EA015173B1 - Комбинированная терапия с использованием антител к egfr и her2 - Google Patents
Комбинированная терапия с использованием антител к egfr и her2 Download PDFInfo
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- EA015173B1 EA015173B1 EA200870141A EA200870141A EA015173B1 EA 015173 B1 EA015173 B1 EA 015173B1 EA 200870141 A EA200870141 A EA 200870141A EA 200870141 A EA200870141 A EA 200870141A EA 015173 B1 EA015173 B1 EA 015173B1
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- antibodies
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- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06000107 | 2006-01-04 | ||
| PCT/EP2006/012133 WO2007076923A1 (en) | 2006-01-04 | 2006-12-15 | Combination therapy using anti-egfr and anti-her2 antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200870141A1 EA200870141A1 (ru) | 2009-02-27 |
| EA015173B1 true EA015173B1 (ru) | 2011-06-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200870141A EA015173B1 (ru) | 2006-01-04 | 2006-12-15 | Комбинированная терапия с использованием антител к egfr и her2 |
Country Status (13)
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| EP (1) | EP1968633B2 (enExample) |
| JP (1) | JP2009522316A (enExample) |
| KR (1) | KR20080110987A (enExample) |
| CN (1) | CN101365486B (enExample) |
| AR (1) | AR059127A1 (enExample) |
| AU (1) | AU2006332212B8 (enExample) |
| BR (1) | BRPI0620888A2 (enExample) |
| CA (1) | CA2636074A1 (enExample) |
| EA (1) | EA015173B1 (enExample) |
| MX (1) | MX2008008564A (enExample) |
| WO (1) | WO2007076923A1 (enExample) |
| ZA (1) | ZA200806723B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2710354C2 (ru) * | 2014-08-29 | 2019-12-25 | Ф.Хоффманн-Ля Рош Аг | Комбинированная терапия на основе нацеленных на опухоль иммуноцитокинов, содержащих вариант il-2, и антител к человеческому pd-l1 |
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| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| PT2163256E (pt) | 2001-05-11 | 2015-11-20 | Ludwig Inst For Cancer Res Ltd | Proteínas de ligação específica e suas utilizações |
| US10118970B2 (en) | 2006-08-30 | 2018-11-06 | Genentech, Inc. | Multispecific antibodies |
| ES2609094T3 (es) | 2007-01-25 | 2017-04-18 | Dana-Farber Cancer Institute, Inc. | Uso de anticuerpos anti-EGFR en el tratamiento de enfermedades mediadas por un EGFR mutante |
| CA2680854C (en) | 2007-03-15 | 2017-02-14 | Ludwig Institute For Cancer Research | Treatment method using egfr antibodies and src inhibitors and related formulations |
| EP2188311B1 (en) | 2007-08-14 | 2016-10-05 | Ludwig Institute for Cancer Research Ltd. | Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof |
| NZ586544A (en) * | 2007-12-26 | 2012-07-27 | Vaccinex Inc | Anti-c35 antibody in combination with an ani-her2 antibody in cancer therapies and methods |
| US8193321B2 (en) | 2008-09-03 | 2012-06-05 | Genentech, Inc. | Multispecific antibodies |
| EP2337800B1 (en) | 2008-09-15 | 2013-10-02 | Yeda Research and Development Co. Ltd. | Antibody combinations and use of same for treating cancer |
| US8728479B2 (en) * | 2009-03-31 | 2014-05-20 | The Trustees Of The University Of Pennsylvania | Antigen-binding proteins comprising recombinant protein scaffolds |
| EP3778917A3 (en) * | 2009-12-04 | 2021-06-09 | F. Hoffmann-La Roche AG | Multispecific antibodies, antibody analogs, compositions, and methods |
| US8609095B2 (en) * | 2010-03-04 | 2013-12-17 | Symphogen A/S | Anti-HER2 antibodies and compositions |
| US9155802B2 (en) | 2010-11-01 | 2015-10-13 | Symphogen A/S | Pan-HER antibody composition |
| WO2012156975A1 (en) | 2011-05-16 | 2012-11-22 | Yeda Research And Development Co. Ltd. | COMBINATIONS OF ANTI ErbB ANTIBODIES FOR THE TREATMENT OF CANCER |
| BR112014027291A2 (pt) | 2012-05-02 | 2017-08-08 | Symphogen As | composições de anticorpos pan-her humanizados |
| EP2968556A1 (en) | 2013-03-13 | 2016-01-20 | University Of Kentucky Research Foundation | Methods of administering igg1 antibodies and methods of suppressing angiogenesis |
| WO2014139131A1 (en) * | 2013-03-14 | 2014-09-18 | Crown Bioscience, Inc. | Use of egfr biomarkers for the treatment of gastric cancer with anti-egfr agents |
| US10683353B2 (en) | 2013-07-11 | 2020-06-16 | The Scripps Research Institute | Coiled coil immunoglobulin fusion proteins and compositions thereof |
| JP2016538283A (ja) | 2013-11-13 | 2016-12-08 | ザイムワークス，インコーポレイテッド | Ｅｇｆｒ及び／またはｈｅｒ２を標的にする一価抗原結合性構築物及びその使用 |
| CN104991065B (zh) * | 2015-07-07 | 2017-01-11 | 复旦大学附属金山医院 | 一种用于诊断乳腺癌的三联标志物及其应用 |
| JP2018062980A (ja) * | 2016-10-12 | 2018-04-19 | 株式会社ジェイテクト | ボールネジ装置、ボールネジ装置の製造方法及びステアリング装置 |
| TW201827077A (zh) * | 2016-12-28 | 2018-08-01 | 美商建南德克公司 | 晚期her2表現癌症之治療 |
| CN117915950A (zh) * | 2021-08-06 | 2024-04-19 | 甘李药业股份有限公司 | 一种多特异性抗体及其用途 |
| CN117430707B (zh) * | 2023-10-25 | 2024-04-19 | 重庆天科雅生物科技有限公司 | 一种cik细胞的制备方法及其在治疗癌症中的用途 |
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| US6270765B1 (en) * | 1995-06-07 | 2001-08-07 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
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| WO1989006692A1 (en) * | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| AU4128089A (en) | 1988-09-15 | 1990-03-22 | Rorer International (Overseas) Inc. | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same |
| KR100240308B1 (ko) | 1991-03-06 | 2000-01-15 | 플레믹 크리스티안 | 인간화된단클론성항체및혼성단클론성항체 |
| CA2103059C (en) * | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| US20030086924A1 (en) | 1999-06-25 | 2003-05-08 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
| US7226592B2 (en) | 2002-10-10 | 2007-06-05 | Merck Patent Gmbh | Bispecific anti-Erb-B antibodies and their use in tumor therapy |
| JP2007522157A (ja) * | 2004-02-12 | 2007-08-09 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 抗ｅｇｆｒ抗体の高濃縮液体製剤 |
| PE20070207A1 (es) * | 2005-07-22 | 2007-03-09 | Genentech Inc | Tratamiento combinado de los tumores que expresan el her |
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2006
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- 2006-12-15 JP JP2008548941A patent/JP2009522316A/ja active Pending
- 2006-12-15 CN CN2006800503998A patent/CN101365486B/zh not_active Expired - Fee Related
- 2006-12-15 MX MX2008008564A patent/MX2008008564A/es not_active Application Discontinuation
- 2006-12-15 KR KR1020087019157A patent/KR20080110987A/ko not_active Withdrawn
- 2006-12-15 AU AU2006332212A patent/AU2006332212B8/en not_active Ceased
- 2006-12-15 CA CA002636074A patent/CA2636074A1/en not_active Abandoned
- 2006-12-15 US US12/086,725 patent/US20090214541A1/en not_active Abandoned
- 2006-12-15 BR BRPI0620888-6A patent/BRPI0620888A2/pt not_active IP Right Cessation
- 2006-12-15 EA EA200870141A patent/EA015173B1/ru not_active IP Right Cessation
- 2006-12-15 EP EP06829664.9A patent/EP1968633B2/en not_active Not-in-force
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2007
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2008
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2014
- 2014-11-10 US US14/536,854 patent/US9522956B2/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6270765B1 (en) * | 1995-06-07 | 2001-08-07 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
Non-Patent Citations (1)
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| DATABASE BIOSIS [Online]. BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; April 2006 (2006-04), HALF ELIZABETH ET AL.: "Combination of cetuximab and trastuzumab cooperatively reduce cell growth and augment NSAID-mediated cell death in human colon cancer cells". XP002426918, Database accession no. PREV200600503002, abstract & GASTROENTEROLOGY, vol. 130, no. 4, Suppl. 2, April 2006 (2006-04), page A184, DIGESTIVE DISEASE WEEK MEETING/107TH ANNUAL MEETING OF THE AMERICAN-GASTROENTEROLOGICAL-ASSOCIATION; LOS ANGELES, CA, USA; MAY 19-24, 2006, ISSN: 0016-5085 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2710354C2 (ru) * | 2014-08-29 | 2019-12-25 | Ф.Хоффманн-Ля Рош Аг | Комбинированная терапия на основе нацеленных на опухоль иммуноцитокинов, содержащих вариант il-2, и антител к человеческому pd-l1 |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0620888A2 (pt) | 2011-11-29 |
| US20090214541A1 (en) | 2009-08-27 |
| CA2636074A1 (en) | 2007-07-12 |
| KR20080110987A (ko) | 2008-12-22 |
| EA200870141A1 (ru) | 2009-02-27 |
| EP1968633A1 (en) | 2008-09-17 |
| WO2007076923A1 (en) | 2007-07-12 |
| CN101365486B (zh) | 2012-10-31 |
| AU2006332212B8 (en) | 2013-05-30 |
| US20150132308A1 (en) | 2015-05-14 |
| EP1968633B2 (en) | 2017-11-01 |
| AU2006332212B2 (en) | 2013-03-28 |
| AR059127A1 (es) | 2008-03-12 |
| JP2009522316A (ja) | 2009-06-11 |
| CN101365486A (zh) | 2009-02-11 |
| AU2006332212A1 (en) | 2007-07-12 |
| US9522956B2 (en) | 2016-12-20 |
| EP1968633B1 (en) | 2014-02-12 |
| ZA200806723B (en) | 2009-09-30 |
| MX2008008564A (es) | 2009-01-29 |
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Legal Events
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |