JP2009528065A5 - - Google Patents
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- Publication number
- JP2009528065A5 JP2009528065A5 JP2008557419A JP2008557419A JP2009528065A5 JP 2009528065 A5 JP2009528065 A5 JP 2009528065A5 JP 2008557419 A JP2008557419 A JP 2008557419A JP 2008557419 A JP2008557419 A JP 2008557419A JP 2009528065 A5 JP2009528065 A5 JP 2009528065A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- seq
- acta
- listeria bacterium
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091033319 polynucleotide Proteins 0.000 claims 16
- 102000040430 polynucleotide Human genes 0.000 claims 16
- 239000002157 polynucleotide Substances 0.000 claims 16
- 241000186781 Listeria Species 0.000 claims 9
- 125000000539 amino acid group Chemical group 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 230000001018 virulence Effects 0.000 claims 4
- 101000576802 Homo sapiens Mesothelin Proteins 0.000 claims 2
- 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 claims 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 102000050405 human PSCA Human genes 0.000 claims 2
- 229930182817 methionine Natural products 0.000 claims 2
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 239000004474 valine Substances 0.000 claims 2
- 102000015693 Actin Depolymerizing Factors Human genes 0.000 claims 1
- 108010038798 Actin Depolymerizing Factors Proteins 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- 241000186779 Listeria monocytogenes Species 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 239000012678 infectious agent Substances 0.000 claims 1
- 101150046348 inlB gene Proteins 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 230000009545 invasion Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 210000001539 phagocyte Anatomy 0.000 claims 1
- 150000003904 phospholipids Chemical group 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 101150093386 prfA gene Proteins 0.000 claims 1
- 101150027417 recU gene Proteins 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77847106P | 2006-03-01 | 2006-03-01 | |
| US60/778,471 | 2006-03-01 | ||
| US78457606P | 2006-03-21 | 2006-03-21 | |
| US60/784,576 | 2006-03-21 | ||
| US11/396,216 US20070207171A1 (en) | 2006-03-01 | 2006-03-30 | Engineered listeria and methods of use thereof |
| US11/395,197 | 2006-03-30 | ||
| US11/396,216 | 2006-03-30 | ||
| US11/395,197 US7935804B2 (en) | 2006-03-01 | 2006-03-30 | Engineered Listeria and methods of use thereof |
| PCT/US2007/005457 WO2007103225A2 (en) | 2006-03-01 | 2007-03-01 | Engineered listeria and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009528065A JP2009528065A (ja) | 2009-08-06 |
| JP2009528065A5 true JP2009528065A5 (cg-RX-API-DMAC7.html) | 2010-04-15 |
| JP5347135B2 JP5347135B2 (ja) | 2013-11-20 |
Family
ID=38475431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008557419A Expired - Fee Related JP5347135B2 (ja) | 2006-03-01 | 2007-03-01 | 遺伝子工学操作されたｌｉｓｔｅｒｉａおよびその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP1991263B8 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5347135B2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1991263T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2532942T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB2451014B (cg-RX-API-DMAC7.html) |
| PT (1) | PT1991263E (cg-RX-API-DMAC7.html) |
| SI (1) | SI1991263T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2007103225A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
| US7935804B2 (en) | 2006-03-01 | 2011-05-03 | Aduro Biotech | Engineered Listeria and methods of use thereof |
| DK2853269T3 (da) * | 2008-05-19 | 2019-08-05 | Advaxis Inc | Dobbelt indgivelsessystem til heterologe antigener, der omfatter en rekombinant Listeria-stamme svækket ved mutation af dal/dat og deletion af ActA, der omfatter et nukleinsyremolekyle, der koder for et listeriolysin O-prostataspecifikt antigenfusionsprotein |
| US9650639B2 (en) | 2008-05-19 | 2017-05-16 | Advaxis, Inc. | Dual delivery system for heterologous antigens |
| US9017660B2 (en) | 2009-11-11 | 2015-04-28 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors |
| US10016617B2 (en) | 2009-11-11 | 2018-07-10 | The Trustees Of The University Of Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers |
| CN102947452A (zh) * | 2010-05-23 | 2013-02-27 | 艾杜罗生物科技公司 | 使用用于癌症的辅佐治疗的李斯特菌属的方法和组合物 |
| CN107412756A (zh) | 2010-10-01 | 2017-12-01 | 宾夕法尼亚大学理事会 | 李斯特菌疫苗载体用于在寄生虫感染的个体中扭转免疫无应答的用途 |
| RS57630B1 (sr) * | 2010-11-17 | 2018-11-30 | Aduro Biotech Inc | Metode i sastavi za uzrokovanje imunog odgovora na egfrviii |
| CN103687611A (zh) | 2011-03-11 | 2014-03-26 | 阿德瓦希斯公司 | 基于李斯特菌属的佐剂 |
| US10058599B2 (en) | 2012-03-12 | 2018-08-28 | Advaxis, Inc. | Suppressor cell function inhibition following Listeria vaccine treatment |
| EP2916854A4 (en) * | 2012-11-06 | 2016-06-22 | Aduro Biotech Inc | BACTERIAL SPECIES WHICH CAN BE MISSED AND METHODS OF PREPARATION AND USE THEREOF |
| KR102160322B1 (ko) * | 2012-12-27 | 2020-09-25 | 아두로 바이오테크, 인코포레이티드 | 항원 서열의 리스테리아 발현을 용이하게 하는 신호 펩타이드 융합 상대 및 이의 제조방법 및 용도 |
| US10925945B2 (en) | 2014-10-13 | 2021-02-23 | Providence Health & Services-Oregon | Bacterial vaccines deficient in the 2-C-methyl-D-erythritol-4-phosphate pathway and methods of preparation and use thereof |
| CN107980044A (zh) | 2015-04-13 | 2018-05-01 | 艾杜罗生物科技公司 | 用于治疗癌症的免疫原性融合蛋白 |
| UY36616A (es) * | 2015-04-13 | 2016-10-31 | Aduro Biotech Inc | Fusiones de variante iii del receptor de factor de crecimiento epidérmico-mesotelina y métodos para usar los mismos |
| IL256381B2 (en) | 2015-06-26 | 2024-12-01 | Cerus Corp | Cryoprecipitate preparations and methods for their preparation |
| CA3003097A1 (en) | 2015-10-23 | 2017-04-27 | Cerus Corporation | Plasma compositions and methods of use thereof |
| AU2016369519B2 (en) | 2015-12-16 | 2023-04-20 | Seattle Project Corp. | Neoantigen identification, manufacture, and use |
| KR102497259B1 (ko) | 2016-06-23 | 2023-02-07 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | Ｌａｇ―３ 항체, 이의 항원-결합 단편 및 이의 약학적 용도 |
| WO2018119462A1 (en) | 2016-12-23 | 2018-06-28 | Cerus Corporation | Systems and methods for testing and screening using compound bound substrates |
| MX390725B (es) | 2017-03-03 | 2025-03-21 | Cerus Corp | Kits y metodos para preparar composiciones de plaquetas con patogeno inactivado. |
| CA3078744A1 (en) | 2017-10-10 | 2019-04-18 | Gritstone Oncology, Inc. | Neoantigen identification using hotspots |
| AU2018373154B2 (en) | 2017-11-22 | 2025-08-07 | Seattle Project Corp. | Reducing junction epitope presentation for neoantigens |
| KR102637862B1 (ko) | 2017-12-13 | 2024-02-19 | 이노비오 파마수티컬즈, 인크. | 메소텔린을 표적으로 하는 암 백신 및 이의 용도 |
| CA3087253A1 (en) | 2017-12-29 | 2019-07-04 | Cerus Corporation | Systems and methods for treating biological fluids |
| CN114173842A (zh) | 2019-06-22 | 2022-03-11 | 塞鲁斯公司 | 生物流体处理系统 |
| EP3991179A1 (en) | 2019-06-28 | 2022-05-04 | Cerus Corporation | System and methods for implementing a biological fluid treatment device |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6551784B2 (en) | 1989-06-07 | 2003-04-22 | Affymetrix Inc | Method of comparing nucleic acid sequences |
| US5783415A (en) | 1991-03-29 | 1998-07-21 | Genentech, Inc. | Method of producing an IL-8 receptor polypeptide |
| IT1262895B (it) | 1992-03-02 | 1996-07-22 | Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico. | |
| IL107366A (en) | 1992-10-23 | 2003-03-12 | Chugai Pharmaceutical Co Ltd | Genes coding for megakaryocyte potentiator |
| US6379943B1 (en) | 1999-03-05 | 2002-04-30 | Merck & Co., Inc. | High-efficiency Cre/loxp based system for construction of adenovirus vectors |
| US7662396B2 (en) * | 2001-03-26 | 2010-02-16 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing the immunogenicity of antigens |
| US5888530A (en) | 1995-07-21 | 1999-03-30 | The General Hospital Corporation | Method of enhancing delivery of a pharmaceutical formulation |
| ATE254931T1 (de) | 1996-01-05 | 2003-12-15 | Us Gov Health & Human Serv | Mesothelinantigen, verfahren und testsatz zur targetierung |
| US6809184B1 (en) | 1997-12-01 | 2004-10-26 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use |
| US6855320B2 (en) * | 2000-03-29 | 2005-02-15 | The Trustees Of The University Of Pennsylvania | Fusion of non-hemolytic, truncated form of listeriolysin O to antigens to enhance immunogenicity |
| AU2001255196A1 (en) * | 2000-03-29 | 2001-10-08 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing immunogenicity of antigens |
| AU6976201A (en) | 2000-06-09 | 2001-12-24 | Us Health | Pegylation of linkers improves antitumor activity and reduces toxicity of immunoconjugates |
| US7425449B2 (en) * | 2002-04-30 | 2008-09-16 | The Regents Of The University Of California | Site specific Listeria integration vectors and methods for using the same |
| AU2004224425B2 (en) | 2003-02-06 | 2010-06-24 | Aduro Biotech | Modified free-living microbes, vaccine compositions and methods of use thereof |
| KR101192652B1 (ko) * | 2003-02-06 | 2012-10-19 | 앤저 테라퓨틱스 인코퍼레이티드 | 비포식 세포로의 침투가 약화된 리스테리아, 리스테리아를 포함하는 백신, 및 그것의 사용방법 |
| US20050147621A1 (en) | 2003-10-10 | 2005-07-07 | Higgins Darren E. | Use of bacterial 5' untranslated regions for nucleic acid expression |
| US20050281783A1 (en) | 2003-10-15 | 2005-12-22 | Kinch Michael S | Listeria-based EphA2 vaccines |
| US7842289B2 (en) | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
| WO2005071088A2 (en) * | 2003-12-24 | 2005-08-04 | Cerus Corporation | Recombinant nucleic acid molecules encoding fusion proteins comprising antigens and bacterial secretory signal polypeptides, expression cassettes, and bacteria, and methods of use thereof |
| EP1786461A4 (en) * | 2004-08-13 | 2010-03-03 | Univ Pennsylvania | ANTIBIOTICINESIS-FREE DNA VACCINES |
| AU2005271246A1 (en) * | 2004-08-13 | 2006-02-16 | The Trustees Of The University Of Pennsylvania | Methods for constructing antibiotic resistance free vaccines |
-
2007
- 2007-03-01 EP EP07752174.8A patent/EP1991263B8/en not_active Not-in-force
- 2007-03-01 JP JP2008557419A patent/JP5347135B2/ja not_active Expired - Fee Related
- 2007-03-01 EP EP14193181.6A patent/EP2860253B1/en not_active Not-in-force
- 2007-03-01 WO PCT/US2007/005457 patent/WO2007103225A2/en not_active Ceased
- 2007-03-01 PT PT07752174T patent/PT1991263E/pt unknown
- 2007-03-01 GB GB0817892A patent/GB2451014B/en not_active Expired - Fee Related
- 2007-03-01 DK DK07752174T patent/DK1991263T3/en active
- 2007-03-01 SI SI200731608T patent/SI1991263T1/sl unknown
- 2007-03-01 ES ES07752174.8T patent/ES2532942T3/es active Active
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