AU2008207369B2 - Immune response enhancing glucans - Google Patents

Immune response enhancing glucans Download PDF

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Publication number
AU2008207369B2
AU2008207369B2 AU2008207369A AU2008207369A AU2008207369B2 AU 2008207369 B2 AU2008207369 B2 AU 2008207369B2 AU 2008207369 A AU2008207369 A AU 2008207369A AU 2008207369 A AU2008207369 A AU 2008207369A AU 2008207369 B2 AU2008207369 B2 AU 2008207369B2
Authority
AU
Australia
Prior art keywords
antibody
glucan
cancer
tumor
vaccine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008207369A
Other languages
English (en)
Other versions
AU2008207369A1 (en
Inventor
Nai-Kong V. Cheung
Rolf Einar Engstad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arcticzymes Technologies ASA
Memorial Sloan Kettering Cancer Center
Original Assignee
Biotec Pharmacon ASA
Sloan Kettering Institute for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/334,763 external-priority patent/US7906492B2/en
Application filed by Biotec Pharmacon ASA, Sloan Kettering Institute for Cancer Research filed Critical Biotec Pharmacon ASA
Publication of AU2008207369A1 publication Critical patent/AU2008207369A1/en
Application granted granted Critical
Publication of AU2008207369B2 publication Critical patent/AU2008207369B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001111Immunoglobulin superfamily
    • A61K39/001113CD22, BL-CAM, siglec-2 or sialic acid- binding Ig-related lectin 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103Receptors for growth factors
    • A61K39/001106Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001124CD20
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001129Molecules with a "CD" designation not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001169Tumor associated carbohydrates
    • A61K39/001171Gangliosides, e.g. GM2, GD2 or GD3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • A61K2039/542Mucosal route oral/gastrointestinal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55583Polysaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2008207369A 2006-01-17 2008-08-18 Immune response enhancing glucans Ceased AU2008207369B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/334,763 2006-01-17
US11/334,763 US7906492B2 (en) 2001-01-16 2006-01-17 Therapy-enhancing glucan
PCT/US2007/001427 WO2007084661A2 (fr) 2006-01-17 2007-01-17 Glucane permettant d'améliorer une thérapie

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/001427 Division WO2007084661A2 (fr) 2006-01-17 2007-01-17 Glucane permettant d'améliorer une thérapie

Publications (2)

Publication Number Publication Date
AU2008207369A1 AU2008207369A1 (en) 2008-09-11
AU2008207369B2 true AU2008207369B2 (en) 2009-12-17

Family

ID=40382391

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008207369A Ceased AU2008207369B2 (en) 2006-01-17 2008-08-18 Immune response enhancing glucans

Country Status (4)

