JP2009523430A5 - - Google Patents
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- Publication number
- JP2009523430A5 JP2009523430A5 JP2008550555A JP2008550555A JP2009523430A5 JP 2009523430 A5 JP2009523430 A5 JP 2009523430A5 JP 2008550555 A JP2008550555 A JP 2008550555A JP 2008550555 A JP2008550555 A JP 2008550555A JP 2009523430 A5 JP2009523430 A5 JP 2009523430A5
- Authority
- JP
- Japan
- Prior art keywords
- aptamer
- test sample
- target molecule
- affinity complex
- aptamer affinity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091023037 Aptamer Proteins 0.000 claims 26
- 238000000034 method Methods 0.000 claims 25
- 239000000523 sample Substances 0.000 claims 23
- 238000012360 testing method Methods 0.000 claims 19
- 210000004027 cell Anatomy 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 150000004676 glycans Chemical class 0.000 claims 3
- 238000002372 labelling Methods 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 229920001282 polysaccharide Polymers 0.000 claims 3
- 239000005017 polysaccharide Substances 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- 108091093037 Peptide nucleic acid Proteins 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 230000003278 mimic effect Effects 0.000 claims 2
- 229920001542 oligosaccharide Polymers 0.000 claims 2
- 150000002482 oligosaccharides Chemical class 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 208000035657 Abasia Diseases 0.000 claims 1
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 238000001190 Q-PCR Methods 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 210000004381 amniotic fluid Anatomy 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 229960000633 dextran sulfate Drugs 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 230000000762 glandular Effects 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 210000002445 nipple Anatomy 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 1
- 150000004713 phosphodiesters Chemical class 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 229920000447 polyanionic polymer Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 210000000582 semen Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 210000001179 synovial fluid Anatomy 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75967506P | 2006-01-17 | 2006-01-17 | |
| US60/759,675 | 2006-01-17 | ||
| PCT/US2007/060557 WO2007084886A2 (en) | 2006-01-17 | 2007-01-16 | Multiplexed analyses of test samples |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014176974A Division JP6144654B2 (ja) | 2006-01-17 | 2014-09-01 | 試験試料の多重化分析 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009523430A JP2009523430A (ja) | 2009-06-25 |
| JP2009523430A5 true JP2009523430A5 (enExample) | 2010-01-28 |
| JP5680827B2 JP5680827B2 (ja) | 2015-03-04 |
Family
ID=38288365
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008550555A Active JP5680827B2 (ja) | 2006-01-17 | 2007-01-16 | 試験試料の多重化分析 |
| JP2014176974A Active JP6144654B2 (ja) | 2006-01-17 | 2014-09-01 | 試験試料の多重化分析 |
| JP2017021895A Active JP6768547B2 (ja) | 2006-01-17 | 2017-02-09 | 試験試料の多重化分析 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014176974A Active JP6144654B2 (ja) | 2006-01-17 | 2014-09-01 | 試験試料の多重化分析 |
| JP2017021895A Active JP6768547B2 (ja) | 2006-01-17 | 2017-02-09 | 試験試料の多重化分析 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20070166740A1 (enExample) |
| EP (3) | EP1994171B1 (enExample) |
| JP (3) | JP5680827B2 (enExample) |
| KR (1) | KR101149688B1 (enExample) |
| CN (1) | CN101374965B (enExample) |
| AU (1) | AU2007205974A1 (enExample) |
| CA (1) | CA2634987C (enExample) |
| DK (1) | DK1994171T3 (enExample) |
| ES (3) | ES2538121T3 (enExample) |
| HU (1) | HUE025489T2 (enExample) |
| PL (1) | PL1994171T3 (enExample) |
| PT (1) | PT1994171E (enExample) |
| SI (1) | SI1994171T1 (enExample) |
| TW (1) | TWI507528B (enExample) |
| WO (1) | WO2007084886A2 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20070166741A1 (en) | 1998-12-14 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
| EP2083269B1 (en) * | 2006-09-27 | 2013-09-04 | National University Corporation Tokyo University of Agriculture and Technology | Method of assaying target substance in sample, aptamer molecule and method of constructing the same |
| US7947447B2 (en) | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US7964356B2 (en) * | 2007-01-16 | 2011-06-21 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US9068216B2 (en) * | 2007-03-22 | 2015-06-30 | Bret T. Barnhizer | Methods and devices for rapid detection and identification of live microorganisms by aptamers and/or antibodies immobilized on permeable membranes |
| AU2013203386B2 (en) * | 2007-07-17 | 2015-10-08 | Somalogic Operating Co., Inc. | Method for generating aptamers with improved off-rates |
| AU2015261546B2 (en) * | 2007-07-17 | 2017-09-28 | Somalogic Operating Co., Inc. | Multiplexed analyses of test samples |
| SI2489743T1 (sl) * | 2007-07-17 | 2015-04-30 | Somalogic, Inc. | Aptameri s 5-(N-naftilno) substituiranimi uridini |
| GB0719367D0 (en) | 2007-10-03 | 2007-11-14 | Procarta Biosystems Ltd | Transcription factor decoys, compositions and methods |
| GB0906130D0 (en) * | 2008-10-03 | 2009-05-20 | Procrata Biosystems Ltd | Transcription factor decoys |
| US8236570B2 (en) | 2009-11-03 | 2012-08-07 | Infoscitex | Methods for identifying nucleic acid ligands |
| US8841429B2 (en) | 2009-11-03 | 2014-09-23 | Vivonics, Inc. | Nucleic acid ligands against infectious prions |
| GB201002413D0 (en) | 2010-02-12 | 2010-03-31 | Procarta Biosystems Ltd | Nucleic acid complexes |
| EP2542266A4 (en) | 2010-03-03 | 2013-10-23 | Somalogic Inc | 4-1BB-BINDING APTAMERS AND USE THEREOF IN THE TREATMENT OF DISEASES AND DISORDERS |
| EP2558586B1 (en) | 2010-04-12 | 2016-10-12 | Somalogic, Inc. | APTAMERS TO ß-NGF AND THEIR USE IN TREATING ß-NGF MEDIATED DISEASES AND DISORDERS |
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| CN103616423A (zh) * | 2013-12-02 | 2014-03-05 | 济南大学 | 一种检测土霉素的竞争型适配体传感器的制备方法及应用 |
| KR101506147B1 (ko) * | 2013-12-13 | 2015-03-26 | 삼성전자 주식회사 | 시약 세트, 시료 검사방법, 미세유동장치 및 검사장치 |
| US10093933B2 (en) * | 2014-02-18 | 2018-10-09 | Somalogic, Inc. | Compositions and methods for detecting microorganisms |
| CN106574925B (zh) * | 2014-05-23 | 2019-07-26 | 萤火虫生物股份有限公司 | 用于生物测定的底物介导的反应器 |
| NO2718257T3 (enExample) * | 2014-05-30 | 2018-04-14 | ||
| US10138486B2 (en) | 2015-03-12 | 2018-11-27 | The Regents Of The University Of Michigan | Inhibitors of DEK protein and related methods |
| ES3013534T3 (en) | 2016-07-01 | 2025-04-14 | Somalogic Operating Co Inc | Oligonucleotides comprising modified nucleosides |
| US11041849B2 (en) | 2016-12-01 | 2021-06-22 | Aptitude Medical Systems, Inc. | Methods and systems for identifying candidate nucleic acid agent |
| WO2018180987A1 (ja) * | 2017-03-29 | 2018-10-04 | 東洋紡株式会社 | 核酸の検出方法 |
| WO2019067415A1 (en) * | 2017-09-27 | 2019-04-04 | Bio-Rad Laboratories, Inc. | DIGITAL AFFINITY LINK ASSAY |
| JP7217913B2 (ja) * | 2018-02-16 | 2023-02-06 | 株式会社日立ハイテクサイエンス | プラスチック標準物質の製造方法 |
| CA3095781A1 (en) * | 2018-04-03 | 2019-10-10 | The Royal Institution For The Advancement Of Learning/Mcgill University | Colocalization-by-linkage sandwich assays |
| CN112105743B (zh) * | 2018-06-08 | 2024-09-13 | 乌尔蒂维尤股份有限公司 | 复用型催化报告分子沉积 |
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| JP7153494B2 (ja) * | 2018-07-27 | 2022-10-14 | シスメックス株式会社 | 生体粒子の測定方法、非特異シグナルの検出方法、生体粒子測定方法及び生体粒子を検出するための試薬キット |
| KR102129937B1 (ko) * | 2018-07-31 | 2020-07-03 | 재단법인 아산사회복지재단 | 종이기반 핵산검출용 키트 및 pcr 증폭산물을 분석하기 위한 방법 |
| CN110824168B (zh) * | 2018-08-10 | 2023-06-09 | 天津医科大学 | 一种多肽探针及其在翻译后修饰的结合蛋白鉴定中的应用 |
| KR102526641B1 (ko) * | 2018-10-25 | 2023-04-26 | 티엘 제노믹스 인크. | 미세유로에 의한 혈구의 분급을 위한 혈액의 전처리 |
| LU101073B1 (en) | 2018-12-21 | 2020-06-24 | Luxembourg Inst Science & Tech List | Dna aptamers specific of adenovirus types |
| CN113624724A (zh) * | 2020-05-07 | 2021-11-09 | 廖世奇 | 一种适配体分子信标对靶分子的多元检测分析方法 |
| CN111735869A (zh) * | 2020-05-29 | 2020-10-02 | 中山大学 | 一种蛋白质的检测试剂及检测方法 |
| CN112180102B (zh) * | 2020-09-29 | 2022-06-14 | 郑州安图生物工程股份有限公司 | 花生过敏原特异性IgE定量检测试剂、试剂盒及其应用 |
| MX2023012081A (es) | 2021-04-13 | 2023-10-25 | Somalogic Operating Co Inc | Nucleosidos modificados. |
| CN113122544A (zh) * | 2021-04-25 | 2021-07-16 | 杭州广科安德生物科技有限公司 | 一种特异性结合timp1蛋白的核酸适配体及其应用 |
| CN113720894B (zh) * | 2021-09-02 | 2022-07-08 | 清华大学 | 一种直接采样电离分析系统及方法、应用 |
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-
2007
- 2007-01-16 SI SI200731656T patent/SI1994171T1/sl unknown
- 2007-01-16 AU AU2007205974A patent/AU2007205974A1/en not_active Abandoned
- 2007-01-16 ES ES13158346.0T patent/ES2538121T3/es active Active
- 2007-01-16 EP EP07718147.7A patent/EP1994171B1/en active Active
- 2007-01-16 WO PCT/US2007/060557 patent/WO2007084886A2/en not_active Ceased
- 2007-01-16 HU HUE07718147A patent/HUE025489T2/en unknown
- 2007-01-16 TW TW096101613A patent/TWI507528B/zh active
- 2007-01-16 CN CN2007800032689A patent/CN101374965B/zh active Active
- 2007-01-16 DK DK07718147.7T patent/DK1994171T3/en active
- 2007-01-16 ES ES07718147.7T patent/ES2538038T3/es active Active
- 2007-01-16 ES ES15158380.4T patent/ES2644499T3/es active Active
- 2007-01-16 PL PL07718147T patent/PL1994171T3/pl unknown
- 2007-01-16 CA CA2634987A patent/CA2634987C/en active Active
- 2007-01-16 KR KR1020087017428A patent/KR101149688B1/ko active Active
- 2007-01-16 EP EP13158346.0A patent/EP2613147B1/en active Active
- 2007-01-16 US US11/623,535 patent/US20070166740A1/en not_active Abandoned
- 2007-01-16 JP JP2008550555A patent/JP5680827B2/ja active Active
- 2007-01-16 EP EP15158380.4A patent/EP2952894B1/en active Active
- 2007-01-16 PT PT77181477T patent/PT1994171E/pt unknown
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2014
- 2014-09-01 JP JP2014176974A patent/JP6144654B2/ja active Active
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2017
- 2017-02-09 JP JP2017021895A patent/JP6768547B2/ja active Active
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