JP2020524696A5 - - Google Patents
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- JP2020524696A5 JP2020524696A5 JP2019570986A JP2019570986A JP2020524696A5 JP 2020524696 A5 JP2020524696 A5 JP 2020524696A5 JP 2019570986 A JP2019570986 A JP 2019570986A JP 2019570986 A JP2019570986 A JP 2019570986A JP 2020524696 A5 JP2020524696 A5 JP 2020524696A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- binding
- antigen
- use according
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102100031506 Complement C5 Human genes 0.000 claims 15
- 239000000427 antigen Substances 0.000 claims 13
- 108091007433 antigens Proteins 0.000 claims 13
- 102000036639 antigens Human genes 0.000 claims 13
- 239000012634 fragment Substances 0.000 claims 13
- 208000009954 pyoderma gangrenosum Diseases 0.000 claims 13
- 208000002874 Acne Vulgaris Diseases 0.000 claims 10
- 206010000496 acne Diseases 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 206010000269 abscess Diseases 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 8
- 210000000440 neutrophil Anatomy 0.000 claims 8
- 210000000106 sweat gland Anatomy 0.000 claims 8
- 239000003112 inhibitor Substances 0.000 claims 7
- 208000011580 syndromic disease Diseases 0.000 claims 7
- 206010000748 Acute febrile neutrophilic dermatosis Diseases 0.000 claims 6
- 108010059426 Anaphylatoxin C5a Receptor Proteins 0.000 claims 6
- 102000005590 Anaphylatoxin C5a Receptor Human genes 0.000 claims 6
- 208000010265 Sweet syndrome Diseases 0.000 claims 6
- 206010053555 Arthritis bacterial Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 208000027866 inflammatory disease Diseases 0.000 claims 5
- 208000017520 skin disease Diseases 0.000 claims 5
- 206010048768 Dermatosis Diseases 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 108091023037 Aptamer Proteins 0.000 claims 3
- 102100032957 C5a anaphylatoxin chemotactic receptor 1 Human genes 0.000 claims 3
- 101710098483 C5a anaphylatoxin chemotactic receptor 1 Proteins 0.000 claims 3
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 206010003246 arthritis Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- YOKBGCTZYPOSQM-HPSWDUTRSA-N (2s)-2-acetamido-n-[(3s,9s,12s,15r,18s)-15-(cyclohexylmethyl)-9-[3-(diaminomethylideneamino)propyl]-12-(1h-indol-3-ylmethyl)-2,8,11,14,17-pentaoxo-1,7,10,13,16-pentazabicyclo[16.3.0]henicosan-3-yl]-3-phenylpropanamide Chemical compound C([C@H](NC(=O)C)C(=O)N[C@@H]1C(N2CCC[C@H]2C(=O)N[C@H](CC2CCCCC2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCC1)=O)C1=CC=CC=C1 YOKBGCTZYPOSQM-HPSWDUTRSA-N 0.000 claims 2
- 108010048280 AcPhe(ornithine-Pro-cyclohexylamine-Trp-Arg) Proteins 0.000 claims 2
- 206010015150 Erythema Diseases 0.000 claims 2
- 206010016207 Familial Mediterranean fever Diseases 0.000 claims 2
- 201000005569 Gout Diseases 0.000 claims 2
- 102100022691 NACHT, LRR and PYD domains-containing protein 3 Human genes 0.000 claims 2
- 101710126825 NACHT, LRR and PYD domains-containing protein 3 Proteins 0.000 claims 2
- 208000025747 Rheumatic disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 231100000321 erythema Toxicity 0.000 claims 2
- 208000002557 hidradenitis Diseases 0.000 claims 2
- 201000007162 hidradenitis suppurativa Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000000968 intestinal effect Effects 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 230000002956 necrotizing effect Effects 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 230000000552 rheumatic effect Effects 0.000 claims 2
- 108020004491 Antisense DNA Proteins 0.000 claims 1
- 108020005544 Antisense RNA Proteins 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000011594 Autoinflammatory disease Diseases 0.000 claims 1
- 102100032996 C5a anaphylatoxin chemotactic receptor 2 Human genes 0.000 claims 1
- 102000003712 Complement factor B Human genes 0.000 claims 1
- 108090000056 Complement factor B Proteins 0.000 claims 1
- 108091008102 DNA aptamers Proteins 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 101000868001 Homo sapiens C5a anaphylatoxin chemotactic receptor 2 Proteins 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 208000006311 Pyoderma Diseases 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 239000003816 antisense DNA Substances 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000024203 complement activation Effects 0.000 claims 1
- 239000003184 complementary RNA Substances 0.000 claims 1
- 229960002224 eculizumab Drugs 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 239000002924 silencing RNA Substances 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17177657 | 2017-06-23 | ||
| EP17177657.8 | 2017-06-23 | ||
| EP17189938.8 | 2017-09-07 | ||
| EP17189938 | 2017-09-07 | ||
| PCT/EP2018/065676 WO2018234118A1 (en) | 2017-06-23 | 2018-06-13 | Treatment of inflammatory diseases with inhibitors of c5a activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020524696A JP2020524696A (ja) | 2020-08-20 |
| JP2020524696A5 true JP2020524696A5 (https=) | 2021-07-26 |
| JP7502865B2 JP7502865B2 (ja) | 2024-06-19 |
Family
ID=62636193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019570986A Active JP7502865B2 (ja) | 2017-06-23 | 2018-06-13 | Ｃ５ａ活性のインヒビターでの炎症性疾患の処置 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP3642230A1 (https=) |
| JP (1) | JP7502865B2 (https=) |
| KR (1) | KR20200020727A (https=) |
| CN (1) | CN111201241A (https=) |
| AU (1) | AU2018286754A1 (https=) |
| CA (1) | CA3066689C (https=) |
| IL (1) | IL271074A (https=) |
| SG (1) | SG11201912882QA (https=) |
| TW (1) | TWI786132B (https=) |
| WO (1) | WO2018234118A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116769024A (zh) | 2016-06-14 | 2023-09-19 | 瑞泽恩制药公司 | 抗c5抗体及其用途 |
| CA3274059A1 (en) | 2017-12-13 | 2026-03-02 | Regeneron Pharmaceuticals, Inc. | Anti-c5 antibody combinations and uses thereof |
| JP7617012B2 (ja) * | 2019-03-14 | 2025-01-17 | モルフォシス・アーゲー | Ｃ５ａＲを標的とする抗体 |
| TWI869528B (zh) | 2020-01-13 | 2025-01-11 | 美商威特拉公司 | C5ar1抗體分子及其用途 |
| PH12022552556A1 (en) * | 2020-03-27 | 2024-04-22 | Inflarx Gmbh | Inhibitors of c5a for the treatment of corona virus infection |
| TW202208427A (zh) | 2020-05-06 | 2022-03-01 | 德商因夫萊亞斯有限公司 | 人源化抗ｃ５ａ抗體 |
| WO2021259160A1 (en) * | 2020-06-24 | 2021-12-30 | Staidson (Beijing) Biopharmaceuticals Co., Ltd. | Antibodies specifically recognizing c5a and uses thereof |
| CA3173944A1 (en) | 2021-01-13 | 2022-07-21 | Visterra, Inc. | Humanized complement 5a receptor 1 antibodies and methods of use thereof |
| US12180274B2 (en) | 2023-05-26 | 2024-12-31 | Inflarx Gmbh | Treatment of pneumonia and ARDS with inhibitors of C5a and IL-6 activity |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4704355A (en) | 1985-03-27 | 1987-11-03 | New Horizons Diagnostics Corporation | Assay utilizing ATP encapsulated within liposome particles |