Country Link
EP (1) EP1984004A4 (fr)
JP (1) JP2009528267A (fr)
AU (1) AU2008207369B2 (fr)
WO (1) WO2007084661A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7906492B2 (en) 2001-01-16 2011-03-15 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
US7507724B2 (en) 2001-01-16 2009-03-24 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
JP5153188B2 (ja) * 2007-03-30 2013-02-27 小林製薬株式会社 Th1/Th2バランス改善剤
WO2009063221A2 (fr) * 2007-11-13 2009-05-22 Biotec Pharmacon Asa Procédés de traitement ou de prévention de maladies inflammatoires du tractus intestinal
JP5242855B2 (ja) * 2010-07-29 2013-07-24 国立大学法人北海道大学 免疫アジュバント
WO2012105219A1 (fr) * 2011-01-31 2012-08-09 オリンパス株式会社 Médicament stimulant l'effet thérapeutique d'anticorps
EP3373006A1 (fr) 2012-04-30 2018-09-12 Biothera, Inc. Procédés d'immunothérapie par bêta-glucane
EP2832360A1 (fr) 2013-07-30 2015-02-04 Fresenius Kabi Deutschland GmbH Polysaccharide pour utilisation dans la prévention de la formation de métastases et/ou de rechute
JP6893594B2 (ja) * 2014-07-10 2021-06-23 ハイバーセル,インク. 腫瘍微小環境に影響する抗癌剤と組み合わせたβ−グルカン
US11815435B2 (en) 2017-02-24 2023-11-14 Hibercell, Inc. Beta glucan immunopharmacodynamics
BR112020018761A2 (pt) * 2018-03-13 2020-12-29 Hibercell, Inc. Imunoterapia combinada com beta-glucano e agonista de cd40
WO2019209890A1 (fr) 2018-04-24 2019-10-31 Memorial Sloan Kettering Cancer Center Procédés d'amélioration de l'immunogénicité de vaccins spécifiques d'un antigène faiblement immunogènes à l'aide de bêta-glucanes de levure oraux
WO2020061203A1 (fr) * 2018-09-21 2020-03-26 Nantcell, Inc. Procédés et compositions pour moduler des cellules suppressives d'origine myéloïde
JP7048102B2 (ja) 2019-05-23 2022-04-05 国立研究開発法人医薬基盤・健康・栄養研究所 免疫賦活活性を有する核酸多糖複合体の抗腫瘍薬としての応用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0759089A1 (fr) * 1994-04-29 1997-02-26 As Biotec-Mackzymal Traitement enzymatique des glycannnes
US5804199A (en) * 1993-07-26 1998-09-08 Akzo Nobel N. V. Oil-based and water-based adjuvant mixture
US20050208079A1 (en) * 2002-05-15 2005-09-22 Antonio Cassone Glucan-based vaccines

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340080C (fr) * 1985-03-11 1998-10-13 Dorothee Herlyn Methode de traitement des tumeurs chez l'humain
US5622939A (en) * 1992-08-21 1997-04-22 Alpha-Beta Technology, Inc. Glucan preparation
WO1991003495A1 (fr) * 1989-09-08 1991-03-21 Alpha Beta Technology, Inc. Procede de production de glucans solubles
US5801005A (en) * 1993-03-17 1998-09-01 University Of Washington Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated
US5696079A (en) * 1993-05-19 1997-12-09 The United States Of America As Represented By The Department Of Health And Human Services Immunologic enhancement with intermittent interleukin-2 therapy
WO1997035619A1 (fr) * 1996-03-28 1997-10-02 Genitrix, L.L.C. Cellules renforcees par opsonine, et procede de modulation d'une reponse immune a un antigene
JP2004507446A (ja) * 2000-02-04 2004-03-11 トーマス・ジェファーソン・ユニバーシティ 低用量ハプテン化腫瘍細胞および腫瘍細胞抽出物の免疫治療
US7507724B2 (en) * 2001-01-16 2009-03-24 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
EP1357919B1 (fr) * 2001-01-16 2017-04-05 Sloan-Kettering Institute For Cancer Research Glucane ameliorant une therapie
JP2006502167A (ja) * 2002-09-04 2006-01-19 バイオポリマー エンジニアリング,インコーポレイテッド 全グルカン粒子および抗体を用いた癌治療
US20070059310A1 (en) * 2005-05-03 2007-03-15 Karel Steven J Therapeutic combination compositions and methods of using same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5804199A (en) * 1993-07-26 1998-09-08 Akzo Nobel N. V. Oil-based and water-based adjuvant mixture
EP0759089A1 (fr) * 1994-04-29 1997-02-26 As Biotec-Mackzymal Traitement enzymatique des glycannnes
US20050208079A1 (en) * 2002-05-15 2005-09-22 Antonio Cassone Glucan-based vaccines

Also Published As

Publication number Publication date
EP1984004A4 (fr) 2010-03-03
JP2009528267A (ja) 2009-08-06
AU2008207369A1 (en) 2008-09-11
EP1984004A2 (fr) 2008-10-29
WO2007084661B1 (fr) 2008-01-10
WO2007084661A2 (fr) 2007-07-26
WO2007084661A3 (fr) 2007-11-08

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired