JP2009524051A5 - - Google Patents
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- Publication number
- JP2009524051A5 JP2009524051A5 JP2008551261A JP2008551261A JP2009524051A5 JP 2009524051 A5 JP2009524051 A5 JP 2009524051A5 JP 2008551261 A JP2008551261 A JP 2008551261A JP 2008551261 A JP2008551261 A JP 2008551261A JP 2009524051 A5 JP2009524051 A5 JP 2009524051A5
- Authority
- JP
- Japan
- Prior art keywords
- hoxa5
- calm
- test compound
- leukemia
- dot1l
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 42
- 101150003074 hoxa5 gene Proteins 0.000 claims 40
- 238000000034 method Methods 0.000 claims 37
- 102100039489 Histone-lysine N-methyltransferase, H3 lysine-79 specific Human genes 0.000 claims 20
- 101000963360 Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-79 specific Proteins 0.000 claims 20
- 208000032839 leukemia Diseases 0.000 claims 17
- 108020001507 fusion proteins Proteins 0.000 claims 16
- 102000037865 fusion proteins Human genes 0.000 claims 16
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 16
- 230000003993 interaction Effects 0.000 claims 14
- 230000002265 prevention Effects 0.000 claims 13
- 230000011987 methylation Effects 0.000 claims 12
- 238000007069 methylation reaction Methods 0.000 claims 12
- 230000000694 effects Effects 0.000 claims 9
- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 claims 8
- 108010033040 Histones Proteins 0.000 claims 7
- 239000012472 biological sample Substances 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 102100033636 Histone H3.2 Human genes 0.000 claims 6
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 5
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 5
- 239000004472 Lysine Substances 0.000 claims 5
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims 4
- 101000718497 Homo sapiens Protein AF-10 Proteins 0.000 claims 4
- 102100026286 Protein AF-10 Human genes 0.000 claims 4
- 239000000523 sample Substances 0.000 claims 4
- 208000010581 Acute myeloid leukemia with minimal differentiation Diseases 0.000 claims 3
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 3
- 108010047956 Nucleosomes Proteins 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 210000001623 nucleosome Anatomy 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 2
- 238000004393 prognosis Methods 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000000423 cell based assay Methods 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 230000030648 nucleus localization Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76070906P | 2006-01-20 | 2006-01-20 | |
| US60/760,709 | 2006-01-20 | ||
| PCT/US2006/046612 WO2007087015A1 (en) | 2006-01-20 | 2006-12-06 | Diagnostic and therapeutic targets for leukemia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009524051A JP2009524051A (ja) | 2009-06-25 |
| JP2009524051A5 true JP2009524051A5 (enExample) | 2010-01-28 |
| JP5167149B2 JP5167149B2 (ja) | 2013-03-21 |
Family
ID=38309541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008551261A Expired - Fee Related JP5167149B2 (ja) | 2006-01-20 | 2006-12-06 | 白血病の診断および治療ターゲット |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8524467B2 (enExample) |
| EP (2) | EP1974055A4 (enExample) |
| JP (1) | JP5167149B2 (enExample) |
| AU (1) | AU2006336552B2 (enExample) |
| CA (1) | CA2623271A1 (enExample) |
| WO (1) | WO2007087015A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2841142C (en) | 2010-06-23 | 2020-12-15 | Ryan D. Morin | Biomarkers for non-hodgkin lymphomas and uses thereof |
| AU2011298987B2 (en) | 2010-09-10 | 2017-09-28 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
| US9175331B2 (en) | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
| TW201733984A (zh) | 2011-04-13 | 2017-10-01 | 雅酶股份有限公司 | 經取代之苯化合物 |
| JO3438B1 (ar) | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
| DK3184523T3 (da) | 2012-04-13 | 2019-08-19 | Epizyme Inc | N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4' -(morphofinomethyl)-[1,1'-biphenyl]-3-carboxamidhydrobromid til anvendelse i behandlingen af en sygdom med celleproliferation i det hæmatologiske system. |
| PE20150886A1 (es) | 2012-10-15 | 2015-06-04 | Epizyme Inc | Compuestos de benceno sustituidos |
| JP6639390B2 (ja) * | 2013-08-02 | 2020-02-05 | メモリアル スローン ケタリング キャンサー センター | Ｄｏｔ１ｌ阻害に反応する白血病の検出および治療方法 |
| SG11201602269QA (en) | 2013-10-16 | 2016-04-28 | Epizyme Inc | Hydrochloride salt form for ezh2 inhibition |
| JP7428717B2 (ja) * | 2019-01-15 | 2024-02-06 | ピーティーシー セラピューティクス， インコーポレイテッド | 急性骨髄性白血病の治療方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5420328A (en) | 1992-09-11 | 1995-05-30 | Affymax Technologies, N.V. | Methods for the synthesis of phosphonate esters |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US5525734A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies N.V. | Methods for synthesizing diverse collections of pyrrolidine compounds |
| US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
| US5817751A (en) | 1994-06-23 | 1998-10-06 | Affymax Technologies N.V. | Method for synthesis of diketopiperazine and diketomorpholine derivatives |
| AU7829398A (en) | 1997-06-09 | 1998-12-30 | University Of Southern California | A cancer diagnostic method based upon dna methylation differences |
| US6555329B2 (en) | 2000-06-09 | 2003-04-29 | Boehringer Ingelheim International Gmbh | Method for identifying compounds altering higher-order chromatin-dependent chromosome stability |
| WO2003016497A2 (en) | 2001-08-17 | 2003-02-27 | Incyte Genomics, Inc. | Molecules for disease detection and treatment |
| US7485414B2 (en) | 2002-08-30 | 2009-02-03 | Rigel Pharmaceuticals, Inc. | Modulators of angiogenesis |
| US7442685B2 (en) * | 2003-06-13 | 2008-10-28 | The University Of North Carolina At Chapel Hill | DOT1 histone methyltransferases as a target for identifying therapeutic agents for leukemia |
| WO2006025832A1 (en) | 2004-08-31 | 2006-03-09 | University Of North Carolina At Chapel Hill | Dot1 histone methyltransferases as a target for identifying therapeutic agents for leukemia |
-
2006
- 2006-12-06 AU AU2006336552A patent/AU2006336552B2/en not_active Ceased
- 2006-12-06 JP JP2008551261A patent/JP5167149B2/ja not_active Expired - Fee Related
- 2006-12-06 WO PCT/US2006/046612 patent/WO2007087015A1/en not_active Ceased
- 2006-12-06 EP EP06839119A patent/EP1974055A4/en not_active Withdrawn
- 2006-12-06 CA CA002623271A patent/CA2623271A1/en not_active Abandoned
- 2006-12-06 US US12/161,482 patent/US8524467B2/en not_active Expired - Fee Related
- 2006-12-06 EP EP13177872.2A patent/EP2730661A1/en not_active Withdrawn
-
2013
- 2013-07-29 US US13/953,190 patent/US20140044740A1/en not_active Abandoned
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