JP2009521683A - アナライザーシステム - Google Patents

アナライザーシステム Download PDF

Info

Publication number
JP2009521683A
JP2009521683A JP2008547558A JP2008547558A JP2009521683A JP 2009521683 A JP2009521683 A JP 2009521683A JP 2008547558 A JP2008547558 A JP 2008547558A JP 2008547558 A JP2008547558 A JP 2008547558A JP 2009521683 A JP2009521683 A JP 2009521683A
Authority
JP
Japan
Prior art keywords
blood
sample
analyzer
blood analyzer
cartridge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008547558A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009521683A5 (enExample
Inventor
パドマナバン,アラヴィンド
コックス,ジェームズ・エイ
フリッツ,バーナード・エス
レザチェク,トム・エム
ルーティマン,ピーター・エル
バーデル,ロン・エル
キャブズ,クレオパトラ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Honeywell International Inc
Original Assignee
Honeywell International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Honeywell International Inc filed Critical Honeywell International Inc
Publication of JP2009521683A publication Critical patent/JP2009521683A/ja
Publication of JP2009521683A5 publication Critical patent/JP2009521683A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/00594Quality control, including calibration or testing of components of the analyser
    • G01N35/00603Reinspection of samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404Handling flow, e.g. hydrodynamic focusing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/49Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/53Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02Analysing fluids
    • G01N29/032Analysing fluids by measuring attenuation of acoustic waves
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5094Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/00594Quality control, including calibration or testing of components of the analyser
    • G01N35/00613Quality control
    • G01N35/00663Quality control of consumables
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04Exchange or ejection of cartridges, containers or reservoirs
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0636Focussing flows, e.g. to laminate flows
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0684Venting, avoiding backpressure, avoid gas bubbles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14Process control and prevention of errors
    • B01L2200/143Quality control, feedback systems
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14Process control and prevention of errors
    • B01L2200/143Quality control, feedback systems
    • B01L2200/146Employing pressure sensors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/02Identification, exchange or storage of information
    • B01L2300/021Identification, e.g. bar codes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/041Connecting closures to device or container
    • B01L2300/044Connecting closures to device or container pierceable, e.g. films, membranes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0672Integrated piercing tool
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877Flow chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/14Means for pressure control
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406Moving fluids with specific forces or mechanical means specific forces capillary forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • B01L9/52Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484Optical investigation techniques, e.g. flow cytometry microstructural devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/011Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells with lysing, e.g. of erythrocytes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/012Red blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/016White blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/018Platelets
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434Optical arrangements
    • G01N2015/1452Adjustment of focus; Alignment
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486Counting the particles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099Characterised by type of test elements
    • G01N2035/00148Test cards, e.g. Biomerieux or McDonnel multiwell test cards
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099Characterised by type of test elements
    • G01N2035/00158Elements containing microarrays, i.e. "biochip"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178Special arrangements of analysers
    • G01N2035/00237Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G01N2035/00247Microvalves
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027General features of the devices
    • G01N2035/1034Transferring microquantities of liquid
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027General features of the devices
    • G01N2035/1048General features of the devices using the transfer device for another function
    • G01N2035/1053General features of the devices using the transfer device for another function for separating part of the liquid, e.g. filters, extraction phase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00Indexing codes associated with group G01N29/00
    • G01N2291/02Indexing codes associated with the analysed material
    • G01N2291/024Mixtures
    • G01N2291/02433Gases in liquids, e.g. bubbles, foams
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00Indexing codes associated with group G01N29/00
    • G01N2291/02Indexing codes associated with the analysed material
    • G01N2291/028Material parameters
    • G01N2291/02836Flow rate, liquid level
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00Indexing codes associated with group G01N29/00
    • G01N2291/02Indexing codes associated with the analysed material
    • G01N2291/028Material parameters
    • G01N2291/02872Pressure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Quality & Reliability (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Ecology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Acoustics & Sound (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
JP2008547558A 2005-12-22 2006-12-22 アナライザーシステム Pending JP2009521683A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75329305P 2005-12-22 2005-12-22
US75501405P 2005-12-29 2005-12-29
US11/615,884 US8383043B2 (en) 2004-05-14 2006-12-22 Analyzer system
PCT/US2006/048847 WO2007075920A2 (en) 2005-12-22 2006-12-22 Hematological analyzer system with removable cartridge

Publications (2)

Publication Number Publication Date
JP2009521683A true JP2009521683A (ja) 2009-06-04
JP2009521683A5 JP2009521683A5 (enExample) 2010-02-18

Family

ID=38180469

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008547558A Pending JP2009521683A (ja) 2005-12-22 2006-12-22 アナライザーシステム

Country Status (4)

Country Link
US (1) US8383043B2 (enExample)
EP (2) EP1963866B1 (enExample)
JP (1) JP2009521683A (enExample)
WO (1) WO2007075920A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023156368A (ja) * 2018-03-01 2023-10-24 ライカ ビオズュステムス ヌスロッホ ゲーエムベーハー 自動封入装置

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4359452B2 (ja) * 2003-06-26 2009-11-04 シスメックス株式会社 試料分析装置
EP1662987B1 (en) * 2003-09-11 2011-11-09 Theranos, Inc. Medical device for analyte monitoring and drug delivery
JP5138223B2 (ja) 2003-10-30 2013-02-06 サイトノーム エスティー リミテッド ライアビリティー カンパニー 流体力学的多層シースフロー構造
US8841076B2 (en) 2005-05-09 2014-09-23 Theranos, Inc. Systems and methods for conducting animal studies
US20070025879A1 (en) * 2005-07-27 2007-02-01 Dakocytomation Denmark A/S Method and apparatus for syringe-based sample introduction within a flow cytometer
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US20080113391A1 (en) * 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
JP5192168B2 (ja) * 2007-03-30 2013-05-08 シスメックス株式会社 設定情報管理システム、設定情報管理方法、バックアッププログラム、及び記憶媒体
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
WO2009027896A1 (en) * 2007-08-24 2009-03-05 Koninklijke Philips Electronics N. V. Microelectronic sensor device with wetting detection
EP2037281B1 (en) * 2007-09-13 2018-10-10 Sysmex Corporation Sample analyzer
EP2062644A1 (en) * 2007-11-26 2009-05-27 Koninklijke Philips Electronics N.V. Micro-fluidic device with degas control
EP2153892A1 (en) * 2008-07-23 2010-02-17 ETH Zurich Microreactor system and method for operating such microreactor system
US8247191B2 (en) * 2008-11-13 2012-08-21 Ritzen Kalle Disposable cassette and method of use for blood analysis on blood analyzer
KR20180078345A (ko) 2009-10-19 2018-07-09 테라노스, 인코포레이티드 통합형 건강 정보 취득 및 분석 시스템
MX336714B (es) 2009-11-24 2016-01-28 Opko Diagnostics Llc Mezclado y entrega de fluidos en sistemas microfluidicos.
BR112012026406B1 (pt) * 2010-04-16 2020-06-09 Opko Diagnostics Llc método de conduzir controle de qualidade para determinar anormalidades na operação de um sistema microfluídico
US8951781B2 (en) * 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
WO2012159021A2 (en) * 2011-05-19 2012-11-22 Hemosonics, Llc Portable hemostasis analyzer
CA2859167C (en) * 2011-12-12 2021-03-16 Step Ahead Innovations, Inc. Submerged chemical indicator and holder
WO2013102093A1 (en) * 2011-12-28 2013-07-04 Ibis Biosciences, Inc. Multiple- analyte assay device and system
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9075042B2 (en) 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
EP2906957A2 (en) * 2012-10-12 2015-08-19 Koninklijke Philips N.V. Optical fill detection
US9949674B2 (en) 2012-12-17 2018-04-24 Abbott Point Of Care Inc. Portable clinical analysis system for hematocrit measurement
CN108680734B (zh) 2012-12-17 2021-06-25 雅培医护站股份有限公司 便携式临床分析系统的操作和核查
CN105008920B (zh) 2012-12-17 2019-03-29 雅培医护站股份有限公司 便携式临床分析系统中的空间方位确定
US9885706B2 (en) 2012-12-17 2018-02-06 Abbott Point Of Care Inc. Portable clinical analysis system for immunometric measurement
EP2932250B1 (en) 2012-12-17 2017-10-04 Abbott Point Of Care, Inc. Self correction for spatial orientation and motion of portable clinical testing devices
EP4220124A1 (en) 2013-03-14 2023-08-02 Cytonome/ST, LLC Hydrodynamic focusing apparatus and methods
CN105745540A (zh) * 2013-09-24 2016-07-06 阿波罗德克斯公司 用于诊断测试的系统和方法
EP3105572B1 (en) * 2014-02-13 2019-04-10 Robert Bosch GmbH Capacitive bubble detection
KR20150111696A (ko) * 2014-03-26 2015-10-06 삼성전자주식회사 혈액 검사기 및 그에 따른 혈액 검사 방법
US20170328924A1 (en) 2014-11-26 2017-11-16 Ronald Jones Automated microscopic cell analysis
US10625259B1 (en) 2014-11-26 2020-04-21 Medica Corporation Automated microscopic cell analysis
US11478789B2 (en) 2014-11-26 2022-10-25 Medica Corporation Automated microscopic cell analysis
US12005441B1 (en) 2014-11-26 2024-06-11 Medica Corporation Automated microscopic cell analysis
US10022720B2 (en) 2015-06-12 2018-07-17 Cytochip Inc. Fluidic units and cartridges for multi-analyte analysis
US10634602B2 (en) 2015-06-12 2020-04-28 Cytochip Inc. Fluidic cartridge for cytometry and additional analysis
CN108027310B (zh) 2015-07-14 2020-12-22 芯易诊有限公司 流体盒中的体积感测
US9366606B1 (en) 2015-08-27 2016-06-14 Ativa Medical Corporation Fluid processing micro-feature devices and methods
US20170059590A1 (en) 2015-08-27 2017-03-02 Ativa Medical Corporation Fluid holding and dispensing micro-feature
US11071982B2 (en) 2015-08-27 2021-07-27 Ativa Medical Corporation Fluid holding and dispensing micro-feature
US10088494B2 (en) * 2016-01-25 2018-10-02 Perkinelmer Health Sciences, Inc. Method and system for microfluidic sample analysis
KR101667351B1 (ko) * 2016-02-18 2016-10-18 주식회사 지노바이오 일회용 분리칩
US10758906B2 (en) 2016-02-18 2020-09-01 Genobio, Inc. Cell separation chip and system
WO2018065115A1 (en) 2016-10-07 2018-04-12 Boehringer Ingelheim Vetmedica Gmbh Method for controlling an analysis device and analysis system
BR112019007117A2 (pt) 2016-10-07 2019-07-02 Boehringer Ingelheim Vetmedica Gmbh cartucho e sistema de análise para testagem de uma amostra
US10710085B2 (en) 2016-10-07 2020-07-14 Boehringer Ingelheim Vetmedica Gmbh Method for controlling an analysis device and analysis system
JP7004333B2 (ja) 2017-02-06 2022-01-21 イーエフエー―エンジニアリング フォー オール エルティーディー. 携帯用のデジタル診断デバイス
CA3061732A1 (en) * 2017-04-28 2018-11-01 Alpha Technologies Services Llc Rheometer docking station
US11491487B2 (en) 2017-10-23 2022-11-08 Cytochip Inc. Devices and methods for measuring analytes and target particles
US11047845B1 (en) * 2017-11-15 2021-06-29 Medica Corporation Control material and methods for cell analyzers
WO2019191531A1 (en) * 2018-03-30 2019-10-03 Idexx Laboratories, Inc. Quality control for point-of-care diagnostic systems
US20200033260A1 (en) * 2018-07-25 2020-01-30 Pauleologos Cusulos Coagulation and aggregation refracted light indexing device and method
EP3894835A1 (en) * 2018-12-11 2021-10-20 Carrier Corporation Calibration of an optical detector using a micro-flow chamber
MX2021011207A (es) 2019-03-18 2021-10-22 Siemens Healthcare Diagnostics Inc Aparatos y metodos para trampas de burbujas en dispositivos fluidicos.
CN113826000A (zh) 2019-04-26 2021-12-21 芯易诊有限公司 用于颗粒尺寸测量中修正的方法及设备
CA3185215A1 (en) * 2020-07-14 2022-01-20 Paul Said Ehrlich PEREZ Device, method, and system for collection of blood
CN115248180A (zh) * 2021-04-26 2022-10-28 帝迈(苏州)生物技术有限公司 Poct血细胞分析仪及其使用方法
US12404951B1 (en) * 2022-03-07 2025-09-02 United States Of America As Represented By The Administrator Of Nasa Microfluidics pressure-based switching and valving array
DE102022202966A1 (de) 2022-03-25 2023-09-28 Robert Bosch Gesellschaft mit beschränkter Haftung Mikrofluidische Kartusche und Verfahren zu ihrer Herstellung, sowie Analysenvorrichtung und Verfahren zu deren Betreiben
WO2025103968A1 (en) * 2023-11-15 2025-05-22 F. Hoffmann-La Roche Ag Ivd system and method of using an ivd consumable device susceptible to environmental conditions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004061418A2 (en) * 2002-12-26 2004-07-22 Meso Scale Technologies, Llc. Assay cartridges and methods of using the same
WO2005114144A1 (en) * 2004-05-14 2005-12-01 Honeywell International, Inc. Portable sample analyzer cartridge

Family Cites Families (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3822095A (en) 1972-08-14 1974-07-02 Block Engineering System for differentiating particles
US3928094A (en) 1975-01-16 1975-12-23 Fairchild Camera Instr Co Method of aligning a wafer beneath a mask and system therefor and wafer having a unique alignment pattern
US3976862A (en) 1975-03-18 1976-08-24 Block Engineering, Inc. Flow stream processor
US4284412A (en) 1979-07-13 1981-08-18 Ortho Diagnostics, Inc. Method and apparatus for automated identification and enumeration of specified blood cell subclasses
JPS58143206A (ja) 1982-02-19 1983-08-25 Canon Inc 位置検知信号処理装置
US4478077A (en) 1982-09-30 1984-10-23 Honeywell Inc. Flow sensor
US4683159A (en) 1982-09-30 1987-07-28 Honeywell Inc. Semiconductor device structure and processing
US4478076A (en) 1982-09-30 1984-10-23 Honeywell Inc. Flow sensor
US4651564A (en) 1982-09-30 1987-03-24 Honeywell Inc. Semiconductor device
US4501144A (en) 1982-09-30 1985-02-26 Honeywell Inc. Flow sensor
JPS6082865A (ja) * 1983-10-12 1985-05-11 Toshiba Corp 自動化学分析装置
US4980292A (en) 1984-10-01 1990-12-25 Baxter International Inc. Tablet dispensing
US4695034A (en) 1984-11-27 1987-09-22 Stec Inc. Fluid control device
US4745279A (en) 1986-01-02 1988-05-17 American Hospital Supply Corporation Hematocrit measuring apparatus
US4704033A (en) 1986-03-06 1987-11-03 Micronix Corporation Multiple wavelength linear zone plate alignment apparatus and method
NL8601000A (nl) 1986-04-21 1987-11-16 Jan Greve T H Twente Afdeling Het gebruik van gepolariseerd licht in stromingscytometrie.
DE3640616A1 (de) 1986-11-27 1988-06-09 Standard Elektrik Lorenz Ag Justiervorrichtung
US4818263A (en) 1987-06-11 1989-04-04 Tektronix, Inc. Method and apparatus for precisely positioning microlenses on optical fibers
US4874949A (en) 1987-09-14 1989-10-17 Vanderbilt University Method of measuring lung vascular function and transcapillary transport by the use of nonradioactive markers
US4911616A (en) 1988-01-19 1990-03-27 Laumann Jr Carl W Micro miniature implantable pump
US5760900A (en) 1989-03-18 1998-06-02 Canon Kabushiki Kaisha Method and apparatus for optically measuring specimen
US4932989A (en) 1989-04-05 1990-06-12 At&T Bell Laboratories Method and apparatus for fabricating microlenses on optical fibers
CH679555A5 (enExample) 1989-04-11 1992-03-13 Westonbridge Int Ltd
CA2016699C (en) 1989-05-15 2003-11-18 Paul N. Marshall Lytic agents and uses thereof
JPH04501449A (ja) 1989-06-14 1992-03-12 ウエストンブリッジ インターナショナル リミティド マイクロポンプ
DE3926066A1 (de) 1989-08-07 1991-02-14 Ibm Deutschland Mikromechanische kompressorkaskade und verfahren zur druckerhoehung bei extrem niedrigem arbeitsdruck
CH681168A5 (en) 1989-11-10 1993-01-29 Westonbridge Int Ltd Micro-pump for medicinal dosing
US5082242A (en) 1989-12-27 1992-01-21 Ulrich Bonne Electronic microvalve apparatus and fabrication
US5244537A (en) 1989-12-27 1993-09-14 Honeywell, Inc. Fabrication of an electronic microvalve apparatus
US5171132A (en) 1989-12-27 1992-12-15 Seiko Epson Corporation Two-valve thin plate micropump
US5050429A (en) 1990-02-22 1991-09-24 Yamatake-Honeywell Co., Ltd. Microbridge flow sensor
US5096388A (en) 1990-03-22 1992-03-17 The Charles Stark Draper Laboratory, Inc. Microfabricated pump
ATE122784T1 (de) * 1990-07-07 1995-06-15 Nestle Sa Dosiervorrichtung.
US5183765A (en) * 1990-10-11 1993-02-02 Drd Diluter Corporation Means and method of measuring and dispensing
EP0483469B1 (en) 1990-10-30 1994-10-12 Hewlett-Packard Company Micropump
DE69129260T2 (de) 1990-11-03 1998-11-19 Horiba Ltd Gerät zur Messung der Teilchengrössenverteilung
US5108623A (en) 1990-11-19 1992-04-28 Gould Inc. Moving web filter assembly
US5194909A (en) 1990-12-04 1993-03-16 Tycko Daniel H Apparatus and method for measuring volume and hemoglobin concentration of red blood cells
DE4119955C2 (de) 1991-06-18 2000-05-31 Danfoss As Miniatur-Betätigungselement
US5176358A (en) 1991-08-08 1993-01-05 Honeywell Inc. Microstructure gas valve control
JP2601075B2 (ja) * 1991-10-21 1997-04-16 株式会社日立製作所 試験片を用いる分析方法および分析装置
EP0648351B1 (en) 1992-07-02 1997-10-08 Indigo N.V. Concentration detector for colored toner
JP3215175B2 (ja) 1992-08-10 2001-10-02 シスメックス株式会社 粒子分析装置
US5441597A (en) 1992-12-01 1995-08-15 Honeywell Inc. Microstructure gas valve control forming method
DE69432410T2 (de) 1993-05-14 2004-03-04 Coulter International Corp., Miami Retikulozyt bestimmungsverfahren und geraet, das lichtstreuungstechniken verwendet
DE69525570T2 (de) 1994-07-28 2002-08-22 Hitachi, Ltd. Probensammler für flüssige Proben
US5601080A (en) 1994-12-28 1997-02-11 Coretech Medical Technologies Corporation Spectrophotometric blood analysis
US5793485A (en) 1995-03-20 1998-08-11 Sandia Corporation Resonant-cavity apparatus for cytometry or particle analysis
US5528045A (en) 1995-04-06 1996-06-18 Becton Dickinson And Company Particle analyzer with spatially split wavelength filter
EP0871539B1 (en) 1995-06-16 2002-02-20 University of Washington Tangential flow planar microfabricated fluid filter
WO1997000442A1 (en) 1995-06-16 1997-01-03 The University Of Washington Microfabricated differential extraction device and method
US5716852A (en) 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5717631A (en) 1995-07-21 1998-02-10 Carnegie Mellon University Microelectromechanical structure and process of making same
US5633724A (en) 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
US5726751A (en) 1995-09-27 1998-03-10 University Of Washington Silicon microchannel optical flow cytometer
IT1280475B1 (it) 1995-11-09 1998-01-20 Fiat Ricerche Dispositivi a microfiltri selettivi di colori e immagini.
DE19546570C1 (de) 1995-12-13 1997-03-27 Inst Mikro Und Informationstec Fluidpumpe
JP3308441B2 (ja) 1995-12-19 2002-07-29 シスメックス株式会社 尿中有形成分分析装置
US5837547A (en) 1995-12-27 1998-11-17 Caribbean Microparticles Corporation Flow cytometer calibration method
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US5851488A (en) * 1996-02-29 1998-12-22 Biocircuits Corporation Apparatus for automatic electro-optical chemical assay determination
US5948684A (en) 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
EP0910474B1 (en) 1996-06-14 2004-03-24 University of Washington Absorption-enhanced differential extraction method
US5764674A (en) 1996-06-28 1998-06-09 Honeywell Inc. Current confinement for a vertical cavity surface emitting laser
US5799030A (en) 1996-07-26 1998-08-25 Honeywell Inc. Semiconductor device with a laser and a photodetector in a common container
US5691486A (en) * 1996-07-30 1997-11-25 Bayer Corporation Apparatus and methods for selecting a variable number of test sample aliquots to mix with respective reagents
CA2267086A1 (en) 1996-10-03 1998-04-09 Didier Maillefer Micro-machined device for fluids and method of manufacture
US6124663A (en) 1996-12-16 2000-09-26 The Boeing Company Fiber optic connector having a microelectromechanical positioning apparatus and an associated fabrication method
US5683159A (en) 1997-01-03 1997-11-04 Johnson; Greg P. Hardware mounting rail
US6097859A (en) 1998-02-12 2000-08-01 The Regents Of The University Of California Multi-wavelength cross-connect optical switch
US5974867A (en) 1997-06-13 1999-11-02 University Of Washington Method for determining concentration of a laminar sample stream
US6139800A (en) 1997-06-23 2000-10-31 Luminex Corporation Interlaced lasers for multiple fluorescence measurement
US6082185A (en) 1997-07-25 2000-07-04 Research International, Inc. Disposable fluidic circuit cards
US5880474A (en) 1997-08-29 1999-03-09 Becton Dickinson And Company Multi-illumination-source flow particle analyzer with inter-location emissions crosstalk cancelation
US6007775A (en) 1997-09-26 1999-12-28 University Of Washington Multiple analyte diffusion based chemical sensor
US5822170A (en) 1997-10-09 1998-10-13 Honeywell Inc. Hydrophobic coating for reducing humidity effect in electrostatic actuators
US6106245A (en) 1997-10-09 2000-08-22 Honeywell Low cost, high pumping rate electrostatically actuated mesopump
US5901939A (en) 1997-10-09 1999-05-11 Honeywell Inc. Buckled actuator with enhanced restoring force
US5836750A (en) 1997-10-09 1998-11-17 Honeywell Inc. Electrostatically actuated mesopump having a plurality of elementary cells
US6054335A (en) 1997-12-12 2000-04-25 Xerox Corporation Fabrication of scanning III-V compound light emitters integrated with Si-based actuators
US6116756A (en) 1997-12-12 2000-09-12 Xerox Corporation Monolithic scanning light emitting devices
CA2320296A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
JP3522535B2 (ja) 1998-05-29 2004-04-26 忠弘 大見 圧力式流量制御装置を備えたガス供給設備
US6091197A (en) 1998-06-12 2000-07-18 Xerox Corporation Full color tunable resonant cavity organic light emitting diode
JP4001436B2 (ja) 1998-07-23 2007-10-31 三菱電機株式会社 光スイッチ及び光スイッチを用いた光路切換装置
DE19835070B4 (de) 1998-08-04 2006-03-16 Carl Zeiss Jena Gmbh Anordnung zur einstellbaren wellenlängenabhängigen Detektion in einem Fluoreszenzmikroskop
DE19849008A1 (de) * 1998-10-23 2000-04-27 Roche Diagnostics Gmbh Spreitschichten, Netzmittel zu ihrer Herstellung und deren Verwendung in Teststreifen
US6032689A (en) 1998-10-30 2000-03-07 Industrial Technology Research Institute Integrated flow controller module
US6602469B1 (en) * 1998-11-09 2003-08-05 Lifestream Technologies, Inc. Health monitoring and diagnostic device and network-based health assessment and medical records maintenance system
US6091537A (en) 1998-12-11 2000-07-18 Xerox Corporation Electro-actuated microlens assemblies
US6184607B1 (en) 1998-12-29 2001-02-06 Honeywell International Inc. Driving strategy for non-parallel arrays of electrostatic actuators sharing a common electrode
US6215221B1 (en) 1998-12-29 2001-04-10 Honeywell International Inc. Electrostatic/pneumatic actuators for active surfaces
US6249341B1 (en) 1999-01-25 2001-06-19 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US6531095B2 (en) * 1999-02-11 2003-03-11 Careside, Inc. Cartridge-based analytical instrument with optical detector
US6097485A (en) 1999-03-08 2000-08-01 Integrated Waveguides, Inc. Microchip optical transport technology for use in a personal flow cytometer
US6179586B1 (en) 1999-09-15 2001-01-30 Honeywell International Inc. Dual diaphragm, single chamber mesopump
US6240944B1 (en) 1999-09-23 2001-06-05 Honeywell International Inc. Addressable valve arrays for proportional pressure or flow control
DE10005735A1 (de) * 2000-02-09 2001-08-23 Evotec Biosystems Ag Verfahren und Vorrichtung zur Abführung suspendierter Mikropartikel aus einem fluidischen Mikrosystem
US6281975B1 (en) 2000-03-07 2001-08-28 Eldex Laboratories, Inc. Capillary flow cell with bulbous ends
US20010030743A1 (en) 2000-03-10 2001-10-18 Carlos Araujo Laser alignment system with plural lasers for impingement on a single target
DE20008228U1 (de) 2000-05-09 2002-01-03 Prüftechnik Dieter Busch AG, 85737 Ismaning Vorrichtung zur quantitativen Beurteilung der fluchtenden Lage zweier Maschinenteile, Werkstücke o.dgl.
US7978329B2 (en) 2000-08-02 2011-07-12 Honeywell International Inc. Portable scattering and fluorescence cytometer
US6597438B1 (en) 2000-08-02 2003-07-22 Honeywell International Inc. Portable flow cytometry
US6970245B2 (en) * 2000-08-02 2005-11-29 Honeywell International Inc. Optical alignment detection system
US6549275B1 (en) 2000-08-02 2003-04-15 Honeywell International Inc. Optical detection system for flow cytometry
US7630063B2 (en) * 2000-08-02 2009-12-08 Honeywell International Inc. Miniaturized cytometer for detecting multiple species in a sample
US7641856B2 (en) * 2004-05-14 2010-01-05 Honeywell International Inc. Portable sample analyzer with removable cartridge
US6700130B2 (en) * 2001-06-29 2004-03-02 Honeywell International Inc. Optical detection system for flow cytometry
US6382228B1 (en) 2000-08-02 2002-05-07 Honeywell International Inc. Fluid driving system for flow cytometry
US7061595B2 (en) * 2000-08-02 2006-06-13 Honeywell International Inc. Miniaturized flow controller with closed loop regulation
US7000330B2 (en) 2002-08-21 2006-02-21 Honeywell International Inc. Method and apparatus for receiving a removable media member
US20030062067A1 (en) * 2001-09-23 2003-04-03 Irm, Llc Closed cell washer
US6781388B2 (en) 2001-09-26 2004-08-24 Delphi Technologies, Inc. Liquid property sensor
US6729856B2 (en) 2001-10-09 2004-05-04 Honeywell International Inc. Electrostatically actuated pump with elastic restoring forces
US20030175980A1 (en) * 2002-03-14 2003-09-18 Hayenga Jon W. Ribbon flow cytometry and cell sorting
US20030207454A1 (en) * 2002-05-01 2003-11-06 Eyster Curt R. Devices and methods for analyte concentration determination
US20040096368A1 (en) * 2002-06-28 2004-05-20 Igen International, Inc. Assay systems and components
US7207939B2 (en) * 2002-10-03 2007-04-24 Coulter International Corp. Apparatus and method for analyzing a liquid in a capillary tube of a hematology instrument
US7079244B2 (en) 2002-11-18 2006-07-18 International Remote Imaging Systems, Inc. Particle analyzer with specimen tube in-line mixer
US7291310B2 (en) 2002-12-17 2007-11-06 The Regents Of The University Of Michigan Microsystem for determining clotting time of blood and low-cost, single-use device for use therein
US20040154933A1 (en) 2003-02-11 2004-08-12 Instrumentation Laboratory Company Polymeric membranes for use in electrochemical sensors
JP3979304B2 (ja) 2003-02-24 2007-09-19 日本光電工業株式会社 フローセル位置決め方法およびフローセル位置調整可能なフローサイトメータ
TW577855B (en) 2003-05-21 2004-03-01 Univ Nat Cheng Kung Chip-type micro-fluid particle 3-D focusing and detection device
JP5138223B2 (ja) * 2003-10-30 2013-02-06 サイトノーム エスティー リミテッド ライアビリティー カンパニー 流体力学的多層シースフロー構造
US20060257854A1 (en) 2004-02-27 2006-11-16 Mcdevitt John T Membrane assay system including preloaded particles
WO2005108963A1 (en) 2004-05-06 2005-11-17 Nanyang Technological University Microfluidic cell sorter system
CN101389947B (zh) * 2005-12-29 2013-08-21 霍尼韦尔国际公司 微流格式的测定工具

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004061418A2 (en) * 2002-12-26 2004-07-22 Meso Scale Technologies, Llc. Assay cartridges and methods of using the same
WO2005114144A1 (en) * 2004-05-14 2005-12-01 Honeywell International, Inc. Portable sample analyzer cartridge

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023156368A (ja) * 2018-03-01 2023-10-24 ライカ ビオズュステムス ヌスロッホ ゲーエムベーハー 自動封入装置
JP7598419B2 (ja) 2018-03-01 2024-12-11 ライカ ビオズュステムス ヌスロッホ ゲーエムベーハー 自動封入装置

Also Published As

Publication number Publication date
US20070166195A1 (en) 2007-07-19
US8383043B2 (en) 2013-02-26
WO2007075920A2 (en) 2007-07-05
EP1963866A2 (en) 2008-09-03
WO2007075920A3 (en) 2007-11-15
EP3121601A1 (en) 2017-01-25
EP1963866B1 (en) 2018-05-16

Similar Documents

Publication Publication Date Title
JP5175213B2 (ja) 携帯用サンプル分析システム
EP1963866B1 (en) Hematological analyzer system with removable cartridge
US8828320B2 (en) Portable sample analyzer cartridge
CN101379386B (zh) 便携式样品分析仪系统
EP1745275B1 (en) Portable sample analyzer cartridge
EP1745285B1 (en) Portable sample analyzer with removable cartridge
CN101262950B (zh) 流量计量分析器
EP1966587B1 (en) Differential white blood count on a disposable card
CN1985168B (zh) 具有可拆卸盒的便携式样本分析仪
US20230264193A1 (en) System for analysis
WO2025210522A1 (en) Automated sample preparation system implemented within a disposable cartridge

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091222

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20091222

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100119

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20111028

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20111102

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120202

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120209

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20120629

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121002

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20121009

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20121207