JP2009530279A5 - - Google Patents
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- Publication number
- JP2009530279A5 JP2009530279A5 JP2009500424A JP2009500424A JP2009530279A5 JP 2009530279 A5 JP2009530279 A5 JP 2009530279A5 JP 2009500424 A JP2009500424 A JP 2009500424A JP 2009500424 A JP2009500424 A JP 2009500424A JP 2009530279 A5 JP2009530279 A5 JP 2009530279A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- polymorph
- solvent
- compound
- phenylacetyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002904 solvent Substances 0.000 claims 21
- -1 4-Chloro-3-methyl-5-isoxazolyl Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 18
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 11
- 238000000034 method Methods 0.000 claims 10
- 159000000000 sodium salts Chemical class 0.000 claims 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 9
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 9
- BWJZHYWAXLWLTB-UHFFFAOYSA-N thiophene-3-sulfonamide Chemical compound NS(=O)(=O)C=1C=CSC=1 BWJZHYWAXLWLTB-UHFFFAOYSA-N 0.000 claims 9
- 239000012047 saturated solution Substances 0.000 claims 8
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 6
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 6
- 239000012296 anti-solvent Substances 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 238000001237 Raman spectrum Methods 0.000 claims 4
- 238000000634 powder X-ray diffraction Methods 0.000 claims 4
- 239000002244 precipitate Substances 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 claims 3
- 229940011051 isopropyl acetate Drugs 0.000 claims 3
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000009245 menopause Effects 0.000 claims 2
- 208000002815 pulmonary hypertension Diseases 0.000 claims 2
- 206010002199 Anaphylactic shock Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000003037 Diastolic Heart Failure Diseases 0.000 claims 1
- 102000002045 Endothelin Human genes 0.000 claims 1
- 108050009340 Endothelin Proteins 0.000 claims 1
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- 102000003951 Erythropoietin Human genes 0.000 claims 1
- 108090000394 Erythropoietin Proteins 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000032456 Hemorrhagic Shock Diseases 0.000 claims 1
- 206010062016 Immunosuppression Diseases 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- 208000030136 Marchiafava-Bignami Disease Diseases 0.000 claims 1
- 208000019255 Menstrual disease Diseases 0.000 claims 1
- 208000029725 Metabolic bone disease Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 206010049771 Shock haemorrhagic Diseases 0.000 claims 1
- 206010047139 Vasoconstriction Diseases 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 208000003455 anaphylaxis Diseases 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 claims 1
- 229940105423 erythropoietin Drugs 0.000 claims 1
- 230000008717 functional decline Effects 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 1
- 201000011461 pre-eclampsia Diseases 0.000 claims 1
- 230000035935 pregnancy Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
- 230000025033 vasoconstriction Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78186106P | 2006-03-13 | 2006-03-13 | |
| PCT/US2007/006277 WO2007106467A2 (en) | 2006-03-13 | 2007-03-12 | Polymorphs of n-(4-chloro-3-methyl-5-isoxazolyl)2-[2-methyl-4,5-(methylenedioxy) phenylacetyl]thiophene-3-sulfonamide, sodium salt |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009530279A JP2009530279A (ja) | 2009-08-27 |
| JP2009530279A5 true JP2009530279A5 (enExample) | 2010-04-30 |
Family
ID=38335653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500424A Withdrawn JP2009530279A (ja) | 2006-03-13 | 2007-03-12 | Ｎ−（４−クロロ−３−メチル−５−イソキサゾリル）２−［２−メチル−４，５−（メチレンジオキシ）フェニルアセチル］チオフェン−３−スルホンアミド、ナトリウム塩の多形 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20090104265A1 (enExample) |
| EP (1) | EP1996582A2 (enExample) |
| JP (1) | JP2009530279A (enExample) |
| KR (1) | KR101019264B1 (enExample) |
| CN (1) | CN101443329A (enExample) |
| AU (1) | AU2007225206B2 (enExample) |
| BR (1) | BRPI0709384A2 (enExample) |
| CA (1) | CA2644134A1 (enExample) |
| IL (1) | IL193682A0 (enExample) |
| MX (1) | MX2008011843A (enExample) |
| NZ (1) | NZ570943A (enExample) |
| RU (1) | RU2412941C2 (enExample) |
| WO (1) | WO2007106467A2 (enExample) |
| ZA (1) | ZA200807302B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008112241A1 (en) * | 2007-03-13 | 2008-09-18 | Encysive Pharmaceuticals, Inc. | Methods an compositions for treatment of an interstitial lung disease |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5793705A (en) * | 1996-09-18 | 1998-08-11 | International Business Machines Corporation | Ultrasonic liquid level gauge for tanks subject to movement and vibration |
| US5783705A (en) * | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
| US20030180352A1 (en) * | 1999-11-23 | 2003-09-25 | Patel Mahesh V. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| JP4097893B2 (ja) * | 2000-12-05 | 2008-06-11 | 株式会社エフ・ティ・エスコーポレーション | 対向ターゲット式スパッタ方法及び導電性膜の形成方法 |
| EP1487424B1 (en) * | 2002-03-15 | 2006-09-13 | Novartis AG | 4-(4-methylpiperazin-1-ylmethyl)-n-(4-methyl-3(4-pyridin-3-yl)pyrimidin-2-yl-amino)phenyl)-benzamide for treating ang ii-mediated diseases |
| GB0223854D0 (en) * | 2002-10-12 | 2002-11-20 | Astrazeneca Ab | Therapeutic treatment |
| US20060205733A1 (en) * | 2004-08-26 | 2006-09-14 | Encysive Pharmaceuticals | Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof |
-
2007
- 2007-03-12 KR KR1020087022438A patent/KR101019264B1/ko not_active Expired - Fee Related
- 2007-03-12 NZ NZ570943A patent/NZ570943A/en not_active IP Right Cessation
- 2007-03-12 US US11/717,498 patent/US20090104265A1/en not_active Abandoned
- 2007-03-12 CN CNA2007800174618A patent/CN101443329A/zh active Pending
- 2007-03-12 RU RU2008136316/04A patent/RU2412941C2/ru not_active IP Right Cessation
- 2007-03-12 CA CA002644134A patent/CA2644134A1/en not_active Abandoned
- 2007-03-12 MX MX2008011843A patent/MX2008011843A/es not_active Application Discontinuation
- 2007-03-12 BR BRPI0709384-5A patent/BRPI0709384A2/pt not_active IP Right Cessation
- 2007-03-12 EP EP07752939A patent/EP1996582A2/en not_active Withdrawn
- 2007-03-12 WO PCT/US2007/006277 patent/WO2007106467A2/en not_active Ceased
- 2007-03-12 AU AU2007225206A patent/AU2007225206B2/en not_active Ceased
- 2007-03-12 JP JP2009500424A patent/JP2009530279A/ja not_active Withdrawn
-
2008
- 2008-08-25 ZA ZA200807302A patent/ZA200807302B/xx unknown
- 2008-08-25 IL IL193682A patent/IL193682A0/en unknown
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