JP2009528267A - 治療を増強するグルカン - Google Patents

治療を増強するグルカン Download PDF

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Publication number
JP2009528267A
JP2009528267A JP2008551413A JP2008551413A JP2009528267A JP 2009528267 A JP2009528267 A JP 2009528267A JP 2008551413 A JP2008551413 A JP 2008551413A JP 2008551413 A JP2008551413 A JP 2008551413A JP 2009528267 A JP2009528267 A JP 2009528267A
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cancer
glucan
antibody
subject
tumor
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JP2008551413A
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Japanese (ja)
Inventor
エングスタッド、ロルフ、エイナル
Original Assignee
スローン − ケッタリング インスティチュート フォー キャンサー リサーチ
バイオテク ファーマコン エイエスエイ
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Priority claimed from US11/334,763 external-priority patent/US7906492B2/en
Application filed by スローン − ケッタリング インスティチュート フォー キャンサー リサーチ, バイオテク ファーマコン エイエスエイ filed Critical スローン − ケッタリング インスティチュート フォー キャンサー リサーチ
Publication of JP2009528267A publication Critical patent/JP2009528267A/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001111Immunoglobulin superfamily
    • A61K39/001113CD22, BL-CAM, siglec-2 or sialic acid- binding Ig-related lectin 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103Receptors for growth factors
    • A61K39/001106Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001124CD20
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001129Molecules with a "CD" designation not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001169Tumor associated carbohydrates
    • A61K39/001171Gangliosides, e.g. GM2, GD2 or GD3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • A61K2039/542Mucosal route oral/gastrointestinal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55583Polysaccharides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2008551413A 2006-01-17 2007-01-17 治療を増強するグルカン Pending JP2009528267A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/334,763 2006-01-17
US11/334,763 US7906492B2 (en) 2001-01-16 2006-01-17 Therapy-enhancing glucan
PCT/US2007/001427 WO2007084661A2 (fr) 2006-01-17 2007-01-17 Glucane permettant d'améliorer une thérapie

Publications (1)

Publication Number Publication Date
JP2009528267A true JP2009528267A (ja) 2009-08-06

Family

ID=40382391

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008551413A Pending JP2009528267A (ja) 2006-01-17 2007-01-17 治療を増強するグルカン

Country Status (4)

Country Link
EP (1) EP1984004A4 (fr)
JP (1) JP2009528267A (fr)
AU (1) AU2008207369B2 (fr)
WO (1) WO2007084661A2 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012014978A1 (fr) * 2010-07-29 2012-02-02 国立大学法人北海道大学 Adjuvant immunitaire
JP2015517115A (ja) * 2012-04-30 2015-06-18 バイオセラ インコーポレイテッド β−グルカン免疫治療方法
JP5990752B2 (ja) * 2011-01-31 2016-09-14 オリンパス株式会社 抗体療法の効果増強剤
JP2017524737A (ja) * 2014-07-10 2017-08-31 バイオセラ,インク. 腫瘍微小環境に影響する抗癌剤と組み合わせたβ−グルカン
JP2021522257A (ja) * 2018-04-24 2021-08-30 メモリアル スローン ケタリング キャンサー センター 経口酵母ベータグルカンを用いる低免疫原性抗原特異的ワクチンの免疫原性強化方法
JP7048102B2 (ja) 2019-05-23 2022-04-05 国立研究開発法人医薬基盤・健康・栄養研究所 免疫賦活活性を有する核酸多糖複合体の抗腫瘍薬としての応用
US11815435B2 (en) 2017-02-24 2023-11-14 Hibercell, Inc. Beta glucan immunopharmacodynamics

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7906492B2 (en) 2001-01-16 2011-03-15 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
US7507724B2 (en) 2001-01-16 2009-03-24 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
JP5153188B2 (ja) * 2007-03-30 2013-02-27 小林製薬株式会社 Th1/Th2バランス改善剤
EP2219655A2 (fr) * 2007-11-13 2010-08-25 Biotec Pharmacon ASA Procédés de traitement ou de prévention de maladies inflammatoires du tractus intestinal
EP2832360A1 (fr) 2013-07-30 2015-02-04 Fresenius Kabi Deutschland GmbH Polysaccharide pour utilisation dans la prévention de la formation de métastases et/ou de rechute
MX2020009510A (es) * 2018-03-13 2021-08-05 Hibercell Inc Inmunoterapia combinada de beta glucano y agonista cd40.
WO2020061203A1 (fr) * 2018-09-21 2020-03-26 Nantcell, Inc. Procédés et compositions pour moduler des cellules suppressives d'origine myéloïde

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000516911A (ja) * 1996-03-28 2000-12-19 ホワイトヘッド インスティテュート フォー バイオメディカル リサーチ オプソニン強化細胞、および抗原に対する免疫応答を調節する方法
JP2004507446A (ja) * 2000-02-04 2004-03-11 トーマス・ジェファーソン・ユニバーシティ 低用量ハプテン化腫瘍細胞および腫瘍細胞抽出物の免疫治療
US20060009419A1 (en) * 2002-09-04 2006-01-12 Ross Gordon D Therapy-enhancing glucan

Family Cites Families (11)

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CA1340080C (fr) * 1985-03-11 1998-10-13 Dorothee Herlyn Methode de traitement des tumeurs chez l'humain
US5622939A (en) * 1992-08-21 1997-04-22 Alpha-Beta Technology, Inc. Glucan preparation
EP0490995A1 (fr) * 1989-09-08 1992-06-24 Alpha Beta Technology Procede de production de glucans solubles
US5801005A (en) * 1993-03-17 1998-09-01 University Of Washington Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated
US5696079A (en) * 1993-05-19 1997-12-09 The United States Of America As Represented By The Department Of Health And Human Services Immunologic enhancement with intermittent interleukin-2 therapy
EP0640348A1 (fr) * 1993-07-26 1995-03-01 Akzo Nobel N.V. Mélange adjuvant à base d'huile et à base d'eau
NO300692B1 (no) * 1994-04-29 1997-07-07 Biotec Mackzymal As Solubilisert forgrenet ß-1,3-glukan og anvendelse derav samt anvendelse av usolubilisert forgrenet ß-1,3-glukan
US7507724B2 (en) * 2001-01-16 2009-03-24 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
WO2002058711A1 (fr) * 2001-01-16 2002-08-01 Sloan-Kettering Institute For Cancer Research Glucane ameliorant une therapie
GB0211118D0 (en) * 2002-05-15 2002-06-26 Polonelli Luciano Vaccines
US20070059310A1 (en) * 2005-05-03 2007-03-15 Karel Steven J Therapeutic combination compositions and methods of using same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000516911A (ja) * 1996-03-28 2000-12-19 ホワイトヘッド インスティテュート フォー バイオメディカル リサーチ オプソニン強化細胞、および抗原に対する免疫応答を調節する方法
JP2004507446A (ja) * 2000-02-04 2004-03-11 トーマス・ジェファーソン・ユニバーシティ 低用量ハプテン化腫瘍細胞および腫瘍細胞抽出物の免疫治療
US20060009419A1 (en) * 2002-09-04 2006-01-12 Ross Gordon D Therapy-enhancing glucan

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012014978A1 (fr) * 2010-07-29 2012-02-02 国立大学法人北海道大学 Adjuvant immunitaire
JP5242855B2 (ja) * 2010-07-29 2013-07-24 国立大学法人北海道大学 免疫アジュバント
JP5990752B2 (ja) * 2011-01-31 2016-09-14 オリンパス株式会社 抗体療法の効果増強剤
JP2015517115A (ja) * 2012-04-30 2015-06-18 バイオセラ インコーポレイテッド β−グルカン免疫治療方法
US10092646B2 (en) 2012-04-30 2018-10-09 Biothera, Inc. Compositions and methods for beta-glucan immunotherapy
US11229701B2 (en) 2012-04-30 2022-01-25 Hibercell, Inc. Methods for identifying beta-glucan binding to immune cells
JP2017524737A (ja) * 2014-07-10 2017-08-31 バイオセラ,インク. 腫瘍微小環境に影響する抗癌剤と組み合わせたβ−グルカン
JP2021020921A (ja) * 2014-07-10 2021-02-18 バイオセラ,インク. 腫瘍微小環境に影響する抗癌剤と組み合わせたβ−グルカン
US11815435B2 (en) 2017-02-24 2023-11-14 Hibercell, Inc. Beta glucan immunopharmacodynamics
JP2021522257A (ja) * 2018-04-24 2021-08-30 メモリアル スローン ケタリング キャンサー センター 経口酵母ベータグルカンを用いる低免疫原性抗原特異的ワクチンの免疫原性強化方法
JP7438131B2 (ja) 2018-04-24 2024-02-26 メモリアル スローン-ケタリング キャンサー センター 経口酵母ベータグルカンを用いる低免疫原性抗原特異的ワクチンの免疫原性強化方法
JP7048102B2 (ja) 2019-05-23 2022-04-05 国立研究開発法人医薬基盤・健康・栄養研究所 免疫賦活活性を有する核酸多糖複合体の抗腫瘍薬としての応用

Also Published As

Publication number Publication date
WO2007084661A2 (fr) 2007-07-26
WO2007084661B1 (fr) 2008-01-10
WO2007084661A3 (fr) 2007-11-08
EP1984004A2 (fr) 2008-10-29
AU2008207369B2 (en) 2009-12-17
EP1984004A4 (fr) 2010-03-03
AU2008207369A1 (en) 2008-09-11

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