JP2009521683A - アナライザーシステム - Google Patents

アナライザーシステム Download PDF

Info

Publication number
JP2009521683A
JP2009521683A JP2008547558A JP2008547558A JP2009521683A JP 2009521683 A JP2009521683 A JP 2009521683A JP 2008547558 A JP2008547558 A JP 2008547558A JP 2008547558 A JP2008547558 A JP 2008547558A JP 2009521683 A JP2009521683 A JP 2009521683A
Authority
JP
Japan
Prior art keywords
blood
sample
analyzer
blood analyzer
cartridge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008547558A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009521683A5 (enExample
Inventor
パドマナバン,アラヴィンド
コックス,ジェームズ・エイ
フリッツ,バーナード・エス
レザチェク,トム・エム
ルーティマン,ピーター・エル
バーデル,ロン・エル
キャブズ,クレオパトラ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Honeywell International Inc
Original Assignee
Honeywell International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Honeywell International Inc filed Critical Honeywell International Inc
Publication of JP2009521683A publication Critical patent/JP2009521683A/ja
Publication of JP2009521683A5 publication Critical patent/JP2009521683A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G01N35/00603—Reinspection of samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/032—Analysing fluids by measuring attenuation of acoustic waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G01N35/00613—Quality control
    • G01N35/00663—Quality control of consumables
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/146—Employing pressure sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0672—Integrated piercing tool
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/14—Means for pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/011—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells with lysing, e.g. of erythrocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/012—Red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/016—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/018—Platelets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/1452—Adjustment of focus; Alignment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486—Counting the particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00148—Test cards, e.g. Biomerieux or McDonnel multiwell test cards
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G01N2035/00247—Microvalves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1053—General features of the devices using the transfer device for another function for separating part of the liquid, e.g. filters, extraction phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/024—Mixtures
    • G01N2291/02433—Gases in liquids, e.g. bubbles, foams
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/028—Material parameters
    • G01N2291/02836—Flow rate, liquid level
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/028—Material parameters
    • G01N2291/02872—Pressure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Quality & Reliability (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Acoustics & Sound (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Ecology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
JP2008547558A 2005-12-22 2006-12-22 アナライザーシステム Pending JP2009521683A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75329305P 2005-12-22 2005-12-22
US75501405P 2005-12-29 2005-12-29
PCT/US2006/048847 WO2007075920A2 (en) 2005-12-22 2006-12-22 Hematological analyzer system with removable cartridge
US11/615,884 US8383043B2 (en) 2004-05-14 2006-12-22 Analyzer system

Publications (2)

Publication Number Publication Date
JP2009521683A true JP2009521683A (ja) 2009-06-04
JP2009521683A5 JP2009521683A5 (enExample) 2010-02-18

Family

ID=38180469

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008547558A Pending JP2009521683A (ja) 2005-12-22 2006-12-22 アナライザーシステム

Country Status (4)

Country Link
US (1) US8383043B2 (enExample)
EP (2) EP1963866B1 (enExample)
JP (1) JP2009521683A (enExample)
WO (1) WO2007075920A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023156368A (ja) * 2018-03-01 2023-10-24 ライカ ビオズュステムス ヌスロッホ ゲーエムベーハー 自動封入装置

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4359452B2 (ja) * 2003-06-26 2009-11-04 シスメックス株式会社 試料分析装置
PT1662987E (pt) * 2003-09-11 2012-02-14 Theranos Inc Dispositivo médico para monitorização de analito e distribuição de droga
SG149889A1 (en) 2003-10-30 2009-02-27 Cytonome Inc Multilayer hydrodynamic sheath flow structure
MX2007013985A (es) * 2005-05-09 2008-02-22 Theranos Inc Sistemas de fluidos de punto de cuidado y usos de los mismos.
US20070025879A1 (en) * 2005-07-27 2007-02-01 Dakocytomation Denmark A/S Method and apparatus for syringe-based sample introduction within a flow cytometer
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) * 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
JP5192168B2 (ja) * 2007-03-30 2013-05-08 シスメックス株式会社 設定情報管理システム、設定情報管理方法、バックアッププログラム、及び記憶媒体
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
WO2009027896A1 (en) * 2007-08-24 2009-03-05 Koninklijke Philips Electronics N. V. Microelectronic sensor device with wetting detection
EP2037281B1 (en) * 2007-09-13 2018-10-10 Sysmex Corporation Sample analyzer
EP2062644A1 (en) * 2007-11-26 2009-05-27 Koninklijke Philips Electronics N.V. Micro-fluidic device with degas control
EP2153892A1 (en) * 2008-07-23 2010-02-17 ETH Zurich Microreactor system and method for operating such microreactor system
US8247191B2 (en) * 2008-11-13 2012-08-21 Ritzen Kalle Disposable cassette and method of use for blood analysis on blood analyzer
AU2010308329B2 (en) 2009-10-19 2016-10-13 Labrador Diagnostics Llc Integrated health data capture and analysis system
PL2504105T3 (pl) 2009-11-24 2021-06-28 Opko Diagnostics, Llc Mieszanie i dostarczanie płynów w układach mikroprzepływowych
JP6104793B2 (ja) 2010-04-16 2017-03-29 オプコ・ダイアグノスティクス・リミテッド・ライアビリティ・カンパニーOpko Diagnostics,Llc マイクロ流体システム内でのフィードバック制御
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
WO2012159021A2 (en) * 2011-05-19 2012-11-22 Hemosonics, Llc Portable hemostasis analyzer
EP2795295B1 (en) * 2011-12-12 2017-10-11 Step Ahead Innovations, Inc. Water-quality monitoring system
US9873119B2 (en) * 2011-12-28 2018-01-23 Ibis Biosciences, Inc. Multiple- analyte assay device and system
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9081001B2 (en) 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
WO2014057480A2 (en) * 2012-10-12 2014-04-17 Koninklijke Philips N.V. Optical fill detection
WO2014099421A1 (en) * 2012-12-17 2014-06-26 Abbott Point Of Care Inc Operation and verification of a portable clinical analysis system
WO2014099419A1 (en) 2012-12-17 2014-06-26 Abbott Point Of Care Inc A portable clinical analysis system for hematocrit measurement
EP2932250B1 (en) 2012-12-17 2017-10-04 Abbott Point Of Care, Inc. Self correction for spatial orientation and motion of portable clinical testing devices
CN105008920B (zh) 2012-12-17 2019-03-29 雅培医护站股份有限公司 便携式临床分析系统中的空间方位确定
WO2014099420A1 (en) 2012-12-17 2014-06-26 Abbott Point Of Care Inc A portable clinical analysis system for immunometric measurement
EP4220124A1 (en) 2013-03-14 2023-08-02 Cytonome/ST, LLC Hydrodynamic focusing apparatus and methods
EP3049810A4 (en) * 2013-09-24 2017-04-26 Apollodx LLC Systems and methods for diagnostic testing
WO2015121206A1 (en) * 2014-02-13 2015-08-20 Robert Bosch Gmbh Capacitive bubble detection
KR20150111696A (ko) * 2014-03-26 2015-10-06 삼성전자주식회사 혈액 검사기 및 그에 따른 혈액 검사 방법
US11478789B2 (en) 2014-11-26 2022-10-25 Medica Corporation Automated microscopic cell analysis
US20170328924A1 (en) 2014-11-26 2017-11-16 Ronald Jones Automated microscopic cell analysis
US10625259B1 (en) 2014-11-26 2020-04-21 Medica Corporation Automated microscopic cell analysis
US12005441B1 (en) 2014-11-26 2024-06-11 Medica Corporation Automated microscopic cell analysis
