JP2009520463A5 - - Google Patents
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- JP2009520463A5 JP2009520463A5 JP2008542539A JP2008542539A JP2009520463A5 JP 2009520463 A5 JP2009520463 A5 JP 2009520463A5 JP 2008542539 A JP2008542539 A JP 2008542539A JP 2008542539 A JP2008542539 A JP 2008542539A JP 2009520463 A5 JP2009520463 A5 JP 2009520463A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- polypeptide
- heptapeptide
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000002773 nucleotide Substances 0.000 claims 136
- 125000003729 nucleotide group Chemical group 0.000 claims 136
- 108090000765 processed proteins & peptides Proteins 0.000 claims 132
- 229920001184 polypeptide Polymers 0.000 claims 129
- 102000004196 processed proteins & peptides Human genes 0.000 claims 129
- 230000027455 binding Effects 0.000 claims 121
- 239000000203 mixture Substances 0.000 claims 79
- 125000003275 alpha amino acid group Chemical group 0.000 claims 63
- 125000000539 amino acid group Chemical group 0.000 claims 60
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 49
- 239000011701 zinc Substances 0.000 claims 49
- 229910052725 zinc Inorganic materials 0.000 claims 49
- 238000006467 substitution reaction Methods 0.000 claims 27
- 229910052717 sulfur Inorganic materials 0.000 claims 27
- 229910052739 hydrogen Inorganic materials 0.000 claims 24
- 102000040430 polynucleotide Human genes 0.000 claims 23
- 108091033319 polynucleotide Proteins 0.000 claims 23
- 239000002157 polynucleotide Substances 0.000 claims 23
- 229910052722 tritium Inorganic materials 0.000 claims 16
- 108090000623 proteins and genes Proteins 0.000 claims 12
- 239000003937 drug carrier Substances 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 108091023040 Transcription factor Proteins 0.000 claims 10
- 102000040945 Transcription factor Human genes 0.000 claims 10
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- 150000007523 nucleic acids Chemical group 0.000 claims 9
- 230000002103 transcriptional effect Effects 0.000 claims 9
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 7
- 102000003964 Histone deacetylase Human genes 0.000 claims 6
- 108090000353 Histone deacetylase Proteins 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 238000010494 dissociation reaction Methods 0.000 claims 6
- 230000005593 dissociations Effects 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 4
- 230000010076 replication Effects 0.000 claims 4
- 125000003412 L-alanyl group Chemical group [H]N([H])[C@@](C([H])([H])[H])(C(=O)[*])[H] 0.000 claims 3
- 125000000570 L-alpha-aspartyl group Chemical group [H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(*)=O 0.000 claims 3
- 125000002059 L-arginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] 0.000 claims 3
- 125000000010 L-asparaginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C(=O)N([H])[H] 0.000 claims 3
- 125000000415 L-cysteinyl group Chemical group O=C([*])[C@@](N([H])[H])([H])C([H])([H])S[H] 0.000 claims 3
- 125000003338 L-glutaminyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C(=O)N([H])[H] 0.000 claims 3
- 125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 claims 3
- 125000002061 L-isoleucyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])[C@](C([H])([H])[H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 3
- 125000001176 L-lysyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C([H])([H])C([H])([H])C(N([H])[H])([H])[H] 0.000 claims 3
- 125000002842 L-seryl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])O[H] 0.000 claims 3
- 125000000769 L-threonyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])[C@](O[H])(C([H])([H])[H])[H] 0.000 claims 3
- 125000002707 L-tryptophyl group Chemical group [H]C1=C([H])C([H])=C2C(C([C@](N([H])[H])(C(=O)[*])[H])([H])[H])=C([H])N([H])C2=C1[H] 0.000 claims 3
- 125000003580 L-valyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(C([H])([H])[H])(C([H])([H])[H])[H] 0.000 claims 3
- 102100025169 Max-binding protein MNT Human genes 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 238000000302 molecular modelling Methods 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 229910052698 phosphorus Inorganic materials 0.000 claims 3
- 108091006106 transcriptional activators Proteins 0.000 claims 3
- 108091008023 transcriptional regulators Proteins 0.000 claims 3
- 108091006107 transcriptional repressors Proteins 0.000 claims 3
- 230000004568 DNA-binding Effects 0.000 claims 2
- 101710185494 Zinc finger protein Proteins 0.000 claims 2
- 102100023597 Zinc finger protein 816 Human genes 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 108010077805 Bacterial Proteins Proteins 0.000 claims 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 108700001094 Plant Genes Proteins 0.000 claims 1
- 108700005077 Viral Genes Proteins 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 102000037983 regulatory factors Human genes 0.000 claims 1
- 108091008025 regulatory factors Proteins 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74052505P | 2005-11-28 | 2005-11-28 | |
| PCT/US2006/061289 WO2007062422A2 (en) | 2005-11-28 | 2006-11-28 | Zinc finger binding domains for tnn |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009520463A JP2009520463A (ja) | 2009-05-28 |
| JP2009520463A5 true JP2009520463A5 (https=) | 2010-01-14 |
Family
ID=38068069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008542539A Pending JP2009520463A (ja) | 2005-11-28 | 2006-11-28 | Ｔｎｎのための亜鉛フィンガー結合ドメイン |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7833784B2 (https=) |
| EP (1) | EP1963499A4 (https=) |
| JP (1) | JP2009520463A (https=) |
| CA (1) | CA2631422A1 (https=) |
| WO (1) | WO2007062422A2 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7329728B1 (en) * | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
| EP1963499A4 (en) | 2005-11-28 | 2009-04-08 | Scripps Research Inst | ZINCFINGER BINDING DOMAIN FOR TNN |
| CA2822302A1 (en) | 2006-02-13 | 2007-08-23 | Alethia Biotherapeutics Inc. | Methods of impairing osteoclast differentiation |
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| WO2008005487A2 (en) * | 2006-06-30 | 2008-01-10 | The Board Of Trustees Of The Leland | Peptide sequences for modulation of protein kinase c |
| HRP20161004T1 (hr) * | 2007-09-27 | 2016-10-21 | Dow Agrosciences Llc | Tehnološki konstruirani proteini cinkovi prsti koji imaju kao cilj gene za sintazu 5-enolpiruvilshikimat-3-fosfata |
| JP5746016B2 (ja) | 2008-04-30 | 2015-07-08 | サンバイオ，インコーポレイティド | Ｄｎａメチル化における改変を伴う神経再生細胞連邦政府の援助に関する申告適用なし |
| US20110318830A1 (en) * | 2008-11-12 | 2011-12-29 | The Regents Of The University Of California | Compositions and methods for re-programming and re-differentiating cells |
| WO2011017315A2 (en) | 2009-08-03 | 2011-02-10 | Recombinetics, Inc. | Methods and compositions for targeted gene modification |
| US8956828B2 (en) * | 2009-11-10 | 2015-02-17 | Sangamo Biosciences, Inc. | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
| WO2012139045A1 (en) | 2011-04-08 | 2012-10-11 | Gilead Biologics, Inc. | Methods and compositions for normalization of tumor vasculature by inhibition of loxl2 |
| EP2806881A1 (en) | 2012-01-27 | 2014-12-03 | SanBio, Inc. | Methods and compositions for modulating angiogenesis and vasculogenesis |
| US11120889B2 (en) | 2012-05-09 | 2021-09-14 | Georgia Tech Research Corporation | Method for synthesizing a nuclease with reduced off-site cleavage |
| HK1210192A1 (en) | 2012-07-19 | 2016-04-15 | Alethia Biotherapeutics Inc. | Anti-siglec-15 antibodies |
| CN112301024A (zh) | 2013-03-15 | 2021-02-02 | 通用医疗公司 | 使用RNA引导的FokI核酸酶(RFN)提高RNA引导的基因组编辑的特异性 |
| WO2014186435A2 (en) | 2013-05-14 | 2014-11-20 | University Of Georgia Research Foundation, Inc. | Compositions and methods for reducing neointima formation |
| ES2966886T3 (es) | 2014-05-09 | 2024-04-24 | Univ Yale | Partículas recubiertas con poliglicerol hiperramificado y métodos de elaboración y uso de las mismas |
| US11918695B2 (en) | 2014-05-09 | 2024-03-05 | Yale University | Topical formulation of hyperbranched polymer-coated particles |
| US20200308590A1 (en) | 2016-02-16 | 2020-10-01 | Yale University | Compositions and methods for treatment of cystic fibrosis |
| JP2019508037A (ja) | 2016-02-16 | 2019-03-28 | イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔ | 標的化遺伝子編集を増強するための組成物およびその使用方法 |
| US20190117799A1 (en) | 2016-04-01 | 2019-04-25 | The Brigham And Women's Hospital, Inc. | Stimuli-responsive nanoparticles for biomedical applications |
| WO2017189870A1 (en) | 2016-04-27 | 2017-11-02 | Massachusetts Institute Of Technology | Stable nanoscale nucleic acid assemblies and methods thereof |
| WO2017189914A1 (en) | 2016-04-27 | 2017-11-02 | Massachusetts Institute Of Technology | Sequence-controlled polymer random access memory storage |
| WO2018081138A1 (en) | 2016-10-24 | 2018-05-03 | Yale University | Biodegradable contraceptive implants |
| US11371023B2 (en) * | 2016-11-22 | 2022-06-28 | Wisconsin Alumni Research Foundation | Artificial transcription factors and uses thereof |
| WO2018112470A1 (en) | 2016-12-16 | 2018-06-21 | The Brigham And Women's Hospital, Inc. | Co-delivery of nucleic acids for simultaneous suppression and expression of target genes |
| WO2018187493A1 (en) | 2017-04-04 | 2018-10-11 | Yale University | Compositions and methods for in utero delivery |
| WO2018195540A1 (en) | 2017-04-21 | 2018-10-25 | The General Hospital Corporation | Inducible, tunable, and multiplex human gene regulation using crispr-cpf1 |
| US10940171B2 (en) | 2017-11-10 | 2021-03-09 | Massachusetts Institute Of Technology | Microbial production of pure single stranded nucleic acids |
| EP3713644B1 (en) | 2017-11-20 | 2024-08-07 | University of Georgia Research Foundation, Inc. | Compositions and methods for modulating hif-2a to improve muscle generation and repair |
| EP3793584A4 (en) * | 2018-05-17 | 2022-10-26 | The General Hospital Corporation | CCCTC BINDING FACTOR VARIATIONS |
| US11939593B2 (en) | 2018-08-01 | 2024-03-26 | University Of Georgia Research Foundation, Inc. | Compositions and methods for improving embryo development |
| EP3844287B1 (en) | 2018-08-31 | 2024-05-22 | Yale University | Compositions and methods for enhancing donor oligonucleotide-based gene editing |
| CA3111186A1 (en) | 2018-08-31 | 2020-03-05 | Yale University | Compositions and methods for enhancing triplex and nuclease-based gene editing |
| WO2020112195A1 (en) | 2018-11-30 | 2020-06-04 | Yale University | Compositions, technologies and methods of using plerixafor to enhance gene editing |
| WO2020154595A1 (en) | 2019-01-24 | 2020-07-30 | Massachusetts Institute Of Technology | Nucleic acid nanostructure platform for antigen presentation and vaccine formulations formed therefrom |
| US11905532B2 (en) | 2019-06-25 | 2024-02-20 | Massachusetts Institute Of Technology | Compositions and methods for molecular memory storage and retrieval |
| WO2021042060A1 (en) | 2019-08-30 | 2021-03-04 | Yale University | Compositions and methods for delivery of nucleic acids to cells |
| CN116529266A (zh) | 2020-08-31 | 2023-08-01 | 耶鲁大学 | 用于将核酸递送到细胞的组合物和方法 |
| JP2024502630A (ja) | 2021-01-12 | 2024-01-22 | マーチ セラピューティクス， インコーポレイテッド | コンテキスト依存性二本鎖ｄｎａ特異的デアミナーゼ及びその使用 |
| JP2024508668A (ja) * | 2021-02-04 | 2024-02-28 | ニューヨーク ユニバーシティ | 内在性転写因子の天然の機能を利用するための操作されたジンクフィンガーの内在性転写因子へのシームレスな組み込み |
| WO2023070043A1 (en) | 2021-10-20 | 2023-04-27 | Yale University | Compositions and methods for targeted editing and evolution of repetitive genetic elements |
| US20230302423A1 (en) | 2022-03-28 | 2023-09-28 | Massachusetts Institute Of Technology | Rna scaffolded wireframe origami and methods thereof |
| CA3262625A1 (en) | 2022-07-22 | 2024-01-25 | The Johns Hopkins University | ADMINISTRATION OF TARGETED INTRACELLULAR CRISPR/CAS SYSTEM ACTIVATED BY DENDRIMER AND GENE EDITING |
| EP4602078A2 (en) | 2022-10-11 | 2025-08-20 | Yale University | Compositions and methods of using cell-penetrating antibodies |
| JP2025540052A (ja) | 2022-12-01 | 2025-12-11 | イェール ユニバーシティー | 細胞内ペイロード送達用刺激応答性トレースレス操作プラットフォーム |
| WO2025224715A1 (en) | 2024-04-26 | 2025-10-30 | King Abdullah Univeristy Of Science And Technology | Methods for improving precise genome modification and reducing unwanted mutations by crispr-cas editing |
| WO2026006832A1 (en) | 2024-06-28 | 2026-01-02 | University Of Connecticut | Gene modulation for treating cancer |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| JP3393867B2 (ja) | 1989-11-13 | 2003-04-07 | マサチユーセツツ・インステイテユート・オブ・テクノロジー | ウィルムス腫瘍遺伝子の位置決定と特徴付け |
| DE69534629D1 (de) | 1994-01-18 | 2005-12-29 | Scripps Research Inst | Derivate von zinkfingerproteinen und methoden |
| USRE39229E1 (en) | 1994-08-20 | 2006-08-08 | Gendaq Limited | Binding proteins for recognition of DNA |
| US5789538A (en) | 1995-02-03 | 1998-08-04 | Massachusetts Institute Of Technology | Zinc finger proteins with high affinity new DNA binding specificities |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
| US7067617B2 (en) | 2001-02-21 | 2006-06-27 | The Scripps Research Institute | Zinc finger binding domains for nucleotide sequence ANN |
| JP2005500061A (ja) | 2001-08-20 | 2005-01-06 | ザ スクリップス リサーチ インスティテュート | Ｃｎｎについての亜鉛フィンガー結合ドメイン |
| US20060078880A1 (en) * | 2002-02-07 | 2006-04-13 | The Scripps Research Institute | Zinc finger libraries |
| EP1963499A4 (en) | 2005-11-28 | 2009-04-08 | Scripps Research Inst | ZINCFINGER BINDING DOMAIN FOR TNN |
-
2006
- 2006-11-28 EP EP06846383A patent/EP1963499A4/en not_active Ceased
- 2006-11-28 WO PCT/US2006/061289 patent/WO2007062422A2/en not_active Ceased
- 2006-11-28 US US11/564,141 patent/US7833784B2/en not_active Expired - Fee Related
- 2006-11-28 CA CA002631422A patent/CA2631422A1/en not_active Abandoned
- 2006-11-28 JP JP2008542539A patent/JP2009520463A/ja active Pending
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