JP7402890B2 - 流体デバイスにおけるバブルトラップのための装置および方法 - Google Patents
流体デバイスにおけるバブルトラップのための装置および方法 Download PDFInfo
- Publication number
- JP7402890B2 JP7402890B2 JP2021556436A JP2021556436A JP7402890B2 JP 7402890 B2 JP7402890 B2 JP 7402890B2 JP 2021556436 A JP2021556436 A JP 2021556436A JP 2021556436 A JP2021556436 A JP 2021556436A JP 7402890 B2 JP7402890 B2 JP 7402890B2
- Authority
- JP
- Japan
- Prior art keywords
- chamber
- substrate
- fluid
- channel
- fluidic device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims description 34
- 239000012530 fluid Substances 0.000 claims description 252
- 239000000758 substrate Substances 0.000 claims description 178
- 230000004888 barrier function Effects 0.000 claims description 37
- 238000005086 pumping Methods 0.000 claims description 17
- 239000000853 adhesive Substances 0.000 claims description 11
- 230000001070 adhesive effect Effects 0.000 claims description 11
- 238000007789 sealing Methods 0.000 claims description 10
- 238000011144 upstream manufacturing Methods 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 238000004891 communication Methods 0.000 claims description 6
- 238000000465 moulding Methods 0.000 claims description 4
- 230000001939 inductive effect Effects 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 239000010410 layer Substances 0.000 description 62
- 239000011888 foil Substances 0.000 description 28
- 229910052751 metal Inorganic materials 0.000 description 26
- 239000002184 metal Substances 0.000 description 26
- 239000008280 blood Substances 0.000 description 20
- 210000004369 blood Anatomy 0.000 description 20
- 238000005259 measurement Methods 0.000 description 14
- 230000001965 increasing effect Effects 0.000 description 7
- 239000002699 waste material Substances 0.000 description 7
- 239000004698 Polyethylene Substances 0.000 description 6
- -1 polyethylene Polymers 0.000 description 6
- 229920000573 polyethylene Polymers 0.000 description 6
- 230000000630 rising effect Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000004593 Epoxy Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000012491 analyte Substances 0.000 description 3
- 238000004159 blood analysis Methods 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 238000001746 injection moulding Methods 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 108010003320 Carboxyhemoglobin Proteins 0.000 description 2
- 108010061951 Methemoglobin Proteins 0.000 description 2
- 108010064719 Oxyhemoglobins Proteins 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000012447 hatching Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000012384 transportation and delivery Methods 0.000 description 2
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 238000011481 absorbance measurement Methods 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000000071 blow moulding Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 239000011247 coating layer Substances 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 108010002255 deoxyhemoglobin Proteins 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000004023 plastic welding Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000013068 supply chain management Methods 0.000 description 1
- 238000003856 thermoforming Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- URYYVOIYTNXXBN-OWOJBTEDSA-N trans-cyclooctene Chemical compound C1CCC\C=C\CC1 URYYVOIYTNXXBN-OWOJBTEDSA-N 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D19/00—Degasification of liquids
- B01D19/0042—Degasification of liquids modifying the liquid flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0689—Sealing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
- B01L2300/021—Identification, e.g. bar codes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
- B01L2300/021—Identification, e.g. bar codes
- B01L2300/022—Transponder chips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0663—Whole sensors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0883—Serpentine channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
- B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Micromachines (AREA)
- Degasification And Air Bubble Elimination (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Description
Claims (18)
- 流体デバイス用の基板であって:
上面(102)及び底面(104);
流体を輸送する第1のチャネル(154)と;
該第1のチャネル(154)に連結され、該第1のチャネルから流体を受けるチャンバ(700)であって、上部および底部を含むチャンバ(700)と;
該チャンバ(700)に連結され、該チャンバ(700)から流体を受ける第2のチャネル(156)と;
チャンバ(700)の上部に隣接し、流体中のバブルが第2のチャネル(156)に入るのを阻止する複数のバリアと
を含み、
チャンバ(700)は、複数の内部表面(712、722、724、726)によって囲まれて、表面712は、チャンバ(700)の上流側の端部を成し、表面722は、チャンバの下流側の端部を成し、表面(724、726)は、チャンバ(700)の側面を成し、
チャンバ(700)は、基板(100)の厚さを通って上面(102)から底面(104)まで延びて、チャンバの上部は、基板の上面(102)と同じ平面内にあることを特徴とする、
前記基板。 - 基板は一体型の本体である、請求項1に記載の基板。
- 第2のチャネル(156)は、チャンバ(700)の底部に近接した位置でチャンバ(700)に連結され、および/または、
第1のチャネル(154)は、チャンバ(700)の底部に近接した位置でチャンバに(700)連結されている、請求項1に記載の基板。 - チャンバ(700)の断面積は、第1のチャネル(154)の断面積および第2のチャネル(156)の断面積よりも大きく、チャンバ、第1のチャネルおよび第2のチャネル
の断面積は、流体の流れ方向に対して直交して測定される、請求項1に記載の基板。 - 複数のバリアは、流体の流れ方向に対して実質的に直交して延びる横ビームを含み、
横ビームは、チャンバ(700)の上部と横ビームとの間で少なくとも1つのバブルを捕捉するように構成され、および/または、
横ビームの上流側の表面はチャンバ(700)の上部に対して実質的に直交し、横ビームの下流側の表面はチャンバ(700)の上部に対して傾斜している、請求項1に記載の基板。 - 複数のバリアは、チャンバ(700)の内壁を含む、請求項1に記載の基板。
- 複数のバリアは、流体の流れ方向に対して実質的に直交して延びる横ビームを含む、、請求項6に記載の基板。
- チャンバ(700)の高さは、複数のバリアのうちの少なくとも1つのバリアの高さよりも大きく、チャンバ(700)の高さは、チャンバ(700)の上部からチャンバ(700)の底部までの距離として測定され、少なくとも1つのバリアの高さは、少なくとも1つのバリアがチャンバ(700)の上部からチャンバ(700)の底部に向かって延びる距離として測定される、請求項1に記載の基板。
- 少なくとも1つのバリアの高さは、チャンバの高さの少なくとも半分である、請求項8に記載の基板。
- 流体デバイスであって:
請求項1~9のいずれか1項に記載の基板と;
第1のチャネル(154)と流体連通し、第1のチャネル(154)の上流にある流体の供給源と;
基板の底面に連結され、チャンバ(700)の底部を封止する下部カバー層と
を含む前記流体デバイス。 - 基板の上面に連結され、チャンバの上部を封止する上部カバー層をさらに含む、請求項10に記載の流体デバイス。
- 上部カバー層および下部カバー層は、接着剤を含む、請求項11に記載の流体デバイス。
- 第2のチャネル(156)と流体連通し、第2のチャネル(156)の下流にあるセンサをさらに含む、請求項10に記載の流体デバイス。
- 請求項10に記載された流体デバイスを製造する方法であって:
請求項1に記載された基板を形成し、
下部カバー層を基板の底面に適用し、チャンバの底部を封止することを含む、前記方法。 - 基板を形成することは、基板を成形することを含む、請求項14に記載の方法。
- 上部カバー層を基板の上面に適用し、チャンバの上部を封止することをさらに含む、請求項14に記載の方法。
- 請求項10に記載された流体デバイスの流体中に混入したバブルを捕捉する方法であっ
て:
流体を、流体デバイスの第1のチャネル(154)を介し、該第1のチャネル(154)から流体を受ける流体デバイスのチャンバ(700)を介し、該チャンバ(700)から流体を受ける流体デバイスの第2のチャネル(156)内に圧送することを含み、チャンバ(700)の上部に隣接した複数のバリアは、流体中のバブルが第2のチャネル(156)に入るのを阻止する、前記方法。 - 流体を第1のチャネル(154)に圧送することは、所定の速度で流体を第1のチャネル(154)に圧送して、バブルがチャンバ(700)の上部に向かって上昇し、複数のバリアによって捕捉されることを可能にするチャンバ(700)内の流体の流速を誘導することを含む、請求項17に記載の方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962819965P | 2019-03-18 | 2019-03-18 | |
US62/819,965 | 2019-03-18 | ||
US201962863546P | 2019-06-19 | 2019-06-19 | |
US62/863,546 | 2019-06-19 | ||
PCT/US2020/019656 WO2020190461A1 (en) | 2019-03-18 | 2020-02-25 | Apparatus and methods for bubble traps in fluidic devices |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2022525536A JP2022525536A (ja) | 2022-05-17 |
JP7402890B2 true JP7402890B2 (ja) | 2023-12-21 |
Family
ID=72520389
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021556436A Active JP7402890B2 (ja) | 2019-03-18 | 2020-02-25 | 流体デバイスにおけるバブルトラップのための装置および方法 |
Country Status (7)
Country | Link |
---|---|
US (1) | US20220203366A1 (ja) |
EP (1) | EP3941629A4 (ja) |
JP (1) | JP7402890B2 (ja) |
CA (1) | CA3133974C (ja) |
IL (1) | IL286384A (ja) |
MX (1) | MX2021011207A (ja) |
WO (1) | WO2020190461A1 (ja) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004093558A (ja) | 2002-07-12 | 2004-03-25 | Mitsubishi Chemicals Corp | 分析用チップ、分析用チップユニット及び分析装置ならびに分析用チップの作製方法 |
JP2013007592A (ja) | 2011-06-23 | 2013-01-10 | Konica Minolta Advanced Layers Inc | フローセル及び流路チップ |
JP2015166707A (ja) | 2014-03-04 | 2015-09-24 | キヤノン株式会社 | マイクロ流路デバイス |
JP2016165704A (ja) | 2015-03-10 | 2016-09-15 | パナソニックIpマネジメント株式会社 | マイクロ流路チップ及びマイクロ流路装置 |
JP2017523435A (ja) | 2014-08-15 | 2017-08-17 | クレティス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングCuretis GmbH | 流体からバブルを分離するための装置 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020022261A1 (en) * | 1995-06-29 | 2002-02-21 | Anderson Rolfe C. | Miniaturized genetic analysis systems and methods |
US8383043B2 (en) * | 2004-05-14 | 2013-02-26 | Honeywell International Inc. | Analyzer system |
WO2004008142A1 (ja) * | 2002-07-12 | 2004-01-22 | Mitsubishi Chemical Corporation | 分析用チップ、分析用チップユニット、分析装置及びそれを用いた分析方法並びに分析用チップの作製方法 |
JP4685611B2 (ja) * | 2005-12-02 | 2011-05-18 | 株式会社エンプラス | 微小流体装置 |
WO2007125642A1 (ja) * | 2006-04-05 | 2007-11-08 | Nikkiso Co., Ltd. | 混合器、混合装置及び医療成分測定ユニット |
-
2020
- 2020-02-25 JP JP2021556436A patent/JP7402890B2/ja active Active
- 2020-02-25 EP EP20774488.9A patent/EP3941629A4/en active Pending
- 2020-02-25 MX MX2021011207A patent/MX2021011207A/es unknown
- 2020-02-25 WO PCT/US2020/019656 patent/WO2020190461A1/en unknown
- 2020-02-25 CA CA3133974A patent/CA3133974C/en active Active
- 2020-02-25 US US17/593,305 patent/US20220203366A1/en active Pending
-
2021
- 2021-09-14 IL IL286384A patent/IL286384A/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004093558A (ja) | 2002-07-12 | 2004-03-25 | Mitsubishi Chemicals Corp | 分析用チップ、分析用チップユニット及び分析装置ならびに分析用チップの作製方法 |
JP2013007592A (ja) | 2011-06-23 | 2013-01-10 | Konica Minolta Advanced Layers Inc | フローセル及び流路チップ |
JP2015166707A (ja) | 2014-03-04 | 2015-09-24 | キヤノン株式会社 | マイクロ流路デバイス |
JP2017523435A (ja) | 2014-08-15 | 2017-08-17 | クレティス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングCuretis GmbH | 流体からバブルを分離するための装置 |
JP2016165704A (ja) | 2015-03-10 | 2016-09-15 | パナソニックIpマネジメント株式会社 | マイクロ流路チップ及びマイクロ流路装置 |
Also Published As
Publication number | Publication date |
---|---|
EP3941629A4 (en) | 2022-05-11 |
MX2021011207A (es) | 2021-10-22 |
US20220203366A1 (en) | 2022-06-30 |
EP3941629A1 (en) | 2022-01-26 |
CA3133974C (en) | 2023-10-03 |
WO2020190461A1 (en) | 2020-09-24 |
JP2022525536A (ja) | 2022-05-17 |
CA3133974A1 (en) | 2020-09-24 |
IL286384A (en) | 2021-10-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2594370C (en) | Diagnostic devices incorporating fluidics and methods of manufacture | |
US7625760B2 (en) | Analyzing cartridge and liquid feed control device | |
JP4660662B2 (ja) | カートリッジ | |
CA2971921A1 (en) | Heterogeneous membrane electrodes | |
US20220357347A1 (en) | Device and method to evaluate a fluid sample on a single-use multianalyte consumable | |
JP7402890B2 (ja) | 流体デバイスにおけるバブルトラップのための装置および方法 | |
US7909063B2 (en) | Microchip inspection system and program employed for the same | |
EP3948304B1 (en) | System for delivering fluid samples through a fluidic device and methods therefor | |
KR102351481B1 (ko) | 미소유체 반응 관찰용 마이크로 플랫폼 | |
US10549480B2 (en) | Ultrasonic welding of a microfluidic device | |
JP2024074812A (ja) | コーティングされた微小突起アレイを組み込んだ診断用消耗品およびその方法 | |
CN113368750A (zh) | 液体处理装置及液体处理方法 | |
US20220205883A1 (en) | Diagnostic consumables incorporating coated micro-projection arrays, and methods thereof | |
WO2009024916A1 (en) | Vent design for biosensor cartridge | |
JP6106446B2 (ja) | 感知センサー及び感知装置 | |
JP2015224920A (ja) | 流体取扱装置 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20211215 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20221130 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20221213 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230313 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20230620 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230915 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20231114 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20231211 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7402890 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |