JP2009528354A5 - - Google Patents

Download PDF

Info

Publication number
JP2009528354A5
JP2009528354A5 JP2008557304A JP2008557304A JP2009528354A5 JP 2009528354 A5 JP2009528354 A5 JP 2009528354A5 JP 2008557304 A JP2008557304 A JP 2008557304A JP 2008557304 A JP2008557304 A JP 2008557304A JP 2009528354 A5 JP2009528354 A5 JP 2009528354A5
Authority
JP
Japan
Prior art keywords
amino
phenyl
benzamide
oxoethyl
thienyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2008557304A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009528354A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/004724 external-priority patent/WO2007100657A2/en
Publication of JP2009528354A publication Critical patent/JP2009528354A/ja
Publication of JP2009528354A5 publication Critical patent/JP2009528354A5/ja
Withdrawn legal-status Critical Current

Links

JP2008557304A 2006-02-28 2007-02-23 ヒストン脱アセチル化酵素のインヒビター Withdrawn JP2009528354A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77771406P 2006-02-28 2006-02-28
PCT/US2007/004724 WO2007100657A2 (en) 2006-02-28 2007-02-23 Inhibitors of histone deacetylase

Publications (2)

Publication Number Publication Date
JP2009528354A JP2009528354A (ja) 2009-08-06
JP2009528354A5 true JP2009528354A5 (https=) 2009-09-24

Family

ID=38459567

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008557304A Withdrawn JP2009528354A (ja) 2006-02-28 2007-02-23 ヒストン脱アセチル化酵素のインヒビター

Country Status (6)

Country Link
US (1) US8168658B2 (https=)
EP (1) EP1991226B1 (https=)
JP (1) JP2009528354A (https=)
AU (1) AU2007221207A1 (https=)
CA (1) CA2642813A1 (https=)
WO (1) WO2007100657A2 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005070020A2 (en) 2004-01-23 2005-08-04 The Regents Of The University Of Colorado Gefitinib sensitivity-related gene expression and products and methods related thereto
ES2537631T3 (es) 2004-05-27 2015-06-10 The Regents Of The University Of Colorado Métodos para la predicción del resultado clínico para inhibidores del receptor del factor de crecimiento epidérmico para pacientes de cáncer
EP2170339B1 (en) * 2007-06-27 2014-10-15 Merck Sharp & Dohme Corp. Pyridyl and pyrimidinyl derivatives as histone deacetylase inhibitors
AU2008269154B2 (en) 2007-06-27 2014-06-12 Merck Sharp & Dohme Llc 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
KR101198057B1 (ko) 2008-01-29 2012-11-07 에프. 호프만-라 로슈 아게 신규한 n-(2-아미노-페닐)-아미드 유도체
WO2009118370A1 (en) 2008-03-27 2009-10-01 Janssen Pharmaceutica Nv Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
MX2010012297A (es) 2008-05-16 2010-12-06 Hoffmann La Roche Nuevas n-(2-amino-fenil)-acrilamidas.
ES2389754T3 (es) 2008-05-23 2012-10-31 Santen Pharmaceutical Co., Ltd Nuevos derivados de tiofendiamina con estructura urea
AU2009289649B2 (en) 2008-09-03 2016-05-05 Biomarin Pharmaceutical Inc. Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
US8202866B2 (en) 2008-09-17 2012-06-19 Hoffmann-La Roche Inc. Ortho-aminoanilides for the treatment of cancer
BRPI1007995A2 (pt) 2009-02-23 2019-09-24 Hoffmann La Roche orto-aminoamidas para o tratamento de cãncer.
JP2013509441A (ja) 2009-10-30 2013-03-14 マサチューセッツ インスティテュート オブ テクノロジー 記憶/認知および不安障害の処置のためのci−994およびジナリンの使用
WO2011106627A1 (en) 2010-02-26 2011-09-01 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US9540395B2 (en) 2011-02-28 2017-01-10 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
SI2734510T1 (sl) 2011-07-22 2019-05-31 Massachusetts Institute Of Technology Aktivatorji histon deacetilaz (HDACS) razreda I in njihove uporabe
DK2970139T3 (en) 2013-03-15 2018-08-13 Biomarin Pharm Inc HDAC inhibitors
CN103880842B (zh) * 2014-02-20 2016-04-13 南通大学 具HDAC抑制活性的β-咔啉类衍生物及制备方法和用途
CN103880841B (zh) * 2014-02-20 2016-04-13 南通大学 含有β-咔啉-3-酰亚肼基的HDAC抑制剂及其制备方法和用途
MX388871B (es) 2014-06-27 2025-03-20 Nogra Pharma Ltd Moduladores del receptor arilo y metodos para elaborar y usar los mismos.
WO2016109501A1 (en) * 2014-12-30 2016-07-07 Karos Pharmaceuticals, Inc. Amide compounds as tryptophan hydroxylase inhibitors
WO2020068950A1 (en) * 2018-09-25 2020-04-02 Regenacy Pharmaceuticals, Llc Hdac1,2 inhibitors

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3324115A1 (de) 1983-07-05 1985-01-17 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3505609A1 (de) 1985-02-19 1986-08-21 Merck Patent Gmbh, 6100 Darmstadt Benzimidazolyl-pyridazinone
US5369108A (en) 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
US5700811A (en) 1991-10-04 1997-12-23 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and method of use thereof
US6069143A (en) 1994-12-20 2000-05-30 Smithkline Beecham Corporation Fibrinogen receptor antagonists
AU709631B2 (en) 1996-06-28 1999-09-02 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
US6174905B1 (en) 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
PH11998001072B1 (en) 1997-05-07 2006-11-21 Univ Pittsburgh Inhibitors of protein isoprenyl transferases
US6506783B1 (en) 1997-05-16 2003-01-14 The Procter & Gamble Company Cancer treatments and pharmaceutical compositions therefor
JP4405602B2 (ja) 1998-04-16 2010-01-27 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト ヒストン脱アセチル化酵素阻害剤
WO1999055663A1 (en) 1998-04-29 1999-11-04 Vertex Pharmaceuticals Incorporated Inhibitors of impdh enzyme
JPH11335375A (ja) 1998-05-20 1999-12-07 Mitsui Chem Inc ヒストン脱アセチル化酵素阻害作用を有するベンズアミド誘導体
FR2783519B1 (fr) 1998-09-23 2003-01-24 Sod Conseils Rech Applic Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
US6653309B1 (en) 1999-04-26 2003-11-25 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme technical field of the invention
CA2374947A1 (en) 1999-05-24 2000-11-30 Robert M. Scarborough Inhibitors of factor xa
NZ517613A (en) 1999-09-08 2004-01-30 Sloan Kettering Inst Cancer Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof
ATE250604T1 (de) 1999-10-27 2003-10-15 Millennium Pharm Inc Pyridyl enthaltende spirocyclische verbindungen als inhibitoren der fibrinogen-abhängigen blutplättchen aggregation
JP4360660B2 (ja) 1999-11-09 2009-11-11 三井化学株式会社 モノアシルフェニレンジアミン誘導体の精製法
EP1748046A3 (en) 1999-11-23 2007-08-22 Methylgene, Inc. Inhibitors of histone deacetylase
CA2397575A1 (en) 2000-01-13 2001-07-19 Tularik Inc. Antibacterial agents
WO2001064642A2 (en) 2000-02-29 2001-09-07 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
WO2002000647A1 (en) 2000-06-23 2002-01-03 Bristol-Myers Squibb Pharma Company Heteroaryl-phenyl substituted factor xa inhibitors
US6849660B1 (en) 2000-08-01 2005-02-01 Isis Pharmaceuticals, Inc. Antimicrobial biaryl compounds
CZ20032531A3 (cs) 2001-03-19 2004-01-14 Ono Pharmaceutical Co., Ltd. Derivát triazaspiro[5.5]undekanu a farmaceutická kompozice obsahující tento derivát jako účinnou složku
TWI239942B (en) 2001-06-11 2005-09-21 Dainippon Pharmaceutical Co N-arylphenylacetamide derivative and pharmaceutical composition containing the same
US7064215B2 (en) 2001-07-03 2006-06-20 Chiron Corporation Indazole benzimidazole compounds
SE0102439D0 (sv) 2001-07-05 2001-07-05 Astrazeneca Ab New compounds
AR034897A1 (es) 2001-08-07 2004-03-24 Hoffmann La Roche Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos
US6897220B2 (en) 2001-09-14 2005-05-24 Methylgene, Inc. Inhibitors of histone deacetylase
CN101851173A (zh) 2001-09-14 2010-10-06 梅特希尔基因公司 组蛋白脱乙酰化酶抑制剂
US7868204B2 (en) 2001-09-14 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
CN100445276C (zh) 2002-03-13 2008-12-24 詹森药业有限公司 用作组蛋白去乙酰酶抑制剂的磺酰基衍生物
HRP20040805A2 (en) 2002-03-13 2005-04-30 Janssen Pharmaceutica N.V. Carbonylamino derivatives as novel inhibitors histone deacetylase
MXPA04008797A (es) 2002-03-13 2004-11-26 Janssen Pharmaceutica Nv Inhibidores de histona desacetilasa.
TWI319387B (en) 2002-04-05 2010-01-11 Astrazeneca Ab Benzamide derivatives
GB0209715D0 (en) 2002-04-27 2002-06-05 Astrazeneca Ab Chemical compounds
AU2003265398A1 (en) 2002-08-09 2004-02-25 Transtech Pharma, Inc. Aryl and heteroaryl compounds and methods to modulate coagulation
CA2497903A1 (en) 2002-09-18 2004-04-01 Ono Pharmaceutical Co., Ltd. Triazaspiro[5.5]undecane derivatives and drugs comprising the same as the active ingredient
AU2003266607A1 (en) 2002-09-25 2004-04-19 Santen Pharmaceutical Co., Ltd. Therapeutic agent for rheumatism containing benzamide derivative as active ingredient
AU2003273701A1 (en) 2002-10-17 2004-05-04 Methylgene Inc. Inhibitors of histone deacetylase
TW200426138A (en) * 2002-12-10 2004-12-01 Hoffmann La Roche Novel arylene-carboxylic acid (2-amino-phenyl)-amide derivatives, their manufacture and use as pharmaceutical agents
EP1738752A1 (en) 2002-12-27 2007-01-03 Schering Aktiengesellschaft Pharmaceutical combinations comprising cis-retine acid
US7381825B2 (en) 2003-03-17 2008-06-03 Takeda San Diego, Inc. Histone deacetylase inhibitors
TW200505902A (en) 2003-03-20 2005-02-16 Schering Corp Cannabinoid receptor ligands
WO2005009971A1 (ja) 2003-07-24 2005-02-03 Astellas Pharma Inc. キノロン誘導体又はその塩
WO2005030705A1 (en) 2003-09-24 2005-04-07 Methylgene, Inc. Inhibitors of histone deacetylase
WO2005053609A2 (en) 2003-11-26 2005-06-16 Guilford Pharmaceuticals Inc. Methods of nad+-dependent deacetylase inhibitors
MXPA06010900A (es) 2004-03-26 2007-02-21 Methylgene Inc Inhibidores de histona desacetilasa.
WO2006001958A2 (en) 2004-05-21 2006-01-05 Merck & Co., Inc. Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity
WO2005121073A1 (en) 2004-06-10 2005-12-22 Cancer Research Technology Limited Inhibitors of histone deacetylase
ES2368930T3 (es) 2004-09-06 2011-11-23 Bayer Pharma Aktiengesellschaft Pirazolopirimidinas como inhibidores de proteína cinasa b (akt).
CA2605110A1 (en) 2005-04-20 2006-11-02 Merck & Co., Inc. Benzothiophene derivatives
CA2612420A1 (en) * 2005-06-24 2007-01-04 Merck & Co., Inc. Modified malonate derivatives
WO2007055942A2 (en) 2005-11-03 2007-05-18 Merck & Co., Inc. Substituted nicotinamide compounds
AU2007208495A1 (en) 2006-01-12 2007-08-02 Merck Sharp & Dohme Corp. Hydroxyalkylarylamide derivatives
CA2635209A1 (en) 2006-01-12 2007-08-02 Merck & Co., Inc. Fluorinated arylamide derivatives
CN101466670B (zh) 2006-04-07 2013-04-17 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂
CA2649861A1 (en) 2006-04-26 2007-11-08 Merck & Co., Inc. Disubstituted aniline compounds
EP2049124A4 (en) 2006-07-20 2010-02-10 Merck & Co Inc PHOSPHOR DERIVATIVES AS HISTONDEACETYLASE HEMMER
EP2170339B1 (en) 2007-06-27 2014-10-15 Merck Sharp & Dohme Corp. Pyridyl and pyrimidinyl derivatives as histone deacetylase inhibitors

