JP2009528309A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009528309A5 JP2009528309A5 JP2008556686A JP2008556686A JP2009528309A5 JP 2009528309 A5 JP2009528309 A5 JP 2009528309A5 JP 2008556686 A JP2008556686 A JP 2008556686A JP 2008556686 A JP2008556686 A JP 2008556686A JP 2009528309 A5 JP2009528309 A5 JP 2009528309A5
- Authority
- JP
- Japan
- Prior art keywords
- dimethyl adamantane
- formamide
- dimethyl
- memantine
- refluxed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- LDDHMLJTFXJGPI-UHFFFAOYSA-N memantine hydrochloride Chemical compound Cl.C1C(C2)CC3(C)CC1(C)CC2(N)C3 LDDHMLJTFXJGPI-UHFFFAOYSA-N 0.000 description 2
- RTPQXHZLCUUIJP-UHFFFAOYSA-N 1,2-dimethyladamantane Chemical compound C1C(C2)CC3CC1C(C)C2(C)C3 RTPQXHZLCUUIJP-UHFFFAOYSA-N 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 229960004640 memantine Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006009279A DE102006009279A1 (de) | 2006-03-01 | 2006-03-01 | Verfahren zur Herstellung von 1-Formamido-3,5-dimethyladamantan |
| DE102006009279.1 | 2006-03-01 | ||
| PCT/EP2007/001433 WO2007101536A1 (de) | 2006-03-01 | 2007-02-20 | Verfahren zur herstellung von 1-formamido-3,5-dimethyladamantan |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009528309A JP2009528309A (ja) | 2009-08-06 |
| JP2009528309A5 true JP2009528309A5 (enExample) | 2010-04-08 |
| JP5345403B2 JP5345403B2 (ja) | 2013-11-20 |
Family
ID=38197988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008556686A Active JP5345403B2 (ja) | 2006-03-01 | 2007-02-20 | １−ホルムアミド−３，５−ジメチルアダマンタンの製造方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8138375B2 (enExample) |
| EP (1) | EP1989175B1 (enExample) |
| JP (1) | JP5345403B2 (enExample) |
| DE (1) | DE102006009279A1 (enExample) |
| ES (1) | ES2392550T3 (enExample) |
| RU (1) | RU2455281C2 (enExample) |
| WO (1) | WO2007101536A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5499016B2 (ja) * | 2008-03-20 | 2014-05-21 | メルツ・ファルマ・ゲーエムベーハー・ウント・コ・カーゲーアーアー | メマンチンの製造方法及び中間生成物 |
| EP2103597A1 (en) | 2008-03-20 | 2009-09-23 | Merz Pharma GmbH & Co.KGaA | Process for the manufacture of memantine and intermediate product |
| US20110288336A1 (en) | 2008-12-17 | 2011-11-24 | Merz Pharma Gmbh & Co. Kgaa | Method for producing memantine |
| EP2389351A1 (en) * | 2009-01-21 | 2011-11-30 | Merz Pharma GmbH & Co. KGaA | A process for preparing memantine |
| JP5778148B2 (ja) | 2009-08-04 | 2015-09-16 | メルク パテント ゲーエムベーハー | 多環式炭水化物を含む電子デバイス |
| JP2013180983A (ja) * | 2012-03-01 | 2013-09-12 | Tokyo Univ Of Agriculture & Technology | Ｎ置換アミド化合物の製造方法 |
| RU2549901C1 (ru) * | 2013-12-30 | 2015-05-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный университет" (ФГБОУ ВПО "КубГУ") | Способ получения n-адамантилированных амидов |
| EP4005565A1 (en) | 2020-11-30 | 2022-06-01 | Merz Pharmaceuticals GmbH | Novel uses of adamantane derivatives |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2318461A1 (de) | 1973-04-12 | 1974-10-31 | Merz & Co | Verfahren zur herstellung von 1,3,5trisubstituierten adamanta-verbindungen |
| JPS63159330A (ja) * | 1986-12-23 | 1988-07-02 | Kawasaki Steel Corp | １，３−ジメチルアダマンタンの製造方法 |
| JPS63295519A (ja) * | 1987-05-27 | 1988-12-01 | Kawasaki Steel Corp | １，３−ジメチルアダマンタンの製造方法 |
| SU1643528A1 (ru) * | 1988-10-03 | 1991-04-23 | Научно-производственное объединение "Комплекс" | Способ получени 1-ацетаминоадамантана |
| ES2059602T3 (es) * | 1989-04-14 | 1994-11-16 | Merz & Co Gmbh & Co | Uso de derivados de adamantano para la prevencion y tratamiento de isquemia cerebral. |
| US5117056A (en) | 1990-12-21 | 1992-05-26 | Air Products And Chemicals, Inc. | Preparation of N-(1-alkoxyalkyl)formamide and bis formamides |
| RU2246482C2 (ru) * | 2002-12-25 | 2005-02-20 | ООО "Циклан" | Способ получения гидрохлорида 1-амино-3,5-диметиладамантана |
| CN100345819C (zh) * | 2003-07-01 | 2007-10-31 | 北京德众万全药物技术开发有限公司 | 一种取代的金刚烷胺类化合物或其盐的制备方法 |
| US20080275112A1 (en) | 2004-07-23 | 2008-11-06 | Schreiner Peter R | Invention Concerning Aminoadamantane Compounds |
-
2006
- 2006-03-01 DE DE102006009279A patent/DE102006009279A1/de not_active Ceased
-
2007
- 2007-02-20 ES ES07722859T patent/ES2392550T3/es active Active
- 2007-02-20 WO PCT/EP2007/001433 patent/WO2007101536A1/de not_active Ceased
- 2007-02-20 JP JP2008556686A patent/JP5345403B2/ja active Active
- 2007-02-20 EP EP07722859A patent/EP1989175B1/de active Active
- 2007-02-20 RU RU2008138891/04A patent/RU2455281C2/ru active
- 2007-02-20 US US12/224,575 patent/US8138375B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009528309A5 (enExample) | ||
| JP2005179362A5 (enExample) | ||
| JP2010521514A5 (enExample) | ||
| JP2002513003A5 (enExample) | ||
| JP2012510480A5 (enExample) | ||
| CN101774941A (zh) | 2-酰基氨基-3-联苯基丙酸的制备及拆分方法 | |
| UA100367C2 (uk) | Спосіб одержання мемантину і його гідрохлориду | |
| JP2011521988A5 (enExample) | ||
| CN103387500A (zh) | 一种米拉贝隆及其中间体的制备方法 | |
| HRP20160518T1 (hr) | Postupci za proizvodnju farmaceutske djelatne tvari | |
| JP2010507589A5 (ja) | Ｃｂ１受容体モジュレーターとしての１，５−ジフェニル−３−ピリジニルアミノ−１，５−ジヒドロピロリジン−２−オン | |
| JP2010168359A5 (enExample) | ||
| CN101928277B (zh) | 4-甲基-3-[[4-(3-吡啶基)-2-嘧啶基]氨基]安息香酸的制备方法、相关中间体及其应用 | |
| CN103848777A (zh) | 一种n-（3-甲氧基丙基）-4-氨基哌啶的合成方法 | |
| CN106810452B (zh) | 一种盐酸西那卡塞的制备方法 | |
| CN110773144A (zh) | 一种用于氰基水解制备酰胺的催化体系及其应用 | |
| CN106146419A (zh) | 黄嘌呤氧化酶抑制剂 | |
| JP2005519117A5 (enExample) | ||
| CN111333543A (zh) | 一种利匹韦林中间体的合成方法 | |
| JP2005213341A5 (enExample) | ||
| CN105315284A (zh) | 阿拉格列汀中间体的制备方法 | |
| JP2012526870A5 (enExample) | ||
| CN102731408A (zh) | 一种阿齐沙坦中间体及其制备方法 | |
| CN101786990A (zh) | 一种具有抗痒活性的化合物 | |
| JP2009013093A5 (enExample) |