GB0602173D0 - Expression system - Google Patents

Expression system

Info

Publication number
GB0602173D0
GB0602173D0 GBGB0602173.7A GB0602173A GB0602173D0 GB 0602173 D0 GB0602173 D0 GB 0602173D0 GB 0602173 A GB0602173 A GB 0602173A GB 0602173 D0 GB0602173 D0 GB 0602173D0
Authority
GB
United Kingdom
Prior art keywords
expression system
promoter
operator sequence
perfect palindrome
operator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0602173.7A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Diosynth Biotechnologies UK Ltd
Original Assignee
Avecia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Ltd filed Critical Avecia Ltd
Priority to GBGB0602173.7A priority Critical patent/GB0602173D0/en
Publication of GB0602173D0 publication Critical patent/GB0602173D0/en
Priority to DK11172432.4T priority patent/DK2386644T3/en
Priority to ES13191424.4T priority patent/ES2569075T3/es
Priority to ES11171994.4T priority patent/ES2445173T3/es
Priority to PCT/GB2007/000351 priority patent/WO2007088371A2/en
Priority to KR1020147026047A priority patent/KR101624345B1/ko
Priority to EP13191424.4A priority patent/EP2695943B1/en
Priority to SG201100858-8A priority patent/SG169390A1/en
Priority to KR1020147017744A priority patent/KR101512776B1/ko
Priority to SG201100857-0A priority patent/SG169389A1/en
Priority to CA2637818A priority patent/CA2637818C/en
Priority to US12/223,527 priority patent/US8530188B2/en
Priority to CN201810774783.7A priority patent/CN108841848B/zh
Priority to EP11172432.4A priority patent/EP2386644B1/en
Priority to DK11171994.4T priority patent/DK2386642T3/en
Priority to KR1020087018552A priority patent/KR101492844B1/ko
Priority to SG201100856-2A priority patent/SG169388A1/en
Priority to EP11172434.0A priority patent/EP2390334B1/en
Priority to ES07712658.9T priority patent/ES2436883T3/es
Priority to CN2007800112768A priority patent/CN101410523B/zh
Priority to PL07712658T priority patent/PL1984506T3/pl
Priority to DK13191424.4T priority patent/DK2695943T3/en
Priority to JP2008552885A priority patent/JP5221385B2/ja
Priority to PL13191424T priority patent/PL2695943T3/pl
Priority to PT77126589T priority patent/PT1984506E/pt
Priority to DK07712658.9T priority patent/DK1984506T3/da
Priority to CA2959915A priority patent/CA2959915C/en
Priority to EP11172429.0A priority patent/EP2386643B1/en
Priority to EP07712658.9A priority patent/EP1984506B1/en
Priority to PL11171994T priority patent/PL2386642T3/pl
Priority to EP11171994.4A priority patent/EP2386642B1/en
Priority to HUE13191424A priority patent/HUE027350T2/hu
Priority to CN201210056815.2A priority patent/CN102690834B/zh
Priority to PT111719944T priority patent/PT2386642E/pt
Priority to ZA200806238A priority patent/ZA200806238B/xx
Priority to ZA2010/04904A priority patent/ZA201004904B/en
Priority to JP2012255098A priority patent/JP5713984B2/ja
Priority to US13/966,600 priority patent/US9677103B2/en
Priority to JP2014168362A priority patent/JP2015006193A/ja
Priority to JP2016031742A priority patent/JP6298481B2/ja
Priority to JP2017041457A priority patent/JP6571707B2/ja
Priority to US15/588,851 priority patent/US11098335B2/en
Priority to US17/377,805 priority patent/US20210348205A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/72—Expression systems using regulatory sequences derived from the lac-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/73—Expression systems using phage (lambda) regulatory sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/78—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Pseudomonas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
GBGB0602173.7A 2006-02-03 2006-02-03 Expression system Ceased GB0602173D0 (en)

Priority Applications (43)

Application Number Priority Date Filing Date Title
GBGB0602173.7A GB0602173D0 (en) 2006-02-03 2006-02-03 Expression system
PT111719944T PT2386642E (pt) 2006-02-03 2007-02-01 Sistema de expressão
PL07712658T PL1984506T3 (pl) 2006-02-03 2007-02-01 System do ekspresji
DK13191424.4T DK2695943T3 (en) 2006-02-03 2007-02-01 Expression system
ES11171994.4T ES2445173T3 (es) 2006-02-03 2007-02-01 Sistema de expresión
PCT/GB2007/000351 WO2007088371A2 (en) 2006-02-03 2007-02-01 Expression system
KR1020147026047A KR101624345B1 (ko) 2006-02-03 2007-02-01 발현 시스템
EP13191424.4A EP2695943B1 (en) 2006-02-03 2007-02-01 Expression system
SG201100858-8A SG169390A1 (en) 2006-02-03 2007-02-01 Expression system
KR1020147017744A KR101512776B1 (ko) 2006-02-03 2007-02-01 발현 시스템
SG201100857-0A SG169389A1 (en) 2006-02-03 2007-02-01 Expression system
CA2637818A CA2637818C (en) 2006-02-03 2007-02-01 Expression system
US12/223,527 US8530188B2 (en) 2006-02-03 2007-02-01 Expression system
CN201810774783.7A CN108841848B (zh) 2006-02-03 2007-02-01 表达系统
EP11172432.4A EP2386644B1 (en) 2006-02-03 2007-02-01 Expression system
DK11171994.4T DK2386642T3 (en) 2006-02-03 2007-02-01 Expression system
KR1020087018552A KR101492844B1 (ko) 2006-02-03 2007-02-01 발현 시스템
SG201100856-2A SG169388A1 (en) 2006-02-03 2007-02-01 Expression system
EP11172434.0A EP2390334B1 (en) 2006-02-03 2007-02-01 Expression system
PL13191424T PL2695943T3 (pl) 2006-02-03 2007-02-01 System do ekspresji
CN2007800112768A CN101410523B (zh) 2006-02-03 2007-02-01 表达系统
DK11172432.4T DK2386644T3 (en) 2006-02-03 2007-02-01 Expression system
JP2008552885A JP5221385B2 (ja) 2006-02-03 2007-02-01 発現系
ES07712658.9T ES2436883T3 (es) 2006-02-03 2007-02-01 Sistema de expresión
ES13191424.4T ES2569075T3 (es) 2006-02-03 2007-02-01 Sistema de expresión
PT77126589T PT1984506E (pt) 2006-02-03 2007-02-01 Sistema de expressão
DK07712658.9T DK1984506T3 (da) 2006-02-03 2007-02-01 Ekspressionssystem
CA2959915A CA2959915C (en) 2006-02-03 2007-02-01 Expression system
EP11172429.0A EP2386643B1 (en) 2006-02-03 2007-02-01 Expression system
EP07712658.9A EP1984506B1 (en) 2006-02-03 2007-02-01 Expression system
PL11171994T PL2386642T3 (pl) 2006-02-03 2007-02-01 System ekspresyjny
EP11171994.4A EP2386642B1 (en) 2006-02-03 2007-02-01 Expression system
HUE13191424A HUE027350T2 (hu) 2006-02-03 2007-02-01 Expressziós rendszer
CN201210056815.2A CN102690834B (zh) 2006-02-03 2007-02-01 表达系统
ZA200806238A ZA200806238B (en) 2006-02-03 2008-07-17 Expression system
ZA2010/04904A ZA201004904B (en) 2006-02-03 2010-07-12 Expression system
JP2012255098A JP5713984B2 (ja) 2006-02-03 2012-11-21 発現系
US13/966,600 US9677103B2 (en) 2006-02-03 2013-08-14 Expression system
JP2014168362A JP2015006193A (ja) 2006-02-03 2014-08-21 発現系
JP2016031742A JP6298481B2 (ja) 2006-02-03 2016-02-23 発現系
JP2017041457A JP6571707B2 (ja) 2006-02-03 2017-03-06 発現系
US15/588,851 US11098335B2 (en) 2006-02-03 2017-05-08 Expression system
US17/377,805 US20210348205A1 (en) 2006-02-03 2021-07-16 Expression System

