AU2006332212B8 - Combination therapy using anti-EGFR and anti-HER2 antibodies - Google Patents

Combination therapy using anti-EGFR and anti-HER2 antibodies Download PDF

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Publication number
AU2006332212B8
AU2006332212B8 AU2006332212A AU2006332212A AU2006332212B8 AU 2006332212 B8 AU2006332212 B8 AU 2006332212B8 AU 2006332212 A AU2006332212 A AU 2006332212A AU 2006332212 A AU2006332212 A AU 2006332212A AU 2006332212 B8 AU2006332212 B8 AU 2006332212B8
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AU
Australia
Prior art keywords
her2
egfr
antibody
tumor
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006332212A
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English (en)
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AU2006332212B2 (en
AU2006332212A1 (en
Inventor
David Azria
Stephen D. Gillies
Christel Larbouret
Andre Pelegrin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
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Institut National de la Sante et de la Recherche Medicale INSERM
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Application filed by Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Publication of AU2006332212A1 publication Critical patent/AU2006332212A1/en
Assigned to L'INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE reassignment L'INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Request for Assignment Assignors: CENTRE REGIONAL DE LUTTE CONTRE LE CANCER, L'INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, MERCK PATENT GMBH, UNIVERSITY OF MONTPELLIER 1
Application granted granted Critical
Publication of AU2006332212B2 publication Critical patent/AU2006332212B2/en
Publication of AU2006332212B8 publication Critical patent/AU2006332212B8/en
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Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2006332212A 2006-01-04 2006-12-15 Combination therapy using anti-EGFR and anti-HER2 antibodies Ceased AU2006332212B8 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06000107.0 2006-01-04
EP06000107 2006-01-04
PCT/EP2006/012133 WO2007076923A1 (en) 2006-01-04 2006-12-15 Combination therapy using anti-egfr and anti-her2 antibodies

Publications (3)

Publication Number Publication Date
AU2006332212A1 AU2006332212A1 (en) 2007-07-12
AU2006332212B2 AU2006332212B2 (en) 2013-03-28
AU2006332212B8 true AU2006332212B8 (en) 2013-05-30

Family

ID=37876938

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006332212A Ceased AU2006332212B8 (en) 2006-01-04 2006-12-15 Combination therapy using anti-EGFR and anti-HER2 antibodies

Country Status (13)

Country Link
US (2) US20090214541A1 (enExample)
EP (1) EP1968633B2 (enExample)
JP (1) JP2009522316A (enExample)
KR (1) KR20080110987A (enExample)
CN (1) CN101365486B (enExample)
AR (1) AR059127A1 (enExample)
AU (1) AU2006332212B8 (enExample)
BR (1) BRPI0620888A2 (enExample)
CA (1) CA2636074A1 (enExample)
EA (1) EA015173B1 (enExample)
MX (1) MX2008008564A (enExample)
WO (1) WO2007076923A1 (enExample)
ZA (1) ZA200806723B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
PT2163256E (pt) 2001-05-11 2015-11-20 Ludwig Inst For Cancer Res Ltd Proteínas de ligação específica e suas utilizações
US10118970B2 (en) 2006-08-30 2018-11-06 Genentech, Inc. Multispecific antibodies
ES2609094T3 (es) 2007-01-25 2017-04-18 Dana-Farber Cancer Institute, Inc. Uso de anticuerpos anti-EGFR en el tratamiento de enfermedades mediadas por un EGFR mutante
CA2680854C (en) 2007-03-15 2017-02-14 Ludwig Institute For Cancer Research Treatment method using egfr antibodies and src inhibitors and related formulations
EP2188311B1 (en) 2007-08-14 2016-10-05 Ludwig Institute for Cancer Research Ltd. Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof
NZ586544A (en) * 2007-12-26 2012-07-27 Vaccinex Inc Anti-c35 antibody in combination with an ani-her2 antibody in cancer therapies and methods
US8193321B2 (en) 2008-09-03 2012-06-05 Genentech, Inc. Multispecific antibodies
EP2337800B1 (en) 2008-09-15 2013-10-02 Yeda Research and Development Co. Ltd. Antibody combinations and use of same for treating cancer
US8728479B2 (en) * 2009-03-31 2014-05-20 The Trustees Of The University Of Pennsylvania Antigen-binding proteins comprising recombinant protein scaffolds
EP3778917A3 (en) * 2009-12-04 2021-06-09 F. Hoffmann-La Roche AG Multispecific antibodies, antibody analogs, compositions, and methods
US8609095B2 (en) * 2010-03-04 2013-12-17 Symphogen A/S Anti-HER2 antibodies and compositions
US9155802B2 (en) 2010-11-01 2015-10-13 Symphogen A/S Pan-HER antibody composition
WO2012156975A1 (en) 2011-05-16 2012-11-22 Yeda Research And Development Co. Ltd. COMBINATIONS OF ANTI ErbB ANTIBODIES FOR THE TREATMENT OF CANCER
BR112014027291A2 (pt) 2012-05-02 2017-08-08 Symphogen As composições de anticorpos pan-her humanizados
EP2968556A1 (en) 2013-03-13 2016-01-20 University Of Kentucky Research Foundation Methods of administering igg1 antibodies and methods of suppressing angiogenesis
WO2014139131A1 (en) * 2013-03-14 2014-09-18 Crown Bioscience, Inc. Use of egfr biomarkers for the treatment of gastric cancer with anti-egfr agents
US10683353B2 (en) 2013-07-11 2020-06-16 The Scripps Research Institute Coiled coil immunoglobulin fusion proteins and compositions thereof
JP2016538283A (ja) 2013-11-13 2016-12-08 ザイムワークス，インコーポレイテッド Ｅｇｆｒ及び／またはｈｅｒ２を標的にする一価抗原結合性構築物及びその使用
HUE047806T2 (hu) * 2014-08-29 2020-05-28 Hoffmann La Roche Kombinációs kezelés tumort célzó IL-2-variáns immuncitokinekkel és humán PD-L1 elleni antitestekkel
CN104991065B (zh) * 2015-07-07 2017-01-11 复旦大学附属金山医院 一种用于诊断乳腺癌的三联标志物及其应用
JP2018062980A (ja) * 2016-10-12 2018-04-19 株式会社ジェイテクト ボールネジ装置、ボールネジ装置の製造方法及びステアリング装置
TW201827077A (zh) * 2016-12-28 2018-08-01 美商建南德克公司 晚期her2表現癌症之治療
CN117915950A (zh) * 2021-08-06 2024-04-19 甘李药业股份有限公司 一种多特异性抗体及其用途
CN117430707B (zh) * 2023-10-25 2024-04-19 重庆天科雅生物科技有限公司 一种cik细胞的制备方法及其在治疗癌症中的用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6270765B1 (en) * 1995-06-07 2001-08-07 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
WO2004032961A1 (en) * 2002-10-10 2004-04-22 Merck Patent Gmbh Bispecific anti-erb-b antibodies and their use in tumor therapy
WO2007013950A2 (en) * 2005-07-22 2007-02-01 Genentech, Inc. Combination therapy of her expressing tumors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006692A1 (en) * 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
AU4128089A (en) 1988-09-15 1990-03-22 Rorer International (Overseas) Inc. Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
KR100240308B1 (ko) 1991-03-06 2000-01-15 플레믹 크리스티안 인간화된단클론성항체및혼성단클론성항체
CA2103059C (en) * 1991-06-14 2005-03-22 Paul J. Carter Method for making humanized antibodies
US20030086924A1 (en) 1999-06-25 2003-05-08 Genentech, Inc. Treatment with anti-ErbB2 antibodies
JP2007522157A (ja) * 2004-02-12 2007-08-09 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 抗ｅｇｆｒ抗体の高濃縮液体製剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6270765B1 (en) * 1995-06-07 2001-08-07 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
WO2004032961A1 (en) * 2002-10-10 2004-04-22 Merck Patent Gmbh Bispecific anti-erb-b antibodies and their use in tumor therapy
WO2007013950A2 (en) * 2005-07-22 2007-02-01 Genentech, Inc. Combination therapy of her expressing tumors

Also Published As

Publication number Publication date
BRPI0620888A2 (pt) 2011-11-29
US20090214541A1 (en) 2009-08-27
CA2636074A1 (en) 2007-07-12
KR20080110987A (ko) 2008-12-22
EA200870141A1 (ru) 2009-02-27
EP1968633A1 (en) 2008-09-17
WO2007076923A1 (en) 2007-07-12
CN101365486B (zh) 2012-10-31
US20150132308A1 (en) 2015-05-14
EP1968633B2 (en) 2017-11-01
AU2006332212B2 (en) 2013-03-28
EA015173B1 (ru) 2011-06-30
AR059127A1 (es) 2008-03-12
JP2009522316A (ja) 2009-06-11
CN101365486A (zh) 2009-02-11
AU2006332212A1 (en) 2007-07-12
US9522956B2 (en) 2016-12-20
EP1968633B1 (en) 2014-02-12
ZA200806723B (en) 2009-09-30
MX2008008564A (es) 2009-01-29

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Legal Events

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PC1 Assignment before grant (sect. 113)

Owner name: L INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE

Free format text: FORMER APPLICANT(S): L INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ; UNIVERSITY OF MONTPELLIER 1 ; MERCK PATENT GMBH ; CENTRE REGIONAL DE LUTTE CONTRE LE CANCER

TH Corrigenda

Free format text: IN VOL 27 , NO 12 , PAGE(S) 1645 UNDER THE HEADING APPLICATIONS ACCEPTED - NAME INDEX UNDER THE NAME L INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, APPLICATION NO. 2006332212, UNDER INID (71) CORRECT THE APPLICANT NAME TO INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired