JP2009525038A5 - - Google Patents
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- Publication number
- JP2009525038A5 JP2009525038A5 JP2008552885A JP2008552885A JP2009525038A5 JP 2009525038 A5 JP2009525038 A5 JP 2009525038A5 JP 2008552885 A JP2008552885 A JP 2008552885A JP 2008552885 A JP2008552885 A JP 2008552885A JP 2009525038 A5 JP2009525038 A5 JP 2009525038A5
- Authority
- JP
- Japan
- Prior art keywords
- plasmid
- promoter
- host cell
- expression system
- operator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013612 plasmid Substances 0.000 claims 19
- 238000000034 method Methods 0.000 claims 10
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 4
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 241000588724 Escherichia coli Species 0.000 claims 3
- 238000011144 upstream manufacturing Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims 1
- 101100084022 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) lapA gene Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 101150009573 phoA gene Proteins 0.000 claims 1
- 230000003362 replicative effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0602173.7A GB0602173D0 (en) | 2006-02-03 | 2006-02-03 | Expression system |
| GB0602173.7 | 2006-02-03 | ||
| PCT/GB2007/000351 WO2007088371A2 (en) | 2006-02-03 | 2007-02-01 | Expression system |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012255098A Division JP5713984B2 (ja) | 2006-02-03 | 2012-11-21 | 発現系 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009525038A JP2009525038A (ja) | 2009-07-09 |
| JP2009525038A5 true JP2009525038A5 (https=) | 2012-04-05 |
| JP5221385B2 JP5221385B2 (ja) | 2013-06-26 |
Family
ID=36100973
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552885A Active JP5221385B2 (ja) | 2006-02-03 | 2007-02-01 | 発現系 |
| JP2012255098A Active JP5713984B2 (ja) | 2006-02-03 | 2012-11-21 | 発現系 |
| JP2014168362A Pending JP2015006193A (ja) | 2006-02-03 | 2014-08-21 | 発現系 |
| JP2016031742A Active JP6298481B2 (ja) | 2006-02-03 | 2016-02-23 | 発現系 |
| JP2017041457A Active JP6571707B2 (ja) | 2006-02-03 | 2017-03-06 | 発現系 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012255098A Active JP5713984B2 (ja) | 2006-02-03 | 2012-11-21 | 発現系 |
| JP2014168362A Pending JP2015006193A (ja) | 2006-02-03 | 2014-08-21 | 発現系 |
| JP2016031742A Active JP6298481B2 (ja) | 2006-02-03 | 2016-02-23 | 発現系 |
| JP2017041457A Active JP6571707B2 (ja) | 2006-02-03 | 2017-03-06 | 発現系 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US8530188B2 (https=) |
| EP (6) | EP1984506B1 (https=) |
| JP (5) | JP5221385B2 (https=) |
| KR (3) | KR101624345B1 (https=) |
| CN (3) | CN102690834B (https=) |
| CA (2) | CA2959915C (https=) |
| DK (4) | DK2695943T3 (https=) |
| ES (3) | ES2569075T3 (https=) |
| GB (1) | GB0602173D0 (https=) |
| HU (1) | HUE027350T2 (https=) |
| PL (3) | PL2695943T3 (https=) |
| PT (2) | PT1984506E (https=) |
| SG (3) | SG169390A1 (https=) |
| WO (1) | WO2007088371A2 (https=) |
| ZA (2) | ZA200806238B (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0602173D0 (en) * | 2006-02-03 | 2006-03-15 | Avecia Ltd | Expression system |
| GB0709061D0 (en) * | 2007-05-11 | 2007-06-20 | Avecia Biolog Ltd | Expression system |
| GB0810154D0 (en) | 2008-06-04 | 2008-07-09 | Avecia Biolog Ltd | Expression vector |
| GB0905331D0 (en) * | 2009-03-27 | 2009-05-13 | Avecia Biolog Ltd | Expression process |
| GB201018664D0 (en) | 2010-11-05 | 2010-12-22 | Msd Biolog Uk Ltd | Expression process |
| GB201021795D0 (en) * | 2010-12-21 | 2011-02-02 | Msd Biolog Uk Ltd | Expression Process |
| GB201209896D0 (en) | 2012-06-01 | 2012-07-18 | Fujifilm Diosynth Biotechnologies Uk Ltd | Process |
| TW201514193A (zh) | 2013-01-31 | 2015-04-16 | Glaxo Group Ltd | 製備蛋白質之方法 |
| US9873891B2 (en) * | 2013-05-03 | 2018-01-23 | Fujifilm Diosynth Biotechnologies Uk Limited | Expression process |
| GB201311837D0 (en) | 2013-07-01 | 2013-08-14 | Fujifilm Diosynth Biotechnologies Uk Ltd | Expression Process |
