JP2009520682A5 - - Google Patents
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- Publication number
- JP2009520682A5 JP2009520682A5 JP2008529406A JP2008529406A JP2009520682A5 JP 2009520682 A5 JP2009520682 A5 JP 2009520682A5 JP 2008529406 A JP2008529406 A JP 2008529406A JP 2008529406 A JP2008529406 A JP 2008529406A JP 2009520682 A5 JP2009520682 A5 JP 2009520682A5
- Authority
- JP
- Japan
- Prior art keywords
- tyr
- compound
- azagly
- asn
- trp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005370388 | 2005-12-22 | ||
| JP2006275843 | 2006-10-06 | ||
| PCT/JP2006/326176 WO2007072997A1 (en) | 2005-12-22 | 2006-12-21 | Metastin derivatives and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010182482A Division JP5298087B2 (ja) | 2005-12-22 | 2010-08-17 | メタスチン誘導体およびその用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009520682A JP2009520682A (ja) | 2009-05-28 |
| JP2009520682A5 true JP2009520682A5 (https=) | 2010-10-07 |
| JP4653840B2 JP4653840B2 (ja) | 2011-03-16 |
Family
ID=37846230
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008529406A Expired - Fee Related JP4653840B2 (ja) | 2005-12-22 | 2006-12-21 | メタスチン誘導体およびその用途 |
| JP2010182482A Expired - Fee Related JP5298087B2 (ja) | 2005-12-22 | 2010-08-17 | メタスチン誘導体およびその用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010182482A Expired - Fee Related JP5298087B2 (ja) | 2005-12-22 | 2010-08-17 | メタスチン誘導体およびその用途 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7960348B2 (https=) |
| EP (1) | EP1963362B1 (https=) |
| JP (2) | JP4653840B2 (https=) |
| KR (1) | KR101368607B1 (https=) |
| AR (1) | AR058584A1 (https=) |
| AU (1) | AU2006328333B2 (https=) |
| BR (1) | BRPI0619399B8 (https=) |
| CA (1) | CA2634647C (https=) |
| CR (1) | CR10019A (https=) |
| CY (1) | CY1112353T1 (https=) |
| DK (1) | DK1963362T3 (https=) |
| ES (1) | ES2375038T3 (https=) |
| GE (1) | GEP20115356B (https=) |
| HR (1) | HRP20110851T1 (https=) |
| IL (1) | IL190888A (https=) |
| JO (1) | JO2799B1 (https=) |
| MA (1) | MA30060B1 (https=) |
| ME (1) | ME01015B (https=) |
| MY (1) | MY151967A (https=) |
| NO (1) | NO341879B1 (https=) |
| NZ (1) | NZ568322A (https=) |
| PE (1) | PE20071141A1 (https=) |
| PL (1) | PL1963362T3 (https=) |
| PT (1) | PT1963362E (https=) |
| RS (1) | RS52007B (https=) |
| RU (1) | RU2430107C2 (https=) |
| SI (1) | SI1963362T1 (https=) |
| TW (1) | TWI386417B (https=) |
| WO (1) | WO2007072997A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060241051A1 (en) | 2002-12-26 | 2006-10-26 | Chieko Kitada | Metastin derivatives and use thereof |
| WO2004080479A1 (ja) | 2003-03-12 | 2004-09-23 | Takeda Pharmaceutical Company Limited | 性腺機能改善剤 |
| AR049938A1 (es) | 2004-06-25 | 2006-09-13 | Takeda Pharmaceutical | Derivados de metastina y utilizacion de los mismos |
| US8404643B2 (en) | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US20090093615A1 (en) * | 2005-12-22 | 2009-04-09 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| TWI386417B (zh) | 2005-12-22 | 2013-02-21 | Takeda Pharmaceutical | 轉移抑素衍生物及其用途 |
