JP2009522316A - 抗ｅｇｆｒ抗体と抗ｈｅｒ２抗体を用いる併用療法 - Google Patents
抗ｅｇｆｒ抗体と抗ｈｅｒ２抗体を用いる併用療法 Download PDFInfo
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- IHIXIJGXTJIKRB-UHFFFAOYSA-N trisodium vanadate Chemical compound [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O IHIXIJGXTJIKRB-UHFFFAOYSA-N 0.000 description 1
- 230000004565 tumor cell growth Effects 0.000 description 1
- 229960001055 uracil mustard Drugs 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 208000024719 uterine cervix neoplasm Diseases 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06000107 | 2006-01-04 | ||
| PCT/EP2006/012133 WO2007076923A1 (en) | 2006-01-04 | 2006-12-15 | Combination therapy using anti-egfr and anti-her2 antibodies |
Publications (2)
| Publication Number | Publication Date |
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| JP2009522316A true JP2009522316A (ja) | 2009-06-11 |
| JP2009522316A5 JP2009522316A5 (enExample) | 2010-02-12 |
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| JP2008548941A Pending JP2009522316A (ja) | 2006-01-04 | 2006-12-15 | 抗ｅｇｆｒ抗体と抗ｈｅｒ２抗体を用いる併用療法 |
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| US (2) | US20090214541A1 (enExample) |
| EP (1) | EP1968633B2 (enExample) |
| JP (1) | JP2009522316A (enExample) |
| KR (1) | KR20080110987A (enExample) |
| CN (1) | CN101365486B (enExample) |
| AR (1) | AR059127A1 (enExample) |
| AU (1) | AU2006332212B8 (enExample) |
| BR (1) | BRPI0620888A2 (enExample) |
| CA (1) | CA2636074A1 (enExample) |
| EA (1) | EA015173B1 (enExample) |
| MX (1) | MX2008008564A (enExample) |
| WO (1) | WO2007076923A1 (enExample) |
| ZA (1) | ZA200806723B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| EP2163256B1 (en) | 2001-05-11 | 2015-09-02 | Ludwig Institute for Cancer Research Ltd. | Specific binding proteins and uses thereof |
| US10118970B2 (en) * | 2006-08-30 | 2018-11-06 | Genentech, Inc. | Multispecific antibodies |
| MX338185B (es) | 2007-01-25 | 2016-04-05 | Dana Farber Cancer Inst Inc | Uso de anticuerpos anti-egfr en el tratamiento de enfermedad mediada por egfr mutante. |
| EP2134854B1 (en) | 2007-03-15 | 2015-04-15 | Ludwig Institute for Cancer Research Ltd. | Treatment method using egfr antibodies and src inhibitors and related formulations |
| WO2009023265A1 (en) | 2007-08-14 | 2009-02-19 | Ludwig Institute For Cancer Research | Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof |
| KR101642846B1 (ko) * | 2007-12-26 | 2016-07-26 | 백시넥스 인코포레이티드 | 항-ｃ35 항체 병용 치료 및 방법 |
| WO2010027981A1 (en) * | 2008-09-03 | 2010-03-11 | Genentech, Inc. | Multispecific antibodies |
| EP2337800B1 (en) | 2008-09-15 | 2013-10-02 | Yeda Research and Development Co. Ltd. | Antibody combinations and use of same for treating cancer |
| US8728479B2 (en) * | 2009-03-31 | 2014-05-20 | The Trustees Of The University Of Pennsylvania | Antigen-binding proteins comprising recombinant protein scaffolds |
| CN102770456B (zh) * | 2009-12-04 | 2018-04-06 | 弗·哈夫曼-拉罗切有限公司 | 多特异性抗体、抗体类似物、组合物和方法 |
| US8609095B2 (en) * | 2010-03-04 | 2013-12-17 | Symphogen A/S | Anti-HER2 antibodies and compositions |
| US9155802B2 (en) | 2010-11-01 | 2015-10-13 | Symphogen A/S | Pan-HER antibody composition |
| EP2710038B1 (en) | 2011-05-16 | 2018-01-17 | Yeda Research and Development Co. Ltd. | COMBINATIONS OF ANTI ErbB ANTIBODIES FOR THE TREATMENT OF CANCER |
| US9527913B2 (en) | 2012-05-02 | 2016-12-27 | Symphogen A/S | Humanized pan-HER antibody compositions |
| US10562974B2 (en) | 2013-03-13 | 2020-02-18 | University Of Kentucky Research Foundation | Methods of administering IgG1 antibodies and methods of suppressing angiogenesis |
| WO2014139131A1 (en) * | 2013-03-14 | 2014-09-18 | Crown Bioscience, Inc. | Use of egfr biomarkers for the treatment of gastric cancer with anti-egfr agents |
| KR102361237B1 (ko) * | 2013-07-11 | 2022-02-09 | 더 스크립스 리서치 인스티튜트 | 코일드 코일 면역글로불린 융합 단백질 및 이것의 조성물 |
| JP2016538283A (ja) | 2013-11-13 | 2016-12-08 | ザイムワークス，インコーポレイテッド | Ｅｇｆｒ及び／またはｈｅｒ２を標的にする一価抗原結合性構築物及びその使用 |
| DK3186283T3 (da) * | 2014-08-29 | 2020-03-02 | Hoffmann La Roche | Kombinationsbehandling med tumormålrettede IL-2- immuncytokinervarianter og antistoffer mod humant PD-L1 |
| CN104991065B (zh) * | 2015-07-07 | 2017-01-11 | 复旦大学附属金山医院 | 一种用于诊断乳腺癌的三联标志物及其应用 |
| JP2018062980A (ja) * | 2016-10-12 | 2018-04-19 | 株式会社ジェイテクト | ボールネジ装置、ボールネジ装置の製造方法及びステアリング装置 |
| AU2017387909A1 (en) * | 2016-12-28 | 2019-06-27 | Genentech, Inc. | Treatment of advanced HER2 expressing cancer |
| CN117915950A (zh) * | 2021-08-06 | 2024-04-19 | 甘李药业股份有限公司 | 一种多特异性抗体及其用途 |
| CN117430707B (zh) * | 2023-10-25 | 2024-04-19 | 重庆天科雅生物科技有限公司 | 一种cik细胞的制备方法及其在治疗癌症中的用途 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2005077414A1 (de) * | 2004-02-12 | 2005-08-25 | Merck Patent Gmbh | Hochkonzentrierte, flüssige formulierungen von anti-egfr-antikörpern |
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| WO1989006692A1 (en) * | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| AU4128089A (en) | 1988-09-15 | 1990-03-22 | Rorer International (Overseas) Inc. | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same |
| WO1992015683A1 (en) * | 1991-03-06 | 1992-09-17 | MERCK Patent Gesellschaft mit beschränkter Haftung | Humanized and chimeric monoclonal antibodies |
| EP0940468A1 (en) * | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Humanized antibody variable domain |
| US6410690B1 (en) * | 1995-06-07 | 2002-06-25 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
| US20030086924A1 (en) | 1999-06-25 | 2003-05-08 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
| MXPA05003796A (es) * | 2002-10-10 | 2006-02-22 | Merck Patent Gmbh | Anticuerpos anti-erb-b biespecificos y su uso en terapia de tumor. |
| PE20070207A1 (es) * | 2005-07-22 | 2007-03-09 | Genentech Inc | Tratamiento combinado de los tumores que expresan el her |
-
2006
- 2006-12-15 CA CA002636074A patent/CA2636074A1/en not_active Abandoned
- 2006-12-15 CN CN2006800503998A patent/CN101365486B/zh not_active Expired - Fee Related
- 2006-12-15 JP JP2008548941A patent/JP2009522316A/ja active Pending
- 2006-12-15 US US12/086,725 patent/US20090214541A1/en not_active Abandoned
- 2006-12-15 AU AU2006332212A patent/AU2006332212B8/en not_active Ceased
- 2006-12-15 BR BRPI0620888-6A patent/BRPI0620888A2/pt not_active IP Right Cessation
- 2006-12-15 KR KR1020087019157A patent/KR20080110987A/ko not_active Withdrawn
- 2006-12-15 MX MX2008008564A patent/MX2008008564A/es not_active Application Discontinuation
- 2006-12-15 WO PCT/EP2006/012133 patent/WO2007076923A1/en not_active Ceased
- 2006-12-15 EP EP06829664.9A patent/EP1968633B2/en not_active Not-in-force
- 2006-12-15 EA EA200870141A patent/EA015173B1/ru not_active IP Right Cessation
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2007
- 2007-01-03 AR ARP070100020A patent/AR059127A1/es unknown
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2008
- 2008-08-01 ZA ZA200806723A patent/ZA200806723B/xx unknown
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2014
- 2014-11-10 US US14/536,854 patent/US9522956B2/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005077414A1 (de) * | 2004-02-12 | 2005-08-25 | Merck Patent Gmbh | Hochkonzentrierte, flüssige formulierungen von anti-egfr-antikörpern |
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| JPN6012011545; Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｊｏｕｒｎａｌ ｏｆ Ｃａｎｃｅｒ ｖｏｌ．１０９, 2004, ｐ．２９１-３０１ * |
| JPN6012011548; Ｏｎｃｏｇｅｎｅ ｖｏｌ．１８, 1999, ｐ．７３１-７３８ * |
| JPN6012011550; Ｃａｎｃｅｒ Ｌｅｔｔｅｒｓ ｖｏｌ．２３０, 2005, ｐ．３３-４６ * |
| JPN6012011554; Ａｎｎａｌｓ ｏｆ Ｏｎｃｏｌｏｇｙ ｖｏｌ．１３, 2002, ｐ．６５-７２ * |
| JPN6012011556; Ｃａｎｃｅｒ ｖｏｌ．８９， ｎｏ．１, 2000, ｐ．７４-８２ * |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP1968633B1 (en) | 2014-02-12 |
| AU2006332212B2 (en) | 2013-03-28 |
| ZA200806723B (en) | 2009-09-30 |
| MX2008008564A (es) | 2009-01-29 |
| EA015173B1 (ru) | 2011-06-30 |
| BRPI0620888A2 (pt) | 2011-11-29 |
| AR059127A1 (es) | 2008-03-12 |
| EA200870141A1 (ru) | 2009-02-27 |
| CN101365486A (zh) | 2009-02-11 |
| US20150132308A1 (en) | 2015-05-14 |
| AU2006332212B8 (en) | 2013-05-30 |
| WO2007076923A1 (en) | 2007-07-12 |
| US9522956B2 (en) | 2016-12-20 |
| AU2006332212A1 (en) | 2007-07-12 |
| EP1968633B2 (en) | 2017-11-01 |
| US20090214541A1 (en) | 2009-08-27 |
| CA2636074A1 (en) | 2007-07-12 |
| KR20080110987A (ko) | 2008-12-22 |
| EP1968633A1 (en) | 2008-09-17 |
| CN101365486B (zh) | 2012-10-31 |
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