| GB201319930D0 (en) | 2013-11-12 | 2013-12-25 | Fujifilm Diosynth Biotechnologies Uk Ltd | Expression process |
| JP6803328B2 (ja) * | 2014-08-28 | 2021-01-06 | シンセティック バイオロジクス，インコーポレイテッド | 大腸菌ベースでのベータラクタマーゼ生産 |
| US9791697B2 (en) | 2015-12-11 | 2017-10-17 | Panasonic Intellectual Property Management Co., Ltd. | Screen |
| EP3436610A1 (en) * | 2016-03-29 | 2019-02-06 | Geltor, Inc. | Expression of proteins in gram-negative bacteria wherein the ratio of periplasmic volume to cytoplasmic volume is between 0.5:1 and 10:1 |
| BR112018072043A2 (pt) | 2016-05-06 | 2019-02-12 | Glaxosmithkline Intellectual Property Development Limited | sequências de sinal e de ácido nucleico recombinantes, proteína de fusão recombinante, vetor de expressão recombinante, e, métodos para produzir uma proteína recombinante e controlar a viscosidade de um caldo de célula hospedeira e a expressão de uma proteína recombinante |
| GB201704659D0 (en) * | 2017-03-24 | 2017-05-10 | Fujifilm Diosynth Biotechnologies Uk Ltd | Expression system |
| US20230151071A1 (en) * | 2020-04-09 | 2023-05-18 | United States Government As Represented By The Department Of Veterans Affairs | Compositions comprising recombinant epo and methods of use thereof |
| US20230167467A1 (en) * | 2020-04-15 | 2023-06-01 | University of Alaska Anchorage | Methods and compositions for the production of isobutene |
| CN118488963A (zh) | 2021-12-17 | 2024-08-13 | 肯特大学 | 囊泡中生产重组生物分子的序列和方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8517071D0 (en) * | 1985-07-05 | 1985-08-14 | Hoffmann La Roche | Gram-positive expression control sequence |
| US5059530A (en) * | 1985-09-30 | 1991-10-22 | Suntory Ltd. | Expression vector for human TNF |
| JPS63267288A (ja) | 1986-12-26 | 1988-11-04 | Hoechst Japan Kk | 増幅された遺伝子によつて蛋白質を生産する方法およびそのための遺伝子 |
| US5510099A (en) * | 1987-05-01 | 1996-04-23 | Stratagene | Mutagenesis testing using transgenic non-human animals carrying test DNA sequences |
| US5223407A (en) * | 1988-08-31 | 1993-06-29 | Allelix Inc. | Excretion of heterologous proteins from e. coli |
| WO1991013979A1 (en) | 1990-03-05 | 1991-09-19 | President And Fellows Of Harvard College | Transgenic mouse overexpressing il-4 and method of use |
| DE4029844A1 (de) * | 1990-09-20 | 1992-03-26 | Boehringer Mannheim Gmbh | Carbamoylsarcosinhydrolase, kloniert |
| US5589392A (en) | 1991-01-14 | 1996-12-31 | Stratagene | Nucleic acid construct encoding a nuclear transport peptide operatively linked to an inducible promoter |
| GB2253210B (en) * | 1991-02-26 | 1995-06-07 | Ici Plc | Soluble heterologous polypeptide produced by culture of recombinant microorganisms |
| GB2253852B (en) | 1991-02-26 | 1995-03-22 | Ici Plc | Vector for expression of heterologous polypeptide comprising inducible selection system |
| CA2130081A1 (en) | 1992-02-14 | 1993-08-19 | Jay M. Short | Mutagenesis testing using transgenic non-human animals carrying test dna sequences |
| WO1998022578A1 (fr) | 1996-11-15 | 1998-05-28 | Institute Of Cytosignal Research, Inc. | Procedes servant a detecter et a isoler des genes |
| WO1998022581A1 (fr) | 1996-11-15 | 1998-05-28 | Institute Of Cytosignal Research, Inc. | Represseur de transcription |
| WO1999005279A1 (en) | 1997-07-25 | 1999-02-04 | Zeneca Limited | Mcp-1 analogs |
| GB9715660D0 (en) * | 1997-07-25 | 1997-10-01 | Zeneca Ltd | Proteins |
| EP1183357A2 (en) * | 1999-05-20 | 2002-03-06 | Scios Inc. | Vascular endothelial growth factor dimers |
| EP1373297A4 (en) | 2001-03-05 | 2005-09-21 | Univ Virginia | A LAC OPERATOR REPRESSOR SYSTEM |
| GB0113318D0 (en) | 2001-06-01 | 2001-07-25 | Lonza Biologics Plc | Method for production of a protein |
| GB0227346D0 (en) * | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| AU2003299732A1 (en) | 2002-12-18 | 2004-07-14 | Genpath Pharmaceuticals, Incorporated | Vectors for inducible rna interference |
| WO2005052151A1 (en) | 2003-11-19 | 2005-06-09 | Dow Global Technologies Inc. | Improved protein expression systems |
| US20060177895A1 (en) * | 2003-12-12 | 2006-08-10 | Chung Chan | Methods for enhancing expression of recombinant proteins |
| WO2005071089A2 (en) | 2004-01-12 | 2005-08-04 | Vertex Pharmaceuticals Incorporated | Dual host expression vector system and screening methods |
| JP4854202B2 (ja) * | 2004-03-31 | 2012-01-18 | 株式会社日本触媒 | 新規改変型ｓ−ヒドロキシニトリルリアーゼ |
| JP2005314252A (ja) * | 2004-04-27 | 2005-11-10 | Okayama Univ | 糖尿病性腎症の予防・治療剤 |
| JP2005341803A (ja) * | 2004-05-31 | 2005-12-15 | Institute Of Physical & Chemical Research | 非対称な塩基配列を認識して切断する酵素Ｉ−ＣｓｍＩ及びその製造方法 |
| GB0602173D0 (en) * | 2006-02-03 | 2006-03-15 | Avecia Ltd | Expression system |
| RU2006129690A (ru) | 2006-08-16 | 2008-02-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ СЕМЕЙСТВА Enterobacteriaceae, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНА ydiN, ГЕНА ydiB ИЛИ ИХ КОМБИНАЦИИ |
| US9388425B2 (en) | 2006-10-20 | 2016-07-12 | Trustees Of Boston University | Tunable genetic switch for regulating gene expression |
-
2006
- 2006-02-03 GB GBGB0602173.7A patent/GB0602173D0/en not_active Ceased
-
2007
- 2007-02-01 EP EP07712658.9A patent/EP1984506B1/en active Active
- 2007-02-01 PT PT77126589T patent/PT1984506E/pt unknown
- 2007-02-01 DK DK13191424.4T patent/DK2695943T3/en active
- 2007-02-01 PL PL13191424T patent/PL2695943T3/pl unknown
- 2007-02-01 CN CN201210056815.2A patent/CN102690834B/zh active Active
- 2007-02-01 EP EP11172434.0A patent/EP2390334B1/en not_active Not-in-force
- 2007-02-01 SG SG201100858-8A patent/SG169390A1/en unknown
- 2007-02-01 ES ES13191424.4T patent/ES2569075T3/es active Active
- 2007-02-01 DK DK07712658.9T patent/DK1984506T3/da active
- 2007-02-01 HU HUE13191424A patent/HUE027350T2/hu unknown
- 2007-02-01 ES ES11171994.4T patent/ES2445173T3/es active Active
- 2007-02-01 PL PL07712658T patent/PL1984506T3/pl unknown
- 2007-02-01 PL PL11171994T patent/PL2386642T3/pl unknown
- 2007-02-01 US US12/223,527 patent/US8530188B2/en active Active
- 2007-02-01 ES ES07712658.9T patent/ES2436883T3/es active Active
- 2007-02-01 SG SG201100857-0A patent/SG169389A1/en unknown
- 2007-02-01 CN CN2007800112768A patent/CN101410523B/zh active Active
- 2007-02-01 JP JP2008552885A patent/JP5221385B2/ja active Active
- 2007-02-01 CA CA2959915A patent/CA2959915C/en active Active
- 2007-02-01 KR KR1020147026047A patent/KR101624345B1/ko active Active
- 2007-02-01 EP EP13191424.4A patent/EP2695943B1/en active Active
- 2007-02-01 DK DK11172432.4T patent/DK2386644T3/en active
- 2007-02-01 EP EP11172432.4A patent/EP2386644B1/en active Active
- 2007-02-01 WO PCT/GB2007/000351 patent/WO2007088371A2/en not_active Ceased
- 2007-02-01 CA CA2637818A patent/CA2637818C/en active Active
- 2007-02-01 KR KR1020087018552A patent/KR101492844B1/ko active Active
- 2007-02-01 KR KR1020147017744A patent/KR101512776B1/ko active Active
- 2007-02-01 CN CN201810774783.7A patent/CN108841848B/zh active Active
- 2007-02-01 EP EP11172429.0A patent/EP2386643B1/en active Active
- 2007-02-01 PT PT111719944T patent/PT2386642E/pt unknown
- 2007-02-01 EP EP11171994.4A patent/EP2386642B1/en active Active
- 2007-02-01 SG SG201100856-2A patent/SG169388A1/en unknown
- 2007-02-01 DK DK11171994.4T patent/DK2386642T3/en active
-
2008
- 2008-07-17 ZA ZA200806238A patent/ZA200806238B/xx unknown
-
2010
- 2010-07-12 ZA ZA2010/04904A patent/ZA201004904B/en unknown
-
2012
- 2012-11-21 JP JP2012255098A patent/JP5713984B2/ja active Active
-
2013
- 2013-08-14 US US13/966,600 patent/US9677103B2/en active Active
-
2014
- 2014-08-21 JP JP2014168362A patent/JP2015006193A/ja active Pending
-
2016
- 2016-02-23 JP JP2016031742A patent/JP6298481B2/ja active Active
-
2017
- 2017-03-06 JP JP2017041457A patent/JP6571707B2/ja active Active
- 2017-05-08 US US15/588,851 patent/US11098335B2/en active Active
-
2021
- 2021-07-16 US US17/377,805 patent/US20210348205A1/en not_active Abandoned
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