Similar Documents

Publication Publication Date Title
JP2009528354A5 (https=)
JP2008502700A5 (https=)
JP2015517981A5 (https=)
RU2361860C2 (ru) Новые замещенные 3-сера-индолы
JP2004508304A5 (https=)
JP2015509543A5 (https=)
JP2994546B2 (ja) スルファモイル基およびアミジノ基を有する化合物および製造方法
JP2007519754A5 (https=)
JP2014511869A5 (https=)
NZ597528A (en) Inhibitors of flaviviridae viruses
HRP20160537T1 (hr) Modulatori indolamina 2,3-dioksigenaze i metode za upotrebu istih
JP2005510500A5 (https=)
HRP20140970T1 (hr) Spoj azolkarboksamida ili njegova sol
JP2011518774A5 (https=)
CA2690226A1 (en) Novel malonic acid sulfonamide derivative and pharmaceutical use thereof
JP2011524906A5 (https=)
JP2006500369A5 (https=)
JP2013509376A5 (https=)
HRP20141048T1 (hr) Spojevi, pripravci i metode
RU2007101073A (ru) Пятичленные гетероциклы, применимые в качестве ингибиторов сериновой протеазы
CA2436526A1 (en) Heterocyclic sulfonamide inhibitors of beta amyloid production
JP2016503786A5 (https=)
JP2010505881A5 (https=)
JP2013517273A5 (https=)
JP2010507096A5 (https=)