JP2009520463A5 - - Google Patents
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- JP2009520463A5 JP2009520463A5 JP2008542539A JP2008542539A JP2009520463A5 JP 2009520463 A5 JP2009520463 A5 JP 2009520463A5 JP 2008542539 A JP2008542539 A JP 2008542539A JP 2008542539 A JP2008542539 A JP 2008542539A JP 2009520463 A5 JP2009520463 A5 JP 2009520463A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- polypeptide
- heptapeptide
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000002773 nucleotide Substances 0.000 claims 136
- 125000003729 nucleotide group Chemical group 0.000 claims 136
- 108090000765 processed proteins & peptides Proteins 0.000 claims 132
- 229920001184 polypeptide Polymers 0.000 claims 129
- 102000004196 processed proteins & peptides Human genes 0.000 claims 129
- 230000027455 binding Effects 0.000 claims 121
- 239000000203 mixture Substances 0.000 claims 79
- 125000003275 alpha amino acid group Chemical group 0.000 claims 63
- 125000000539 amino acid group Chemical group 0.000 claims 60
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 49
- 239000011701 zinc Substances 0.000 claims 49
- 229910052725 zinc Inorganic materials 0.000 claims 49
- 238000006467 substitution reaction Methods 0.000 claims 27
- 229910052717 sulfur Inorganic materials 0.000 claims 27
- 229910052739 hydrogen Inorganic materials 0.000 claims 24
- 102000040430 polynucleotide Human genes 0.000 claims 23
- 108091033319 polynucleotide Proteins 0.000 claims 23
- 239000002157 polynucleotide Substances 0.000 claims 23
- 229910052722 tritium Inorganic materials 0.000 claims 16
- 108090000623 proteins and genes Proteins 0.000 claims 12
- 239000003937 drug carrier Substances 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 108091023040 Transcription factor Proteins 0.000 claims 10
- 102000040945 Transcription factor Human genes 0.000 claims 10
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- 150000007523 nucleic acids Chemical group 0.000 claims 9
- 230000002103 transcriptional effect Effects 0.000 claims 9
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 7
- 102000003964 Histone deacetylase Human genes 0.000 claims 6
- 108090000353 Histone deacetylase Proteins 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 238000010494 dissociation reaction Methods 0.000 claims 6
- 230000005593 dissociations Effects 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 4
- 230000010076 replication Effects 0.000 claims 4
- 125000003412 L-alanyl group Chemical group [H]N([H])[C@@](C([H])([H])[H])(C(=O)[*])[H] 0.000 claims 3
- 125000000570 L-alpha-aspartyl group Chemical group [H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(*)=O 0.000 claims 3
- 125000002059 L-arginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] 0.000 claims 3
- 125000000010 L-asparaginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C(=O)N([H])[H] 0.000 claims 3
- 125000000415 L-cysteinyl group Chemical group O=C([*])[C@@](N([H])[H])([H])C([H])([H])S[H] 0.000 claims 3
- 125000003338 L-glutaminyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C(=O)N([H])[H] 0.000 claims 3
- 125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 claims 3
- 125000002061 L-isoleucyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])[C@](C([H])([H])[H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 3
- 125000001176 L-lysyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C([H])([H])C([H])([H])C(N([H])[H])([H])[H] 0.000 claims 3