| TWI404726B (zh) * | 2006-10-25 | 2013-08-11 | Takeda Pharmaceutical | 腫瘤轉移抑制素衍生物及其用途 |
| WO2009131191A1 (ja) | 2008-04-24 | 2009-10-29 | 武田薬品工業株式会社 | メタスチン誘導体およびその用途 |
| PT2314609T (pt) * | 2008-07-30 | 2017-03-06 | Takeda Pharmaceuticals Co | Derivado de metastina e sua utilização |
| US20110312898A1 (en) * | 2008-12-29 | 2011-12-22 | Takeda Pharmaceutical Company Limited | Prophylactic / therapeutic agent for cancer |
| KR20120098906A (ko) * | 2009-12-22 | 2012-09-05 | 다케다 야쿠힌 고교 가부시키가이샤 | 서방성 제제 |
| BR112012032544A2 (pt) * | 2010-06-25 | 2016-10-11 | Takeda Pharmaceutical | formulação de liberação prolongada, uso de um composto, e, método para produzir a formulação de liberação prolongada. |
| WO2013017631A1 (en) | 2011-08-04 | 2013-02-07 | Msd Oss B.V. | Kisspeptide-pentasaccharide conjugates |
| US9517210B2 (en) | 2012-07-12 | 2016-12-13 | Takeda Pharmaceutical Company Limited | Method for producing microcapsule powder |
| WO2015112703A1 (en) * | 2014-01-22 | 2015-07-30 | The Johns Hopkins University | Compositions and methods for treating diabetes |
| JP6253146B2 (ja) * | 2014-02-04 | 2017-12-27 | 国立大学法人山口大学 | 新規なペプチド誘導体及びこれを含有する医薬 |
| MA46353A (fr) * | 2016-09-30 | 2019-08-07 | Myovant Sciences Gmbh | Méthodes de traitement de l'infertilité féminine |
| ES2912929T5 (en) | 2016-09-30 | 2025-05-09 | Sumitomo Pharma Switzerland Gmbh | Methods of treating uterine fibroids and endometriosis |
| TWI810193B (zh) * | 2017-07-05 | 2023-08-01 | 大陸商尚華醫藥科技（江西）有限公司 | 一種Kiss1肽類化合物、其應用及含其的組合物 |
| CA3185151A1 (en) | 2020-05-29 | 2021-12-02 | Myovant Sciences Gmbh | Combination solid oral dosage forms of gonadotropin-releasing hormone antagonists |
| US12521455B2 (en) | 2024-04-08 | 2026-01-13 | Radionetics Oncology, Inc. | Kisspeptin receptor (KISS1R) targeted therapeutics and uses thereof |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL74827A (en) | 1984-05-21 | 1989-06-30 | Salk Inst For Biological Studi | Peptides active as gnrh antagonists and pharmaceutical compositions containing them |
| MX9100717A (es) | 1990-08-24 | 1992-04-01 | Syntex Inc | Antagonistas de la bradiquinina |
| CA2229201A1 (en) | 1995-10-19 | 1997-04-24 | Satoshi Sasaki | Quinoline derivatives, their production and use |
| JPH09169735A (ja) | 1995-10-19 | 1997-06-30 | Takeda Chem Ind Ltd | キノリン誘導体、その製造法および用途 |
| JP2000510453A (ja) | 1996-04-19 | 2000-08-15 | ノボ ノルディスク アクティーゼルスカブ | 成長ホルモン遊離特性を有する化合物 |
| WO1998039448A2 (en) | 1997-03-07 | 1998-09-11 | Human Genome Sciences, Inc. | 186 human secreted proteins |
| JP4486187B2 (ja) * | 1998-10-27 | 2010-06-23 | 武田薬品工業株式会社 | 新規ｇ蛋白質共役型レセプター蛋白質、そのｄｎａおよびそのリガンド |
| US6528054B1 (en) | 1998-12-28 | 2003-03-04 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of breast cancer |
| HUP0201804A2 (en) | 1999-06-28 | 2002-09-28 | Basf Ag | Method for preventing tumoral growth |
| KR100815041B1 (ko) | 1999-08-02 | 2008-03-18 | 아처 다니엘 미드랜드 캄파니 | 아미노산 생산의 대사 공학 |
| CN1411509A (zh) * | 1999-12-17 | 2003-04-16 | 武田药品工业株式会社 | Kiss－1肽的制造方法 |
| PL366626A1 (en) | 2000-03-29 | 2005-02-07 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US20050240008A1 (en) * | 2000-03-30 | 2005-10-27 | Tetsuya Ohtaki | Novel protein, dna thereof and process for producing the same |
| US7834141B1 (en) | 2000-03-31 | 2010-11-16 | Theresa Siler-Khodr | Non-mammalian GnRH analogs and uses thereof in tumor cell growth regulation and cancer therapy |
| RU2311920C2 (ru) | 2000-09-20 | 2007-12-10 | Корикса Корпорейшн | Композиции и способы для лечения и диагностики рака легких |
| JP2003026601A (ja) | 2000-11-29 | 2003-01-29 | Takeda Chem Ind Ltd | 医薬組成物およびその製造法 |
| JP2002320496A (ja) | 2001-02-26 | 2002-11-05 | Takeda Chem Ind Ltd | 新規マウス型ＫｉＳＳ−１レセプタータンパク質およびそのＤＮＡ |
| WO2002085399A1 (fr) | 2001-04-20 | 2002-10-31 | Takeda Chemical Industries, Ltd. | Preparations contenant un peptide |
| KR100599419B1 (ko) * | 2001-05-17 | 2006-07-10 | 가부시키가이샤 시마즈세이사쿠쇼 | 펩티드의 제조법 |
| DE60219645T2 (de) * | 2001-09-19 | 2007-08-09 | Takeda Pharmaceutical Co. Ltd. | Antikörper gegen metastin und dessen verwendung zur diagnose von schwangerschaft |
| US20050176091A1 (en) * | 2002-01-11 | 2005-08-11 | Takao Yamada | Process for producing kiss-1 peptide |
| JP2003300906A (ja) | 2002-04-12 | 2003-10-21 | Daiichi Fine Chemical Co Ltd | がん転移抑制因子の安定化 |
| BR0314912A (pt) | 2002-10-25 | 2005-08-02 | Paradigm Therapeutics Ltd | Método para produzir uma célula compreendendo em gene gpr54 funcionalmente inativo, constructo de ácido nucléico, composição, método para prover uma indicação de utilidade no diagnóstico de uma doença ou de uma condição, uso de um polipeptìdio gpr54, de um agonista, de um antanogista ou de um modulador da atividade do polipeptìdio gpr54 |
| JP4804714B2 (ja) * | 2002-12-26 | 2011-11-02 | 武田薬品工業株式会社 | メタスチン誘導体およびその用途 |
| US20060241051A1 (en) * | 2002-12-26 | 2006-10-26 | Chieko Kitada | Metastin derivatives and use thereof |
| US6800611B2 (en) * | 2003-01-06 | 2004-10-05 | Takeda Chemical Industries, Ltd. | Metastin derivatives and their use |
| KR100595364B1 (ko) | 2003-02-20 | 2006-07-03 | 재단법인 목암생명공학연구소 | Ｌｋ8 단백질을 유효성분으로 포함하는 항암제 |
| WO2004080479A1 (ja) | 2003-03-12 | 2004-09-23 | Takeda Pharmaceutical Company Limited | 性腺機能改善剤 |
| EP1464652A1 (en) | 2003-04-02 | 2004-10-06 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | GPR54 receptor agonist and antagonist useful for the treatment of gonadotropin related diseases |
| US20050002935A1 (en) | 2003-04-17 | 2005-01-06 | Vincent Ling | Use of B7-H3 as an immunoregulatory agent |
| WO2004096855A2 (en) | 2003-04-28 | 2004-11-11 | Wyeth | Methods utilising g-protein coupled receptor 54 |
| WO2004101747A2 (en) | 2003-05-07 | 2004-11-25 | The General Hospital Corporation | Identification and use of gpr54 and its ligands for reproductive disorders and contraception |
| ATE399763T1 (de) | 2003-05-30 | 2008-07-15 | Prozymex As | Proteasehemmer |
| DE60336353D1 (de) | 2003-11-03 | 2011-04-21 | Beijing Sunbio Biotech Co Ltd | Rekombinantes protein mit krebsunterdrückender wirkung, sein codierendes gen und seine verwendung |
| RU2333221C2 (ru) | 2003-11-03 | 2008-09-10 | Бейцзин Санбио Байотек Ко., Лтд. | Рекомбинантный белок, обладающий противораковым действием, кодирующий его ген и его применение |
| WO2005095973A2 (en) | 2004-03-25 | 2005-10-13 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 54 (gpr54) |
| AR049938A1 (es) * | 2004-06-25 | 2006-09-13 | Takeda Pharmaceutical | Derivados de metastina y utilizacion de los mismos |
| US7725869B1 (en) * | 2005-04-07 | 2010-05-25 | Xilinx, Inc. | Method and apparatus for modeling multiple instances of an electronic circuit using an imperative programming language description |
| WO2007084211A2 (en) | 2005-11-11 | 2007-07-26 | The General Hospital Corporation | Use of gpr54 ligands for treatment of reproductive disorders, proliferative disorders, and for contraception |
| TWI386417B (zh) | 2005-12-22 | 2013-02-21 | Takeda Pharmaceutical | 轉移抑素衍生物及其用途 |
| US8404643B2 (en) * | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US20090093615A1 (en) * | 2005-12-22 | 2009-04-09 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US20090099334A1 (en) * | 2005-12-22 | 2009-04-16 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| TWI404726B (zh) | 2006-10-25 | 2013-08-11 | Takeda Pharmaceutical | 腫瘤轉移抑制素衍生物及其用途 |
-
2006
- 2006-12-20 TW TW095147852A patent/TWI386417B/zh active
- 2006-12-20 AR ARP060105651A patent/AR058584A1/es active IP Right Grant
- 2006-12-21 ME MEP-2009-175A patent/ME01015B/me unknown
- 2006-12-21 GE GEAP200610770A patent/GEP20115356B/en unknown
- 2006-12-21 JO JO2006486A patent/JO2799B1/en active
- 2006-12-21 HR HR20110851T patent/HRP20110851T1/hr unknown
- 2006-12-21 PE PE2006001686A patent/PE20071141A1/es active IP Right Grant
- 2006-12-21 CA CA2634647A patent/CA2634647C/en active Active
- 2006-12-21 JP JP2008529406A patent/JP4653840B2/ja not_active Expired - Fee Related
- 2006-12-21 PT PT06843555T patent/PT1963362E/pt unknown
- 2006-12-21 AU AU2006328333A patent/AU2006328333B2/en not_active Ceased
- 2006-12-21 RS RS20110437A patent/RS52007B/sr unknown
- 2006-12-21 KR KR1020087012506A patent/KR101368607B1/ko active Active
- 2006-12-21 RU RU2008125063/04A patent/RU2430107C2/ru active
- 2006-12-21 MY MYPI20082169 patent/MY151967A/en unknown
- 2006-12-21 ES ES06843555T patent/ES2375038T3/es active Active
- 2006-12-21 BR BRPI0619399A patent/BRPI0619399B8/pt not_active IP Right Cessation
- 2006-12-21 WO PCT/JP2006/326176 patent/WO2007072997A1/en not_active Ceased
- 2006-12-21 SI SI200631152T patent/SI1963362T1/sl unknown
- 2006-12-21 EP EP06843555A patent/EP1963362B1/en active Active
- 2006-12-21 PL PL06843555T patent/PL1963362T3/pl unknown
- 2006-12-21 DK DK06843555.1T patent/DK1963362T3/da active
- 2006-12-21 NZ NZ568322A patent/NZ568322A/en unknown
- 2006-12-21 US US12/158,251 patent/US7960348B2/en active Active
-
2008
- 2008-04-15 IL IL190888A patent/IL190888A/en active IP Right Grant
- 2008-05-26 CR CR10019A patent/CR10019A/es unknown
- 2008-06-10 NO NO20082595A patent/NO341879B1/no unknown
- 2008-06-18 MA MA31044A patent/MA30060B1/fr unknown
-
2010
- 2010-08-17 JP JP2010182482A patent/JP5298087B2/ja not_active Expired - Fee Related
-
2011
- 2011-11-18 CY CY20111101116T patent/CY1112353T1/el unknown
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