CA2623271A1 - Interaction between dot1l polypeptide and calm-af10 fusion protein as a therapeutic target for leukemia - Google Patents
Interaction between dot1l polypeptide and calm-af10 fusion protein as a therapeutic target for leukemia Download PDFInfo
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- CA2623271A1 CA2623271A1 CA002623271A CA2623271A CA2623271A1 CA 2623271 A1 CA2623271 A1 CA 2623271A1 CA 002623271 A CA002623271 A CA 002623271A CA 2623271 A CA2623271 A CA 2623271A CA 2623271 A1 CA2623271 A1 CA 2623271A1
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- calm
- hoxa5
- leukemia
- polypeptide
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- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
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- General Physics & Mathematics (AREA)
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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| WO (1) | WO2007087015A1 (enExample) |
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| US20130102477A1 (en) | 2010-06-23 | 2013-04-25 | Ryan D. Morin | Biomarkers for non-hodgkin lymphomas and uses thereof |
| US9175331B2 (en) | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
| RU2618475C2 (ru) | 2010-09-10 | 2017-05-03 | Эпизайм, Инк. | Ингибиторы ezh2 человека и способы их применения |
| TW201733984A (zh) | 2011-04-13 | 2017-10-01 | 雅酶股份有限公司 | 經取代之苯化合物 |
| JO3438B1 (ar) | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
| LT2836491T (lt) | 2012-04-13 | 2017-03-27 | Epizyme, Inc. | Žmogaus histono metiltransferazės ezh2 slopiklio druskos forma |
| CN105102431B (zh) | 2012-10-15 | 2018-03-02 | Epizyme股份有限公司 | 经取代的苯化合物 |
| EP3027774B1 (en) * | 2013-08-02 | 2020-07-15 | Memorial Sloan-Kettering Cancer Center | Methods for the detection and treatment of leukemias that are responsive to dot1l inhibition |
| CA2925889C (en) | 2013-10-16 | 2020-09-29 | Epizyme, Inc. | Hydrochloride salt form for ezh2 inhibition |
| EP3911418A1 (en) * | 2019-01-15 | 2021-11-24 | PTC Therapeutics, Inc. | Method for treating an acute myeloid leukemia |
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| US5420328A (en) | 1992-09-11 | 1995-05-30 | Affymax Technologies, N.V. | Methods for the synthesis of phosphonate esters |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US5525734A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies N.V. | Methods for synthesizing diverse collections of pyrrolidine compounds |
| US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
| US5817751A (en) | 1994-06-23 | 1998-10-06 | Affymax Technologies N.V. | Method for synthesis of diketopiperazine and diketomorpholine derivatives |
| AU7829398A (en) * | 1997-06-09 | 1998-12-30 | University Of Southern California | A cancer diagnostic method based upon dna methylation differences |
| US6555329B2 (en) * | 2000-06-09 | 2003-04-29 | Boehringer Ingelheim International Gmbh | Method for identifying compounds altering higher-order chromatin-dependent chromosome stability |
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| US7485414B2 (en) * | 2002-08-30 | 2009-02-03 | Rigel Pharmaceuticals, Inc. | Modulators of angiogenesis |
| US7442685B2 (en) * | 2003-06-13 | 2008-10-28 | The University Of North Carolina At Chapel Hill | DOT1 histone methyltransferases as a target for identifying therapeutic agents for leukemia |
| WO2006025832A1 (en) | 2004-08-31 | 2006-03-09 | University Of North Carolina At Chapel Hill | Dot1 histone methyltransferases as a target for identifying therapeutic agents for leukemia |
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| AU2006336552B2 (en) | 2012-12-20 |
| EP2730661A1 (en) | 2014-05-14 |
| JP2009524051A (ja) | 2009-06-25 |
| US8524467B2 (en) | 2013-09-03 |
| US20140044740A1 (en) | 2014-02-13 |
| WO2007087015A1 (en) | 2007-08-02 |
| JP5167149B2 (ja) | 2013-03-21 |
| EP1974055A4 (en) | 2010-01-27 |
| AU2006336552A1 (en) | 2007-08-02 |
| EP1974055A1 (en) | 2008-10-01 |
| US20090061443A1 (en) | 2009-03-05 |
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