US10634602B2 (en) 2015-06-12 2020-04-28 Cytochip Inc. Fluidic cartridge for cytometry and additional analysis
WO2016200922A1 (en) 2015-06-12 2016-12-15 Cytochip Inc. Fluidic units and cartridges for multi-analyte analysis
EP3322968B1 (en) 2015-07-14 2024-02-21 Cytochip Inc. Volume sensing in a fluidic cartridge
US9366606B1 (en) 2015-08-27 2016-06-14 Ativa Medical Corporation Fluid processing micro-feature devices and methods
US20170059590A1 (en) 2015-08-27 2017-03-02 Ativa Medical Corporation Fluid holding and dispensing micro-feature
US11071982B2 (en) 2015-08-27 2021-07-27 Ativa Medical Corporation Fluid holding and dispensing micro-feature
US10088494B2 (en) * 2016-01-25 2018-10-02 Perkinelmer Health Sciences, Inc. Method and system for microfluidic sample analysis
KR101667351B1 (ko) * 2016-02-18 2016-10-18 주식회사 지노바이오 일회용 분리칩
WO2017142190A1 (ko) 2016-02-18 2017-08-24 주식회사 지노바이오 셀 분리칩 및 시스템
CN109803762B (zh) * 2016-10-07 2022-04-01 勃林格殷格翰维特梅迪卡有限公司 用于控制分析装置和分析系统的方法
KR20190065365A (ko) * 2016-10-07 2019-06-11 베링거잉겔하임베트메디카게엠베하 분석 디바이스 및 분석 시스템을 제어하기 위한 방법
BR112019007117A2 (pt) 2016-10-07 2019-07-02 Boehringer Ingelheim Vetmedica Gmbh cartucho e sistema de análise para testagem de uma amostra
IL312536B2 (en) 2017-02-06 2025-06-01 E F A Eng For All Ltd Test Chip in a Portable Digital Diagnostic Device
WO2023079436A1 (en) * 2021-11-02 2023-05-11 E.F.A. Engineering For All Ltd. Micromixer and method for concentration measurement of unknown sample
US11493418B2 (en) * 2017-04-28 2022-11-08 Alpha Technologies Services Llc Rheometer docking station
US11491487B2 (en) 2017-10-23 2022-11-08 Cytochip Inc. Devices and methods for measuring analytes and target particles
US11047845B1 (en) * 2017-11-15 2021-06-29 Medica Corporation Control material and methods for cell analyzers
WO2019191531A1 (en) 2018-03-30 2019-10-03 Idexx Laboratories, Inc. Quality control for point-of-care diagnostic systems
US20200033260A1 (en) * 2018-07-25 2020-01-30 Pauleologos Cusulos Coagulation and aggregation refracted light indexing device and method
EP3861318B1 (en) 2018-10-02 2023-03-29 Instrumentation Laboratory Company Disposable hemolysis sensor
ES3074987T3 (es) * 2018-12-11 2026-07-24 Carrier Corp Calibración de un detector óptico usando una cámara de microflujo
JP7402890B2 (ja) 2019-03-18 2023-12-21 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド 流体デバイスにおけるバブルトラップのための装置および方法
US11988590B2 (en) 2019-04-26 2024-05-21 Cytochip Inc. Methods and devices for correction in particle size measurement
WO2022013759A1 (en) * 2020-07-14 2022-01-20 Vital Biosciences Inc. Device, method, and system for collection of blood
CN115248180A (zh) * 2021-04-26 2022-10-28 帝迈(苏州)生物技术有限公司 Poct血细胞分析仪及其使用方法
US12404951B1 (en) * 2022-03-07 2025-09-02 United States Of America As Represented By The Administrator Of Nasa Microfluidics pressure-based switching and valving array
DE102022202966A1 (de) 2022-03-25 2023-09-28 Robert Bosch Gesellschaft mit beschränkter Haftung Mikrofluidische Kartusche und Verfahren zu ihrer Herstellung, sowie Analysenvorrichtung und Verfahren zu deren Betreiben
EP4484924A1 (en) * 2023-06-26 2025-01-01 F. Hoffmann-La Roche AG Detection of air bubbles in optical detection unit
WO2025103968A1 (en) * 2023-11-15 2025-05-22 F. Hoffmann-La Roche Ag Ivd system and method of using an ivd consumable device susceptible to environmental conditions
US12584902B2 (en) 2023-12-10 2026-03-24 Instrumentation Laboratory Company Acoustic separation of a test sample
CN119177149A (zh) * 2024-09-12 2024-12-24 深圳市真迈生物科技有限公司 流体系统、控制方法、测序系统和存储介质
WO2026111903A1 (en) * 2024-11-25 2026-05-28 Siemens Healthcare Diagnostics Inc. System and method for barcode scanning using historical user insertion data

