AU2008207369B2 - Immune response enhancing glucans - Google Patents
Immune response enhancing glucans Download PDFInfo
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- AU2008207369B2 AU2008207369B2 AU2008207369A AU2008207369A AU2008207369B2 AU 2008207369 B2 AU2008207369 B2 AU 2008207369B2 AU 2008207369 A AU2008207369 A AU 2008207369A AU 2008207369 A AU2008207369 A AU 2008207369A AU 2008207369 B2 AU2008207369 B2 AU 2008207369B2
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PCT/US2007/001427 WO2007084661A2 (fr) | 2006-01-17 | 2007-01-17 | Glucane permettant d'améliorer une thérapie |
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US7906492B2 (en) | 2001-01-16 | 2011-03-15 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
US7507724B2 (en) | 2001-01-16 | 2009-03-24 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
JP5153188B2 (ja) * | 2007-03-30 | 2013-02-27 | 小林製薬株式会社 | Th1/Th2バランス改善剤 |
WO2009063221A2 (fr) * | 2007-11-13 | 2009-05-22 | Biotec Pharmacon Asa | Procédés de traitement ou de prévention de maladies inflammatoires du tractus intestinal |
JP5242855B2 (ja) * | 2010-07-29 | 2013-07-24 | 国立大学法人北海道大学 | 免疫アジュバント |
WO2012105219A1 (fr) * | 2011-01-31 | 2012-08-09 | オリンパス株式会社 | Médicament stimulant l'effet thérapeutique d'anticorps |
EP3373006A1 (fr) | 2012-04-30 | 2018-09-12 | Biothera, Inc. | Procédés d'immunothérapie par bêta-glucane |
EP2832360A1 (fr) | 2013-07-30 | 2015-02-04 | Fresenius Kabi Deutschland GmbH | Polysaccharide pour utilisation dans la prévention de la formation de métastases et/ou de rechute |
JP6893594B2 (ja) * | 2014-07-10 | 2021-06-23 | ハイバーセル,インク. | 腫瘍微小環境に影響する抗癌剤と組み合わせたβ−グルカン |
US11815435B2 (en) | 2017-02-24 | 2023-11-14 | Hibercell, Inc. | Beta glucan immunopharmacodynamics |
BR112020018761A2 (pt) * | 2018-03-13 | 2020-12-29 | Hibercell, Inc. | Imunoterapia combinada com beta-glucano e agonista de cd40 |
WO2019209890A1 (fr) | 2018-04-24 | 2019-10-31 | Memorial Sloan Kettering Cancer Center | Procédés d'amélioration de l'immunogénicité de vaccins spécifiques d'un antigène faiblement immunogènes à l'aide de bêta-glucanes de levure oraux |
WO2020061203A1 (fr) * | 2018-09-21 | 2020-03-26 | Nantcell, Inc. | Procédés et compositions pour moduler des cellules suppressives d'origine myéloïde |
JP7048102B2 (ja) | 2019-05-23 | 2022-04-05 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 免疫賦活活性を有する核酸多糖複合体の抗腫瘍薬としての応用 |
Citations (3)
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EP0759089A1 (fr) * | 1994-04-29 | 1997-02-26 | As Biotec-Mackzymal | Traitement enzymatique des glycannnes |
US5804199A (en) * | 1993-07-26 | 1998-09-08 | Akzo Nobel N. V. | Oil-based and water-based adjuvant mixture |
US20050208079A1 (en) * | 2002-05-15 | 2005-09-22 | Antonio Cassone | Glucan-based vaccines |
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CA1340080C (fr) * | 1985-03-11 | 1998-10-13 | Dorothee Herlyn | Methode de traitement des tumeurs chez l'humain |
US5622939A (en) * | 1992-08-21 | 1997-04-22 | Alpha-Beta Technology, Inc. | Glucan preparation |
WO1991003495A1 (fr) * | 1989-09-08 | 1991-03-21 | Alpha Beta Technology, Inc. | Procede de production de glucans solubles |
US5801005A (en) * | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
US5696079A (en) * | 1993-05-19 | 1997-12-09 | The United States Of America As Represented By The Department Of Health And Human Services | Immunologic enhancement with intermittent interleukin-2 therapy |
WO1997035619A1 (fr) * | 1996-03-28 | 1997-10-02 | Genitrix, L.L.C. | Cellules renforcees par opsonine, et procede de modulation d'une reponse immune a un antigene |
JP2004507446A (ja) * | 2000-02-04 | 2004-03-11 | トーマス・ジェファーソン・ユニバーシティ | 低用量ハプテン化腫瘍細胞および腫瘍細胞抽出物の免疫治療 |
US7507724B2 (en) * | 2001-01-16 | 2009-03-24 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
EP1357919B1 (fr) * | 2001-01-16 | 2017-04-05 | Sloan-Kettering Institute For Cancer Research | Glucane ameliorant une therapie |
JP2006502167A (ja) * | 2002-09-04 | 2006-01-19 | バイオポリマー エンジニアリング,インコーポレイテッド | 全グルカン粒子および抗体を用いた癌治療 |
US20070059310A1 (en) * | 2005-05-03 | 2007-03-15 | Karel Steven J | Therapeutic combination compositions and methods of using same |
-
2007
- 2007-01-17 WO PCT/US2007/001427 patent/WO2007084661A2/fr active Application Filing
- 2007-01-17 JP JP2008551413A patent/JP2009528267A/ja active Pending
- 2007-01-17 EP EP07718218A patent/EP1984004A4/fr not_active Withdrawn
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2008
- 2008-08-18 AU AU2008207369A patent/AU2008207369B2/en not_active Ceased
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5804199A (en) * | 1993-07-26 | 1998-09-08 | Akzo Nobel N. V. | Oil-based and water-based adjuvant mixture |
EP0759089A1 (fr) * | 1994-04-29 | 1997-02-26 | As Biotec-Mackzymal | Traitement enzymatique des glycannnes |
US20050208079A1 (en) * | 2002-05-15 | 2005-09-22 | Antonio Cassone | Glucan-based vaccines |
Also Published As
Publication number | Publication date |
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EP1984004A4 (fr) | 2010-03-03 |
JP2009528267A (ja) | 2009-08-06 |
AU2008207369A1 (en) | 2008-09-11 |
EP1984004A2 (fr) | 2008-10-29 |
WO2007084661B1 (fr) | 2008-01-10 |
WO2007084661A2 (fr) | 2007-07-26 |
WO2007084661A3 (fr) | 2007-11-08 |
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