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0602173.7A GB0602173D0 (en) 2006-02-03 2006-02-03 Expression system

Publications (1)

Publication Number Publication Date
GB0602173D0 true GB0602173D0 (en) 2006-03-15

Family

ID=36100973

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0602173.7A Ceased GB0602173D0 (en) 2006-02-03 2006-02-03 Expression system

Country Status (15)

Country Link
US (4) US8530188B2 (https=)
EP (6) EP1984506B1 (https=)
JP (5) JP5221385B2 (https=)
KR (3) KR101624345B1 (https=)
CN (3) CN102690834B (https=)
CA (2) CA2959915C (https=)
DK (4) DK2695943T3 (https=)
ES (3) ES2569075T3 (https=)
GB (1) GB0602173D0 (https=)
HU (1) HUE027350T2 (https=)
PL (3) PL2695943T3 (https=)
PT (2) PT1984506E (https=)
SG (3) SG169390A1 (https=)
WO (1) WO2007088371A2 (https=)
ZA (2) ZA200806238B (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0602173D0 (en) * 2006-02-03 2006-03-15 Avecia Ltd Expression system
GB0709061D0 (en) * 2007-05-11 2007-06-20 Avecia Biolog Ltd Expression system
GB0810154D0 (en) 2008-06-04 2008-07-09 Avecia Biolog Ltd Expression vector
GB0905331D0 (en) * 2009-03-27 2009-05-13 Avecia Biolog Ltd Expression process
GB201018664D0 (en) 2010-11-05 2010-12-22 Msd Biolog Uk Ltd Expression process
GB201021795D0 (en) * 2010-12-21 2011-02-02 Msd Biolog Uk Ltd Expression Process
GB201209896D0 (en) 2012-06-01 2012-07-18 Fujifilm Diosynth Biotechnologies Uk Ltd Process
TW201514193A (zh) 2013-01-31 2015-04-16 Glaxo Group Ltd 製備蛋白質之方法
US9873891B2 (en) * 2013-05-03 2018-01-23 Fujifilm Diosynth Biotechnologies Uk Limited Expression process
GB201311837D0 (en) 2013-07-01 2013-08-14 Fujifilm Diosynth Biotechnologies Uk Ltd Expression Process
GB201319930D0 (en) 2013-11-12 2013-12-25 Fujifilm Diosynth Biotechnologies Uk Ltd Expression process
JP6803328B2 (ja) * 2014-08-28 2021-01-06 シンセティック バイオロジクス，インコーポレイテッド 大腸菌ベースでのベータラクタマーゼ生産
US9791697B2 (en) 2015-12-11 2017-10-17 Panasonic Intellectual Property Management Co., Ltd. Screen
EP3436610A1 (en) * 2016-03-29 2019-02-06 Geltor, Inc. Expression of proteins in gram-negative bacteria wherein the ratio of periplasmic volume to cytoplasmic volume is between 0.5:1 and 10:1
BR112018072043A2 (pt) 2016-05-06 2019-02-12 Glaxosmithkline Intellectual Property Development Limited sequências de sinal e de ácido nucleico recombinantes, proteína de fusão recombinante, vetor de expressão recombinante, e, métodos para produzir uma proteína recombinante e controlar a viscosidade de um caldo de célula hospedeira e a expressão de uma proteína recombinante
GB201704659D0 (en) * 2017-03-24 2017-05-10 Fujifilm Diosynth Biotechnologies Uk Ltd Expression system
US20230151071A1 (en) * 2020-04-09 2023-05-18 United States Government As Represented By The Department Of Veterans Affairs Compositions comprising recombinant epo and methods of use thereof
US20230167467A1 (en) * 2020-04-15 2023-06-01 University of Alaska Anchorage Methods and compositions for the production of isobutene
CN118488963A (zh) 2021-12-17 2024-08-13 肯特大学 囊泡中生产重组生物分子的序列和方法

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JP2005341803A (ja) * 2004-05-31 2005-12-15 Institute Of Physical & Chemical Research 非対称な塩基配列を認識して切断する酵素Ｉ−ＣｓｍＩ及びその製造方法
GB0602173D0 (en) * 2006-02-03 2006-03-15 Avecia Ltd Expression system
RU2006129690A (ru) 2006-08-16 2008-02-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ СЕМЕЙСТВА Enterobacteriaceae, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНА ydiN, ГЕНА ydiB ИЛИ ИХ КОМБИНАЦИИ
US9388425B2 (en) 2006-10-20 2016-07-12 Trustees Of Boston University Tunable genetic switch for regulating gene expression

Also Published As

Publication number Publication date
WO2007088371A3 (en) 2007-10-04
PT2386642E (pt) 2014-02-12
JP2017136072A (ja) 2017-08-10
JP6571707B2 (ja) 2019-09-04
JP2009525038A (ja) 2009-07-09
EP2386644B1 (en) 2015-12-16
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US11098335B2 (en) 2021-08-24
CN101410523A (zh) 2009-04-15
EP2386642A2 (en) 2011-11-16
EP2390334A2 (en) 2011-11-30
CN108841848B (zh) 2022-03-29
KR101512776B1 (ko) 2015-04-16
US20090170160A1 (en) 2009-07-02
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EP2695943A1 (en) 2014-02-12
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HUE027350T2 (hu) 2016-09-28
EP2386643A3 (en) 2012-11-28
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JP2016136959A (ja) 2016-08-04
EP2386642A3 (en) 2012-06-13
SG169390A1 (en) 2011-03-30
PT1984506E (pt) 2013-09-06
CA2959915A1 (en) 2007-08-09
SG169388A1 (en) 2011-03-30
US20210348205A1 (en) 2021-11-11
PL2695943T3 (pl) 2016-07-29
EP2390334B1 (en) 2016-08-10
ZA201004904B (en) 2011-03-30
US20170240943A1 (en) 2017-08-24
ES2445173T3 (es) 2014-02-28
EP1984506A2 (en) 2008-10-29
CN108841848A (zh) 2018-11-20
KR20140119202A (ko) 2014-10-08
CN102690834B (zh) 2018-09-04
JP2013078323A (ja) 2013-05-02
EP2386644A3 (en) 2012-11-28
ES2436883T3 (es) 2014-01-07
PL1984506T3 (pl) 2013-11-29
JP6298481B2 (ja) 2018-03-20
CA2959915C (en) 2022-11-15
KR20080098013A (ko) 2008-11-06
EP2386644A2 (en) 2011-11-16
EP2386643B1 (en) 2017-04-12
CN102690834A (zh) 2012-09-26
DK2386642T3 (en) 2014-02-17
JP2015006193A (ja) 2015-01-15
US9677103B2 (en) 2017-06-13
KR101492844B1 (ko) 2015-02-16
WO2007088371A2 (en) 2007-08-09
ZA200806238B (en) 2010-10-27
CA2637818A1 (en) 2007-08-09
CN101410523B (zh) 2012-05-16
CA2637818C (en) 2017-05-02
US20140065670A1 (en) 2014-03-06
KR20140090699A (ko) 2014-07-17
PL2386642T3 (pl) 2014-04-30
ES2569075T3 (es) 2016-05-06
US8530188B2 (en) 2013-09-10
EP1984506B1 (en) 2013-06-05
DK1984506T3 (da) 2013-09-16

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