JP2009523010A5 - - Google Patents

Info

Publication number

JP2009523010A5

JP2009523010A5 JP2008538188A JP2008538188A JP2009523010A5 JP 2009523010 A5 JP2009523010 A5 JP 2009523010A5 JP 2008538188 A JP2008538188 A JP 2008538188A JP 2008538188 A JP2008538188 A JP 2008538188A JP 2009523010 A5 JP2009523010 A5 JP 2009523010A5

Authority

JP

Japan

Prior art keywords

formulation

antibody

motomeko

seq

administered

Prior art date

2006-10-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000000203 mixture Substances 0.000 claims 28
• 239000004480 active ingredient Substances 0.000 claims 12
• 108010060818 Toll-Like Receptor 9 Proteins 0.000 claims 10
• 102100033117 Toll-like receptor 9 Human genes 0.000 claims 10
• 125000003275 alpha amino acid group Chemical group 0.000 claims 10
• 239000008194 pharmaceutical composition Substances 0.000 claims 10
• 229940044616 toll-like receptor 7 agonist Drugs 0.000 claims 10
• 208000036142 Viral infection Diseases 0.000 claims 8
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• 102000040430 polynucleotide Human genes 0.000 claims 7
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• 102000014150 Interferons Human genes 0.000 claims 6
• 102000045716 human TLR3 Human genes 0.000 claims 6
• 229960002751 imiquimod Drugs 0.000 claims 6
• DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical group C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 claims 6
• 229960001438 immunostimulant agent Drugs 0.000 claims 6
• 239000003022 immunostimulating agent Substances 0.000 claims 6
• 229940079322 interferon Drugs 0.000 claims 6
• 229950010550 resiquimod Drugs 0.000 claims 6
• BXNMTOQRYBFHNZ-UHFFFAOYSA-N resiquimod Chemical compound C1=CC=CC2=C(N(C(COCC)=N3)CC(C)(C)O)C3=C(N)N=C21 BXNMTOQRYBFHNZ-UHFFFAOYSA-N 0.000 claims 6
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• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
• 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
• 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 1
• 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 1
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• 102000004127 Cytokines Human genes 0.000 claims 1
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• -1 MIP1-α Proteins 0.000 claims 1
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• 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
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• 102000002689 Toll-like receptor Human genes 0.000 claims 1
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