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004061418A2 (en) * 2002-12-26 2004-07-22 Meso Scale Technologies, Llc. Assay cartridges and methods of using the same
WO2005114144A1 (en) * 2004-05-14 2005-12-01 Honeywell International, Inc. Portable sample analyzer cartridge

Family Cites Families (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3822095A (en) * 1972-08-14 1974-07-02 Block Engineering System for differentiating particles
US3928094A (en) 1975-01-16 1975-12-23 Fairchild Camera Instr Co Method of aligning a wafer beneath a mask and system therefor and wafer having a unique alignment pattern
US3976862A (en) * 1975-03-18 1976-08-24 Block Engineering, Inc. Flow stream processor
US4284412A (en) * 1979-07-13 1981-08-18 Ortho Diagnostics, Inc. Method and apparatus for automated identification and enumeration of specified blood cell subclasses
JPS58143206A (ja) * 1982-02-19 1983-08-25 Canon Inc 位置検知信号処理装置
US4683159A (en) 1982-09-30 1987-07-28 Honeywell Inc. Semiconductor device structure and processing
US4478076A (en) 1982-09-30 1984-10-23 Honeywell Inc. Flow sensor
US4651564A (en) 1982-09-30 1987-03-24 Honeywell Inc. Semiconductor device
US4501144A (en) 1982-09-30 1985-02-26 Honeywell Inc. Flow sensor
US4478077A (en) 1982-09-30 1984-10-23 Honeywell Inc. Flow sensor
JPS6082865A (ja) * 1983-10-12 1985-05-11 Toshiba Corp 自動化学分析装置
US4980292A (en) 1984-10-01 1990-12-25 Baxter International Inc. Tablet dispensing
US4695034A (en) * 1984-11-27 1987-09-22 Stec Inc. Fluid control device
US4745279A (en) * 1986-01-02 1988-05-17 American Hospital Supply Corporation Hematocrit measuring apparatus
US4704033A (en) * 1986-03-06 1987-11-03 Micronix Corporation Multiple wavelength linear zone plate alignment apparatus and method
NL8601000A (nl) * 1986-04-21 1987-11-16 Jan Greve T H Twente Afdeling Het gebruik van gepolariseerd licht in stromingscytometrie.
DE3640616A1 (de) 1986-11-27 1988-06-09 Standard Elektrik Lorenz Ag Justiervorrichtung
US4818263A (en) * 1987-06-11 1989-04-04 Tektronix, Inc. Method and apparatus for precisely positioning microlenses on optical fibers
US4874949A (en) * 1987-09-14 1989-10-17 Vanderbilt University Method of measuring lung vascular function and transcapillary transport by the use of nonradioactive markers
US4911616A (en) * 1988-01-19 1990-03-27 Laumann Jr Carl W Micro miniature implantable pump
US5760900A (en) * 1989-03-18 1998-06-02 Canon Kabushiki Kaisha Method and apparatus for optically measuring specimen
US4932989A (en) * 1989-04-05 1990-06-12 At&T Bell Laboratories Method and apparatus for fabricating microlenses on optical fibers
CH679555A5 (enExample) * 1989-04-11 1992-03-13 Westonbridge Int Ltd
CA2016699C (en) * 1989-05-15 2003-11-18 Paul N. Marshall Lytic agents and uses thereof
ATE110142T1 (de) * 1989-06-14 1994-09-15 Westonbridge Int Ltd Mikropumpe.
DE3926066A1 (de) * 1989-08-07 1991-02-14 Ibm Deutschland Mikromechanische kompressorkaskade und verfahren zur druckerhoehung bei extrem niedrigem arbeitsdruck
CH681168A5 (en) * 1989-11-10 1993-01-29 Westonbridge Int Ltd Micro-pump for medicinal dosing
US5244537A (en) * 1989-12-27 1993-09-14 Honeywell, Inc. Fabrication of an electronic microvalve apparatus
US5171132A (en) 1989-12-27 1992-12-15 Seiko Epson Corporation Two-valve thin plate micropump
US5082242A (en) * 1989-12-27 1992-01-21 Ulrich Bonne Electronic microvalve apparatus and fabrication
US5050429A (en) 1990-02-22 1991-09-24 Yamatake-Honeywell Co., Ltd. Microbridge flow sensor
US5096388A (en) * 1990-03-22 1992-03-17 The Charles Stark Draper Laboratory, Inc. Microfabricated pump
