CN111201241A - 用C5a活性抑制剂治疗炎性疾病 - Google Patents

用C5a活性抑制剂治疗炎性疾病 Download PDF

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Publication number
CN111201241A
CN111201241A CN201880041303.4A CN201880041303A CN111201241A CN 111201241 A CN111201241 A CN 111201241A CN 201880041303 A CN201880041303 A CN 201880041303A CN 111201241 A CN111201241 A CN 111201241A
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CN
China
Prior art keywords
antibody
antigen
binding
binding fragment
compound
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Pending
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CN201880041303.4A
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English (en)
Chinese (zh)
Inventor
郭仁峰
尼尔斯·R·里德曼
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InflaRx GmbH
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InflaRx GmbH
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Publication date
Application filed by InflaRx GmbH filed Critical InflaRx GmbH
Publication of CN111201241A publication Critical patent/CN111201241A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
CN201880041303.4A 2017-06-23 2018-06-13 用C5a活性抑制剂治疗炎性疾病 Pending CN111201241A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP17177657 2017-06-23
EP17177657.8 2017-06-23
EP17189938.8 2017-09-07
EP17189938 2017-09-07
PCT/EP2018/065676 WO2018234118A1 (en) 2017-06-23 2018-06-13 Treatment of inflammatory diseases with inhibitors of c5a activity

Publications (1)

Publication Number Publication Date
CN111201241A true CN111201241A (zh) 2020-05-26

Family

ID=62636193

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880041303.4A Pending CN111201241A (zh) 2017-06-23 2018-06-13 用C5a活性抑制剂治疗炎性疾病

Country Status (10)

Country Link
EP (1) EP3642230A1 (https=)
JP (1) JP7502865B2 (https=)
KR (1) KR20200020727A (https=)
CN (1) CN111201241A (https=)
AU (1) AU2018286754A1 (https=)
CA (1) CA3066689C (https=)
IL (1) IL271074A (https=)
SG (1) SG11201912882QA (https=)
TW (1) TWI786132B (https=)
WO (1) WO2018234118A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114364695A (zh) * 2020-06-24 2022-04-15 舒泰神（北京）生物制药股份有限公司 特异性识别c5a的抗体及其应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116769024A (zh) 2016-06-14 2023-09-19 瑞泽恩制药公司 抗c5抗体及其用途
CA3274059A1 (en) 2017-12-13 2026-03-02 Regeneron Pharmaceuticals, Inc. Anti-c5 antibody combinations and uses thereof
JP7617012B2 (ja) * 2019-03-14 2025-01-17 モルフォシス・アーゲー Ｃ５ａＲを標的とする抗体
TWI869528B (zh) 2020-01-13 2025-01-11 美商威特拉公司 C5ar1抗體分子及其用途
PH12022552556A1 (en) * 2020-03-27 2024-04-22 Inflarx Gmbh Inhibitors of c5a for the treatment of corona virus infection
TW202208427A (zh) 2020-05-06 2022-03-01 德商因夫萊亞斯有限公司 人源化抗ｃ５ａ抗體
CA3173944A1 (en) 2021-01-13 2022-07-21 Visterra, Inc. Humanized complement 5a receptor 1 antibodies and methods of use thereof
US12180274B2 (en) 2023-05-26 2024-12-31 Inflarx Gmbh Treatment of pneumonia and ARDS with inhibitors of C5a and IL-6 activity

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CN1604909A (zh) * 2001-10-17 2005-04-06 昆士兰大学 作为g蛋白－偶联受体拮抗剂的环肽
CN1997384A (zh) * 2004-03-26 2007-07-11 普罗米克斯有限公司 使用补体C5a受体调节剂治疗神经系统病症
CN105392803A (zh) * 2013-05-08 2016-03-09 诺和诺德股份有限公司 C5aR拮抗剂的用途
WO2016102877A1 (fr) * 2014-12-23 2016-06-30 Galderma Research & Development Nouveaux composés antagonistes des récepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies médiées par des chimiokines
CN106132982A (zh) * 2014-03-20 2016-11-16 因弗拉克斯有限责任公司 用于治疗病毒性肺炎的C5a抑制剂
CN111108118A (zh) * 2017-04-03 2020-05-05 因弗拉克斯有限责任公司 用C5a活性抑制剂治疗炎性疾病

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CN1997384A (zh) * 2004-03-26 2007-07-11 普罗米克斯有限公司 使用补体C5a受体调节剂治疗神经系统病症
CN105392803A (zh) * 2013-05-08 2016-03-09 诺和诺德股份有限公司 C5aR拮抗剂的用途
CN106132982A (zh) * 2014-03-20 2016-11-16 因弗拉克斯有限责任公司 用于治疗病毒性肺炎的C5a抑制剂
WO2016102877A1 (fr) * 2014-12-23 2016-06-30 Galderma Research & Development Nouveaux composés antagonistes des récepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies médiées par des chimiokines
CN111108118A (zh) * 2017-04-03 2020-05-05 因弗拉克斯有限责任公司 用C5a活性抑制剂治疗炎性疾病

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114364695A (zh) * 2020-06-24 2022-04-15 舒泰神（北京）生物制药股份有限公司 特异性识别c5a的抗体及其应用
CN114364695B (zh) * 2020-06-24 2024-07-12 舒泰神（北京）生物制药股份有限公司 特异性识别c5a的抗体及其应用
US12534521B2 (en) 2020-06-24 2026-01-27 Staidson (Beijing) Biopharmaceuticals Co., Ltd. Antibodies specifically recognizing C5A and uses thereof

Also Published As

Publication number Publication date
EP3642230A1 (en) 2020-04-29
KR20200020727A (ko) 2020-02-26
SG11201912882QA (en) 2020-01-30
JP2020524696A (ja) 2020-08-20
IL271074A (en) 2020-01-30
AU2018286754A1 (en) 2019-12-19
JP7502865B2 (ja) 2024-06-19
WO2018234118A1 (en) 2018-12-27
CA3066689C (en) 2024-01-16
CA3066689A1 (en) 2018-12-27
TW201904611A (zh) 2019-02-01
TWI786132B (zh) 2022-12-11

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Application publication date: 20200526