| WO1991004014A1 (en) | 1989-09-21 | 1991-04-04 | Synergen, Inc. | Method for transporting compositions across the blood brain barrier |
| DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| AUPO755097A0 (en) | 1997-06-25 | 1997-07-17 | University Of Queensland, The | Receptor agonist and antagonist |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| AUPR833401A0 (en) * | 2001-10-17 | 2001-11-08 | University Of Queensland, The | G protein-coupled receptor antagonists |
| HUE038239T2 (hu) | 2004-02-12 | 2018-10-29 | Archemix Llc | Komplementrendszerrel összefüggõ rendellenességek kezelésében alkalmazható aptamer terapeutikumok |
| SG151283A1 (en) * | 2004-03-26 | 2009-04-30 | Promics Pty Ltd | Treatment of neurological conditions using complement c5a receptor modulators |
| CN101553244B (zh) | 2006-07-21 | 2013-01-02 | 普罗米克斯有限公司 | 内膜增生和相关病状的治疗 |
| GB0617734D0 (en) | 2006-09-08 | 2006-10-18 | Evolutec Ltd | Method of treating peripheral nerve disorders |
| RS54998B1 (sr) | 2008-12-22 | 2016-11-30 | Chemocentryx Inc | Antagonisti c5ar |
| GB0905790D0 (en) | 2009-04-03 | 2009-05-20 | Alligator Bioscience Ab | Novel polypeptides and use thereof |
| EP2327725A1 (en) | 2009-11-26 | 2011-06-01 | InflaRx GmbH | Anti-C5a binding moieties with high blocking activity |
| RS56332B1 (sr) | 2010-06-24 | 2017-12-29 | Chemocentryx Inc | Antagonisti c5ar |
| IL288931B2 (en) | 2013-03-14 | 2025-05-01 | Alnylam Pharmaceuticals Inc | Compositions comprising a complementary portion of C5 IRNA and methods of using them |
| JP2016523829A (ja) | 2013-05-08 | 2016-08-12 | ノヴォ ノルディスク アー／エス | Ｃ５ａｒアンタゴニストの使用 |
| CA2940319A1 (en) * | 2014-03-20 | 2015-09-24 | Inflarx Gmbh | Inhibitors of c5a for the treatment of viral pneumonia |
| WO2016044419A1 (en) | 2014-09-16 | 2016-03-24 | Alnylam Pharmaceuticals, Inc. | Complement component c5 irna compositions and methods of use thereof |
| WO2016061066A1 (en) | 2014-10-15 | 2016-04-21 | Alexion Pharmaceuticals, Inc. | Methods of replicating a large scale eculizumab production cell culture |
| FR3030515B1 (fr) * | 2014-12-23 | 2017-01-20 | Galderma Res & Dev | Nouveaux composes antagonistes des recepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies mediees par des chimiokines |
| EP3313437A1 (en) | 2015-06-26 | 2018-05-02 | Alexion Pharmaceuticals, Inc. | A method for treating a patient in compliance with vaccination with eculizumab or an eculizumab variant |
| EP3439658B1 (en) | 2016-04-04 | 2021-11-24 | ChemoCentryx, Inc. | Soluble c5ar antagonists |
| TWI826364B (zh) | 2017-04-03 | 2023-12-21 | 德商因夫萊亞斯有限公司 | 活性抑制劑於發炎性疾病之治療 |
-
2018
- 2018-06-13 TW TW107120362A patent/TWI786132B/zh active
- 2018-06-13 KR KR1020197038211A patent/KR20200020727A/ko not_active Ceased
- 2018-06-13 CA CA3066689A patent/CA3066689C/en active Active
- 2018-06-13 CN CN201880041303.4A patent/CN111201241A/zh active Pending
- 2018-06-13 AU AU2018286754A patent/AU2018286754A1/en not_active Abandoned
- 2018-06-13 EP EP18732016.3A patent/EP3642230A1/en active Pending
- 2018-06-13 JP JP2019570986A patent/JP7502865B2/ja active Active
- 2018-06-13 WO PCT/EP2018/065676 patent/WO2018234118A1/en not_active Ceased
- 2018-06-13 SG SG11201912882QA patent/SG11201912882QA/en unknown
-
2019
- 2019-12-01 IL IL271074A patent/IL271074A/en unknown
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