3385384T3 (pl) | 2004-02-12 | 2021-03-08 | Archemix Llc | Aptamerowe środki terapeutyczne użyteczne w leczeniu zaburzeń powiązanych z dopełniaczem |
| EP2049141A4 (en) | 2006-07-21 | 2011-10-26 | Promics Pty Ltd | TREATMENT OF INTIMAL HYPERPLASIA AND ASSOCIATED DISEASES |
| MX2009001914A (es) * | 2006-08-22 | 2009-03-31 | G2 Inflammation Pty Ltd | Anticuerpos anti-c5ar con propiedades mejoradas. |
| GB0617734D0 (en) | 2006-09-08 | 2006-10-18 | Evolutec Ltd | Method of treating peripheral nerve disorders |
| WO2011056972A2 (en) * | 2009-11-04 | 2011-05-12 | Case Western Reserve University | Compositions and methods of treating a t cell mediated disorder |
| CA2965223C (en) | 2008-12-22 | 2019-09-24 | Chemocentryx, Inc. | C5ar antagonists |
| EP2327725A1 (en) * | 2009-11-26 | 2011-06-01 | InflaRx GmbH | Anti-C5a binding moieties with high blocking activity |
| PT2585064T (pt) | 2010-06-24 | 2017-08-08 | Chemocentryx Inc | Antagonistas do c5ar |
| CA3216595A1 (en) | 2013-03-14 | 2014-10-02 | Kevin Fitzgerald | Complement component c5 irna compositions and methods of use thereof |
| EP3119802B1 (en) * | 2014-03-20 | 2019-12-04 | InflaRx GmbH | Inhibitors of c5a for the treatment of viral pneumonia |
| WO2016044419A1 (en) | 2014-09-16 | 2016-03-24 | Alnylam Pharmaceuticals, Inc. | Complement component c5 irna compositions and methods of use thereof |
| WO2016061066A1 (en) | 2014-10-15 | 2016-04-21 | Alexion Pharmaceuticals, Inc. | Methods of replicating a large scale eculizumab production cell culture |
| FR3030515B1 (fr) * | 2014-12-23 | 2017-01-20 | Galderma Res & Dev | Nouveaux composes antagonistes des recepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies mediees par des chimiokines |
| EP3313437A1 (en) | 2015-06-26 | 2018-05-02 | Alexion Pharmaceuticals, Inc. | A method for treating a patient in compliance with vaccination with eculizumab or an eculizumab variant |
| AU2017246228B2 (en) | 2016-04-04 | 2021-04-15 | Chemocentryx, Inc. | Soluble C5aR antagonists |
| TWI826364B (zh) * | 2017-04-03 | 2023-12-21 | 德商因夫萊亞斯有限公司 | 活性抑制劑於發炎性疾病之治療 |
| US10376595B2 (en) | 2017-04-03 | 2019-08-13 | Inflarx Gmbh | Treatment of inflammatory diseases with inhibitors of C5a activity |
| US11149009B2 (en) | 2019-03-11 | 2021-10-19 | Inflarx Gmbh | Fused piperidinyl bicyclic and related compounds as modulators of C5A receptor |
-
2018
- 2018-01-03 TW TW107100139A patent/TWI826364B/zh active
- 2018-01-03 PL PL18701250T patent/PL3411400T3/pl unknown
- 2018-01-03 EP EP18701250.5A patent/EP3411400B1/en active Active
- 2018-01-03 AU AU2018249310A patent/AU2018249310A1/en not_active Abandoned
- 2018-01-03 JP JP2020502768A patent/JP7486415B2/ja active Active
- 2018-01-03 KR KR1020197031043A patent/KR20190138806A/ko not_active Ceased
- 2018-01-03 SG SG11201807998WA patent/SG11201807998WA/en unknown
- 2018-01-03 WO PCT/EP2018/050146 patent/WO2018184739A1/en not_active Ceased
- 2018-01-03 MX MX2019011825A patent/MX2019011825A/es unknown
- 2018-01-03 CN CN201880037003.9A patent/CN111108118A/zh active Pending
- 2018-01-03 EP EP23179884.4A patent/EP4272821A3/en active Pending
- 2018-01-03 DK DK18701250.5T patent/DK3411400T3/da active
- 2018-01-03 EP EP21197604.8A patent/EP3978523A1/en active Pending
- 2018-01-03 ES ES18701250T patent/ES2893769T3/es active Active
- 2018-01-03 IL IL261809A patent/IL261809B2/en unknown
- 2018-01-03 TW TW112106878A patent/TW202348249A/zh unknown
- 2018-01-03 CA CA3058023A patent/CA3058023A1/en active Pending
- 2018-06-13 US US16/007,634 patent/US11273225B2/en active Active
- 2018-09-24 CL CL2018002698A patent/CL2018002698A1/es unknown
-
2019
- 2019-10-02 ZA ZA2019/06485A patent/ZA201906485B/en unknown
-
2022
- 2022-08-10 JP JP2022127667A patent/JP2022176946A/ja not_active Withdrawn
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