JP2009528354A - ヒストン脱アセチル化酵素のインヒビター - Google Patents

ヒストン脱アセチル化酵素のインヒビター Download PDF

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Publication number
JP2009528354A
JP2009528354A JP2008557304A JP2008557304A JP2009528354A JP 2009528354 A JP2009528354 A JP 2009528354A JP 2008557304 A JP2008557304 A JP 2008557304A JP 2008557304 A JP2008557304 A JP 2008557304A JP 2009528354 A JP2009528354 A JP 2009528354A
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Japan
Prior art keywords
amino
phenyl
benzamide
oxoethyl
thienyl
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JP2008557304A
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Japanese (ja)
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JP2009528354A5 (https=
Inventor
グリム，ジョナサン，ビー
ハッブズ，ジェド，エル
ミラー，トーマス
オッテ，カリン，エム
シリファイバン，フェン
スタントン，マシュー，ジー
ウィルソン，ケヴィン
ウィッター，デイビッド
チョウ，ファ
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Merck and Co Inc
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Merck and Co Inc
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Publication of JP2009528354A publication Critical patent/JP2009528354A/ja
Publication of JP2009528354A5 publication Critical patent/JP2009528354A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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JP2008557304A 2006-02-28 2007-02-23 ヒストン脱アセチル化酵素のインヒビター Withdrawn JP2009528354A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77771406P 2006-02-28 2006-02-28
PCT/US2007/004724 WO2007100657A2 (en) 2006-02-28 2007-02-23 Inhibitors of histone deacetylase

Publications (2)

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JP2009528354A true JP2009528354A (ja) 2009-08-06
JP2009528354A5 JP2009528354A5 (https=) 2009-09-24

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JP2008557304A Withdrawn JP2009528354A (ja) 2006-02-28 2007-02-23 ヒストン脱アセチル化酵素のインヒビター

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US (1) US8168658B2 (https=)
EP (1) EP1991226B1 (https=)
JP (1) JP2009528354A (https=)
AU (1) AU2007221207A1 (https=)
CA (1) CA2642813A1 (https=)
WO (1) WO2007100657A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011526936A (ja) * 2008-09-17 2011-10-20 エフ．ホフマン−ラ ロシュ アーゲー 癌の処理のための新規オルト−アミノアニリド
JP2019065037A (ja) * 2011-02-28 2019-04-25 バイオマリン ファーマシューティカル インク ヒストン脱アセチル化酵素阻害剤

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005070020A2 (en) 2004-01-23 2005-08-04 The Regents Of The University Of Colorado Gefitinib sensitivity-related gene expression and products and methods related thereto
ES2537631T3 (es) 2004-05-27 2015-06-10 The Regents Of The University Of Colorado Métodos para la predicción del resultado clínico para inhibidores del receptor del factor de crecimiento epidérmico para pacientes de cáncer
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