EP0465687B1 (fr) * 1990-07-07 1995-05-17 Societe Des Produits Nestle S.A. Dispositif doseur
US5183765A (en) * 1990-10-11 1993-02-02 Drd Diluter Corporation Means and method of measuring and dispensing
DE69104585T2 (de) * 1990-10-30 1995-05-18 Hewlett Packard Co Mikropumpe.
EP0485817B1 (en) * 1990-11-03 1998-04-15 Horiba, Ltd. Apparatus for measuring a particle size distribution
US5108623A (en) * 1990-11-19 1992-04-28 Gould Inc. Moving web filter assembly
US5194909A (en) * 1990-12-04 1993-03-16 Tycko Daniel H Apparatus and method for measuring volume and hemoglobin concentration of red blood cells
DE4119955C2 (de) * 1991-06-18 2000-05-31 Danfoss As Miniatur-Betätigungselement
US5176358A (en) 1991-08-08 1993-01-05 Honeywell Inc. Microstructure gas valve control
JP2601075B2 (ja) * 1991-10-21 1997-04-16 株式会社日立製作所 試験片を用いる分析方法および分析装置
EP0648351B1 (en) * 1992-07-02 1997-10-08 Indigo N.V. Concentration detector for colored toner
JP3215175B2 (ja) * 1992-08-10 2001-10-02 シスメックス株式会社 粒子分析装置
US5441597A (en) * 1992-12-01 1995-08-15 Honeywell Inc. Microstructure gas valve control forming method
WO1994027146A1 (en) * 1993-05-14 1994-11-24 Coulter Corporation Reticulocyte analyzing method and apparatus utilizing light scatter techniques
EP0694784B1 (en) 1994-07-28 2002-02-27 Hitachi, Ltd. Liquid sampling apparatus
US5601080A (en) * 1994-12-28 1997-02-11 Coretech Medical Technologies Corporation Spectrophotometric blood analysis
US5793485A (en) * 1995-03-20 1998-08-11 Sandia Corporation Resonant-cavity apparatus for cytometry or particle analysis
US5528045A (en) * 1995-04-06 1996-06-18 Becton Dickinson And Company Particle analyzer with spatially split wavelength filter
AU6541596A (en) * 1995-06-16 1997-01-15 University Of Washington Microfabricated differential extraction device and method
US5922210A (en) * 1995-06-16 1999-07-13 University Of Washington Tangential flow planar microfabricated fluid filter and method of using thereof
US5716852A (en) * 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5717631A (en) * 1995-07-21 1998-02-10 Carnegie Mellon University Microelectromechanical structure and process of making same
US5633724A (en) * 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
US5726751A (en) * 1995-09-27 1998-03-10 University Of Washington Silicon microchannel optical flow cytometer
IT1280475B1 (it) 1995-11-09 1998-01-20 Fiat Ricerche Dispositivi a microfiltri selettivi di colori e immagini.
DE19546570C1 (de) * 1995-12-13 1997-03-27 Inst Mikro Und Informationstec Fluidpumpe
JP3308441B2 (ja) * 1995-12-19 2002-07-29 シスメックス株式会社 尿中有形成分分析装置
US5837547A (en) * 1995-12-27 1998-11-17 Caribbean Microparticles Corporation Flow cytometer calibration method
US5863502A (en) * 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US5851488A (en) * 1996-02-29 1998-12-22 Biocircuits Corporation Apparatus for automatic electro-optical chemical assay determination
US5948684A (en) * 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
US5971158A (en) * 1996-06-14 1999-10-26 University Of Washington Absorption-enhanced differential extraction device
US5764674A (en) * 1996-06-28 1998-06-09 Honeywell Inc. Current confinement for a vertical cavity surface emitting laser
US5799030A (en) * 1996-07-26 1998-08-25 Honeywell Inc. Semiconductor device with a laser and a photodetector in a common container
US5691486A (en) * 1996-07-30 1997-11-25 Bayer Corporation Apparatus and methods for selecting a variable number of test sample aliquots to mix with respective reagents
AU717626B2 (en) * 1996-10-03 2000-03-30 Debiotech S.A. Micro-machined device for fluids and method of manufacture
US6124663A (en) * 1996-12-16 2000-09-26 The Boeing Company Fiber optic connector having a microelectromechanical positioning apparatus and an associated fabrication method
US5683159A (en) * 1997-01-03 1997-11-04 Johnson; Greg P. Hardware mounting rail
US6097859A (en) * 1998-02-12 2000-08-01 The Regents Of The University Of California Multi-wavelength cross-connect optical switch
US5974867A (en) 1997-06-13 1999-11-02 University Of Washington Method for determining concentration of a laminar sample stream
AU8148898A (en) * 1997-06-23 1999-01-04 Luminex Corporation Interlaced lasers for multiple fluorescence measurement
US6082185A (en) * 1997-07-25 2000-07-04 Research International, Inc. Disposable fluidic circuit cards
US5880474A (en) * 1997-08-29 1999-03-09 Becton Dickinson And Company Multi-illumination-source flow particle analyzer with inter-location emissions crosstalk cancelation
US6007775A (en) 1997-09-26 1999-12-28 University Of Washington Multiple analyte diffusion based chemical sensor
US5822170A (en) * 1997-10-09 1998-10-13 Honeywell Inc. Hydrophobic coating for reducing humidity effect in electrostatic actuators
US5901939A (en) * 1997-10-09 1999-05-11 Honeywell Inc. Buckled actuator with enhanced restoring force
US6106245A (en) * 1997-10-09 2000-08-22 Honeywell Low cost, high pumping rate electrostatically actuated mesopump
US5836750A (en) 1997-10-09 1998-11-17 Honeywell Inc. Electrostatically actuated mesopump having a plurality of elementary cells
US6054335A (en) * 1997-12-12 2000-04-25 Xerox Corporation Fabrication of scanning III-V compound light emitters integrated with Si-based actuators
US6116756A (en) * 1997-12-12 2000-09-12 Xerox Corporation Monolithic scanning light emitting devices
CA2320296A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
JP3522535B2 (ja) 1998-05-29 2004-04-26 忠弘 大見 圧力式流量制御装置を備えたガス供給設備
US6091197A (en) * 1998-06-12 2000-07-18 Xerox Corporation Full color tunable resonant cavity organic light emitting diode
JP4001436B2 (ja) * 1998-07-23 2007-10-31 三菱電機株式会社 光スイッチ及び光スイッチを用いた光路切換装置
DE19835070B4 (de) 1998-08-04 2006-03-16 Carl Zeiss Jena Gmbh Anordnung zur einstellbaren wellenlängenabhängigen Detektion in einem Fluoreszenzmikroskop
DE19849008A1 (de) * 1998-10-23 2000-04-27 Roche Diagnostics Gmbh Spreitschichten, Netzmittel zu ihrer Herstellung und deren Verwendung in Teststreifen
US6032689A (en) * 1998-10-30 2000-03-07 Industrial Technology Research Institute Integrated flow controller module
US6602469B1 (en) * 1998-11-09 2003-08-05 Lifestream Technologies, Inc. Health monitoring and diagnostic device and network-based health assessment and medical records maintenance system
US6091537A (en) * 1998-12-11 2000-07-18 Xerox Corporation Electro-actuated microlens assemblies
US6215221B1 (en) * 1998-12-29 2001-04-10 Honeywell International Inc. Electrostatic/pneumatic actuators for active surfaces
US6184607B1 (en) * 1998-12-29 2001-02-06 Honeywell International Inc. Driving strategy for non-parallel arrays of electrostatic actuators sharing a common electrode
US6249341B1 (en) * 1999-01-25 2001-06-19 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US6531095B2 (en) * 1999-02-11 2003-03-11 Careside, Inc. Cartridge-based analytical instrument with optical detector
US6097485A (en) * 1999-03-08 2000-08-01 Integrated Waveguides, Inc. Microchip optical transport technology for use in a personal flow cytometer
US6179586B1 (en) * 1999-09-15 2001-01-30 Honeywell International Inc. Dual diaphragm, single chamber mesopump
US6240944B1 (en) 1999-09-23 2001-06-05 Honeywell International Inc. Addressable valve arrays for proportional pressure or flow control
DE10005735A1 (de) * 2000-02-09 2001-08-23 Evotec Biosystems Ag Verfahren und Vorrichtung zur Abführung suspendierter Mikropartikel aus einem fluidischen Mikrosystem
US6281975B1 (en) * 2000-03-07 2001-08-28 Eldex Laboratories, Inc. Capillary flow cell with bulbous ends
US20010030743A1 (en) 2000-03-10 2001-10-18 Carlos Araujo Laser alignment system with plural lasers for impingement on a single target
DE20008228U1 (de) 2000-05-09 2002-01-03 Prüftechnik Dieter Busch AG, 85737 Ismaning Vorrichtung zur quantitativen Beurteilung der fluchtenden Lage zweier Maschinenteile, Werkstücke o.dgl.
US6970245B2 (en) * 2000-08-02 2005-11-29 Honeywell International Inc. Optical alignment detection system
US7978329B2 (en) * 2000-08-02 2011-07-12 Honeywell International Inc. Portable scattering and fluorescence cytometer
US7641856B2 (en) * 2004-05-14 2010-01-05 Honeywell International Inc. Portable sample analyzer with removable cartridge
US6700130B2 (en) * 2001-06-29 2004-03-02 Honeywell International Inc. Optical detection system for flow cytometry
US6597438B1 (en) * 2000-08-02 2003-07-22 Honeywell International Inc. Portable flow cytometry
US7553453B2 (en) * 2000-06-02 2009-06-30 Honeywell International Inc. Assay implementation in a microfluidic format
US7630063B2 (en) * 2000-08-02 2009-12-08 Honeywell International Inc. Miniaturized cytometer for detecting multiple species in a sample
US6549275B1 (en) * 2000-08-02 2003-04-15 Honeywell International Inc. Optical detection system for flow cytometry
US7000330B2 (en) 2002-08-21 2006-02-21 Honeywell International Inc. Method and apparatus for receiving a removable media member
US6382228B1 (en) * 2000-08-02 2002-05-07 Honeywell International Inc. Fluid driving system for flow cytometry
US7061595B2 (en) * 2000-08-02 2006-06-13 Honeywell International Inc. Miniaturized flow controller with closed loop regulation
WO2003027221A1 (en) * 2001-09-23 2003-04-03 Irm Llc Closed cell washer
US6781388B2 (en) * 2001-09-26 2004-08-24 Delphi Technologies, Inc. Liquid property sensor
US6729856B2 (en) 2001-10-09 2004-05-04 Honeywell International Inc. Electrostatically actuated pump with elastic restoring forces
US20030175980A1 (en) * 2002-03-14 2003-09-18 Hayenga Jon W. Ribbon flow cytometry and cell sorting
US20030207454A1 (en) 2002-05-01 2003-11-06 Eyster Curt R. Devices and methods for analyte concentration determination
WO2004003219A2 (en) * 2002-06-28 2004-01-08 Igen International, Inc. Improved assay systems and components
US7207939B2 (en) * 2002-10-03 2007-04-24 Coulter International Corp. Apparatus and method for analyzing a liquid in a capillary tube of a hematology instrument
US7079244B2 (en) * 2002-11-18 2006-07-18 International Remote Imaging Systems, Inc. Particle analyzer with specimen tube in-line mixer
US7291310B2 (en) 2002-12-17 2007-11-06 The Regents Of The University Of Michigan Microsystem for determining clotting time of blood and low-cost, single-use device for use therein
US20040154933A1 (en) * 2003-02-11 2004-08-12 Instrumentation Laboratory Company Polymeric membranes for use in electrochemical sensors
JP3979304B2 (ja) 2003-02-24 2007-09-19 日本光電工業株式会社 フローセル位置決め方法およびフローセル位置調整可能なフローサイトメータ
TW577855B (en) 2003-05-21 2004-03-01 Univ Nat Cheng Kung Chip-type micro-fluid particle 3-D focusing and detection device
SG149889A1 (en) * 2003-10-30 2009-02-27 Cytonome Inc Multilayer hydrodynamic sheath flow structure
US20060257854A1 (en) 2004-02-27 2006-11-16 Mcdevitt John T Membrane assay system including preloaded particles
US20080213821A1 (en) 2004-05-06 2008-09-04 Nanyang Technological University Microfluidic Cell Sorter System

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004061418A2 (en) * 2002-12-26 2004-07-22 Meso Scale Technologies, Llc. Assay cartridges and methods of using the same
WO2005114144A1 (en) * 2004-05-14 2005-12-01 Honeywell International, Inc. Portable sample analyzer cartridge

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023156368A (ja) * 2018-03-01 2023-10-24 ライカ ビオズュステムス ヌスロッホ ゲーエムベーハー 自動封入装置
JP7598419B2 (ja) 2018-03-01 2024-12-11 ライカ ビオズュステムス ヌスロッホ ゲーエムベーハー 自動封入装置

Also Published As

Publication number Publication date
WO2007075920A3 (en) 2007-11-15
WO2007075920A2 (en) 2007-07-05
EP1963866B1 (en) 2018-05-16
EP3121601A1 (en) 2017-01-25
US8383043B2 (en) 2013-02-26
EP1963866A2 (en) 2008-09-03
US20070166195A1 (en) 2007-07-19

Similar Documents

Publication Publication Date Title
JP5175213B2 (ja) 携帯用サンプル分析システム
EP1963866B1 (en) Hematological analyzer system with removable cartridge
US8828320B2 (en) Portable sample analyzer cartridge
CN101379386B (zh) 便携式样品分析仪系统
EP1745275B1 (en) Portable sample analyzer cartridge
EP1745285B1 (en) Portable sample analyzer with removable cartridge
CN101262950B (zh) 流量计量分析器
CN1985168B (zh) 具有可拆卸盒的便携式样本分析仪
WO2007084232A1 (en) Differential white blood count on a disposable card
US20230264193A1 (en) System for analysis
WO2025210522A1 (en) Automated sample preparation system implemented within a disposable cartridge

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091222

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20091222

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100119

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20111028

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20111102

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120202

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120209

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20120629

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121002

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20121009

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20121207