- 125000002842 L-seryl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])O[H] 0.000 claims 3
- 125000000769 L-threonyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])[C@](O[H])(C([H])([H])[H])[H] 0.000 claims 3
- 125000002707 L-tryptophyl group Chemical group [H]C1=C([H])C([H])=C2C(C([C@](N([H])[H])(C(=O)[*])[H])([H])[H])=C([H])N([H])C2=C1[H] 0.000 claims 3
- 125000003580 L-valyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(C([H])([H])[H])(C([H])([H])[H])[H] 0.000 claims 3
- 102100025169 Max-binding protein MNT Human genes 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 238000000302 molecular modelling Methods 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 229910052698 phosphorus Inorganic materials 0.000 claims 3
- 108091006106 transcriptional activators Proteins 0.000 claims 3
- 108091008023 transcriptional regulators Proteins 0.000 claims 3
- 108091006107 transcriptional repressors Proteins 0.000 claims 3
- 230000004568 DNA-binding Effects 0.000 claims 2
- 101710185494 Zinc finger protein Proteins 0.000 claims 2
- 102100023597 Zinc finger protein 816 Human genes 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 108010077805 Bacterial Proteins Proteins 0.000 claims 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 108700001094 Plant Genes Proteins 0.000 claims 1
- 108700005077 Viral Genes Proteins 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 102000037983 regulatory factors Human genes 0.000 claims 1
- 108091008025 regulatory factors Proteins 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74052505P | 2005-11-28 | 2005-11-28 | |
| PCT/US2006/061289 WO2007062422A2 (en) | 2005-11-28 | 2006-11-28 | Zinc finger binding domains for tnn |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009520463A JP2009520463A (ja) | 2009-05-28 |
| JP2009520463A5 true JP2009520463A5 (https=) | 2010-01-14 |
Family
ID=38068069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008542539A Pending JP2009520463A (ja) | 2005-11-28 | 2006-11-28 | Ｔｎｎのための亜鉛フィンガー結合ドメイン |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7833784B2 (https=) |
| EP (1) | EP1963499A4 (https=) |
| JP (1) | JP2009520463A (https=) |
| CA (1) | CA2631422A1 (https=) |
| WO (1) | WO2007062422A2 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7329728B1 (en) * | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
| JP2009520463A (ja) | 2005-11-28 | 2009-05-28 | ザ スクリプス リサーチ インスティテュート | Ｔｎｎのための亜鉛フィンガー結合ドメイン |
| CA2822302A1 (en) | 2006-02-13 | 2007-08-23 | Alethia Biotherapeutics Inc. | Methods of impairing osteoclast differentiation |
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| US20090081786A1 (en) * | 2006-06-30 | 2009-03-26 | Viktoria Kheifets | Peptide sequences for modulation of protein kinase C |
| DK2205749T3 (en) * | 2007-09-27 | 2016-08-22 | Dow Agrosciences Llc | MODIFIED PROTEINS zinc finger, which target the 5-enolpyruvylshikimate-3-phosphate synthase genes |
| ES2594229T3 (es) * | 2008-04-30 | 2016-12-16 | Sanbio, Inc. | Células de regeneración nerviosa con alteraciones en la metilación del ADN |
| US20110318830A1 (en) * | 2008-11-12 | 2011-12-29 | The Regents Of The University Of California | Compositions and methods for re-programming and re-differentiating cells |
| EP2462230B1 (en) | 2009-08-03 | 2015-07-15 | Recombinetics, Inc. | Methods and compositions for targeted gene modification |
| US8956828B2 (en) | 2009-11-10 | 2015-02-17 | Sangamo Biosciences, Inc. | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
| WO2012139045A1 (en) | 2011-04-08 | 2012-10-11 | Gilead Biologics, Inc. | Methods and compositions for normalization of tumor vasculature by inhibition of loxl2 |
| CN112386681A (zh) | 2012-01-27 | 2021-02-23 | 桑比欧公司 | 用于调节血管生成和血管发生的方法和组合物 |
| US11120889B2 (en) | 2012-05-09 | 2021-09-14 | Georgia Tech Research Corporation | Method for synthesizing a nuclease with reduced off-site cleavage |
| US9493562B2 (en) | 2012-07-19 | 2016-11-15 | Alethia Biotherapeutics Inc. | Anti-Siglec-15 antibodies |
| AU2014227653B2 (en) | 2013-03-15 | 2017-04-20 | The General Hospital Corporation | Using RNA-guided foki nucleases (RFNs) to increase specificity for RNA-guided genome editing |
| WO2014186435A2 (en) | 2013-05-14 | 2014-11-20 | University Of Georgia Research Foundation, Inc. | Compositions and methods for reducing neointima formation |
| US11918695B2 (en) | 2014-05-09 | 2024-03-05 | Yale University | Topical formulation of hyperbranched polymer-coated particles |
| WO2015172149A1 (en) | 2014-05-09 | 2015-11-12 | Yale University | Hyperbranched polyglycerol-coated particles and methods of making and using thereof |
| CA3014795A1 (en) | 2016-02-16 | 2017-08-24 | Yale University | Compositions and methods for treatment of cystic fibrosis |
| US11136597B2 (en) | 2016-02-16 | 2021-10-05 | Yale University | Compositions for enhancing targeted gene editing and methods of use thereof |
| WO2017173453A1 (en) | 2016-04-01 | 2017-10-05 | The Brigham And Women's Hospital, Inc. | Stimuli-responsive nanoparticles for biomedical applications |
| US11514331B2 (en) | 2016-04-27 | 2022-11-29 | Massachusetts Institute Of Technology | Sequence-controlled polymer random access memory storage |
| WO2017189870A1 (en) | 2016-04-27 | 2017-11-02 | Massachusetts Institute Of Technology | Stable nanoscale nucleic acid assemblies and methods thereof |
| WO2018081138A1 (en) | 2016-10-24 | 2018-05-03 | Yale University | Biodegradable contraceptive implants |
| US11371023B2 (en) * | 2016-11-22 | 2022-06-28 | Wisconsin Alumni Research Foundation | Artificial transcription factors and uses thereof |
| WO2018112470A1 (en) | 2016-12-16 | 2018-06-21 | The Brigham And Women's Hospital, Inc. | Co-delivery of nucleic acids for simultaneous suppression and expression of target genes |
| WO2018187493A1 (en) | 2017-04-04 | 2018-10-11 | Yale University | Compositions and methods for in utero delivery |
| CN110799205A (zh) | 2017-04-21 | 2020-02-14 | 通用医疗公司 | 利用CRISPR-Cpf1的可诱导、可调和多重的人类基因调节 |
| WO2019094928A1 (en) | 2017-11-10 | 2019-05-16 | Massachusetts Institute Of Technology | Microbial production of pure single stranded nucleic acids |
| EP3713644B1 (en) | 2017-11-20 | 2024-08-07 | University of Georgia Research Foundation, Inc. | Compositions and methods for modulating hif-2a to improve muscle generation and repair |
| CA3100726A1 (en) | 2018-05-17 | 2019-11-21 | The General Hospital Corporation | Ccctc-binding factor variants |
| US11939593B2 (en) | 2018-08-01 | 2024-03-26 | University Of Georgia Research Foundation, Inc. | Compositions and methods for improving embryo development |
| JP7570107B2 (ja) | 2018-08-31 | 2024-10-21 | イェール ユニバーシティー | ドナーオリゴヌクレオチドベースの遺伝子編集を亢進するための組成物および方法 |
| SG11202101984PA (en) | 2018-08-31 | 2021-03-30 | Univ Yale | Compositions and methods for enhancing triplex and nuclease-based gene editing |
| WO2020112195A1 (en) | 2018-11-30 | 2020-06-04 | Yale University | Compositions, technologies and methods of using plerixafor to enhance gene editing |
| EP3914708A1 (en) | 2019-01-24 | 2021-12-01 | Massachusetts Institute Of Technology | Nucleic acid nanostructure platform for antigen presentation and vaccine formulations formed therefrom |
| US11905532B2 (en) | 2019-06-25 | 2024-02-20 | Massachusetts Institute Of Technology | Compositions and methods for molecular memory storage and retrieval |
| AU2020336992A1 (en) | 2019-08-30 | 2022-04-14 | Yale University | Compositions and methods for delivery of nucleic acids to cells |
| CA3193424A1 (en) | 2020-08-31 | 2022-03-03 | Yale University | Compositions and methods for delivery of nucleic acids to cells |
| JP2024502630A (ja) | 2021-01-12 | 2024-01-22 | マーチ セラピューティクス， インコーポレイテッド | コンテキスト依存性二本鎖ｄｎａ特異的デアミナーゼ及びその使用 |
| KR20230147644A (ko) * | 2021-02-04 | 2023-10-23 | 뉴욕 유니버시티 | 천연 기능을 징발하기 위한 내인성 전사 인자에 조작된 징크 핑거의 원활한 통합 |
| WO2023070043A1 (en) | 2021-10-20 | 2023-04-27 | Yale University | Compositions and methods for targeted editing and evolution of repetitive genetic elements |
| WO2023192872A1 (en) | 2022-03-28 | 2023-10-05 | Massachusetts Institute Of Technology | Rna scaffolded wireframe origami and methods thereof |
| JP2025523965A (ja) | 2022-07-22 | 2025-07-25 | ザ・ジョンズ・ホプキンス・ユニバーシティー | デンドリマーが可能にする標的化細胞内ｃｒｉｓｐｒ／ｃａｓシステム送達および遺伝子編集 |
| WO2024081736A2 (en) | 2022-10-11 | 2024-04-18 | Yale University | Compositions and methods of using cell-penetrating antibodies |
| AU2023406926A1 (en) | 2022-12-01 | 2025-06-26 | Yale University | Stimuli-responsive traceless engineering platform for intracellular payload delivery |
| WO2025224715A1 (en) | 2024-04-26 | 2025-10-30 | King Abdullah Univeristy Of Science And Technology | Methods for improving precise genome modification and reducing unwanted mutations by crispr-cas editing |
| WO2026006832A1 (en) | 2024-06-28 | 2026-01-02 | University Of Connecticut | Gene modulation for treating cancer |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| JP3393867B2 (ja) | 1989-11-13 | 2003-04-07 | マサチユーセツツ・インステイテユート・オブ・テクノロジー | ウィルムス腫瘍遺伝子の位置決定と特徴付け |
| DE69534629D1 (de) | 1994-01-18 | 2005-12-29 | Scripps Research Inst | Derivate von zinkfingerproteinen und methoden |
| ATE524545T1 (de) | 1994-08-20 | 2011-09-15 | Gendaq Ltd | Verbesserungen bei oder im zusammenhang mit bindeproteinen zur erkennung von dna |
| US5789538A (en) | 1995-02-03 | 1998-08-04 | Massachusetts Institute Of Technology | Zinc finger proteins with high affinity new DNA binding specificities |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
| US7067617B2 (en) | 2001-02-21 | 2006-06-27 | The Scripps Research Institute | Zinc finger binding domains for nucleotide sequence ANN |
| US20040224385A1 (en) | 2001-08-20 | 2004-11-11 | Barbas Carlos F | Zinc finger binding domains for cnn |
| CA2475276A1 (en) * | 2002-02-07 | 2003-08-14 | The Scripps Research Institute | Zinc finger libraries |
| JP2009520463A (ja) | 2005-11-28 | 2009-05-28 | ザ スクリプス リサーチ インスティテュート | Ｔｎｎのための亜鉛フィンガー結合ドメイン |
-
2006
- 2006-11-28 JP JP2008542539A patent/JP2009520463A/ja active Pending
- 2006-11-28 US US11/564,141 patent/US7833784B2/en not_active Expired - Fee Related
- 2006-11-28 EP EP06846383A patent/EP1963499A4/en not_active Ceased
- 2006-11-28 CA CA002631422A patent/CA2631422A1/en not_active Abandoned
- 2006-11-28 WO PCT/US2006/061289 patent/WO2007062422A2/en not_active Ceased
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